KR20210097848A - Topical solution for stimulating hair growth - Google Patents

Abstract

The present invention relates to an external use solution for promoting hair growth. More specifically, the present invention relates to an external use solution for promoting hair growth which uses an extract obtained by immersing Pinellia ternate, Syzygium aromaticum, Rubus coreanus, Zanthoxylum piperitum, Vitex rotundifolia, Salvia miltiorrhiza, and Thuja orientalis powder in oil and ethanol, followed by aging the same for a certain period of time, and then the external use solution is directly applied to various hair loss phenomena, thereby having an excellent effect of promoting hair growth and preventing hair loss, and also having no side effects to the human body by using herbal ingredients.

Description

External solution for promoting hair growth {TOPICAL SOLUTION FOR STIMULATING HAIR GROWTH}

The present invention relates to an external solution for promoting hair growth, and more particularly, using an extract extracted by immersing banha, cloves, bokbunja, sancho, manhyeongja, ginseng and white ginseng powder in oil and ethanol, respectively, and aging for a certain period of time. It relates to an external solution for promoting hair growth that has excellent effects of promoting hair growth and preventing hair loss as well as having no side effects to the human body using herbal ingredients by preparing the agent and directly applying it to various hair loss phenomena.

In general, alopecia refers to a condition in which hair is shed and genital or lost, and is also called sokbaljeung (禿髮症) or dokdubyeong (禿頭病). Alopecia areata is a typical example of alopecia.

Hair usually has a lifespan and is constantly falling out and growing again, so hair loss of around 70 to 80 per day is physiological. Alopecia is also called baldness due to an abnormal amount of hair loss and sparse hair, or partial loss of a lot of hair. In severe cases, it may be a symptom of a systemic disease, so you should see a dermatologist.

The causes of such alopecia are usually divided into congenital, which is the cause of heredity, and acquired, which is influenced by other environments. decreased secretion), seborrheic dermatitis and atopic constitution, and physical stimulation. In particular, excessive fat intake and pollution are known to be the main causes.

Currently, as a preventive and therapeutic agent for such alopecia, a method using bay leaf extract as an active ingredient [Korean Patent Publication No. 91 - 106] is disclosed, as well as a hair growth promoting agent using a pine leaf extract [Korean Patent Publication No. 96 - 40346] , a hair growth promoter using quartz porphyry [Korea Patent Publication No. 90-64], and a hair growth promoter using silkworms [Korea Patent Publication No. 90-2757], etc. are disclosed.

However, they have problems such as not being able to obtain the expected hair growth promoting effect and hair loss prevention effect, and thus the need for improvement has emerged.

The present invention prepares an external solution in which various herbal ingredients are immersed in oil and ethanol, respectively, and then aged for a certain period of time, and each resultant extract is mixed. An object of the present invention is to provide an external solution for promoting hair growth that has no side effects.

As can be seen from the experimental results as described above, after about 15 days have elapsed after the external solution according to the present invention is applied to the patient's skin, the hair loss phenomenon is remarkably stopped. In addition, it has an excellent effect in the case of hair loss due to side effects of drug administration and radiotherapy, and when applied to atopic hair loss phenomenon, not only atopic dermatitis itself but also atopic hair loss phenomenon is prevented, and also due to alopecia areata It shows a particularly excellent effect in case of hair loss.

In addition, the external solution according to the present invention has the advantage that there are almost no side effects due to its use because all herbal ingredients are used as active ingredients.

The present invention is characterized as an external solution for promoting hair growth, which contains extracts of a mixture of banja, cloves, bokbunja, sancho, manhyeongja, dansam, and white ginseng as active ingredients.

In addition, the present invention is an oil obtained by immersing 20 to 40 parts by weight of an effective powder consisting of cloves, bokbunja, sancho, manhyeongja, dansam and white ginseng in 100 parts by weight of oil and 100 parts by weight of ethanol, respectively, and aging for 5 to 10 days. It includes a method for preparing an external solution for promoting hair growth, characterized in that the extract and the ethanol extract are mixed in a weight ratio of 1: 10 to 15.

The present invention will be described in more detail as follows.

The present invention relates to an external solution for promoting hair growth in which an extract of a mixture of herbal ingredients such as Banha, cloves, bokbunja, Sancho, Manhyeongja, dansam, and white ginseng is immersed as active ingredients in oil and ethanol, and the resulting extract is mixed. This will be described in more detail along with the characteristics of each required active ingredient according to the manufacturing process as follows. The present invention is first prepared in powder form as herbal ingredients such as Banha, cloves, bokbunja, sancho, manhyeongja, dansam, and white ginseng. Here, if we look at each of these components in more detail, first, Banha (半夏; Pinelliae Rhizoma) is a tuber from which the cork layer of Pinellia ternata Breitenbach (Cheonnamseong and Araceae) has been removed. It is distributed all over the country, and its types include raw banha collected in summer and autumn and dried in the sun, cheongbanha prepared with alum, strong banha prepared with ginger and alum, and cloth made with alum, lime, licorice and ginger. Banha-guk is made by fermenting fermented rice with wheat flour, jeoksodu, and passers-by by making powdered banha and gangbanha into powder. In addition, these banha (半夏) have effects such as humidity control hwadam (燥濕化痰) and river area (降逆止嘔). for external use).

In addition, cloves (丁香; caryophylli Flos) use the buds of cloves [Eugenia caryophyllata Thumb (Myrtaceae)], and in China, it is customarily called as 公丁香. In general, it is mainly produced in Tanzania, Malaysia, Indonesia, etc., and is also cultivated in Guangdong, China. Usually, between September and March of the following year, when the bud changes from green to red, the flower bud is picked and removed. It is used as it is, and its efficacy and effect include on-junggangyeok (溫中降逆) and on-shinzoyang (溫腎助阳), so use 1 to 3g each.

And, as another active ingredient, bokbunja (Rubi Fructus) is used, which is an unripe fruit of the bokbunja strawberry [Rubus coreanus Miq. Cook it a little and then use the dry one. As the efficacy and effect of this ingredient, it has the characteristics of boshin fixation (補腎固精) and accumulating oil (縮尿止遺), so it is abalone (煎服) by 3 to 10g.

Zanthoxyli Fructus is the pericarp of Zanthoxylum piperitum DC or other closely related plants ( Rutaceae). Dry in the sun and use it as it is, or use it with vinegar. In general, it has effects such as warm and middle pain (溫中止痛), humidity control insecticide (燥濕殺蟲), Ikhwapyeongcheon (益火平喘), etc., so an appropriate amount of 3 to 6g is used for external use.

Manhyeong-ja (蔓荊子; Viticis Fructus) is the fruit of Vitex rotundifolia L. fil. It has effects such as dissipation wind fever and cheongni boss (淸利頭目), and it is preferable to take 5 to 10 g per day. Salviae Radix is mainly produced in Anhui, Jiangsu, and Sichuan in China. Take 5 ~ 15g as a decoction. Finally, white jain (Thujae Semen) is the seed of Thuja orientalis Linne (Cupressaceae), which is collected when it matures in early winter, removes the seed coat, and uses only the seed and dried. It is distributed all over the country and China, especially in Jecheon in North Chungcheong Province and Shandong, Hanam, and Hebei in China. These drugs have the effect of conscience and eyesin (養心安神), yunjangtongpyeon (潤腸通便), and generally take 10 to 20g each.

In the present invention, the seven herbal ingredients described above are first powdered in the range of 80 to 100 mesh using a bead mill, and then the herbal medicine is added to each of 100 parts by weight of oil and 100 parts by weight of ethanol. It is characterized in that the active ingredient is extracted by sufficiently immersing 20 to 40 parts by weight of the mixed powder of the ingredients for 5 to 10 days. At this time, the reason that the total content of the herbal ingredients is limited to 20 to 40 parts by weight based on 100 parts by weight of oil and ethanol as described above. This is because, when immersed in excess of 40 parts by weight, improvement in drug efficacy is not expected as well as non-economical problems. In addition, the use ratio of the herbal ingredients used at this time is preferably within the range of 1:10 for each ingredient, and it is also preferable to contain each ingredient in the same weight ratio. Here, the oil is preferably a mixture of one or two or more selected from sesame oil, perilla oil, and white phosphorus oil prepared by a conventional method, in particular, 50% by weight of sesame oil, 20% by weight of perilla oil, and 30% by weight of white phosphorus oil Mixing is more preferable.

The present invention prepares an external solution according to the present invention by mixing an oil extract extracted with an active ingredient by the above method: an ethanol extract in a ratio of 1: 10 to 15. In the case of oil extracts, components with characteristics such as volatile cloves and wild peppers are extracted, and in the case of ethanol extracts, components with characteristics such as banhwa, bokbunja, manhyeongja, ginseng, and white ginseng are extracted. The topical solution is effective in promoting hair growth and preventing hair loss, as well as having no side effects on the human body by using herbal ingredients.

The formulation according to the present invention prepared above is in the form of a liquid formulation for external use, and has a very convenient advantage in its use. Also, it is preferable to use 1,000 to 3,000 mg per day when administering the drug, and therefore, 1 to It is preferable to administer to the skin at a time, about 1 to 3 cc.

Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited by the examples.

Example

First, each of banha, cloves, bokbunja, sancho, manhyeongja, dansam and white ginseng were powdered into a mesh size, and then the same amount was taken and mixed evenly in a stirrer. 30 g of the herbal powder thus mixed was immersed in 100 cc of oil (a mixture of 50% by weight of sesame oil, 20% by weight of perilla oil, and 30% by weight of white phosphorus oil) for 7 days. Then, 30 g of the herbal powder prepared above was again immersed in 100 cc of ethanol for 7 days. Then, 5% by weight of the oil extract, 55% by weight of the ethanol extract, and 40% by weight of purified water were sufficiently mixed in a stirrer to prepare an external solution.

Experimental Example 1: When applied to the hair loss area following drug administration and radiation treatment

Using the external solution for promoting hair growth prepared in the above example, 3 cc each was applied to the hair loss site of 10 patients with hair loss due to weakening or radiation exposure twice a day for 6 months. As a result, it was found that there was an excellent effect such as the generation of new hair roots in 8 patients with hair loss.

Comparative Experimental Example 1: When applied to the hair loss area following drug administration and radiation treatment

Currently, there are hair growth agents on the market in Korea that improve blood flow around the scalp hair follicles and treat them. ), Moxidil (Hanmi Pharm), Minoxidil (Hyundai Pharm), Dr. Mo (Pacific Pharm), Grovis (Kyungin Pharm), and China 101 and China (Hwataek Estrus), but these are weakened or radioactive under the same conditions as above. As a result of applying it to the hair loss area of 10 patients with hair loss due to exposure, it did not show the expected effect. Experimental Example 2: When applied to the hair loss area due to atopic dermatitis

In general, people with atopic constitution are prone to atopic dermatitis as well as atopic alopecia. Therefore, the topical solution prepared in Example 1 was applied to the hair loss area due to atopic dermatitis for the same conditions and period as in Experimental Example 1. As a result, it showed the effect of not only treating atopic dermatitis, but also allowing new hair follicles to grow.

Comparative Experimental Example 2: When applied to the hair loss area due to atopic dermatitis

Using the hair growth agent used in Comparative Experimental Example 1, it was applied to the hair loss area due to atopic dermatitis under the same conditions and period as in Experimental Example 1. applied. As a result, it did not show any effect on the treatment for atopic dermatitis.

Experimental Example 3: When applied to alopecia areata

The topical solution prepared in Example 1 was applied to the hair loss area due to alopecia areata under the same conditions and period as in Experimental Example 1. As a result, a very good effect was exhibited even by visual observation. Comparative Experimental Example 3: When applied to alopecia areata

Apply the hair growth agents used in Comparative Experimental Example 1 to the hair loss site due to alopecia areata under the same conditions and period as in Experimental Example 1 did. As a result, the above formulations did not show any therapeutic effect on alopecia areata visually. Experimental Example 4: Experiment on skin toxicity

The external solution for promoting hair growth according to the present invention did not show any side effects or toxicity because it was composed of all herbal herbal ingredients such as banja, cloves, bokbunja, sancho, manhyeongja, dansam, and white ginseng.

Claims (4)

An external solution for promoting hair growth, characterized in that it contains extracts of banja, cloves, bokbunja, sancho, manhyeongja, ginseng and white ginseng as active ingredients.
The external use for promoting hair growth according to claim 1, wherein the active ingredients are each contained in the same weight ratio.
[Claim 3] The external solution for hair growth promotion according to claim 1 or 2, wherein the active ingredient is contained in a mixture of oil extract and ethanol extract in a weight ratio of 1: 10 to 15.
The external solution for hair growth promotion according to claim 3, wherein the oil component in the oil extract is at least one selected from sesame oil, perilla oil, and white phosphorus oil.