CN102793640A - Vitiligo covering composition and preparation method thereof - Google Patents
Vitiligo covering composition and preparation method thereof Download PDFInfo
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- CN102793640A CN102793640A CN2012103035304A CN201210303530A CN102793640A CN 102793640 A CN102793640 A CN 102793640A CN 2012103035304 A CN2012103035304 A CN 2012103035304A CN 201210303530 A CN201210303530 A CN 201210303530A CN 102793640 A CN102793640 A CN 102793640A
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Abstract
A deep-sea seaweed extract having a vitiligo covering effect is characterized in that: raw materials of the extract include 60-80 parts of blue algae, 40-60 parts of green algae, 25-40 parts of brown algae, 15-30 parts of red algae, 12-26 parts of fucus, and 5-15 parts of beets; and the preparation method includes extracting a crude extract A by ultrasonic extraction, then preparing a fine extract B by using a supercritical CO2 fluid extraction method, and obtaining white powder of the deep-sea algae extract after recrystallization. Daubing the deep-sea seaweed extract of the invention by external use, a color similar to the color of skin can be quickly formed on white spots to cover the white spots, the skin is colored safely, and the effect is naturally beautiful, very uniform and lasting. Under normal circumstances, the coloring can last for 5-15 days.
Description
Technical field
The invention belongs to the cosmetic field that vitiligo hides; Be specifically related to a kind of vitiligo and hide composition and method of making the same, this vitiligo covering compositions has the white macula of covering and beautifies skin function, and it is with respect to existing covering agent; Painted fast, painted lasting, and effect is very natural.
Background technology
Vitiligo is a kind of pigmented dermatosis of common pilosity.It is characteristic that this disease forms white macula with local or general property depigmentation, is a kind of acquired limitation or general property depigmentation of skin, is the common skin diseases of an influence beauty treatment, is prone to diagnosis, and treatment is difficult.To be posteriority lose the white patch of the limitation that takes place because of skin pigment takes off to vitiligo, makes local skin be white macula appearance, medically usually this pathological changes depigmentation.Vitiligo all has generation all over the world, China has ten million people morbidity approximately, and sickness rate is about 1%-2%, is one of world's dermatosis three big pertinacious diseases.
At present, the therapy for vitiligo method is varied, comprising Western medicine therapy, herbal treatment, the combined therapy of Chinese and Western medicine and physical therapy therapy etc.Yet because leucoderma disease is because of complicacy, its pathogeny is clear and definite fully as yet at present, therefore, treats quite difficulty of vitiligo effectively, and this has greatly influenced the life quality of patients with vitiligo.
In numerous therapy of vitiligo schemes, the most frequently used method comprises that oral Fructus Psoraleae combines the therapy of ultraviolet radiation.For example, people such as Bian Ertang, " Chinese medicine adds long wave ultraviolet therapy vitiligo 70 examples and analyzes "; " practical Chinese medicine journal; The 3rd phase of nineteen ninety-five discloses the Therapeutic Method that oral Chinese medicine combines the irradiation long wave ultraviolet, and prescriptions of Chinese medicine wherein is the Radix Astragali, the Radix Angelicae Dahuricae, Fructus Psoraleae, Radix Polygoni Multiflori Preparata Radix Salviae Miltiorrhizae.Liu Cuijie etc.; " vifiligo pill is united the leukodermic observation of curative effect of narrow spectrum ultraviolet B radiation irradiation treatment " " 2008 national combination of Chinese and Western medicine skin cypridology academic meeting paper compilation "; Also disclose the Therapeutic Method that oral vifiligo pill combines ultraviolet B radiation, the main component of vifiligo pill wherein is Fructus Psoraleae, the Radix Astragali, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Cyperi, Semen Persicae, Radix Salviae Miltiorrhizae, Zaocys, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni, Rhizoma Dioscoreae, Rhizoma Zingiberis, Radix Gentianae and Fructus Tribuli.Though above-mentioned Therapeutic Method has certain effect, it has all utilized ultraviolet, and well-knownly is; The vitiligo affected part lacks the protection system of normal skin; Very low for ultraviolet defensive ability/resistance ability, therefore, contact ultraviolet for a long time and not only can not play good therapeutic effect; Possibly increase damage on the contrary, severe patient even possibly cause skin carcinoma to skin.
Occur with head, face, neck and limb end because leukodermic affected part is many, therefore, dressing is difficult to hide patient's white macula, and this has greatly influenced the daily routines of patients with vitiligo.In the last few years, utilized dihydroxyacetone and skin can form artificial brown's principle, domestic-developed numerous treatments or hide leukodermic medicine or cosmetic composition.99114078.8 disclose a kind of externally-applied medicinal composition, its ethanol extraction and laurocapram by mustine hydrochlcride, dihydroxyacetone, Fructus Psoraleae and Flos Carthami is formed.200410070380.2 disclose a kind of leukoderma covering agent of long-lasting water proof and wearable, it is made up of food coloring, essence, dihydroxyacetone, ethanol and water.200510002653.4 disclose a kind of treatment skin pigment reduction external used medicine, comprised dihydroxyacetone, vinegar, ethanol, water and essence.200610137625.8 disclose a kind of treatment skin pigment reduction external used medicine equally, it is processed by ethanol, Radix Polygoni Multiflori, Fructus Psoraleae, the Flos Sophorae Immaturus, dihydroxyacetone.
Though the leukodermic effect of covering of can both playing to a certain extent of above-mentioned therapy of vitiligo or covering compositions; But, because dihydroxyacetone and skin keratin effect need 8 hours time, therefore; Patients with vitiligo often need use in night; Could form at second day stable painted, thereby do not influence its work or daily routines, this has greatly influenced ease of use.Secondly; Dead skin cells in dihydroxyacetone and the keratodermatitis interacts and forms brown is a kind of of short duration coloring reaction; General this color can not continue to surpass 3-5 days time; Along with painted variation, tangible contrast can appear in the color of affected part color and normal skin, and needs of patients is smeared Masking sol adjustment again.
Secondly, the unstability of dihydroxyacetone in aqueous solution restricted the development that contains the dihydroxyacetone compositions, and dihydroxyacetone is very sensitive to light, heat, humidity, air and alkaline pH value.As time goes on, the color of dihydroxyacetone goods can be deepened gradually, and is accompanied by a kind of strange taste; Make that user is difficult to accept; And hiding leukodermic effect is not remarkable especially, and the aberration that is difficult to remedy is arranged, and be difficult to painted hot summer; Coloring effect is unstable, also has much human that allergic phenomena is arranged.More than all development and application that all seriously limits this type covering agent.
Therefore, seek a kind of both safety, stable again to have very good effect and painted persistent vitiligo to hide product be the urgent demand that faces at present.
Summary of the invention
In order to overcome the deficiency of prior art, the inventor is through hiding discovering of product to vitiligo for many years, has surprising effect aspect the vitiligo covering from the active substance of some deep-sea extracting algae; After external is applied to the vitiligo affected part, not only can form the color close fast at the white macula place and then hide white macula with the colour of skin, and dye safety; Effect is natural beauty more; Very evenly and lasting, generally speaking, paintedly can continue 5-15 days.The inventor also further finds, some active factors in the extract also has preserves moisture, skin moistening, reparation skin, improves the effect of oils and fats distribution etc., and therefore, life-time service product of the present invention has certain skin metabolism and improves function.Form because this extract is the pure natural substance extraction, it is as safe as a house, the toxic and side effects that has no.
Therefore; An object of the present invention is to provide a kind of deep-sea Sargassum extract with vitiligo covering effect, the raw material of this extract is: cyanophyceae 60-80 part, chlorella 40-60 part, Brown algae 25-40 part, red algae 15-30 part, Fucus Vesiculosus 12-26 part, Radix Betae 5-15 part.This preparation method of extract is for obtaining crude extract A with ultrasonic extraction earlier; Utilize supercritical C02 fluid extraction legal system to get extract B then; Obtain the extract that the white crystalline powder mixture is the application through recrystallization again, we are referred to as " the shining skin of ACS algae alive is plain ".
Another purpose of the application provides a kind of method for preparing with deep-sea Sargassum extract of vitiligo covering effect, and its concrete preparation process is:
1) take by weighing raw material cyanophyceae 60-80 part, chlorella 40-60 part, Brown algae 25-40 part, red algae 15-30 part, Fucus Vesiculosus 12-26 part, Radix Betae 5-15 part respectively by formula ratio, subsequent use;
2) raw material with steps A joins in the extraction pot, and adds the water of 10 to 15 times of weight of raw material, regulates pH value 3-4 and soaks after 24 hours; Boiled 5 to 8 hours; Natural cooling carries out continuous ultrasound then and extracted 6 to 12 hours and filtered, and concentrated extracting solution obtains crude extract A;
3) utilize the supercritical carbon dioxide extraction technology that crude extract A is further extracted, wherein the temperature of extraction is 35-55 ℃, and pressure is 8-30MP, obtains extract B after 10 hours;
4) at 35-45 ℃, stir down extract B is dissolved in 95% the ethanol, when crude extract B dissolves fully, move to rapidly and lower the temperature in the ice-water bath, separate out white powder, be deep-sea of the present invention Sargassum extract (ACS live the shining skin of algae plain).
Another purpose of the application provides a kind of compositions with vitiligo covering effect, it is characterized in that said composition comprises deep-sea of the present invention Sargassum extract, water and cosmetics or pharmaceutically acceptable carrier.
The common cosmetics and the instance of pharmaceutically acceptable carrier include but not limited to: Percutaneous absorption enhancer, solubilizing agent, cosolvent, antioxidant, chelating agen, antiseptic, surfactant, base oil, flavouring agent, pigment etc. or their combination.
The compositions that the present invention has vitiligo covering effect can be common liquid in this area or ointment form, for example, and solution, Emulsion, ointment etc.
Description of drawings
Fig. 1-2 uses the effect contrast figure of compositions for the back of the hand portion
Fig. 3-4 uses the effect contrast figure of compositions for cervical region
Fig. 5-7 does not use compositions respectively the time, uses the effect contrast figure after 3 hours and 15 days
The specific embodiment
Extract embodiment 1
1) take by weighing 60 parts of cyanophyceaes, 40 parts of chlorellas, 25 parts of Brown algaes, 15 parts of red algaes, 12 parts of Fucus Vesiculosus, 5 parts of Radix Betaes, subsequent use;
2) raw material with steps A joins in the extraction pot, and adds the water of 10 times of weight of raw material, regulates pH value 3 and soaks after 24 hours, boils 5 hours, and natural cooling carried out supersound extraction 6 hours and filtration then, and concentrated extracting solution obtains crude extract A;
3) utilize the supercritical carbon dioxide extraction technology that crude extract A is further extracted, wherein the temperature of extraction is 35 ℃, and pressure is 8MP, obtains extract B;
4) at 35 ℃, stir down extract B is dissolved in 95% the ethanol, when crude extract B dissolves fully, move to rapidly and lower the temperature in the ice-water bath, separate out white powder, be deep-sea of the present invention Sargassum extract.
Extract embodiment 2
1) take by weighing 65 parts of raw material cyanophyceaes, 48 parts of chlorellas, 26 parts of Brown algaes, 18 parts of red algaes, 14 parts of Fucus Vesiculosus, 7 parts of Radix Betaes respectively by formula ratio, subsequent use;
2) raw material with steps A joins in the extraction pot, and adds the water of 10 times of weight of raw material, regulates pH value 3 and soaks after 24 hours, boils 5 hours, and natural cooling carried out supersound extraction 8 hours and filtration then, and concentrated extracting solution obtains crude extract A;
3) utilize the supercritical carbon dioxide extraction technology that crude extract A is further extracted, wherein the temperature of extraction is 40 ℃, and pressure is 8MP, obtains extract B;
4) at 36 ℃, stir down extract B is dissolved in 95% the ethanol, when crude extract B dissolves fully, move to rapidly and lower the temperature in the ice-water bath, separate out white powder, be deep-sea of the present invention Sargassum extract.
Extract embodiment 3
1) take by weighing 70 parts of raw material cyanophyceaes, 55 parts of chlorellas, 30 parts of Brown algaes, 25 parts of red algaes, 18 parts of Fucus Vesiculosus, 9 parts of Radix Betaes respectively by formula ratio, subsequent use;
2) raw material with steps A joins in the extraction pot, and adds the water of 14 times of weight of raw material, regulates pH value 4 and soaks after 24 hours, boils 7 hours, and natural cooling carried out supersound extraction 10 hours and filtration then, and concentrated extracting solution obtains crude extract A;
3) utilize the supercritical carbon dioxide extraction technology that crude extract A is further extracted, wherein the temperature of extraction is 45 ℃, and pressure is 25MP, obtains extract B;
4) at 38 ℃, stir down extract B is dissolved in 95% the ethanol, when crude extract B dissolves fully, move to rapidly and lower the temperature in the ice-water bath, separate out white powder, be deep-sea of the present invention Sargassum extract.
Extract embodiment 4
1) take by weighing 75 parts of raw material cyanophyceaes, 58 parts of chlorellas, 35 parts of Brown algaes, 27 parts of red algaes, 22 parts of Fucus Vesiculosus, 12 parts of Radix Betaes respectively by formula ratio, subsequent use;
2) raw material with steps A joins in the extraction pot, and adds the water of 14 times of weight of raw material, regulates pH value 4 and soaks after 24 hours, boils 8 hours, and natural cooling carried out supersound extraction 12 hours and filtration then, and concentrated extracting solution obtains crude extract A;
3) utilize the supercritical carbon dioxide extraction technology that crude extract A is further extracted, wherein the temperature of extraction is 50 ℃, and pressure is 30MP, obtains extract B;
4) at 40 ℃, stir down extract B is dissolved in 95% the ethanol, when crude extract B dissolves fully, move to rapidly and lower the temperature in the ice-water bath, separate out white powder, be deep-sea of the present invention Sargassum extract.
Extract embodiment 6
1) take by weighing 80 parts of raw material cyanophyceaes, 60 parts of chlorellas, 40 parts of Brown algaes, 30 parts of red algaes, 26 parts of Fucus Vesiculosus, 15 parts of Radix Betaes respectively by formula ratio, subsequent use;
2) raw material with steps A joins in the extraction pot, and adds the water of 15 times of weight of raw material, regulates pH value 4 and soaks after 24 hours, boils 8 hours, and natural cooling carried out supersound extraction 11 hours and filtration then, and concentrated extracting solution obtains crude extract A;
3) utilize the supercritical carbon dioxide extraction technology that crude extract A is further extracted, wherein the temperature of extraction is 55 ℃, and pressure is 30MP, obtains extract B;
4) at 45 ℃, stir down extract B is dissolved in 95% the ethanol, when crude extract B dissolves fully, move to rapidly and lower the temperature in the ice-water bath, separate out white powder, be deep-sea of the present invention Sargassum extract.
Embodiment 7
The extract of embodiment 1 and water according to 1: 5 mixed of weight ratio, are obtained the aqueous solution of deep-sea Sargassum extract.
Embodiment 8
The extract of embodiment 1, water, Fructus Citri Limoniae essence according to 1: 8: 0.01 mixed of weight ratio, are obtained the compositions of deep-sea Sargassum extract.
Embodiment 9
The extract of embodiment 2, water, ascorbic acid according to 1: 6: 0.02 mixed of weight ratio, are obtained the compositions of deep-sea Sargassum extract.
Embodiment 10
With the extract of embodiment 5, water, dehydrated alcohol, EDTA according to weight ratio 1: 4: 0.5: 0.03 mixed obtains the compositions of deep-sea Sargassum extract.
Embodiment 11
With the extract of embodiment 6, water, methyl parahydroxybenzoate, flavoring orange essence, sodium thiosulfate according to weight ratio 1: 8: 0.01: 0.02: 0.03 mixed obtains the compositions of deep-sea Sargassum extract.
Be effect and the experiment of local irritation safety evaluatio and the data of compositions of the present invention below:
Experiment one: local excitation test
Adopt 20 of mices, back QUMAO area 2cmX2cm.Be divided into 2 groups at random: the aqueous solution group of blank group, embodiment 7,10 every group.Smear the water of equivalent and the aqueous solution of embodiment 7, every day 2 times, continuous 30 days respectively in 2 groups of mice depilation districts.During this period, each organizes mice depilation in per 3 days once.Experimental result shows that blank group mouse skin hair color is constant, and uses the mice of the aqueous solution of embodiment 7 to begin to deepen smearing 2 hours skin colors, and color tends towards stability and is dark brown after using 3 days.When 30 day experimental period finished, having any different in two groups of mouse test positions, red, any dermal toxicity effect such as swell, come out in a rash does not appear all on color.
Test two: coloring effect test
Get 0.5 milliliter of the aqueous solution of the embodiment of the invention 7; On hand, cervical region and the shirtfront of patients with vitiligo, smear evenly respectively with the fine, soft fur pen; After smearing 3 hours, observe the dye effect; The result shows, all forms the color close with skin at hand, cervical region and anterior part of chest, and concrete effect is referring to accompanying drawing 1-4.
Experiment three: painted endurance life test
Smear the aqueous solution of embodiment 7 at patient's arm, observe respectively and smear change color preceding, after 3 hours and 15 days, concrete effect is referring to accompanying drawing 5-7.
Experiment four: stability test
The aqueous solution of getting embodiment 7 is packed in the open glass bottle; Subsequently the open glass bottle is positioned in the constant temperature humidity chamber; Adjust the temperature to 55 degree, humidity is 75% to carry out accelerated stability test, after 3 months, 6 months, 1 year, take out the variation of observing solution and carry out staining test.Experimental result shows that solution is having no variation aspect color, clarity, abnormal smells from the patient and the coloring effect behind the accelerated stability test.
Claims (6)
1. deep-sea Sargassum extract with vitiligo covering effect; The raw material that it is characterized in that this extract is: cyanophyceae 60-80 part, chlorella 40-60 part, Brown algae 25-40 part, red algae 15-30 part, Fucus Vesiculosus 12-26 part, Radix Betae 5-15 part; Its preparation method is for obtaining crude extract A with ultrasonic extraction earlier; Utilize the supercritical carbon dioxide extraction legal system to get extract B then, promptly obtain the deep-sea Sargassum extract of white powder again through recrystallization.
2. one kind prepares the said method with deep-sea Sargassum extract of vitiligo covering effect of claim 1, it is characterized in that comprising following step:
1) take by weighing raw material cyanophyceae 60-80 part, chlorella 40-60 part, Brown algae 25-40 part, red algae 15-30 part, Fucus Vesiculosus 12-26 part, Radix Betae 5-15 part respectively by formula ratio, subsequent use;
2) raw material with steps A joins in the extraction pot, and adds the water of 10 to 15 times of weight of raw material, regulates pH value 3-4 and soaks after 24 hours; Boiled 5 to 8 hours; Natural cooling carries out continuous ultrasound then and extracted 6 to 12 hours and filtered, and concentrated extracting solution obtains crude extract A;
3) utilize the supercritical carbon dioxide extraction technology that crude extract A is further extracted, wherein the temperature of extraction is 35-55 ℃, and pressure is 8-30MP, obtains extract B after 10 hours;
4) at 35-45 ℃, stir down extract B is dissolved in 95% the ethanol, when crude extract B dissolves fully, move to rapidly and lower the temperature in the ice-water bath, separate out white powder, be deep-sea of the present invention Sargassum extract.
3. compositions with vitiligo covering effect is characterized in that comprising the deep-sea Sargassum extract of claim 1.
4. the compositions with vitiligo covering effect according to claim 3 is characterized in that further comprising water and cosmetics or pharmaceutically acceptable carrier.
5. the compositions with vitiligo covering effect according to claim 4 is characterized in that cosmetics and pharmaceutically acceptable carrier are Percutaneous absorption enhancer, solubilizing agent, cosolvent, antioxidant, chelating agen, antiseptic, surfactant, base oil, flavouring agent, pigment etc. or their combination.
6. the compositions with vitiligo covering effect according to claim 5 is characterized in that said composition is the form of solution, Emulsion or ointment etc.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168051A (en) * | 2015-09-16 | 2015-12-23 | 任海锋 | Skin color coverage foundation |
| CN105250166A (en) * | 2015-09-25 | 2016-01-20 | 北京盖百霖白癜风遮盖医学研究院 | Vitiligo covering composition capable of realizing beautiful and natural covering |
| CN109771317A (en) * | 2019-03-08 | 2019-05-21 | 唐凯 | A kind of covering composition of leucoderma and scar hickie |
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| WO2006126675A1 (en) * | 2005-05-27 | 2006-11-30 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Agent for external application to the skin |
| CN102078279A (en) * | 2010-12-28 | 2011-06-01 | 海南京润珍珠生物技术股份有限公司 | BB Cream (Blemish Balm Cream) added with dense silica-coated pearl powder |
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2012
- 2012-08-24 CN CN 201210303530 patent/CN102793640B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2006126675A1 (en) * | 2005-05-27 | 2006-11-30 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Agent for external application to the skin |
| CN102078279A (en) * | 2010-12-28 | 2011-06-01 | 海南京润珍珠生物技术股份有限公司 | BB Cream (Blemish Balm Cream) added with dense silica-coated pearl powder |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168051A (en) * | 2015-09-16 | 2015-12-23 | 任海锋 | Skin color coverage foundation |
| CN105250166A (en) * | 2015-09-25 | 2016-01-20 | 北京盖百霖白癜风遮盖医学研究院 | Vitiligo covering composition capable of realizing beautiful and natural covering |
| CN105250166B (en) * | 2015-09-25 | 2018-08-31 | 北京盖百霖白癜风遮盖医学研究院 | It is a kind of to cover more beautiful, natural leucoderma covering composition |
| CN109771317A (en) * | 2019-03-08 | 2019-05-21 | 唐凯 | A kind of covering composition of leucoderma and scar hickie |
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| CN102793640B (en) | 2013-07-10 |
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Effective date of registration: 20170605 Address after: 100068, 106, Fengtai District, Majiabao East Road, Beijing ocean new natural 720 room Patentee after: Beijing three li Biotechnology Co., Ltd. Address before: 100068, 106, Fengtai District, Majiabao East Road, Beijing ocean new natural 720 room Patentee before: Hu Fagang |
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