KR20210096123A - Nlrp 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물 - Google Patents

Nlrp 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물 Download PDF

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KR20210096123A
KR20210096123A KR1020217017180A KR20217017180A KR20210096123A KR 20210096123 A KR20210096123 A KR 20210096123A KR 1020217017180 A KR1020217017180 A KR 1020217017180A KR 20217017180 A KR20217017180 A KR 20217017180A KR 20210096123 A KR20210096123 A KR 20210096123A
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alkyl
aryl
compound
hydroxy
optionally substituted
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쇼미르 고쉬
개리 글릭
제이슨 카츠
윌리엄 로쉬
한스 마틴 자이델
둥-밍 선
샹카르 벤카트라만
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노파르티스 아게
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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KR1020217017180A 2018-11-13 2019-11-11 Nlrp 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물 Pending KR20210096123A (ko)

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
US201862760248P 2018-11-13 2018-11-13
US201862760244P 2018-11-13 2018-11-13
US201862760209P 2018-11-13 2018-11-13
US62/760,209 2018-11-13
US62/760,244 2018-11-13
US62/760,248 2018-11-13
US201862768811P 2018-11-16 2018-11-16
US62/768,811 2018-11-16
US201862769151P 2018-11-19 2018-11-19
US201862769165P 2018-11-19 2018-11-19
US62/769,165 2018-11-19
US62/769,151 2018-11-19
US201962795919P 2019-01-23 2019-01-23
US62/795,919 2019-01-23
US201962796356P 2019-01-24 2019-01-24
US201962796361P 2019-01-24 2019-01-24
US62/796,361 2019-01-24
US62/796,356 2019-01-24
US201962836577P 2019-04-19 2019-04-19
US201962836585P 2019-04-19 2019-04-19
US201962836575P 2019-04-19 2019-04-19
US62/836,585 2019-04-19
US62/836,577 2019-04-19
US62/836,575 2019-04-19
US201962895595P 2019-09-04 2019-09-04
US62/895,595 2019-09-04
PCT/US2019/060770 WO2020102096A1 (en) 2018-11-13 2019-11-11 Compounds and compositions for treating conditions associated with nlrp activity

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US (1) US20230031406A1 (https=)
EP (2) EP3880660B1 (https=)
JP (2) JP7730759B2 (https=)
KR (1) KR20210096123A (https=)
CN (2) CN113166065B (https=)
AU (1) AU2019379109B2 (https=)
BR (1) BR112021008969A2 (https=)
CA (1) CA3114918A1 (https=)
CL (1) CL2021001228A1 (https=)
CO (1) CO2021006075A2 (https=)
CR (1) CR20210235A (https=)
DK (1) DK3880660T3 (https=)
EC (2) ECSP21033236A (https=)
ES (1) ES3042546T3 (https=)
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HR (1) HRP20251344T1 (https=)
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JO (1) JOP20210105B1 (https=)
LT (1) LT3880660T (https=)
MA (1) MA54229B1 (https=)
MX (1) MX2021005529A (https=)
MY (1) MY206733A (https=)
PE (1) PE20211698A1 (https=)
PH (1) PH12021500025A1 (https=)
PL (1) PL3880660T3 (https=)
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RS (1) RS67257B1 (https=)
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EP3649112A1 (en) * 2017-07-07 2020-05-13 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
EP3668843A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
MA49903A (fr) 2017-08-15 2020-06-24 Inflazome Ltd Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3
UY37848A (es) 2017-08-15 2019-03-29 Inflazome Ltd Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3
WO2019092171A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
CN111315733A (zh) 2017-11-09 2020-06-19 英夫拉索姆有限公司 新颖磺酰胺甲酰胺化合物
US11905252B2 (en) 2018-03-02 2024-02-20 Inflazome Limited Compounds
CA3105521A1 (en) 2018-07-20 2020-01-23 F. Hoffmann-La Roche Ag Sulfonimidamide compounds as inhibitors of interleukin-1 activity
JP7392169B2 (ja) * 2019-11-12 2023-12-05 成都百裕制薬股▲ふん▼有限公司 アミド誘導体及びその調製方法並びに医薬における応用
PH12022551767A1 (en) * 2020-01-22 2023-11-29 Hoffmann La Roche Sulfonimidamide compounds as nlrp3 modulators
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
CN117279903A (zh) * 2021-02-10 2023-12-22 杭州英创医药科技有限公司 作为nlrp3抑制剂的化合物
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
CN116635373A (zh) * 2021-05-10 2023-08-22 成都百裕制药股份有限公司 酰胺衍生物及其应用
CN116917282A (zh) * 2021-05-10 2023-10-20 成都百裕制药股份有限公司 酰胺衍生物及其应用
CN116635374B (zh) * 2021-05-10 2025-05-06 康百达（四川）生物医药科技有限公司 酰胺衍生物及其应用
CN114989058B (zh) * 2022-06-02 2024-04-16 中国科学院成都生物研究所 一种手性氯代砜亚胺类化合物及其衍生物的制备方法
CN115974745B (zh) * 2022-12-27 2025-06-03 瑞石生物医药有限公司 一类含引达省的化合物及其医药用途
CN116253664A (zh) * 2023-02-01 2023-06-13 山东海科创新研究院有限公司 基于双液相微乳化缩合工艺的accp制备方法
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies

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