JP7730759B2 - Ｎｌｒｐ活性に関連する病態を治療するための化合物及び組成物 - Google Patents

Ｎｌｒｐ活性に関連する病態を治療するための化合物及び組成物

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JP7730759B2
JP7730759B2 JP2021525223A JP2021525223A JP7730759B2 JP 7730759 B2 JP7730759 B2 JP 7730759B2 JP 2021525223 A JP2021525223 A JP 2021525223A JP 2021525223 A JP2021525223 A JP 2021525223A JP 7730759 B2 JP7730759 B2 JP 7730759B2
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alkyl
aryl
hydroxy
halo
optionally substituted
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JP2022507065A (ja
JPWO2020102096A5 (https=
JP2022507065A5 (https=
Inventor
ゴーシュ，ショミアー
グリック，ギャリー
カッツ，ジェイソン
ルーシュ，ウィリアム
マーティン ザイデル，ハンス
シェン，ドン－ミン
ヴェンカトラマン，シャンカー
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ノバルティス アーゲー
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Urology & Nephrology (AREA)
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  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
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  • Communicable Diseases (AREA)
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JP2021525223A 2018-11-13 2019-11-11 Ｎｌｒｐ活性に関連する病態を治療するための化合物及び組成物 Active JP7730759B2 (ja)

Priority Applications (1)

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JP2024091521A JP2024113083A (ja) 2018-11-13 2024-06-05 Ｎｌｒｐ活性に関連する病態を治療するための化合物及び組成物

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
US201862760248P 2018-11-13 2018-11-13
US201862760244P 2018-11-13 2018-11-13
US201862760209P 2018-11-13 2018-11-13
US62/760,209 2018-11-13
US62/760,244 2018-11-13
US62/760,248 2018-11-13
US201862768811P 2018-11-16 2018-11-16
US62/768,811 2018-11-16
US201862769151P 2018-11-19 2018-11-19
US201862769165P 2018-11-19 2018-11-19
US62/769,165 2018-11-19
US62/769,151 2018-11-19
US201962795919P 2019-01-23 2019-01-23
US62/795,919 2019-01-23
US201962796356P 2019-01-24 2019-01-24
US201962796361P 2019-01-24 2019-01-24
US62/796,361 2019-01-24
US62/796,356 2019-01-24
US201962836577P 2019-04-19 2019-04-19
US201962836585P 2019-04-19 2019-04-19
US201962836575P 2019-04-19 2019-04-19
US62/836,585 2019-04-19
US62/836,577 2019-04-19
US62/836,575 2019-04-19
US201962895595P 2019-09-04 2019-09-04
US62/895,595 2019-09-04
PCT/US2019/060770 WO2020102096A1 (en) 2018-11-13 2019-11-11 Compounds and compositions for treating conditions associated with nlrp activity

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JP2022507065A JP2022507065A (ja) 2022-01-18
JPWO2020102096A5 JPWO2020102096A5 (https=) 2022-11-22
JP2022507065A5 JP2022507065A5 (https=) 2022-11-22
JP7730759B2 true JP7730759B2 (ja) 2025-08-28

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JP2024091521A Pending JP2024113083A (ja) 2018-11-13 2024-06-05 Ｎｌｒｐ活性に関連する病態を治療するための化合物及び組成物

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US (1) US20230031406A1 (https=)
EP (2) EP3880660B1 (https=)
JP (2) JP7730759B2 (https=)
KR (1) KR20210096123A (https=)
CN (2) CN113166065B (https=)
AU (1) AU2019379109B2 (https=)
BR (1) BR112021008969A2 (https=)
CA (1) CA3114918A1 (https=)
CL (1) CL2021001228A1 (https=)
CO (1) CO2021006075A2 (https=)
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JO (1) JOP20210105B1 (https=)
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EP3649112A1 (en) * 2017-07-07 2020-05-13 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
EP3668843A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
MA49903A (fr) 2017-08-15 2020-06-24 Inflazome Ltd Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3
UY37848A (es) 2017-08-15 2019-03-29 Inflazome Ltd Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3
WO2019092171A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
CN111315733A (zh) 2017-11-09 2020-06-19 英夫拉索姆有限公司 新颖磺酰胺甲酰胺化合物
US11905252B2 (en) 2018-03-02 2024-02-20 Inflazome Limited Compounds
CA3105521A1 (en) 2018-07-20 2020-01-23 F. Hoffmann-La Roche Ag Sulfonimidamide compounds as inhibitors of interleukin-1 activity
JP7392169B2 (ja) * 2019-11-12 2023-12-05 成都百裕制薬股▲ふん▼有限公司 アミド誘導体及びその調製方法並びに医薬における応用
PH12022551767A1 (en) * 2020-01-22 2023-11-29 Hoffmann La Roche Sulfonimidamide compounds as nlrp3 modulators
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
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