KR20210068408A - 가용성 bcma에 대한 항체 - Google Patents

가용성 bcma에 대한 항체 Download PDF

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Publication number
KR20210068408A
KR20210068408A KR1020217008023A KR20217008023A KR20210068408A KR 20210068408 A KR20210068408 A KR 20210068408A KR 1020217008023 A KR1020217008023 A KR 1020217008023A KR 20217008023 A KR20217008023 A KR 20217008023A KR 20210068408 A KR20210068408 A KR 20210068408A
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KR
South Korea
Prior art keywords
sbcma
antibody
seq
set forth
monoclonal antibody
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Pending
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KR1020217008023A
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English (en)
Korean (ko)
Inventor
아그니에츠카 키엘체프스카
브라이언 찬
Original Assignee
암젠 인크
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Application filed by 암젠 인크 filed Critical 암젠 인크
Publication of KR20210068408A publication Critical patent/KR20210068408A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • G01N33/57426—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020217008023A 2018-09-28 2019-09-27 가용성 bcma에 대한 항체 Pending KR20210068408A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862738997P 2018-09-28 2018-09-28
US62/738,997 2018-09-28
PCT/US2019/053433 WO2020069303A1 (en) 2018-09-28 2019-09-27 Antibodies against soluble bcma

Publications (1)

Publication Number Publication Date
KR20210068408A true KR20210068408A (ko) 2021-06-09

Family

ID=68296657

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217008023A Pending KR20210068408A (ko) 2018-09-28 2019-09-27 가용성 bcma에 대한 항체

Country Status (11)

Country Link
US (1) US11505614B2 (https=)
EP (1) EP3856781A1 (https=)
JP (2) JP7596260B2 (https=)
KR (1) KR20210068408A (https=)
CN (1) CN112703204B (https=)
AR (1) AR116548A1 (https=)
BR (1) BR112021005669A2 (https=)
MA (1) MA53732A (https=)
TW (1) TW202028239A (https=)
UY (1) UY38393A (https=)
WO (1) WO2020069303A1 (https=)

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* Cited by examiner, † Cited by third party
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LT3819007T (lt) * 2019-11-11 2024-10-10 Amgen Research (Munich) Gmbh Dozavimo režimas, skirtas anti-bcma agentams
JP2025542567A (ja) * 2022-11-04 2025-12-26 ミンク セラピューティクス，インコーポレイティッド Ｂ細胞成熟抗原（ｂｃｍａ）キメラ抗原受容体インバリアントナチュラルキラーｔ細胞及びその用途
WO2024168192A1 (en) * 2023-02-10 2024-08-15 Celgene Corporation Assessment of bcma in biological samples
CN119529089B (zh) * 2023-08-28 2025-11-18 菲鹏生物股份有限公司 一种抗生长刺激表达基因2蛋白的抗体及其应用

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Also Published As

Publication number Publication date
TW202028239A (zh) 2020-08-01
JP2024147571A (ja) 2024-10-16
US11505614B2 (en) 2022-11-22
JP7596260B2 (ja) 2024-12-09
WO2020069303A1 (en) 2020-04-02
BR112021005669A2 (pt) 2021-06-22
MA53732A (fr) 2022-01-05
JP2022501389A (ja) 2022-01-06
EP3856781A1 (en) 2021-08-04
CN112703204B (zh) 2024-10-01
CN112703204A (zh) 2021-04-23
US20200102398A1 (en) 2020-04-02
AR116548A1 (es) 2021-05-19
UY38393A (es) 2020-03-31

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