KR20210010682A - Cleansing composition for women's vagina comprising natural - Google Patents

Abstract

The present invention relates to a composition for feminine washes comprising a natural extract. The present invention relates to a composition for feminine washes having excellent preventive and therapeutic effects of vaginal diseases, and at the same time, including natural extracts, thereby causing little irritation when used, providing a healthier environment, and having excellent antibacterial activity.

Description

Composition for feminine cleansing agent containing natural extract {CLEANSING COMPOSITION FOR WOMEN'S VAGINA COMPRISING NATURAL}

The present invention relates to a composition for a feminine cleanser comprising a natural extract. More specifically, it relates to a composition for a female cleanser for the prevention and treatment of diseases related to the vagina of women, including a natural extract as a main component.

A woman's vagina is the passageway between the vulva and the uterus, and is the most humid and warm place in a woman's body. Therefore, since it is an environment suitable for bacteria or fungi, which are the main causes of vaginitis, there is a high possibility of disease. Under normal conditions, many lactobacilli inhabit the vagina and make the vagina weakly acidic to suppress the growth of pathogens or fungi, but women who take antibiotics for a long time, take contraceptives for a long time, use tampons or loops, or are pregnant, childbirth, lactation, menopause, etc. When the balance of the vagina is broken due to changes in the balance of hormones, vaginitis may occur due to the proliferation of opportunistic pathogens that normally inhibit growth under normal conditions in the vagina. As vaginitis, bacterial vaginosis, Candida vaginitis, Trichomonas vaginitis, and atrophic vaginitis have been reported.

The most common disease is bacterial vaginosis, which is caused by Gardnerella vaginalis. This vaginitis is caused by overgrowth of anaerobic bacteria that existed in less than 1% while the number of lactic acid bacteria in the vagina decreases due to an imbalance in vaginal acidity. Although the causative factor that causes changes in the normal vaginal flora is not known, it is estimated that repeated alkalizing of the vagina with frequent intercourse or vaginal washing plays a role. When the lactic acid bacteria that produce hydrogen peroxide, which should normally be present, are lost, the regeneration of the normal vaginal flora becomes difficult, so recurrence of bacterial vaginosis often occurs.

In addition, women with bacterial vaginosis have a higher frequency of serious sequelae, such as pelvic inflammatory disease (PID), post-abortion PID, postoperative cuff cellulitis, and abnormal cervical papillae. There is a risk of premature labor, preterm labor, chorioamnionitis, and endometritis after cesarean section.

Candida vaginitis, a common disease along with bacterial vaginitis, is a disease in which the fungus Candida albicans lives in the moist vagina and causes inflammation.About 75% of women live with the vagina more than once during their lives. It is a common disease in which 45% of women suffer from candidal vaginitis of the vulva and have more than two recurrences per year. Candida (mainly Candida albicans), which is normally held in the oral, intestine, and vagina of a healthy person, is extremely weak due to a cold, diabetes, or AIDS when the female hormone status is abnormal due to pregnancy or long-term use of oral contraceptives. When it does, it causes an infection. Obesity, antibiotic allergy, and taking corticosteroids used to treat arthritis can also cause the disease. In the case of outbreaks caused by the administration of antibiotics, antibiotics are caused by killing beneficial lactic acid bacteria in the vagina, and in this case, the possibility of recurrence is high. It can also occur if you wear tight girdles or pants that prevent ventilation, or if you wear wet panties because you do not dry the vulva after bathing, or if you do not change pads frequently during menstruation. Only 50% of women living with Candida albicans in the vagina have symptoms. The main symptoms are itching due to increased coldness and inflammatory reactions in the skin, and skin peeling or pus occurs depending on the type and severity of the disease or secondary bacterial infection. There are differences, such as coming out. Characteristic symptoms include dark and white secretions, and the vulva is very sensitive to nerves, causing pain or sometimes swelling and inflammation. There are burning sensation, dyspareunia, swelling, and vulvar pain, and clinical findings include erythema, congestion, epidermal detachment, vesicles, pustules, and the like.

To prevent such female diseases, cleaners (vaginal cleaners) and vulvar cleaners are often used. As a topical cleaning agent generally used to prevent vaginitis, a transparent or lotion that is synthesized by sulfonating fatty acids or distilled lauryl alcohol and synthesizing emollients, thickeners, nutrients, foaming agents, organic disinfectants, etc. lotion) type has been shipped. There are also surfactants with detergency and povidone-iodine as pharmaceuticals as main components. Povidone-iodine, a disinfectant by the above chemical synthesis, is known to be effective in the prevention and treatment of Candida vaginitis, Trichomonas vaginitis and other vaginal infections, but itching sensation, burning sensation due to hypersensitivity symptoms such as iodine or damage to the mucous membrane, skin ulcers It is known that it may cause contact dermatitis, and may cause hypothyroidism by increasing the level of inorganic iodine in the vagina or total iodine in the blood.

As a conventional technique for solving the side effects caused by the use of disinfectants as pharmaceuticals as described above, in the case of healthy women, the vaginal acidity is maintained at pH 3.2 by secretion of lactic acid by beneficial microorganisms in the vagina. Based on the fact that harmful bacteria are inhibited from proliferation or killed, a buffered solution formulation of pH 3.5 with lactose as a main component and lactoserum extracted from milk has been proposed, but this is not a feminine cleanser, but rather a normal vaginal pH. It is a vaginal acidity maintenance agent that keeps it in a state, and it is difficult to expect fundamental treatment and prevention.

Therefore, it can keep the vaginal pH in a normal state, which can be effective in preventing such diseases related to the vagina of women, and it is a hypoallergenic and easy-to-use feminine cleaner or vulvar cleaner. There is a need to develop feminine cleansers that can provide a healthier environment.

KR 10-2015-0148530 B1

It is an object of the present invention to provide a composition for a feminine cleansing agent comprising a natural extract effective in preventing or treating women's related diseases.

Another object of the present invention is to provide a composition for a feminine cleaner having excellent antimicrobial activity, which is excellent in preventing and treating diseases related to the vagina, and at the same time, there is little irritation when used, including a natural extract, and can provide a healthier environment. Is to do.

In order to achieve the above object, a composition for a feminine cleanser comprising a natural extract according to an embodiment of the present invention is propolis; Collagen peptide; Black yeast; Chitosan; Angelicae extract, centella extract, grapefruit seed extract, and a natural extract selected from the group consisting of a mixture thereof; And water-soluble vitamins; Includes.

The composition is for the prevention or treatment of diseases related to the vagina, and the diseases related to the vagina include vaginosis, vaginal dryness, vaginal mycosis and hypochondriasis.

The composition includes those having an antimicrobial effect on the fungus Candida albicans.

The water-soluble vitamins include those selected from the group consisting of vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, and biotin.

The composition further includes other additives, and the other additives include excipients, disintegrants and lubricants.

The composition includes a composition that is a cleaning composition or a tablet for vaginal insertion.

The composition further comprises a second natural extract, and the second natural extract includes one selected from the group consisting of beetroot extract, island body extract, and mixtures thereof.

Hereinafter, the present invention will be described in more detail.

As used herein, the term'extract' has the meaning commonly used as a crude extract in the art as described above, but broadly includes a fraction obtained by further fractionating the extract. That is, the extract includes not only those obtained using the above-described extraction solvent, but also those obtained by additionally applying a purification process thereto. For example, fractions obtained by passing the extract through an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatography (made for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through the purification method are also included in the extract of the present invention.

The composition for a feminine cleanser comprising a natural extract according to an embodiment of the present invention is propolis; Collagen peptide; Black yeast; Chitosan; Angelicae extract, centella extract, grapefruit seed extract, and a natural extract selected from the group consisting of a mixture thereof; And water-soluble vitamins; Includes.

The propolis is a natural antibacterial substance as a mixture of resinous substances collected from plants such as tree shoots and sap by bees. It has antibacterial, bactericidal and immune activation, immune function strengthening, cell activation and cell regeneration, anti-allergic, gene damage defense, blood vessel strengthening, antioxidant, and anticancer drug side effects. Also, propolis works to control symptoms.

The propolis is included for antibacterial, anti-inflammatory and antioxidant effects, and natural extracts are included for skin trouble relief, moisturizing, skin softening, skin elasticity, skin regeneration, improved blood circulation, and soothing sensitive skin.

That is, as propolis is included in the composition for feminine cleansing, it may exhibit antibacterial, anti-inflammatory and antioxidant effects for the prevention or treatment of vaginal-related diseases, but this may cause skin irritation. And, in the present invention, this problem is to be solved by additionally including a natural extract.

Black yeast (Aureobasidium pullulans) contains a large amount of beta-glucan and is known to be excellent in moisturizing, elasticity, and atopic pruritus. Since beta-glocans constitute the cell wall of yeast, amino acids that act as natural moisturizing factors add elasticity as well as moisturization, and excellent skin affinity can increase immunity.

Chitosan is a material processed so that chitin contained in crustaceans is absorbed by the human body. It has the effect of discharging heavy metals and pollutants in the body, and can increase excellent antibacterial and moisturizing effects.

Angelica has known various pharmacological effects. Representatively, it has been found that anemia treatment, sedation, analgesic effect, tonic, menstrual pain treatment, menopausal symptom treatment, abdominal pain treatment, wound treatment, arthritis treatment, diabetic hypertension treatment. lost. It is known that there are various substances of the coumarin family in Angelica, and it was reported long ago (1967) that a large amount of decursin and decursinol angelate is contained, and recently, dihydropyrano coumarin-based substances have been reported to have anticancer effects. did.

Centella asiatica extract is a plant that originates in the tropical regions of the Indian Ocean and grows ideally at an altitude of 600 meters above sea level in humid and shady areas, and is also called gotu kola, indian pennywork or tiger grass. These centella asiaticoside, madecasosside, asiatic acid and madecassic acid, called triterpenoids (saponins), are present in the body, and they regulate collagen synthesis in the human body. It is known to promote blood circulation by strengthening the vestibule, and to help improve memory.

Grapefruits Seed is a natural antioxidant extracted from grapefruit seeds. It is a natural sterilization, disinfection, and preservative. Medically, it is used as an internal medicine for bacterial or bacterial infections, as well as external medicine for wounds, otitis media, and sore throat. In addition, it has a strong sterilizing effect against decaying and pathogenic microorganisms such as bacteria and fungi.

The black yeast, chitosan, angelica extract, centella extract and grapefruit seed extract may be included in an amount of 0.1 to 1.5% by weight, respectively, based on the total weight, and are not limited to the above examples.

The natural extract refers to an extract extracted by a general extraction method that can be extracted by an expert in the art, and the extract may be used in a powder form, but is not limited to the above example.

The composition is for the prevention or treatment of diseases related to the vagina, and the diseases related to the vagina include vaginosis, vaginal dryness, vaginal mycosis and hypochondriasis.

The vaginal-related disease refers to an infection or inflammatory condition of the vagina characterized by symptoms such as vaginal discharge, smell, burning, itching, dyspareunia, and urinary pain.

Vaginal dyslexia is a symptom of sagging the muscles around the vagina and the muscles at the entrance to the vagina, and the fascia relaxes due to the slowing of the vaginal mucosa.Because the elasticity of the vagina decreases, the sexual sensation may be weakened, leading to insensitivity during sexual intercourse. Comes to the situation.

Vaginal dryness is a phenomenon in which vaginal secretions that should normally come out due to a decrease in blood flow and blood circulation around the uterus and vagina are reduced or the epithelial cells of the vagina and urethra that lose elasticity and flexibility become thinner when female hormones decrease. do. If the vaginal dryness lasts for a long time, the immunity decreases, and you may be exposed to various diseases, and there is a risk of urinary incontinence and uterine dislocation due to decreased contractility.

Vaginal mycosis is a vaginitis caused by Candida and is one of the most common vaginitis that causes inflammation when Candida lives in the moist vagina. The main symptom is coldness and an inflammatory reaction to the skin, which makes you feel itchy. In addition, there are differences, such as peeling of the skin or pus, depending on the type and severity of the disease and secondary bacterial infection.

Hypogonadism is a type of circulation disorder caused by poor circulation of the entire body or parts of the body, and is a symptom of an increase in the amount of cold, a secretion secreted in the female genitals. The reason for this secretion is a natural phenomenon to protect the genital organs from various harmful bacteria, but when the amount of the secretion increases, it is heavily buried in the underwear, and the amount is always moist and moist, leading to a smell, and the most common cause of vaginitis. Candida albicans is susceptible to exposure.

The present invention is for the prevention and treatment of diseases as described above, and can be used for both prevention and treatment of diseases related to the vagina, and is not limited to the above examples.

The composition includes those having an antimicrobial effect on the fungus Candida albicans.

The fungi include Candida albicans, Candidan tropicalis, and Candida glabrata, among which Candida albicans is 85-90% of the most common cause of vaginitis. Occupies the degree.

However, as the incidence of vulvovaginitis caused by Candida other than Candida albicans is gradually increasing, Candida fungi are present not only in the vagina, but also in the oral cavity, bronchi, and intestines, and are commonly found in healthy bodies, thus exhibiting the antimicrobial activity of the fungi. You need a composition that represents.

Preferably, the antimicrobial activity is capable of inhibiting or inhibiting the development and life function of the fungi Candida albicans, Candida tropicalis, and Candida glabrata. will be.

The water-soluble vitamins include those selected from the group consisting of vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, and biotin.

The water-soluble vitamin may be selected from the group consisting of vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, and biotin, but preferably includes vitamin C, that is, ascorbic acid. , Is not limited to examples.

The water-soluble vitamin, preferably ascorbic acid, is included in order to exhibit an anti-inflammatory effect by maintaining the pH in the vagina to be weakly acidic. In general, the composition for feminine cleansers used sodium salt, lactic acid buffer solution, etc. in order to maintain the pH in the vagina as weakly acidic. While this is an ingredient added to maintain a weakly acidic pH in the vagina, ascorbic acid in the present invention has antioxidant effects, growth and recovery of skin tissue, prevention of cancer-causing substances, etc., as well as maintaining a weakly acidic environment in the vagina. Can show the effect of.

The composition further includes other additives, and the other additives include excipients, disintegrants and lubricants.

The excipient is selected from the group consisting of Prosolve, starch, microcrystalline cellulose, mannitol, lactose, low-substituted hydroxypropyl cellulose, sucralose, and mixtures thereof, specifically Prosolve (Prosolve SMCC90), starch (Starch 1500 ), microcrystalline cellulose (microcrystalline cellulose PH102), and mannitol (mannitol 160C), but are not limited to the above examples.

The disintegrant is selected from the group consisting of crospovidone, sodium starch gluconate, croscarmellose sodium, polysorbate, sodium lyryl sulfate, and mixtures thereof, and more specifically crospovidone (crospovidone CL-SF), It is not limited to the above example.

The lubricant is selected from the group consisting of magnesium stearate, light anhydrous silicic acid, talc, glyceryl behenate, and mixtures thereof, and more specifically magnesium stararate, and is not limited to the above examples.

Preferably, according to an embodiment of the present invention, the composition for a feminine cleanser is 0.2 to 3.0% by weight of propolis, 0.1 to 1.5% by weight of collagen peptide, 0.1 to 1.5% by weight of black yeast, 0.1 to 1.5% by weight of chitosan, 0.1 to 1.5% by weight of angelica extract To 1.5% by weight, centella asiatica extract 0.1 to 1.5% by weight, grapefruit seed extract 0.1 to 1.5% by weight, water-soluble vitamins 0.5 to 5% by weight, Prosolve 15 to 30% by weight, starch 15 to 30% by weight, microcrystalline cellulose 10 to 20 It may include weight %, mannitol 20 to 40 weight %, crospovidone 1 to 10 weight %, and magnesium stearate 0.5 to 5 weight %.

When the composition for feminine cleansing agent contains less than 0.2% by weight of propolis, a problem of insufficient antibacterial, anti-inflammatory and antioxidant effects occurs, and when it contains more than 3.0% by weight, problems of rash and shortness of breath may occur. .

When the collagen peptide is included in an amount of less than 0.1% by weight based on the total weight, there is a problem that the elasticity enhancement and skin regeneration effect is insufficient, and when it is included in more than 1.5% by weight, acne occurrence and allergic reactions are caused. have.

Therefore, when used as a composition for a feminine cleanser within the above range, it is possible to provide a composition for a feminine cleanser having excellent moisturizing, skin elasticity, antibacterial and antifungal effects for the prevention or treatment of diseases related to the vagina.

The composition includes a composition that is a cleaning composition or a tablet for vaginal insertion.

The present invention is a composition for a feminine cleanser, the formulation may be a formulation for parenteral administration, and in one embodiment, a solution, a gel, a cleaning composition, a tablet for vaginal insertion, a suppository form, a cream, an ointment, a dressing It may be a liquid formulation such as a solution, a spray, and other coating agents, a solution type, a suspension type, an emulsion type, etc., and a sterilized aqueous solution, a non-aqueous solution, a suspension, an emulsion, a freeze-dried preparation, a suppository, a cream, an ointment, Jelly, foam, detergents or vaginal inserts, preferably liquids, gels, cleaning compositions, and tablets for vaginal insertion may be included.

The formulation may be prepared by adding, for example, a dissolution aid, an emulsifier, a buffer for pH adjustment, etc. to sterile water. As the non-aqueous solvent or suspension solvent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate may be used.

As the suppository, witepsol, macrogol, tween 61, cacao butter, laurin paper, glycero gelatin, and the like may be used. More specifically, the composition for feminine cleaner may include a carrier for formulating it in addition to the antibacterial composition. As the carrier, a binder, a lubricant, a suspension solvent, a solubilizing agent, a buffering agent, a preservative, a lubricant, an isotonic agent, a stabilizer, a dispersing agent, a suspending agent, a coloring agent, a fragrance, and the like may be used.

According to an embodiment of the present invention, the preferred dosage of the composition for feminine cleansing agent varies depending on the condition and weight of the patient, the degree of disease, the drug type, the route and duration of administration, but may be appropriately selected by those skilled in the art.

According to an embodiment of the present invention, the dosage of the composition for feminine cleansing agent may be appropriately selected by those skilled in the art in consideration of the administration method, the age, sex and weight of the user, and the severity of the disease. In one embodiment, based on the composition, it may be administered in 0.0001mg/kg to 1000mg/kg, and in order to be more effective, 0.01mg/kg to 100mg/kg. Administration may be administered once a day, or may be divided several times. The above dosage does not in any way limit the scope of the present invention.

In addition, the composition for feminine cleansing agent according to an embodiment of the present invention may further include a compound or natural extract having inhibitory activity against known vaginal-related diseases in addition to the antibacterial composition.

The composition for a feminine cleaner according to an embodiment of the present invention may be applied directly to animals including humans. The animal is a group of organisms corresponding to plants, mainly ingesting organic matter as nutrients, and refers to that the digestion, excretion and respiratory organs are differentiated, and in detail, it may be a vertebrate, more specifically, a mammal. Specifically, the mammal may be a human.

The composition further comprises a second natural extract, and the second natural extract includes one selected from the group consisting of beetroot extract, island body extract, counter electrode extract, and mixtures thereof.

Preferably, the composition for feminine cleansing agent of the present invention may further include those selected from the group consisting of guret extract, island body extract, counter electrode extract, and mixtures thereof in addition to the natural extract.

Angelica dahurica BENTH (Angelica dahurica BENTH) is a biennial or triennial plant of the parsley family, a dicotyledonous plant, and has a thick rhizome, and the stem stands upright and grows to a height of 1.5m while pruning branches. The leaves are divided twice in the shape of a feather, and the broken pieces are oval or lanceolate, with a sharp tip, and the edges are unevenly split or serrated. It is distributed nationwide, and it grows in wet places such as mountain streams. It has the effect of pain relief and small bells, and the applied diseases include headache, migraine, various neuralgia, toothache, and abdominal pain.

Island body (Dystaenia takesimana (NAK.) KITAGAWA.) is a perennial plant of the Aperaceae family of dicotyledons. It is a perennial plant that grows all over Ulleungdo. It is said to be ragweed that pigs eat well in Ulleungdo. It is a perennial plant that grows up to 2m tall and has 4-5 nodes. The stem is hollow and the leaves are dislocated. The petiole is long and the bottom part is wide, so it wraps around the main stem. In oriental medicine, the root is used as a medicinal herb, and it is effective in cheongyeol, detoxification, sanpung, sodam, and hagi.

The Euphorbia pekinensis Rupr. is a perennial plant growing in the mountains and reaches 80 cm in height, has thick roots, and grows upright. Leaves grow alternately, obtuse or acute, acute, the back side is white and there are fine serrations at the edge. The flower is greenish yellow and hangs at the end of the main stem in June. Fruits are capsules, with wart-like projections, and seeds are wide oval and flat outside.

As the above extract, island body extract, and counter electrode extract are additionally included, moisturizing, skin elasticity, antibacterial and antifungal effects for the prevention or treatment of diseases related to the vagina are increased due to the mixing action between the respective constituents.

In addition, when the natural extract is used in combination, it provides excellent moisturizing, skin elasticity, antibacterial and antifungal effects for the prevention or treatment of diseases related to the vagina, and at the same time provides a composition for feminine cleansers with little irritation by natural extracts. Makes it possible.

Preferably, according to an embodiment of the present invention, the composition for feminine cleansing agent is 0.2 to 3.0% by weight of propolis, 0.1 to 1.5% by weight of collagen peptide, 0.1 to 1.5% by weight of beetroot extract, 0.1 to 1.5% by weight of island body extract, and counteract extract 0.1 to 1.5% by weight, black yeast 0.1 to 1.5% by weight, chitosan 0.1 to 1.5% by weight, Angelicae extract 0.1 to 1.5% by weight, centella extract 0.1 to 1.5% by weight, grapefruit seed extract 0.1 to 1.5% by weight, water-soluble vitamin 0.5 to 5% by weight, 15 to 30% by weight of Prosolve, 15 to 30% by weight of starch, 10 to 20% by weight of microcrystalline cellulose, 20 to 40% by weight of mannitol, 1 to 10% by weight of crospovidone, and 0.5 to 5% by weight of magnesium stearate. Can include.

According to the composition for a feminine cleansing agent comprising the natural extract of the present invention, it exhibits the effect of preventing or treating diseases related to the vagina, and at the same time, including the natural extract, there is little irritation when used, and a healthier environment can be provided.

1 is a photograph of a result of measuring pH after dissolving a composition for a female cleanser according to an embodiment of the present invention in purified water.
2 is an experimental result of the moisturizing effect of a composition for a female cleanser according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein.

[Production Example: Preparation of composition for feminine cleaner]

One. Preparation of composition for feminine cleaner

Propolis, collagen peptide, black yeast, chitosan, angelica extract, centella asiatica extract and grapefruit seed extract were pulverized with a mixer, and apologized through a 30 mesh sieve to prepare the first mixture, excipients Prosolve SMCC90, starch Starch1500 , Microcrystalline cellulose PH102, mannitol 160C, ascorbic acid as a water-soluble vitamin, and crospovidone CL-SF as a disintegrant were put in a 30 mesh sieve and apologized to prepare a second mixture.

The prepared first mixture and the second mixture were mixed, and 0.89% by weight of magnesium stearate as a lubricant was added thereto, followed by mixing and tableting to prepare a composition for a feminine cleaner.

More specific content was prepared as shown in Table 1 below.

Experiment number Propolis Collagen peptide Black yeast Chitosan Angelica extract Centella asiatica extract Grapefruit seed extract IV 1 0.5 0.3 0.1 0.1 0.1 0.1 0.1 IV 2 0.5 0.3 0.3 0.3 0.3 0.3 0.3 IV 3 One 0.3 One One One One One IV 4 One 0.3 1.5 1.5 1.5 1.5 1.5 IV 5 3 0.3 1.5 1.5 1.5 1.5 1.5 IV 6 0.4 0.3 - 0.3 0.3 0.3 0.3 IV 7 0.4 0.3 0.3 - 0.3 0.3 0.3 IV 8 0.4 0.3 0.3 0.3 - 0.3 0.3 IV 9 0.4 0.3 0.3 0.3 0.3 - 0.3 IV 10 0.4 0.3 0.3 0.3 0.3 0.3 -

(Unit: wt%, excipient Prosolve SMCC90 25.56 wt%, microcrystalline cellulose PH102 14.84 wt%, mannitol 160C 29.67 wt%, water-soluble vitamin ascorbic acid 1.13 wt%, disintegrant crospovidone CL-SF 4.45 wt%, The remaining starch Starch1500)

2. Composition for feminine cleansing agent containing the second natural extract

Using the same ingredient content and manufacturing method as the method for preparing the composition for female cleanser (IV 2), a female cleanser in a specific content as shown in Table 2 below by additionally adding the second natural extract, Guritdae extract, island body extract, and Daegeuk extract. A composition for use was prepared.

Experiment number Honeysuckle extract Island Body Extract Counter electrode extract IT 1 0.05 0.05 0.05 IT 2 0.3 0.3 0.3 IT 3 0.5 0.5 0.5 IT 4 One One One IT 5 1.5 1.5 1.5 IT 6 2 2 2

(Unit: wt%)

[Experimental Example 1: Evaluation of antibacterial activity against Candada albicans]

After spreading the pre-cultured Candida albicans (Candida albicans) in a plate medium for measuring the disk diffusion method (Sabouraud Dextrose Agar.Difco.USA) by 100 µl and smeared, the prepared experiment numbers IV 1 to 10 and IT After dropping a sample at a concentration of 5 mg/disc on a sterilized paper disc of compositions for feminine cleaners 1 to 6, it was placed on the medium.

As a control for this, an antifungal agent, Itraconazol, was dropped onto a paper disk at a concentration of 100 µg/disk and then placed on a medium. After culturing the plate medium at 28° C. for 48 hours, the size of the growth inhibition ring (Clean Zone) was measured. The results are shown in Table 3 below.

As shown in Table 3 below, the composition for a female cleanser of the present invention exhibited a strong growth inhibition effect compared to itraconazole (antifungal agent, patent 10-0592066) as a control group.

Growth inhibition ring size (mm) IV 1 30 IV 2 27 IV 3 26 IV 4 31 IV 5 27 IV 6 34 IV 7 32 IV 8 34 IV 9 32 IV 10 31 IT 1 29 IT 2 28 IT 3 25 IT 4 24 IT 5 27 IT 6 29 Control 35

As shown in Table 3, the effect of reducing the size of the growth inhibition ring (Clean Zone) was excellent in IT 1 to IT 6, which additionally includes a beetroot extract, an island body extract, and a counter electrode extract, and the best in IT 3 to IT 6 It was confirmed that the effect of reducing the size of the growth inhibition ring (Clean Zone) appeared.

Accordingly, it was confirmed that the composition for a feminine cleanser of the present invention has a strong antibacterial activity against Candida albicans.

[Experimental Example 2: Itching reduction effect test]

80 women aged 20 to 40 who feel itchy were selected and divided into 16 groups of 5 people, and the composition for feminine cleaners of experiment numbers IV 1 to 10 and IT 1 to 6 was diluted in water and used for 10 days. After that, the anti-itch effect was evaluated, and the results are shown in Table 4. The score ranges from 10 points to 1 point, and the higher the score, the better the anti-itch effect.

Anti-itch effect IV 1 6.2 IV 2 7.4 IV 3 7.6 IV 4 5.6 IV 5 7.4 IV 6 3.2 IV 7 4.0 IV 8 3.4 IV 9 3.8 IV 10 4.2 IT 1 6.8 IT 2 7.2 IT 3 8.6 IT 4 8.8 IT 5 7.4 IT 6 7.0

As shown in Table 4 above, it was confirmed that the itching reduction effect was excellent in IT 1 to IT 6, which additionally included the beetroot extract, the island body extract, and the counter electrode extract, and the most excellent itching reducing effect was shown in IT 3 to IT 6. .

[Experimental Example 3: Skin irritation occurrence test]

For the same 16 groups as in Experimental Example 2, in addition to the anti-itch effect, a questionnaire on whether or not stimulation occurred was additionally conducted, and the results are shown in Tables 5 and 6 below.

[Evaluation standard]

◎: No stimulation at all

○: almost no stimulation

△: There is a slight irritation, so it is preferable not to use it for sensitive mucous membranes.

Х: Severe irritation, cannot be used

IV 1 IV 2 IV 3 IV 4 IV 5 IV 6 IV 7 IV 8 IV 9 IV 10 One ○ ○ ○ △ ○ △ △ Х Х △ 2 ○ ○ ○ ○ ○ Х Х Х △ Х 3 ○ ○ ○ △ ○ Х △ Х Х Х 4 ○ ○ ○ ○ ○ △ △ △ Х Х 5 △ ○ ◎ ○ ◎ △ Х Х Х △

IT 1 IT 2 IT 3 IT 4 IT 5 IT 6 One ○ ○ ◎ ○ ○ △ 2 ○ ○ ◎ ◎ △ △ 3 △ △ ○ ◎ ○ △ 4 △ △ ○ ◎ △ △ 5 △ ○ ◎ ○ △ △

According to Tables 5 and 6, in the case of IV 1 to 5, it was evaluated that there was little skin irritation, whereas in the case of IV 6 and IV 10, skin irritation occurred.

In the case of IT 1 to IT 6, overall skin irritation was evaluated as not severe, and IT 3 and IT 4 received the best evaluation.

[Experimental Example 4: Moisturizing property evaluation]

For the same 16 groups as in Experimental Example 2, a questionnaire survey was additionally conducted on moisturizing properties in addition to whether or not stimulation occurred, and the results are shown in FIG. 2 below.

As shown in FIG. 2 below, it was confirmed that the moisturizing performance was excellent in IT 1 to IT 6, which additionally includes a copper stalk extract, an island body extract, and a counter electrode extract, and the best moisturizing effect was shown in IT 3 to IT 6.

[Experimental Example 5: Evaluation of cleaning power]

For the same 16 groups as in Experimental Example 2, in addition to the anti-itch effect, a questionnaire survey on detergency, cleanliness, and aroma when used as a female cleanser was further conducted, and the results are shown in Tables 7 and 8 below.

The score ranges from 10 points to 1 point, and the higher the score, the better detergency, cleanliness, fragrance, and overall preference.

IV 1 IV 2 IV 3 IV 4 IV 5 IV 6 IV 7 IV 8 IV 9 IV 10 Cleaning power 6.8 8.4 8.0 6.8 8.0 5.2 3.6 6.0 5.4 6.0 Cleanliness 6.4 8.2 7.8 6.2 8.2 5.8 3.2 5.8 5.6 5.4 incense 6.2 8.4 8.2 7.4 8.0 3.0 6.0 5.2 6.0 5.6 Overall preference map 6.2 8.4 8.0 7 8.1 5 3.2 5.2 5.8 5.8

IT 1 IT 2 IT 3 IT 4 IT 5 IT 6 Cleaning power 7.8 8.0 9.0 8.8 8.0 7.2 Cleanliness 7.4 8.2 8.8 9.2 7.6 6.8 incense 7.2 8.4 8.2 8.4 7.4 7.2 Overall preference map 7.2 8.2 8.8 9.0 8.0 7.0

According to Tables 7 and 8, IV1 to IV3 and IV 5 received excellent evaluations in detergency, cleanliness, fragrance, and overall preference, and among them, IV2, IV3 and IV5 received the best evaluation.

In addition, the composition for feminine cleansing agent containing the extract of Goridae, Island body extract, and Daepoleon received excellent overall evaluation, and in particular, received the best evaluation in IT 3 and IT 4.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention defined in the following claims are also present. It belongs to the scope of rights of

Claims (7)

Propolis; Collagen peptide; Black yeast; Chitosan;
Angelicae extract, centella extract, grapefruit seed extract, and a natural extract selected from the group consisting of a mixture thereof; And
Water-soluble vitamins;
Containing
Composition for feminine cleansers. The method of claim 1,
The composition is for the prevention or treatment of diseases related to the vagina, the diseases related to the vagina are vaginal laxia, vaginal dryness, vaginal mycosis and hypochondriasis
Composition for feminine cleansers. The method of claim 1,
The composition has an antibacterial effect on the fungus Candida albicans
Composition for feminine cleansers. The method of claim 1,
The water-soluble vitamin is selected from the group consisting of vitamin C, vitamin B ₁ , vitamin B ₂ , niacin, vitamin B ₆ , vitamin B ₁₂ , folic acid and biotin.
Composition for feminine cleansers. The method of claim 1,
The composition further comprises other additives,
The other additives are excipients, disintegrants and lubricants
Composition for feminine cleansers. The method of claim 1,
The composition is a cleaning composition or a composition for vaginal insertion. The method of claim 1,
The composition further comprises a second natural extract,
The second natural extract is selected from the group consisting of beetroot extract, island body extract, and mixtures thereof
Composition for feminine cleansers.

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