KR20210008497A - Atxn3 발현 감소용 화합물 및 방법 - Google Patents

Atxn3 발현 감소용 화합물 및 방법 Download PDF

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KR20210008497A
KR20210008497A KR1020207035007A KR20207035007A KR20210008497A KR 20210008497 A KR20210008497 A KR 20210008497A KR 1020207035007 A KR1020207035007 A KR 1020207035007A KR 20207035007 A KR20207035007 A KR 20207035007A KR 20210008497 A KR20210008497 A KR 20210008497A
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modified
certain embodiments
seq
oligomeric compound
nucleobase
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수잔 엠. 프라이어
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아이오니스 파마수티컬즈, 인코포레이티드
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020207035007A 2018-05-09 2019-05-09 Atxn3 발현 감소용 화합물 및 방법 Withdrawn KR20210008497A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862669238P 2018-05-09 2018-05-09
US62/669,238 2018-05-09
PCT/US2019/031562 WO2019217708A1 (en) 2018-05-09 2019-05-09 Compounds and methods for reducing atxn3 expression

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KR20210008497A true KR20210008497A (ko) 2021-01-22

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US (2) US11434488B2 (https=)
EP (2) EP4663758A3 (https=)
JP (1) JP2021522800A (https=)
KR (1) KR20210008497A (https=)
CN (1) CN112189053B (https=)
AR (1) AR115375A1 (https=)
AU (1) AU2019266307A1 (https=)
BR (1) BR112020021253A2 (https=)
CA (1) CA3098144A1 (https=)
CL (1) CL2020002888A1 (https=)
CO (1) CO2020013433A2 (https=)
CR (1) CR20200604A (https=)
EA (1) EA202092500A1 (https=)
JO (1) JOP20200283A1 (https=)
MX (1) MX2020011911A (https=)
PE (1) PE20212131A1 (https=)
PH (1) PH12020500668A1 (https=)
SG (1) SG11202010215TA (https=)
TW (1) TW202003541A (https=)
UY (1) UY38225A (https=)
WO (1) WO2019217708A1 (https=)

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JOP20190104A1 (ar) 2016-11-10 2019-05-07 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن atxn3
SG11202006528XA (en) 2018-01-12 2020-08-28 Bristol Myers Squibb Co Antisense oligonucleotides targeting alpha-synuclein and uses thereof
CN120310791A (zh) 2018-01-12 2025-07-15 百时美施贵宝公司 靶向α-突触核蛋白的反义寡核苷酸及其用途
EP4663758A3 (en) 2018-05-09 2026-04-29 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing atxn3 expression
WO2020172559A1 (en) * 2019-02-22 2020-08-27 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing atxn3 expression
CN113950529A (zh) 2019-06-06 2022-01-18 豪夫迈·罗氏有限公司 靶向atxn3的反义寡核苷酸
US12565653B2 (en) 2019-11-22 2026-03-03 Alnylam Pharmaceuticals, Inc. ATAXIN3 (ATXN3) RNAi agent compositions and methods of use thereof
CN120505310A (zh) * 2020-02-28 2025-08-19 Ionis制药公司 用于调节smn2的化合物和方法
JP7776420B2 (ja) * 2020-05-12 2025-11-26 田辺三菱製薬株式会社 Ａｔａｘｉｎ ３発現を調節するための化合物、方法及び医薬組成物
US20230212572A1 (en) * 2020-06-09 2023-07-06 Roche Innovation Center Copenhagen A/S Guanosine Analogues for Use in Therapeutics Polynucleotides
US20230060373A1 (en) 2020-12-03 2023-03-02 Hoffmann-La Roche Inc. Antisense Oligonucleotides Targeting ATXN3
AR124229A1 (es) 2020-12-03 2023-03-01 Hoffmann La Roche Oligonucleótidos antisentido que actúan sobre atxn3
WO2025252669A1 (en) 2024-06-03 2025-12-11 Evotec International Gmbh Modified oligonucleotides for reducing atxn3 expression

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