KR20200089289A - 비골수제거 골수 재건을 위한 방법 및 조성물 - Google Patents

비골수제거 골수 재건을 위한 방법 및 조성물 Download PDF

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KR20200089289A
KR20200089289A KR1020207016902A KR20207016902A KR20200089289A KR 20200089289 A KR20200089289 A KR 20200089289A KR 1020207016902 A KR1020207016902 A KR 1020207016902A KR 20207016902 A KR20207016902 A KR 20207016902A KR 20200089289 A KR20200089289 A KR 20200089289A
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cells
cell
hiv
expression
vector
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세르하트 검룩크
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위어드 사이언스 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/50—Physical structure
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Biomedical Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
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  • Cell Biology (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • AIDS & HIV (AREA)
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KR1020207016902A 2017-11-15 2018-11-15 비골수제거 골수 재건을 위한 방법 및 조성물 Ceased KR20200089289A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762586813P 2017-11-15 2017-11-15
US62/586,813 2017-11-15
PCT/US2018/061211 WO2019099619A1 (en) 2017-11-15 2018-11-15 Methods and compositions for non-myeloablative bone marrow reconstitution

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KR20200089289A true KR20200089289A (ko) 2020-07-24

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KR1020207016902A Ceased KR20200089289A (ko) 2017-11-15 2018-11-15 비골수제거 골수 재건을 위한 방법 및 조성물

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US (2) US12194062B2 (https=)
EP (2) EP3710013B1 (https=)
JP (3) JP7568507B2 (https=)
KR (1) KR20200089289A (https=)
CN (1) CN111417407A (https=)
AU (2) AU2018367546B2 (https=)
BR (1) BR112020009377A2 (https=)
CA (1) CA3082404A1 (https=)
ES (1) ES3039609T3 (https=)
IL (1) IL274632B2 (https=)
MX (2) MX2020004811A (https=)
SG (1) SG11202004145QA (https=)
WO (1) WO2019099619A1 (https=)

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US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
CN115605084A (zh) * 2020-01-31 2023-01-13 S·居姆吕克曲（Ca） 用于提供化学保护作用的组合物和方法
US12390491B2 (en) * 2020-01-31 2025-08-19 Gtech Bio Llc Compositions and methods for providing chemoprotective effects

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IL109168A0 (en) * 1993-04-01 1994-06-24 Univ Columbia A retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs
US7345025B2 (en) * 2001-07-10 2008-03-18 Johnson & Johnson Research Pty. Limited Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
US7737124B2 (en) 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
US20030099621A1 (en) * 2001-11-29 2003-05-29 Robert Chow Stem cell screening and transplantation therapy for HIV infection
CA2668608A1 (en) * 2006-11-08 2008-06-05 Aldagen, Inc. Methods for using aldhbr cells to supplement stem cell transplantation
WO2009094456A2 (en) * 2008-01-22 2009-07-30 Johns Hopkins University Use of high-dose, post-transplantation oxazaphosphorine drugs for reduction of transplant rejection
EP3659435A1 (en) 2009-07-15 2020-06-03 Calimmune, Inc. Dual vector for inhibition of human immunodeficiency virus
US8837250B2 (en) 2010-07-20 2014-09-16 Taiwan Semiconductor Manufacturing Co., Ltd. Method and apparatus for word line decoder layout
MX370404B (es) * 2011-12-22 2019-12-11 Yeda Res & Dev Uso de una terapia de combinación para inducir un injerto estable y a largo plazo.
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
JP2016522679A (ja) * 2013-04-04 2016-08-04 プレジデント アンド フェローズ オブ ハーバード カレッジ ＣＲＩＳＰＲ／Ｃａｓ系を用いたゲノム編集の治療的使用

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CA3082404A1 (en) 2019-05-23
JP2021503015A (ja) 2021-02-04
AU2024216450A1 (en) 2024-09-26
MX2025004115A (es) 2025-05-02
JP7787265B2 (ja) 2025-12-16
JP7568507B2 (ja) 2024-10-16
EP4674969A2 (en) 2026-01-07
SG11202004145QA (en) 2020-06-29
IL274632A (en) 2020-06-30
ES3039609T3 (en) 2025-10-23
EP3710013C0 (en) 2025-07-30
EP3710013A1 (en) 2020-09-23
MX2020004811A (es) 2020-10-07
CN111417407A (zh) 2020-07-14
US12194062B2 (en) 2025-01-14
EP3710013A4 (en) 2021-06-16
AU2018367546A1 (en) 2020-05-28
EP3710013B1 (en) 2025-07-30
JP2025000910A (ja) 2025-01-07
US20190269734A1 (en) 2019-09-05
US20250228898A1 (en) 2025-07-17
IL274632B1 (en) 2024-08-01
WO2019099619A1 (en) 2019-05-23
JP2026050368A (ja) 2026-03-19
AU2018367546B2 (en) 2024-07-18
BR112020009377A2 (pt) 2020-11-24
IL274632B2 (en) 2024-12-01

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