CN111417407A - 用于非清髓性骨髓重建的方法和组合物 - Google Patents

用于非清髓性骨髓重建的方法和组合物 Download PDF

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CN111417407A
CN111417407A CN201880077273.2A CN201880077273A CN111417407A CN 111417407 A CN111417407 A CN 111417407A CN 201880077273 A CN201880077273 A CN 201880077273A CN 111417407 A CN111417407 A CN 111417407A
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cells
cell
hiv
expression
vector
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S·居姆吕克曲
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Strange Science Co ltd
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN201880077273.2A 2017-11-15 2018-11-15 用于非清髓性骨髓重建的方法和组合物 Pending CN111417407A (zh)

Applications Claiming Priority (3)

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US201762586813P 2017-11-15 2017-11-15
US62/586,813 2017-11-15
PCT/US2018/061211 WO2019099619A1 (en) 2017-11-15 2018-11-15 Methods and compositions for non-myeloablative bone marrow reconstitution

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CN111417407A true CN111417407A (zh) 2020-07-14

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US (2) US12194062B2 (https=)
EP (2) EP3710013B1 (https=)
JP (3) JP7568507B2 (https=)
KR (1) KR20200089289A (https=)
CN (1) CN111417407A (https=)
AU (2) AU2018367546B2 (https=)
BR (1) BR112020009377A2 (https=)
CA (1) CA3082404A1 (https=)
ES (1) ES3039609T3 (https=)
IL (1) IL274632B2 (https=)
MX (2) MX2020004811A (https=)
SG (1) SG11202004145QA (https=)
WO (1) WO2019099619A1 (https=)

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US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
CN115605084A (zh) * 2020-01-31 2023-01-13 S·居姆吕克曲（Ca） 用于提供化学保护作用的组合物和方法
US12390491B2 (en) * 2020-01-31 2025-08-19 Gtech Bio Llc Compositions and methods for providing chemoprotective effects

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US6268138B1 (en) * 1993-04-01 2001-07-31 The Trustees Of Columbia University In The City Of New York Retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs
US20100129329A1 (en) * 2006-11-08 2010-05-27 Aldagen, Inc. METHODS FOR USING ALDHbr CELLS TO SUPPLEMENT STEM CELL TRANSPLANTATION
US20120148577A1 (en) * 2008-01-22 2012-06-14 Accentia Biopharmaceuticals, Inc. Use of high-dose, post-transplantation oxazaphosphorine drugs for reduction of transplant rejection
US20120201794A1 (en) * 2009-07-15 2012-08-09 Calimmune Inc. Dual vector for inhibition of human immunodeficiency virus

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US7345025B2 (en) * 2001-07-10 2008-03-18 Johnson & Johnson Research Pty. Limited Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
US7737124B2 (en) 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
US20030099621A1 (en) * 2001-11-29 2003-05-29 Robert Chow Stem cell screening and transplantation therapy for HIV infection
US8837250B2 (en) 2010-07-20 2014-09-16 Taiwan Semiconductor Manufacturing Co., Ltd. Method and apparatus for word line decoder layout
MX370404B (es) * 2011-12-22 2019-12-11 Yeda Res & Dev Uso de una terapia de combinación para inducir un injerto estable y a largo plazo.
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
JP2016522679A (ja) * 2013-04-04 2016-08-04 プレジデント アンド フェローズ オブ ハーバード カレッジ ＣＲＩＳＰＲ／Ｃａｓ系を用いたゲノム編集の治療的使用

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US6268138B1 (en) * 1993-04-01 2001-07-31 The Trustees Of Columbia University In The City Of New York Retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs
US20100129329A1 (en) * 2006-11-08 2010-05-27 Aldagen, Inc. METHODS FOR USING ALDHbr CELLS TO SUPPLEMENT STEM CELL TRANSPLANTATION
US20120148577A1 (en) * 2008-01-22 2012-06-14 Accentia Biopharmaceuticals, Inc. Use of high-dose, post-transplantation oxazaphosphorine drugs for reduction of transplant rejection
US20120201794A1 (en) * 2009-07-15 2012-08-09 Calimmune Inc. Dual vector for inhibition of human immunodeficiency virus

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MICHELE MAGNI ET AL: "Induction of Cyclophosphamide-Resistance by Aldehyde-Dehydrogenase Gene Transfer", 《BLOOD》 *

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CA3082404A1 (en) 2019-05-23
JP2021503015A (ja) 2021-02-04
AU2024216450A1 (en) 2024-09-26
KR20200089289A (ko) 2020-07-24
MX2025004115A (es) 2025-05-02
JP7787265B2 (ja) 2025-12-16
JP7568507B2 (ja) 2024-10-16
EP4674969A2 (en) 2026-01-07
SG11202004145QA (en) 2020-06-29
IL274632A (en) 2020-06-30
ES3039609T3 (en) 2025-10-23
EP3710013C0 (en) 2025-07-30
EP3710013A1 (en) 2020-09-23
MX2020004811A (es) 2020-10-07
US12194062B2 (en) 2025-01-14
EP3710013A4 (en) 2021-06-16
AU2018367546A1 (en) 2020-05-28
EP3710013B1 (en) 2025-07-30
JP2025000910A (ja) 2025-01-07
US20190269734A1 (en) 2019-09-05
US20250228898A1 (en) 2025-07-17
IL274632B1 (en) 2024-08-01
WO2019099619A1 (en) 2019-05-23
JP2026050368A (ja) 2026-03-19
AU2018367546B2 (en) 2024-07-18
BR112020009377A2 (pt) 2020-11-24
IL274632B2 (en) 2024-12-01

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