KR20200044957A - Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질 - Google Patents

Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질 Download PDF

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KR20200044957A
KR20200044957A KR1020207009780A KR20207009780A KR20200044957A KR 20200044957 A KR20200044957 A KR 20200044957A KR 1020207009780 A KR1020207009780 A KR 1020207009780A KR 20207009780 A KR20207009780 A KR 20207009780A KR 20200044957 A KR20200044957 A KR 20200044957A
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ser
thr
seq
antigen
gly
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그레고리 피. 창
안 에프. 청
윌리암 해니
브래들리 엠. 룬드
비안카 프린츠
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드래곤플라이 쎄라퓨틱스, 인크.
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Priority to KR1020247038586A priority Critical patent/KR20240167101A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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KR1020207009780A 2017-09-07 2018-09-07 Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질 Ceased KR20200044957A (ko)

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Application Number Priority Date Filing Date Title
KR1020247038586A KR20240167101A (ko) 2017-09-07 2018-09-07 Nkg2d, cd16 및 넥틴4에 결합하는 단백질

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762555110P 2017-09-07 2017-09-07
US62/555,110 2017-09-07
US201762566824P 2017-10-02 2017-10-02
US62/566,824 2017-10-02
PCT/US2018/050073 WO2019051308A1 (en) 2017-09-07 2018-09-07 NKG2D, CD16 BINDING PROTEINS AND ANTIGEN ASSOCIATED WITH A TUMOR

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KR1020217007213A Division KR20210030503A (ko) 2017-09-07 2018-09-07 Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질
KR1020247038586A Division KR20240167101A (ko) 2017-09-07 2018-09-07 Nkg2d, cd16 및 넥틴4에 결합하는 단백질

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KR1020247038586A Pending KR20240167101A (ko) 2017-09-07 2018-09-07 Nkg2d, cd16 및 넥틴4에 결합하는 단백질
KR1020207009780A Ceased KR20200044957A (ko) 2017-09-07 2018-09-07 Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질
KR1020217007213A Ceased KR20210030503A (ko) 2017-09-07 2018-09-07 Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질

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US (3) US20200277383A1 (OSRAM)
EP (2) EP3925976A1 (OSRAM)
JP (4) JP7431392B2 (OSRAM)
KR (3) KR20240167101A (OSRAM)
CN (3) CN119735693A (OSRAM)
AU (3) AU2018329937B2 (OSRAM)
BR (1) BR112020004489A2 (OSRAM)
CA (2) CA3074840A1 (OSRAM)
IL (2) IL273067A (OSRAM)
MX (2) MX420258B (OSRAM)
RU (1) RU2021110369A (OSRAM)
SG (2) SG10202102502VA (OSRAM)
WO (1) WO2019051308A1 (OSRAM)

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CN113563474B (zh) * 2021-06-11 2023-05-02 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） EpCAM-CD16-NKG2D三特异性抗体及其应用
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