KR20200037388A - Nkg2d, cd16, 및 egfr, hla-e, ccr4 또는 pd-l1에 결합하는 단백질 - Google Patents

Nkg2d, cd16, 및 egfr, hla-e, ccr4 또는 pd-l1에 결합하는 단백질 Download PDF

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KR20200037388A
KR20200037388A KR1020207007137A KR20207007137A KR20200037388A KR 20200037388 A KR20200037388 A KR 20200037388A KR 1020207007137 A KR1020207007137 A KR 1020207007137A KR 20207007137 A KR20207007137 A KR 20207007137A KR 20200037388 A KR20200037388 A KR 20200037388A
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ser
seq
gly
antigen
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그레고리 피. 창
안 에프. 청
진얀 두
아샤 그린버그
윌리암 해니
드루브 캄 세티
니콜라이 바그트만
브래들리 엠. 룬드
비안카 프린츠
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드래곤플라이 쎄라퓨틱스, 인크.
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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  • Peptides Or Proteins (AREA)
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KR1020207007137A 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, hla-e, ccr4 또는 pd-l1에 결합하는 단백질 Ceased KR20200037388A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762546300P 2017-08-16 2017-08-16
US201762546297P 2017-08-16 2017-08-16
US62/546,300 2017-08-16
US62/546,297 2017-08-16
US201762552152P 2017-08-30 2017-08-30
US62/552,152 2017-08-30
US201762555114P 2017-09-07 2017-09-07
US62/555,114 2017-09-07
PCT/US2018/000212 WO2019035939A1 (en) 2017-08-16 2018-08-16 PROTEINS BINDING TO NKG2D, CD16 AND EGFR, HLA-E, CCR4, OR PD-L1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217006762A Division KR20210029298A (ko) 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, ccr4 또는 pd-l1에 결합하는 단백질

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KR20200037388A true KR20200037388A (ko) 2020-04-08

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KR1020207007137A Ceased KR20200037388A (ko) 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, hla-e, ccr4 또는 pd-l1에 결합하는 단백질
KR1020217006762A Abandoned KR20210029298A (ko) 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, ccr4 또는 pd-l1에 결합하는 단백질

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KR1020217006762A Abandoned KR20210029298A (ko) 2017-08-16 2018-08-16 Nkg2d, cd16, 및 egfr, ccr4 또는 pd-l1에 결합하는 단백질

Country Status (12)

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US (2) US20200216544A1 (enrdf_load_stackoverflow)
EP (2) EP3668893A4 (enrdf_load_stackoverflow)
JP (2) JP2020531438A (enrdf_load_stackoverflow)
KR (2) KR20200037388A (enrdf_load_stackoverflow)
CN (2) CN111065649A (enrdf_load_stackoverflow)
AU (2) AU2018318698A1 (enrdf_load_stackoverflow)
BR (1) BR112020003050A2 (enrdf_load_stackoverflow)
CA (3) CA3073117A1 (enrdf_load_stackoverflow)
IL (2) IL272553A (enrdf_load_stackoverflow)
MX (2) MX2020001805A (enrdf_load_stackoverflow)
SG (2) SG11201913969SA (enrdf_load_stackoverflow)
WO (1) WO2019035939A1 (enrdf_load_stackoverflow)

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EP4273258A3 (en) 2017-02-20 2024-01-17 Dragonfly Therapeutics, Inc. Proteins binding her2, nkg2d and cd16
EA202091887A1 (ru) 2018-02-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры
FI3749346T3 (fi) 2018-02-08 2024-09-04 Dragonfly Therapeutics Inc Nkg2d-reseptoriin kohdistuvat vasta-aineen vaihtelevan domeenin yhdistelmät
TW201942134A (zh) 2018-02-20 2019-11-01 美商蜻蜓醫療公司 結合cd33、nkg2d及cd16之多特異性結合蛋白及使用方法
KR20210010508A (ko) * 2018-05-16 2021-01-27 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 섬유아세포 활성 단백질에 결합하는 단백질
EA202091977A1 (ru) * 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
TW202019479A (zh) 2018-08-08 2020-06-01 美商蜻蜓醫療公司 結合bcma、nkg2d及cd16之多特異性結合蛋白及使用方法
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
US20230067182A1 (en) * 2019-11-29 2023-03-02 Boe Technology Group Co., Ltd. Data Processing Device and Method, and Computer Readable Storage Medium
EP4137510A4 (en) * 2020-04-16 2023-11-01 YiChen Therapeutics Limited PD-1 MUTANT POLYPEPTIDE AND PRODUCTION AND USE THEREOF
WO2021226193A1 (en) * 2020-05-06 2021-11-11 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and clec12a
ES3031307T3 (en) * 2020-08-05 2025-07-07 Dragonfly Therapeutics Inc Proteins binding nkg2d, cd16 and egfr
CN112029001B (zh) * 2020-09-02 2022-09-06 南京北恒生物科技有限公司 靶向nk激活性受体的嵌合抗原受体
CN117222663A (zh) 2021-03-03 2023-12-12 蜻蜓疗法股份有限公司 使用结合nkg2d、cd16和肿瘤相关抗原的多特异性结合蛋白治疗癌症的方法
CN115246886A (zh) * 2021-04-27 2022-10-28 丹生医药技术(上海)有限公司 一种抗egfr/vegf双功能融合蛋白及其用途
MX2024000501A (es) * 2021-07-14 2024-01-31 Jiangsu Hengrui Pharmaceuticals Co Ltd Molecula de union a antigeno que se une especificamente a hgfr y egfr, y su uso farmaceutico.
CN116284430A (zh) * 2021-07-30 2023-06-23 广东菲鹏制药股份有限公司 靶向肿瘤的il15融合蛋白及其应用
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