KR20200035973A - 비대성 심근병증의 치료에서 사용하기 위한 마바캄텐 - Google Patents

비대성 심근병증의 치료에서 사용하기 위한 마바캄텐 Download PDF

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Publication number
KR20200035973A
KR20200035973A KR1020207004507A KR20207004507A KR20200035973A KR 20200035973 A KR20200035973 A KR 20200035973A KR 1020207004507 A KR1020207004507 A KR 1020207004507A KR 20207004507 A KR20207004507 A KR 20207004507A KR 20200035973 A KR20200035973 A KR 20200035973A
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South Korea
Prior art keywords
compound
subject
daily dose
plasma concentration
weeks
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KR1020207004507A
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English (en)
Korean (ko)
Inventor
마크 제이. 세미그란
준 에이치. 리
조셉 램빙
에릭 그린
마크 에반칙
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미요카디아, 인크.
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Application filed by 미요카디아, 인크. filed Critical 미요카디아, 인크.
Priority to KR1020257024814A priority Critical patent/KR20250116181A/ko
Publication of KR20200035973A publication Critical patent/KR20200035973A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
KR1020207004507A 2017-08-04 2018-08-03 비대성 심근병증의 치료에서 사용하기 위한 마바캄텐 Ceased KR20200035973A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257024814A KR20250116181A (ko) 2017-08-04 2018-08-03 비대성 심근병증의 치료에서 사용하기 위한 마바캄텐

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762541591P 2017-08-04 2017-08-04
US62/541,591 2017-08-04
US201762584537P 2017-11-10 2017-11-10
US62/584,537 2017-11-10
US201862639922P 2018-03-07 2018-03-07
US62/639,922 2018-03-07
US201862671585P 2018-05-15 2018-05-15
US62/671,585 2018-05-15
PCT/US2018/045180 WO2019028360A1 (en) 2017-08-04 2018-08-03 MAVACAMTEN FOR USE IN THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257024814A Division KR20250116181A (ko) 2017-08-04 2018-08-03 비대성 심근병증의 치료에서 사용하기 위한 마바캄텐

Publications (1)

Publication Number Publication Date
KR20200035973A true KR20200035973A (ko) 2020-04-06

Family

ID=63350605

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020207004507A Ceased KR20200035973A (ko) 2017-08-04 2018-08-03 비대성 심근병증의 치료에서 사용하기 위한 마바캄텐
KR1020257024814A Pending KR20250116181A (ko) 2017-08-04 2018-08-03 비대성 심근병증의 치료에서 사용하기 위한 마바캄텐

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020257024814A Pending KR20250116181A (ko) 2017-08-04 2018-08-03 비대성 심근병증의 치료에서 사용하기 위한 마바캄텐

Country Status (28)

Country Link
US (6) US20200054636A1 (enExample)
EP (2) EP4659806A3 (enExample)
JP (3) JP2020529996A (enExample)
KR (2) KR20200035973A (enExample)
CN (2) CN111182901A (enExample)
AU (3) AU2018311974B2 (enExample)
CA (1) CA3071948A1 (enExample)
DK (1) DK3661514T3 (enExample)
ES (1) ES3055679T3 (enExample)
FI (1) FI3661514T3 (enExample)
HR (1) HRP20251598T1 (enExample)
HU (1) HUE073047T2 (enExample)
IL (3) IL322175A (enExample)
LT (1) LT3661514T (enExample)
MA (1) MA49760B1 (enExample)
MX (3) MX2020001406A (enExample)
MY (1) MY208231A (enExample)
PL (1) PL3661514T3 (enExample)
PT (1) PT3661514T (enExample)
RS (1) RS67534B1 (enExample)
RU (1) RU2020109345A (enExample)
SG (2) SG10202112960QA (enExample)
SI (1) SI3661514T1 (enExample)
SM (1) SMT202500413T1 (enExample)
TW (1) TWI907332B (enExample)
UA (1) UA130213C2 (enExample)
UY (1) UY37834A (enExample)
WO (1) WO2019028360A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202006296YA (en) 2018-01-19 2020-08-28 Cytokinetics Inc Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
EP3814343B1 (en) 2018-06-26 2023-01-11 Cytokinetics, Inc. Cardiac sarcomere inhibitors
WO2020257609A1 (en) * 2019-06-21 2020-12-24 MyoKardia, Inc. Diagnostics and treatments for cardiac disease
CN110698415B (zh) * 2019-10-21 2023-05-09 上海先行医药开发有限公司 一种肌球蛋白抑制剂及其制备方法和用途
CA3157629A1 (en) * 2019-11-10 2021-05-14 MyoKardia, Inc. Methods of treatment with myosin modulator
IL294501A (en) * 2020-01-28 2022-09-01 Teva Pharmaceuticals Int Gmbh Crystalline forms of Mawakamatan and procedures for obtaining them
KR20230079053A (ko) * 2020-08-28 2023-06-05 미요카디아, 인크. 미오신 조절제를 이용한 치료 방법
EP4249474A4 (en) 2020-11-20 2024-04-17 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Triazine dione derivative, preparation method therefor and application thereof in medicine
WO2022162701A1 (en) * 2021-02-01 2022-08-04 Dr. Reddy's Laboratories Limited Process for preparation of mavacamten and solid state forms thereof
KR20240015622A (ko) 2021-03-04 2024-02-05 싸이토키네틱스, 인코포레이티드 심장 근절 억제제
CN112939876A (zh) * 2021-03-10 2021-06-11 杭州科巢生物科技有限公司 Mavacamten的晶型I及其制备方法
WO2022189599A1 (en) 2021-03-12 2022-09-15 Sandoz Ag Crystalline forms of mavacamten for the treatment of hcm
EP4370116B1 (en) * 2021-07-16 2025-01-15 Cytokinetics, Inc. Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy
US20240389972A1 (en) * 2021-09-24 2024-11-28 Koninklijke Philips N.V. METHODS AND SYSTEMS FOR GENERATING LIKELIHOOD OF HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF)
CA3268270A1 (en) 2022-09-26 2024-04-04 Edgewise Therapeutics, Inc. 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND ASSOCIATED USES
WO2024097284A1 (en) * 2022-11-02 2024-05-10 MyoKardia, Inc. Mavacamten and derivatives thereof for use in treating atrial dysfunction
KR20250174911A (ko) 2023-03-27 2025-12-15 엣지와이즈 테라퓨틱스, 인크. 퀴놀리논 아미드 화합물 및 이의 용도
JP7858148B1 (ja) 2023-03-27 2026-05-13 エッジワイズ セラピューティクス， インコーポレイテッド キナゾリンジオン化合物およびその使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202000071T1 (it) 2013-06-21 2020-03-13 Myokardia Inc Composti di pirimidinadione contro le condizioni cardiache

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Publication number Publication date
ES3055679T3 (en) 2026-02-13
EP3661514A1 (en) 2020-06-10
HRP20251598T1 (hr) 2026-01-30
LT3661514T (lt) 2025-11-10
AU2026205064A1 (en) 2026-07-16
AU2018311974B2 (en) 2024-03-07
SMT202500413T1 (it) 2025-11-10
IL328587A (en) 2026-07-01
TWI907332B (zh) 2025-12-11
EP4659806A2 (en) 2025-12-10
MA49760A (fr) 2020-06-10
JP2025020292A (ja) 2025-02-12
US20250213565A1 (en) 2025-07-03
DK3661514T3 (da) 2025-12-15
TW201916882A (zh) 2019-05-01
HUE073047T2 (hu) 2025-12-28
FI3661514T3 (fi) 2025-12-12
JP2023065372A (ja) 2023-05-12
RU2020109345A (ru) 2021-09-06
MX2020001406A (es) 2020-03-09
EP4659806A3 (en) 2026-02-18
KR20250116181A (ko) 2025-07-31
PL3661514T3 (pl) 2026-02-23
MX2024000348A (es) 2024-01-26
CA3071948A1 (en) 2019-02-07
SI3661514T1 (sl) 2026-01-30
SG10202112960QA (en) 2021-12-30
AU2024203872A1 (en) 2024-06-27
US20220226324A1 (en) 2022-07-21
IL322175A (en) 2025-09-01
RS67534B1 (sr) 2026-01-30
MA49760B1 (fr) 2025-11-28
CN111182901A (zh) 2020-05-19
US20260007671A1 (en) 2026-01-08
AU2018311974A1 (en) 2020-02-06
US20240423981A1 (en) 2024-12-26
UY37834A (es) 2019-02-28
PT3661514T (pt) 2025-12-10
EP3661514B1 (en) 2025-09-17
US20200054636A1 (en) 2020-02-20
IL272300B2 (en) 2025-12-01
UA130213C2 (uk) 2025-12-24
MY208231A (en) 2025-04-25
MX2024008096A (es) 2024-07-15
CN118593507A (zh) 2024-09-06
IL272300A (en) 2020-03-31
JP2020529996A (ja) 2020-10-15
WO2019028360A1 (en) 2019-02-07
SG11202000549TA (en) 2020-02-27
IL272300B1 (en) 2025-08-01
US20220313695A1 (en) 2022-10-06

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