KR20200034781A - 1,2-다이하이드로-3H-피라졸로[3,4-d]피리미딘-3-온 유사체 - Google Patents

1,2-다이하이드로-3H-피라졸로[3,4-d]피리미딘-3-온 유사체 Download PDF

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Publication number
KR20200034781A
KR20200034781A KR1020207005636A KR20207005636A KR20200034781A KR 20200034781 A KR20200034781 A KR 20200034781A KR 1020207005636 A KR1020207005636 A KR 1020207005636A KR 20207005636 A KR20207005636 A KR 20207005636A KR 20200034781 A KR20200034781 A KR 20200034781A
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South Korea
Prior art keywords
cancer
alkyl
optionally substituted
compound
unsubstituted
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KR1020207005636A
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English (en)
Korean (ko)
Inventor
피터 친후아 후앙
브랜트 클레이튼 보렌
케빈 듀언 번커
후이 리우
순일 팔리왈
Original Assignee
리커리엄 아이피 홀딩스, 엘엘씨
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Publication of KR20200034781A publication Critical patent/KR20200034781A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020207005636A 2017-08-01 2018-07-31 1,2-다이하이드로-3H-피라졸로[3,4-d]피리미딘-3-온 유사체 Ceased KR20200034781A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762539734P 2017-08-01 2017-08-01
US62/539,734 2017-08-01
PCT/US2018/044580 WO2019028008A1 (en) 2017-08-01 2018-07-31 1,2-DIHYDRO-3H-PYRAZOLO [3,4-D] PYRIMIDIN-3-ONE ANALOGUES

Publications (1)

Publication Number Publication Date
KR20200034781A true KR20200034781A (ko) 2020-03-31

Family

ID=65233095

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207005636A Ceased KR20200034781A (ko) 2017-08-01 2018-07-31 1,2-다이하이드로-3H-피라졸로[3,4-d]피리미딘-3-온 유사체

Country Status (16)

Country Link
US (2) US11124518B2 (https=)
EP (1) EP3661918B1 (https=)
JP (1) JP7203816B2 (https=)
KR (1) KR20200034781A (https=)
CN (1) CN111094253B (https=)
AR (1) AR112774A1 (https=)
AU (1) AU2018312448B2 (https=)
BR (1) BR112020002104A2 (https=)
CA (1) CA3071405A1 (https=)
ES (1) ES2980537T3 (https=)
IL (1) IL272262A (https=)
MX (1) MX2020001235A (https=)
RU (1) RU2020105058A (https=)
SG (1) SG11202000789WA (https=)
TW (1) TW201910335A (https=)
WO (1) WO2019028008A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019074979A1 (en) 2017-10-09 2019-04-18 Girafpharma, Llc HETEROCYCLIC COMPOUNDS AND USES THEREOF
US10807994B2 (en) 2017-10-09 2020-10-20 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
EP3758706A4 (en) * 2018-02-28 2021-11-24 The Regents Of The University Of Colorado WEE1 KINASE INHIBITORS AND METHODS OF TREATING CANCER USING THEREOF
MX2020009372A (es) * 2018-03-09 2020-10-14 Recurium Ip Holdings Llc 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-onas sustituidas.
CN110872296B (zh) * 2018-08-31 2023-05-23 上海弘翊生物科技有限公司 一种二氢异吲哚-1H-吡唑并[3,4-d]嘧啶酮化合物、其制备方法和应用
CN113939296A (zh) * 2019-04-09 2022-01-14 诺维逊生物股份有限公司 杂环化合物及其用途
US20220220115A1 (en) * 2019-04-09 2022-07-14 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
WO2020210381A1 (en) * 2019-04-09 2020-10-15 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
WO2020210320A1 (en) * 2019-04-11 2020-10-15 Recurium Ip Holdings, Llc Substituted l,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones
CN112142748B (zh) * 2019-06-28 2023-07-04 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用
KR20220042127A (ko) 2019-06-28 2022-04-04 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 피라졸로피리미딘 화합물, 그의 제조 방법 및 그의 응용
CN112442049A (zh) * 2019-09-03 2021-03-05 微境生物医药科技(上海)有限公司 作为Wee1抑制剂的嘧啶衍生物
AU2020384291A1 (en) 2019-11-15 2022-05-26 Recurium Ip Holdings, Llc Chiral synthesis of a tertiary alcohol
AU2020407070A1 (en) * 2019-12-20 2022-07-14 Recurium Ip Holdings, Llc Combinations
AU2021271844A1 (en) * 2020-05-15 2022-12-08 Recurium Ip Holdings, Llc Mono- and combination therapies
US12522607B2 (en) 2020-06-17 2026-01-13 Wigen Biomedicine Technology (shanghai) Co., Ltd. Substituted pyrazolo[3,4-d]pyrimidines as wee-1 inhibitors
BR112023000350A2 (pt) 2020-07-09 2023-03-28 Recurium Ip Holdings Llc Sais e formas de um inibidor de wee1
CN114805357B (zh) * 2021-01-21 2023-12-19 四川大学 一种靶向setdb1-ttd的小分子抑制剂及其制药用途
AU2022265032A1 (en) * 2021-04-30 2023-11-16 Wigen Biomedicine Technology (shanghai) Co., Ltd. Fused ring compound as wee-1 inhibitor, and preparation method therefor and use thereof
AU2022287033B2 (en) * 2021-06-04 2025-04-17 Aprea Therapeutics, Inc. Pyridopyrimidine derivatives useful as wee1 kinase inhibitors
WO2023016417A1 (zh) * 2021-08-11 2023-02-16 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮化合物
WO2023045942A1 (zh) * 2021-09-22 2023-03-30 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮化合物
WO2023166080A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combination treatments comprising a ctps1 inhibitor and a wee1 inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1846408B1 (en) 2005-01-14 2013-03-20 Janssen Pharmaceutica NV 5-membered annelated heterocyclic pyrimidines as kinase inhibitors
AR060635A1 (es) * 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
EP2213673B1 (en) * 2007-10-23 2013-06-05 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
ME03455B (me) * 2012-09-10 2020-01-20 Principia Biopharma Inc Jedinjenja pirazolopirimidina kao inhibitori kinaze
GB201612092D0 (en) 2016-07-12 2016-08-24 Almac Discovery Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
EP3661918A4 (en) 2021-05-12
AU2018312448B2 (en) 2022-09-15
BR112020002104A2 (pt) 2020-08-04
CN111094253B (zh) 2023-08-29
ES2980537T3 (es) 2024-10-01
US20200157112A1 (en) 2020-05-21
US20210317124A1 (en) 2021-10-14
EP3661918A1 (en) 2020-06-10
SG11202000789WA (en) 2020-02-27
RU2020105058A (ru) 2021-09-02
EP3661918B1 (en) 2024-05-08
AU2018312448A1 (en) 2020-02-13
RU2020105058A3 (https=) 2021-11-17
IL272262A (en) 2020-03-31
CA3071405A1 (en) 2019-02-07
AR112774A1 (es) 2019-12-11
US11124518B2 (en) 2021-09-21
MX2020001235A (es) 2020-07-20
CN111094253A (zh) 2020-05-01
WO2019028008A1 (en) 2019-02-07
JP7203816B2 (ja) 2023-01-13
EP3661918C0 (en) 2024-05-08
TW201910335A (zh) 2019-03-16
JP2020529993A (ja) 2020-10-15

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