KR20200012833A - 통증 치료용 11,13-개질된 색시톡신 - Google Patents

통증 치료용 11,13-개질된 색시톡신 Download PDF

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Publication number
KR20200012833A
KR20200012833A KR1020197031530A KR20197031530A KR20200012833A KR 20200012833 A KR20200012833 A KR 20200012833A KR 1020197031530 A KR1020197031530 A KR 1020197031530A KR 20197031530 A KR20197031530 A KR 20197031530A KR 20200012833 A KR20200012833 A KR 20200012833A
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South Korea
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alkyl
compound
halo
formula
optionally substituted
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KR1020197031530A
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English (en)
Korean (ko)
Inventor
존 멀케이
하산 파조헤쉬
조지 밀자니크
안톤 델위그
제이콥 베클리
그랜트 마사아키 시부야
보이스 저스틴 두
Original Assignee
사이트원 테라퓨틱스, 인코포레이티드
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
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Application filed by 사이트원 테라퓨틱스, 인코포레이티드, 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티, 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 filed Critical 사이트원 테라퓨틱스, 인코포레이티드
Publication of KR20200012833A publication Critical patent/KR20200012833A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020197031530A 2017-03-29 2018-03-29 통증 치료용 11,13-개질된 색시톡신 Ceased KR20200012833A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762478523P 2017-03-29 2017-03-29
US62/478,523 2017-03-29
PCT/US2018/025301 WO2018183781A1 (en) 2017-03-29 2018-03-29 11,13-modified saxitoxins for the treatment of pain

Publications (1)

Publication Number Publication Date
KR20200012833A true KR20200012833A (ko) 2020-02-05

Family

ID=62063184

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197031530A Ceased KR20200012833A (ko) 2017-03-29 2018-03-29 통증 치료용 11,13-개질된 색시톡신

Country Status (11)

Country Link
US (2) US11236097B2 (https=)
EP (1) EP3601291A1 (https=)
JP (1) JP7090100B2 (https=)
KR (1) KR20200012833A (https=)
CN (1) CN110831945B (https=)
AU (1) AU2018243463C1 (https=)
BR (1) BR112019020111A2 (https=)
CA (1) CA3058214A1 (https=)
IL (1) IL269599B2 (https=)
MX (1) MX2019011530A (https=)
WO (1) WO2018183781A1 (https=)

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CA3058214A1 (en) 2017-03-29 2018-10-04 The Board Of Trustees Of The Leland Stanford Junior University 11,13-modified saxitoxins for the treatment of pain
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CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
JP2024520646A (ja) 2021-06-04 2024-05-24 バーテックス ファーマシューティカルズ インコーポレイテッド ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド類似体
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
CA3221788A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
MA64856B1 (fr) 2021-06-04 2026-02-27 Vertex Pharmaceuticals Incorporated Formes de dosage solides et regimens de dosage comprenant le [[3-(3,4-difluoro-2-méthoxy-phényl)-4,5-diméthyl-5-(trifluorométhyl) tétrahydrofuranne-2-carbonyl]amino]pyridine-2-carboxamide
JP2024520643A (ja) 2021-06-04 2024-05-24 バーテックス ファーマシューティカルズ インコーポレイテッド ナトリウムチャネルの調節因子としてのヒドロキシ及び（ハロ）アルコキシ置換テトラヒドロフラン
WO2022256676A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran analogs as modulators of sodium channels
JP2025513452A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
AU2023257313A1 (en) 2022-04-22 2024-10-31 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
GEAP202516634A (en) 2022-04-22 2025-02-25 Vertex Pharma Heteroaryl compounds for the treatment of pain
UY40234A (es) 2022-04-22 2023-11-15 Vertex Pharma Compuestos heteroarilo para el tratamiento del dolor
AU2023391870A1 (en) 2022-12-06 2025-06-05 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
WO2025090511A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing modulators of sodium channels and solid forms of the same for treating pain
WO2025090480A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025090465A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025090516A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing compounds for treating pain and solid forms thereof
WO2025122953A1 (en) 2023-12-07 2025-06-12 Vertex Pharmaceuticals Incorporated Dosing regimens and formulations of suzetrigine for use in the treatment of acute and chronic pain
US20260001877A1 (en) 2024-06-28 2026-01-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2026013449A2 (en) 2024-07-11 2026-01-15 Sea4Us - Biotecnologia E Recursos Marinhos, Sa Oxazolidone-derived compounds and their use in the treatment of chronic and acute pain
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain

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Publication number Publication date
US20220259218A1 (en) 2022-08-18
US11834456B2 (en) 2023-12-05
RU2019134300A3 (https=) 2021-05-25
RU2019134300A (ru) 2021-04-29
IL269599A (en) 2019-11-28
AU2018243463B2 (en) 2022-05-19
EP3601291A1 (en) 2020-02-05
MX2019011530A (es) 2020-01-27
WO2018183781A1 (en) 2018-10-04
IL269599B2 (en) 2023-07-01
AU2018243463C1 (en) 2022-12-01
US11236097B2 (en) 2022-02-01
BR112019020111A2 (pt) 2020-05-05
CA3058214A1 (en) 2018-10-04
JP7090100B2 (ja) 2022-06-23
CN110831945B (zh) 2023-08-08
IL269599B1 (en) 2023-03-01
AU2018243463A8 (en) 2019-11-07
JP2020515610A (ja) 2020-05-28
CN110831945A (zh) 2020-02-21
US20200102318A1 (en) 2020-04-02
AU2018243463A1 (en) 2019-10-31

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