KR20190110736A - 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 - Google Patents

신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 Download PDF

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Publication number
KR20190110736A
KR20190110736A KR1020180032548A KR20180032548A KR20190110736A KR 20190110736 A KR20190110736 A KR 20190110736A KR 1020180032548 A KR1020180032548 A KR 1020180032548A KR 20180032548 A KR20180032548 A KR 20180032548A KR 20190110736 A KR20190110736 A KR 20190110736A
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KR
South Korea
Prior art keywords
triazol
aminomethyl
dihydro
hydrochloride
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020180032548A
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English (en)
Korean (ko)
Inventor
한태동
탁희재
김은경
최수빈
박솔
김동훈
김소영
최현호
김태왕
주미경
하나리
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주식회사유한양행
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Priority to KR1020180032548A priority Critical patent/KR20190110736A/ko
Priority to PCT/IB2019/052278 priority patent/WO2019180646A1/en
Priority to AU2019237344A priority patent/AU2019237344B2/en
Priority to JP2020550176A priority patent/JP7383627B2/ja
Priority to CA3093057A priority patent/CA3093057A1/en
Priority to CN201980020696.5A priority patent/CN111886233B/zh
Priority to US16/359,985 priority patent/US10995086B2/en
Priority to EP19772403.2A priority patent/EP3768675B1/en
Priority to KR1020207029750A priority patent/KR102788118B1/ko
Priority to TW108109864A priority patent/TWI803600B/zh
Priority to ARP190100713A priority patent/AR115007A1/es
Publication of KR20190110736A publication Critical patent/KR20190110736A/ko
Priority to US17/208,887 priority patent/US11780830B2/en
Priority to JP2023128580A priority patent/JP2023145748A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020180032548A 2018-03-21 2018-03-21 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 Pending KR20190110736A (ko)

Priority Applications (13)

Application Number Priority Date Filing Date Title
KR1020180032548A KR20190110736A (ko) 2018-03-21 2018-03-21 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
EP19772403.2A EP3768675B1 (en) 2018-03-21 2019-03-20 Novel triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same
KR1020207029750A KR102788118B1 (ko) 2018-03-21 2019-03-20 신규한 트리아졸론 유도체 또는 그의 염, 및 그를 포함하는 제약 조성물
JP2020550176A JP7383627B2 (ja) 2018-03-21 2019-03-20 新規トリアゾロン誘導体またはその塩、およびこれらを含む医薬組成物
CA3093057A CA3093057A1 (en) 2018-03-21 2019-03-20 Novel triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same
CN201980020696.5A CN111886233B (zh) 2018-03-21 2019-03-20 三唑酮衍生物或其盐以及包含其的药物组合物
US16/359,985 US10995086B2 (en) 2018-03-21 2019-03-20 Triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same
PCT/IB2019/052278 WO2019180646A1 (en) 2018-03-21 2019-03-20 Novel triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same
AU2019237344A AU2019237344B2 (en) 2018-03-21 2019-03-20 Novel triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same
TW108109864A TWI803600B (zh) 2018-03-21 2019-03-21 新穎的三唑酮衍生物或其鹽及包含彼等之醫藥組合物
ARP190100713A AR115007A1 (es) 2018-03-21 2019-03-21 Derivados de triazolona o sales de los mismos y composiciones farmacéuticas que comprenden los mismos
US17/208,887 US11780830B2 (en) 2018-03-21 2021-03-22 Triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same
JP2023128580A JP2023145748A (ja) 2018-03-21 2023-08-07 新規トリアゾロン誘導体またはその塩、およびこれらを含む医薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020180032548A KR20190110736A (ko) 2018-03-21 2018-03-21 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물

Publications (1)

Publication Number Publication Date
KR20190110736A true KR20190110736A (ko) 2019-10-01

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020180032548A Pending KR20190110736A (ko) 2018-03-21 2018-03-21 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR1020207029750A Active KR102788118B1 (ko) 2018-03-21 2019-03-20 신규한 트리아졸론 유도체 또는 그의 염, 및 그를 포함하는 제약 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020207029750A Active KR102788118B1 (ko) 2018-03-21 2019-03-20 신규한 트리아졸론 유도체 또는 그의 염, 및 그를 포함하는 제약 조성물

Country Status (10)

Country Link
US (2) US10995086B2 (https=)
EP (1) EP3768675B1 (https=)
JP (2) JP7383627B2 (https=)
KR (2) KR20190110736A (https=)
CN (1) CN111886233B (https=)
AR (1) AR115007A1 (https=)
AU (1) AU2019237344B2 (https=)
CA (1) CA3093057A1 (https=)
TW (1) TWI803600B (https=)
WO (1) WO2019180646A1 (https=)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022224195A1 (en) * 2021-04-22 2022-10-27 Yuhan Corporation Triazolones, tetrazolones, and imidazolones, or their salts, and pharmaceutical compositions comprising the same

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JP2023145748A (ja) 2023-10-11
CN111886233B (zh) 2024-01-02
JP7383627B2 (ja) 2023-11-20
EP3768675B1 (en) 2026-04-01
WO2019180646A1 (en) 2019-09-26
EP3768675A4 (en) 2021-12-22
AU2019237344B2 (en) 2023-07-06
US10995086B2 (en) 2021-05-04
US20190322655A1 (en) 2019-10-24
KR20200124759A (ko) 2020-11-03
AR115007A1 (es) 2020-11-18
CA3093057A1 (en) 2019-09-26
TW202003508A (zh) 2020-01-16
CN111886233A (zh) 2020-11-03
EP3768675A1 (en) 2021-01-27
KR102788118B1 (ko) 2025-03-31
TWI803600B (zh) 2023-06-01
US11780830B2 (en) 2023-10-10
AU2019237344A1 (en) 2020-10-01
JP2021518384A (ja) 2021-08-02
US20210317110A1 (en) 2021-10-14

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