KR20190086386A - Compositions comprising phlorotannin for improving female sexual dysfunction - Google Patents

Abstract

The present invention relates to a composition having an effect of improving a sexual function of women by applying the same to a vagina of women. More specifically, the present invention relates to the composition and related products for use in improving the sexual function of women by applying the composition containing a phlorotannin compound as an active component to inside and outside the vagina in a form of a spray or the like.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for improving female sexual function comprising phlorotannin as an active ingredient. [0002]

The present invention relates to compositions that have the effect of improving sexual function in women by applying to the quality of women. More particularly, the present invention relates to compositions and related products for use in improving the sexual function of women by applying a composition comprising a phlorotannin compound as an active ingredient to the inside and outside of the vagina in the form of spray or the like.

Female Sexual Dysfunction (FSD) refers to a variety of disorders or impairments of sexual function, a lack of desire for sexual activity, repeated failures to reach or maintain sexual arousal, sufficient orgasms to follow excitement Can not, and pain during intercourse. It is estimated that 43% of women in the United States suffer from sexual dysfunction, and this is a very serious problem that affects a growing number of women negatively. Frustration, including the tendency to stop sexual intercourse, affects many young women or postmenopausal women.

Female sexual dysfunction and sexual dysfunction can be divided into the following six kinds of wholesalers.

* Desire

* Arousal

* Lubrication

* Orgasm

* Satisfaction

Pain

These multiple aspects of female sexual function are examined by the interaction of different cognitive, emotional, and organic factors, and it is difficult to expect a satisfactory effect with fragmented approaches. For example, after the discovery of the erectile function promoting effect of men associated with vasoactive ingredients, research has been conducted on the same principle in women, but it fails to normalize female sexual functions.

Korean Application No. 2010-0029788

Despite the fact that female sexual dysfunction is manifested by multiple factors, the current approach has been to use a method that is very fragmentary, invasive, or worrying about side effects, such as pharmacologic vasodilators, hormones, surgical implantation of physical implants, etc. have. Therefore, there is a demand for a product which can be used with ease by women. However, it is difficult to achieve satisfactory satisfaction with a substance or method that exhibits an effect for only a part of the six factors of female sexual function.

Accordingly, the present inventors intend to provide a substance and a product which can be safely and easily used by anyone, exhibit a total effect on six factors quickly, and can expect fundamental improvement effects by continuous use.

In order to achieve the above object, the present invention provides a composition for improving female sexual function comprising a phlorotannin compound as an active ingredient.

The present invention also provides a product having the female sexual function-improving effect comprising the composition.

The composition and the product containing the fluorotannine of the present invention as an effective ingredient are safe as natural origin materials, easy to use, and have the effect of improving all six aspects of female sexual function. It can also provide a fundamental improvement effect by continuous use.

1 is a view for explaining the effect of the present invention.

Hereinafter, the present invention will be described in detail.

Based on several prior literature, the risk factors that cause female sexual dysfunction can be analyzed as follows.

* Depression, anxiety,

* Cardiovascular disease

* Nervous system abnormality

* Side effects caused by antidepressants, antihypertensives

Emotional or psychological stress, especially stress related to partner relationships

The above risk factors are the factors that cause problems in the operation of the central feedback system and the local feedback system, which are necessary for sexual activation and function completion. More specifically, it can be considered as a negative factor in the feedback action between the central nervous system, which is closely related to the sexual activity of the densely distributed local nervous system and the vascular system, and which senses sexual excitement and satisfaction.

As a method for improving such a feedback action, the present inventors have adopted a strategy of simultaneously activating the local nervous system and the vascular system. The present inventors have found that a natural ingredient having absolute safety in a human body can be applied directly to the local and the vaginal zone of a woman to provide a safe and non-allergic stimulant, promptly accelerate peripheral blood circulation, It has been found that a composition containing phlorotannin as an active ingredient can achieve this purpose. That is, it has been confirmed that a composition comprising phlorotannin as an active ingredient can totally improve six aspects of female sexual function, and the present invention has been completed.

The fluorotannine of the present invention does not cause allergies when applied directly to the skin, and has antimicrobial and anti-inflammatory activity, thereby reducing skin infections and inflammation, thereby reducing pain during sexual intercourse as well as preventing damage to the vaginal wall . In addition, it is strong in acidity and excellent in stability when considering that the vagina is acidic.

Therefore, a composition containing phlorotannin as an active ingredient can be prepared as a liquid spray or a cream-like product which is easy to apply to local areas, and used for the inside and outside of the vagina, thereby improving female sexual function.

The phlorotannin contained in the female sexual function-improving composition of the present invention can be obtained by any conventional method, and can be synthesized using a commercially available reagent or extracted and isolated from natural products, particularly seaweeds.

Florotannine, an active ingredient of the composition of the present invention, can be extracted from brown algae and specifically includes Eisenia bicyclis, Eisenia arborea, Eisenia desmarestioides, Eisenia galapagensis, Eisenia masonii, Ecklonia kurome, Ecklonia cava, Ecklonia stolonifera, Sea bamboo (Ecklonia maxima), Ecologia radiata For example, Ecklonia radiata, Ecklonia bicyclis, Ecklonia biruncinate, Ecklonia buccinalis, Ecklonia caepaestipes, Ecklonia exasperta, Ecklonia fastigiata, Ecklonia brevipes, Ecklonia arborea, Eclonia latifopa, At least one member selected from the group consisting of Ecklonia latifolia, Ecklonia muratii, Ecklonia radicosa, Ecklonia richardiana and Ecklonia wrightii Can be extracted.

 The fluorotannine compound, which is an effective component of the composition of the present invention, is particularly preferably an excora compound among the fluorotannine compounds. The excitonic compounds are relatively small in molecular weight and have three or five fused ring systems. They have a planar structure and are easily absorbed through the skin, which can quickly reach the blood vessels and nervous system have.

The fluorotannine compound which is an effective component of the composition of the present invention may more preferably be one or more compounds selected from the compounds represented by the following general formulas (1) to (12).

[Chemical Formula 1]

(2)

(3)

[Chemical Formula 4]

[Chemical Formula 5]

[Chemical Formula 6]

(7)

[Chemical Formula 8]

[Chemical Formula 9]

[Chemical formula 10]

(11)

[Chemical Formula 12]

The composition for improving female sexual function of the present invention may contain 0.1 to 100% by weight of the above-mentioned flurothanine compound.

The composition of the present invention may further contain 0 to 99.9% by weight of at least one selected from the group consisting of purified water, carnitol components such as mannitol, alginic acid, fucoidan, laminaran, and fucosterol and fucoxanthin as lipid components can do.

The composition for improving female sexual function of the present invention is particularly useful for treating at least one kind of phlorotannin selected from the following formulas (1) to (7) having excellent activities related to blood circulation promotion A more excellent effect can be obtained when at least one kind of fluorotannine selected from the formulas (8) to (12) having excellent activity (having the characteristic that fused rings having five rings are bonded) is combined.

The composition for improving female sexual function of the present invention preferably comprises at least one phlorotannin selected from phlorotannines represented by formulas (1) to (7) and at least one phlorotannin selected from phlorotannin represented by formulas (8) to 1: 10 to 10: 1, the effect can be more excellent.

More preferably, the phlorotannin contained in the composition contains 0.5 to 5.0% by weight of phlorotannin of formula (1), 0.5 to 5.0% by weight of fluorotannin of formula (2) 0.5 to 5 wt% of tannin, 0.5 to 5 wt% of fluorotannine of formula (4), 0.1 to 2 wt% of fluorotannine of formula (5), 0.2 to 3 wt% of fluorotannin of formula (6) 0.2 to 3 wt% of a fluorotannine of the formula (8), 0.2 to 3 wt% of a fluorotannin of the formula (9), 0.2 to 3 wt% of a fluorotannin of the formula (10) By weight, and 0.01 to 1% by weight of a fluorotannine represented by the general formula (12).

The fluorotannine composition can be commercialized in the form of liquid spray, cream, gel, and the like. The fluorotannine composition in the product may contain 0.001 to 1% by weight, preferably 0.01 to 0.5% by weight, more preferably 0.02 to 0.2% by weight, based on the total weight of the product. When the content of the phlorotannin compound is included, the effect of improving female sexual function is excellent.

The product for improving female sexual function of the present invention comprises a phlorotannin composition and purified water, and further contains ethanol, glycerin, 1,2-hexanediol, vitamin, vitamin C, arginine, flavor, ylang ylang, Glycereth-26 PCA isostearate GPI-25), and a fermented green tea extract.

The product for improving female sexual function of the present invention may preferably further contain 0.001 to 1% by weight of arginine.

The daily use amount of the phlorotannin contained in the composition for improving female sexual function and the product of the present invention is preferably about 0.1 to 100 mg, but the usage amount is not limited to the above range.

Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are intended to further illustrate the present invention, and the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Production Example 1. Preparation of a fluorotannine compound

In order to prepare a composition comprising the phlorotannin of the present invention as an active ingredient, the extract was extracted from Ecklonia cava , a brown algae collected from the sea of Jeju Island, by the following method.

The sensillae were washed with distilled water to remove foreign substances, dried in shade, and then disrupted. 500 g of the above menthol was added to the extraction container, 20 times of 30 wt% aqueous solution of menthol was added thereto, and the mixture was refluxed at 75 to 80 ° C for 4 hours to obtain an extract. The extract was filtered through a filter net of 10 mu m, and the filtered extract was concentrated under reduced pressure in a water bath at 55 DEG C to obtain a first-extracted concentrate. The primary extract concentrate was dried in a vacuum drier at 90 캜 for 8 hours or more at a pressure of 70 torr and pulverized to obtain 170 g of a primary extract. The primary extract was dissolved in hot water at 50 캜, adsorbed on an adsorbent resin, washed with water, and eluted with a solvent to obtain a fluorotannin eluate. The eluate was filtered through a 1 탆 filter net, and the filtered extract was concentrated under reduced pressure in a water bath at 55 캜 to obtain a second extract concentrate. The second extract concentrate was dried in a vacuum drier at 90 DEG C for 8 hours or more at a pressure of 70 torr and pulverized to obtain 30 g of a second extract. The secondary extract was dissolved in the alcohol and the filter aid (diatomite or bentonite) was added and filtered to obtain an eluate. The eluate was filtered through a 1 탆 filter net, and the filtrate was concentrated under reduced pressure in a water bath at 55 캜 to obtain a concentrate. The concentrate was dried in a vacuum drier at 90 DEG C for 8 hours or more at a pressure of 70 torr and pulverized to obtain 19 g of a composition.

The composition thus obtained was loaded on liquid chromatography to separate the compounds, and 12.4 g and 2.9 g of fractions I and II were obtained as a fluorotannin fraction, respectively. The two fractions thus obtained were each dissolved in 60% methanol, filtered through a 0.2 μm membrane filter, and loaded onto high performance liquid chromatography. In high performance liquid chromatography, HP ODS Hypersil was used as the column, distilled water and methanol were used as the solvent, and the solvent supply was linearly gradient from methanol 15% to 70% over a period of 30 minutes at a flow rate of 1.0 ml / The compounds of formulas (1) to (7) were separated from fraction I, and the compounds of formulas (8) to (12) were separated from fraction II. The chemical compositions (on a dry weight basis) of the extracted fluorotannine fractions I and II are shown in Tables 1 and 2 below.

Composition of the sample (% by weight) Fraction I
Formula 1 (2) (3) Formula 4 Formula 5 6 Formula 7 11.5 19.1 10.4 9.2 3.7 5.8 40.3

Composition of the sample (% by weight) Fraction II
8 Formula 9 10 Formula 11 Formula 12 31.1 26.5 30.5 9.9 2.0

Preparation Example 2. Preparation of a composition containing a fluorotannine compound

Fractions I and F were mixed at a weight ratio of 1: 0 to 0: 1 as shown in Table 3 below to prepare Compositions 1 to 5. Compositions 6 to 10 were also prepared by mixing one or more of the compounds of Formulas 1 to 12 isolated in Fraction I and Fraction II as shown in Table 4 below.

ingredient Composition 1 Composition 2 Composition 3 Composition 4 Composition 5 Fraction I 100 80 50 20 0 Fraction II 0 20 50 80 100 Sum 100 100 100 100 100

Unit (wt%)

ingredient Composition 6 Composition 7 Composition 8 Composition 9 Composition 10 Formula 1 100 0 0 0 0 Formula 2 50%
4 50% 0 100 0 0 0 10 0 0 100 0 0 (7) 40%
60% 0 0 0 100 0 (3) 80%
20% 0 0 0 0 100 Sum 100 100 100 100 100

Unit (wt%)

Examples 1 to 10. Effect of the composition containing the phlorotannin compound on female sexual function

Table 3 and Table 4 evaluated the female sexual function improving effect on the composition.

In order to confirm the female sexual function when the composition was sprayed into the vulva and the vagina, a saline solution (Comparative Example 1, including ethanol) and a composition 1 to 10 containing no 0.1% (Table 5). Each of them was placed in 5 small spray containers of 30 mL each, and then given to applicants of 55 women aged 31 to 59 years, who usually feel uncomfortable with their sex life, and allowed to freely use for 4 weeks. Female Sexual Function Index: Rosen et al., Journal of Sex & Marital Therapy, 26: 191-208 (2000)). The FSFI consists of 19 items (see Table 6 below), and consists of six domains: Desire, Arousal, Lubrication, Orgasm, Satisfaction and Pain. And 1 to 5 points for each item. The higher the score, the higher the sexual function.

ingredient Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Composition 1 - 0.1 - - - - - - - - - Composition 2 - - 0.1 - - - - - - - - Composition 3 - - - 0.1 - - - - - - - Composition 4 - - - - 0.1 - - - - - - Composition 5 - - - - - 0.1 - - - - - Composition 6 - - - - - - 0.1 - - - - Composition 7 - - - - - - - 0.1 - - - Composition 8 - - - - - - - - 0.1 - - Composition 9 - - - - - - - - - 0.1 - Composition 10 - - - - - - - - - - 0.1 ethanol 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 Saline solution 99.05 98.95 98.95 98.95 98.95 98.95 98.95 98.95 98.95 98.95 98.95 Sum 100 100 100 100 100 100 100 100 100 100 100

Unit (wt%)

Question score 1. During the last four weeks, how often have you experienced sexual desire or concern? 5 = almost always or always; 4 = most of the time (more than half); 3 = Occasionally (about half); 2 = several times (less than half);
1 = almost or never 2. How would you rate your level of sexual desire or interest over the past four weeks? 5 = very high; 4 = High; 3 = medium; 2 = low; 1 = very low or none at all 3. How often during the last four weeks did you feel sexual excitement during or during sexual intercourse? 0 = No sexual activity; 5 = almost always or always; 4 = most of the time (more than half); 3 = Occasionally (about half); 2 = several times (less than half); 1 = almost or never 4. How do you rate the level of sexual excitement during sexual activity or sexual intercourse during the last four weeks? 0 = No sexual activity; 5 = very high; 4 = High; 3 = Medium; 2 = low; 1 = very low or none at all 5. How confident were you in the past four weeks of being sexually excited during sexual activity or sexual intercourse? 0 = No sexual activity; 5 = very high confidence; 4 = high confidence; 3 = Usually confident; 2 = low confidence; 1 = very low or no confidence 6. How often during the last four weeks have you been satisfied with your sexual activity during sexual activity or sexual intercourse? 0 = No sexual activity; 5 = almost always or always; 4 = most (more than half); 3 = Occasionally (about half); 2 = several times (less than half); 1 = almost or never 7. How often during the last four weeks have sexual activity or sexual intercourse lubrication (vaginal) in the vagina? 0 = No sexual activity; 5 = almost always or always; 4 = most (more than half); 3 = Occasionally (about half); 2 = several times (less than half); 1 = almost or never 8. How difficult was the lubrication (wetting) of the vagina during sexual intercourse or intercourse during the last four weeks? 0 = No sexual activity; 1 = very difficult or impossible; 2 = very difficult; 3 = difficulty; 4 = somewhat difficult; 5 = Not difficult 9. During the last four weeks, how often have you maintained lubrication (wetting) in your vagina until sexual activity or sexual intercourse is completed? 0 = No sexual activity; 5 = almost always or always; 4 = most of the time (more than half); 3 = Occasionally (about half); 2 = several times (less than half); 1 = almost or never 10. How difficult was it to maintain lubrication in the vagina until sexual activity or sexual intercourse was completed during the last four weeks? 0 = No sexual activity; 1 = very difficult or impossible; 2 = very difficult; 3 = difficulty; 4 = somewhat difficult; 5 = Not difficult 11. How often have you reached orgasm when you have had sexual stimulation or sexual intercourse during the last four weeks (climax)? 0 = No sexual activity; 5 = almost always or always; 4 = most (more than half); 3 = Occasionally (about half); 2 = several times (less than half); 1 = almost or never 12. How difficult was it to reach orgasm when sexual stimulation or intercourse during the last four weeks (climax)? 0 = No sexual activity; 1 = very difficult or impossible; 2 = very difficult; 3 = difficulty; 4 = somewhat difficult; 5 = Not difficult 13. How satisfied were you with reaching the orgasm during sexual intercourse or sexual intercourse during the last four weeks (climax)? 0 = No sexual activity; 5 = Very satisfied; 4 = approximately satisfied; 3 = unsatisfied with satisfaction; 2 = dissatisfied; 1 = Very dissatisfied 14. How satisfied are you with the level of emotional intimacy among the sexual activities between you and your spouse during the past four weeks? 0 = No sexual activity; 5 = Very satisfied; 4 = approximately satisfied; 3 = unsatisfied with satisfaction; 2 = dissatisfied; 1 = Very dissatisfied 15. How satisfied were you with your partner during the last four weeks? 5 = Very satisfied; 4 = approximately satisfied; 3 = unsatisfied with satisfaction; 2 = dissatisfied; 1 = Very dissatisfied 16. How satisfied are you with your overall sexuality during the last four weeks? 5 = Very satisfied; 4 = approximately satisfied; 3 = unsatisfied with satisfaction; 2 = dissatisfied; 1 = Very dissatisfied 17. How often have you experienced discomfort or pain during vaginal inser- tion (intercourse) during the past 4 weeks? 0 = did not attempt sexual intercourse; 1 = almost always or always; 2 = most (more than half); 3 = Occasionally (about half); 4 = several times (less than half); 5 = Almost never or never 18. How often have you experienced discomfort or pain after vaginal insertion (after intercourse) during the past 4 weeks? 0 = did not attempt sexual intercourse; 1 = almost always or always; 2 = most (more than half); 3 = Occasionally (about half); 4 = several times (less than half); 5 = Almost never or never 19. How do you assess the degree of discomfort or pain (grade) after vaginal insertion or vaginal insertion for the past 4 weeks? 0 = did not attempt sexual intercourse; 1 = very high; 2 = High; 3 = Medium; 4 = low; 5 = very low or none at all

Domain score and total score are calculated as shown in the following Equation 1 by using the weights of the respective domains in Table 7 below.

domain Item number Score range weight Desire 1,2 1-5 0.6 Arousal 3,4,5,6 0-5 0.3 Lubrication 7,8,9,10 0-5 0.3 Orgasm 11, 12, 13, 0-5 0.4 Satisfaction 14,15,16 1-5 0.4 Pain 17, 18, 19 0-5 0.4

[Equation 1]

Full Scale Score = Σ (S _i × F _i ) (i = 1 to 19)

Where Si is the total score of the items in each domain and Fi is the weight for each domain.

The comparative examples and the FSFI evaluation (mean value for each 5 persons) at the time of using each composition are shown in Table 8 below.

domain Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Desire 3.0 3.6 4.7 4.2 4.6 4.4 3.4 3.7 4.5 4.9 4.5 Arousal 2.6 4.8 5.3 5.2 5.2 5.3 4.7 5.1 5.4 5.3 5.2 Lubrication 2.8 5.1 5.7 5.3 5.5 4.3 5.2 5.5 4 5.6 5.3 Orgasm 2.9 4.1 5.4 5.3 4.9 4.6 4 4.4 4.6 5.8 5.2 Satisfaction 3.2 3.8 5.3 5.5 4.5 4.6 3.6 3.8 4.2 5.7 5.4 Pain 3.9 4.5 5.8 5.6 5.4 4.3 4.4 4.9 4.3 5.8 5.4 Full Scale 18.5 25.9 32.1 31.2 30.0 27.6 25.3 27.4 27 33.1 31

As a result of the evaluation, it was confirmed that when the composition of the present invention was used, female sexual function was significantly increased in all six domains. Especially in the case of a composition comprising a compound of fraction I and a compound of fraction II.

Production Example 3. Preparation of female sexual function spray liquid using composition

Using the composition 3 and the ingredients shown in Table 9 below, a female sexual function-improving spray liquid was prepared and placed in a spray bottle of 30 mL each to complete the product.

Raw material name Content (% by weight) Purified water 97.46 glycerin 1.00 1,2-hexanediol 1.00 Composition 3 0.08 Vitamin C 0.01 Arginine 0.02 Ylang ylang yu 0.08 Glycereth-26 PCA Isostearate (Emalex GPI-25) 0.30 Fermented green tea extract 0.05 Sum 100.00

Example 11. Effects of Products Containing Florotannine Compounds on Female Sexual Function

The results of the FSFI test for 10 applicants of 31- to 59-year-old women who normally experience the inconvenience to the daily life of the product manufactured in Production Example 3 are shown in Table 10 below. And showed better effect than the test product using saline solution.

domain Example 11 Desire 5.5 Arousal 5.6 Lubrication 5.5 Orgasm 5.6 Satisfaction 5.5 Pain 5.7 Full Scale 33.4

As described above, the composition and the product containing the phlorotannin of the present invention as an active ingredient are safe as natural origin materials, easy to use, and exhibit all the six aspects of female sexual function, thus being useful as a composition for improving female sexual function Lt; / RTI >

Claims (10)

A composition for improving female sexual function comprising a phlorotannin compound as an active ingredient. The composition for improving female sexual function according to claim 1, wherein the phlorotannin compound is an exocyclic compound. [3] The composition for improving female sexual function according to claim 1, wherein the fluorotannine compound is at least one selected from the group consisting of fluorotannines represented by the following formulas (1) to (12).
[Chemical Formula 1]

(2)

(3)

[Chemical Formula 4]

[Chemical Formula 5]

[Chemical Formula 6]

(7)

[Chemical Formula 8]

[Chemical Formula 9]

[Chemical formula 10]

(11)

[Chemical Formula 12]

The composition for improving female sexual function according to claim 1, wherein the composition comprises 0.1 to 100% by weight of the total fluorotannin compound. The composition according to claim 1, wherein the composition comprises at least one selected from the group consisting of the fluorotannines represented by the formulas (1) to (7), and at least one selected from the group consisting of the fluorotannines represented by the formulas (8) By weight, based on the total weight of the composition. The composition according to claim 1, wherein the fluorotannine contained in the composition is 0.5 to 5.0% by weight of fluorotannine of Formula 1, 0.5 to 5.0% by weight of fluorotannin of Formula 2, 0.5 to 5 wt% of tannin, 0.5 to 5 wt% of fluorotannine of formula (4), 0.1 to 2 wt% of fluorotannine of formula (5), 0.2-3 wt% of fluorotannine of formula (6) 0.2 to 3% by weight of fluorotannin of formula (8), 0.2 to 3% by weight of fluorotannin of formula (9), 0.2 to 3% by weight of fluorotannin of formula (10) 2% by weight, and 0.01 to 1% by weight of phlorotannin of the formula (12). The method of claim 1, wherein the fluorotannine compound is selected from the group consisting of Eisenia bicyclis, Eisenia arborea, Eisenia desmarestioides, Eisenia galapagensis, (Ecklonia radiata), Eclonia bacillus (Ecklonia spp.), Ecklonia cava, Ecklonia stolonifera, Sea bamboo (Ecklonia maxima), Ecklonia radiata, Ecklonia bicyclis), Ecklonia biruncinate, Ecklonia buccinalis, Ecklonia caepaestipes, Ecklonia exasperta, Ecologia pasty, Ecklonia fastigiata, Ecklonia brevipes, Ecklonia arborea, Ecklonia latifolia, Ecklonia latifolia, wherein the composition is extracted from at least one member selected from the group consisting of lonia muratii, Ecklonia radicosa, Ecklonia richardiana and Ecklonia wrightii. . A product for improving female sexual function, characterized in that it is in the form of a liquid spray, cream or gel containing the composition of claim 1 and purified water and used for the inside and the outside of a woman's vagina. The product for improving female sexual function according to claim 8, wherein the daily use amount of the phlorotannin compound contained in the product is 0.1 to 100 mg. [Claim 8] The composition according to claim 8, which is selected from the group consisting of ethanol, glycerin, 1,2-hexanediol, vitamin, arginine, flavor, ylang ylang, Glycereth-26 PCA isostearate (Emalex GPI- [Claim 7] The product for improving female sexual function according to claim 1,

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