KR20190079031A - 신규한 크로노박터 사카자키 특이 박테리오파지 cs4 및 이를 포함하는 항균 조성물 - Google Patents

신규한 크로노박터 사카자키 특이 박테리오파지 cs4 및 이를 포함하는 항균 조성물 Download PDF

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KR20190079031A
KR20190079031A KR1020170180928A KR20170180928A KR20190079031A KR 20190079031 A KR20190079031 A KR 20190079031A KR 1020170180928 A KR1020170180928 A KR 1020170180928A KR 20170180928 A KR20170180928 A KR 20170180928A KR 20190079031 A KR20190079031 A KR 20190079031A
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연영은
김영주
한범구
김현일
박철세
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Abstract

본 발명은 크로노박터 사카자키(Cronobacter sakazakii)에 특이적인 사멸능을 갖는 신규 박테리오파지 CS4, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물, 상기 박테리오파지 CS4를 식품에 처리하는 단계를 포함하는 크로노박터 사카자키균이 제거된 식품 제조 방법 및 상기 박테리오파지를 인간을 제외한 개체에 투여하는 단계를 포함하는 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 CS4를 이용한 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 크로노박터 사카자키에 대한 특이성이 매우 높고, 상기 박테리오파지 CS4는 상기 크로노박터 사카자키에 감염하여 크로노박터 사카자키 균주 내에서 증식함으로써 용균 활성이 우수하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 CS4는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 의한 인간을 제외한 개체의 감염성 질병의 예방 또는 치료방법, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물 분야에서 다양하게 사용될 수 있다.

Description

신규한 크로노박터 사카자키 특이 박테리오파지 CS4 및 이를 포함하는 항균 조성물{Novel Cronobacter sakazakii specific bacteriophage CS4 and antibacterial composition comprising the same}
본 발명은 크로노박터 사카자키(Cronobacter sakazakii)에 특이적인 사멸능을 갖는 신규 박테리오파지 CS4, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물, 상기 박테리오파지 CS4를 식품에 처리하는 단계;를 포함하는 크로노박터 사카자키균이 제거된 식품 제조 방법 및 상기 박테리오파지를 인간을 제외한 개체에 투여하는 단계를 포함하는 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다.
크로노박터 사카자키(Cronobacter sakazakii)는 장내세균과에 속하는 그람 음성의 간균으로 포자를 형성하지 않는 통성혐기성균이다. 토양이나 물 등의 다양한 환경과 육류, 채소류, 유제품에 이르기까지 광범위한 식품군에서 검출되고 있다. 모든 연령대에서 질환을 일으킬 수 있으나 면역력이 약한 신생아 및 저체중아에 감염될 위험이 높으며 발생 빈도는 낮으나 장염, 패혈증, 수막염 등을 유발하는 고위험균이다. 1958년 영국에서 최초로 사카자키에 의한 감염 보고가 있었고 그 이후 연구자들에 의해 이유식과 분말우유가 신생아의 사카자키균 감염의 원인으로 밝혀졌다.
크로노박터 사카자키는 건조 및 훈제, 튀김 제품류, 즉석 식품과 같은 가공 식품뿐만 아니라 동물이나 식물성 원료의 산물 또는 신선한 제품에서 검출된다. 축산물의 경우 원료 동물의 장내미생물에 의해서 추가로 오염될 수 있다. 식품의 가공 과정에서 물, 토양, 먼지 등 환경적인 요인을 처리하지 않은 모든 원료는 잠재적인 오염 물질이며, 부적절한 위생 관리로 인하여 작업자와 장비를 통해 사카자키균의 오염의 가능성이 있다. 광범위한 식품에서 검출될 가능성이 있기 때문에 위생 관리에 대한 규칙을 준수해야 한다. 건강한 사람에게는 영향을 크게 미치지 않지만 신생아, 노인 및 면역 결핍 환자의 경우 심각한 질병과 사망을 유발할 수 있는데 특히 위장 계통과 신경계에 영향을 미치는 것으로 밝혀졌다.
사카자키균에 의한 질병은 모든 연령층에서 발생할 수 있으나, 주로 28일 이하의 신생아에 관해 보고된 사례들이 많다. 대략적으로 감염된 신생아수의 반 정도가 출생체중이 2 kg 이하였고, 이 중 3분의 2정도가 37주 이하인 조산아였다. 또한 면역력이 약한 신생아가 감염에 더 민감한 경향을 보였으며, 감염 시 20-40%의 사망률을 보이고 있다. 이러한 사카자키균 감염 발생은 오염된 유아용 조제분유가 원인으로 감염 시 패혈증, 뇌수막염, 괴사성 장염 등을 유발한다. 뇌수막염을 앓은 뒤에 살아남은 대부분의 환자는 수두증, 사지 마비, 발달 지체 등의 심각한 신경계 후유증을 앓고 있다. 또한 괴사성 장염이 발생한 신생아들의 29%에서 사카자키균이 발견되었다는 연구가 보고되었다. 크로노박터 사카자키는 열에 매우 안정한 것으로 나타나며 분유 제조 시 건조 공정을 거쳐도 생육이 가능하고, 건조한 조제분유에서도 스스로 캡슐화하여 분유의 유통기한인 24개월 동안 장기 지속성을 나타내기 때문에 유아용 조제분유의 안정성 관리가 요구된다.
한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지의 활용이 크게 주목을 받고 있다. 자연 친화적 방식의 선호로 인하여 박테리오파지에 대한 관심은 어느 때보다 높다고 할 수 있다. 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.
이에 본 발명자들은 크로노박터 사카자키(Cronobacter sakazakii)에 특이적인 용균활성을 갖는 박테리오파지를 분리하고, 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 크로노박터 사카자키(Cronobacter sakazakii)를 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.
본 발명의 목적은 크로노박터 사카자키(Cronobacter sakazakii)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 CS4를 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 CS4를 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물을 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 CS4를 식품에 처리하는 단계;를 포함하는 크로노박터 사카자키균이 제거된 식품 제조 방법을 제공하는 것이다.
본 발명의 또 다른 목적은 상기 박테리오파지 CS4를 인간을 제외한 개체에 투여하는 단계를 포함하는, 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 크로노박터 사카자키(Cronobacter sakazakii)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 CS4를 제공한다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 항생용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 사료 첨가용 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 소독제를 제공한다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 세척제를 제공한다.
또한, 본 발명은 박테리오파지 CS4를 포함하는, 식품 조성물을 제공한다.
또한, 본 발명은 상기 박테리오파지 CS4를 식품에 처리하는 단계;를 포함하는 크로노박터 사카자키균이 제거된 식품 제조 방법을 제공한다.
또한, 본 발명은 상기 박테리오파지 CS4를 인간을 제외한 개체에 투여하는 단계를 포함하는, 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 CS4를 이용한 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 크로노박터 사카자키에 대한 특이성이 매우 높고, 상기 박테리오파지 CS4는 상기 크로노박터 사카자키에 감염하여 크로노박터 사카자키 균주 내에서 증식함으로써 용균 활성이 우수하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 CS4는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 의한 인간을 제외한 개체의 감염성 질병의 예방 또는 치료방법, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물 분야에서 다양하게 사용될 수 있다.
도 1은 박테리오파지 CS4의 크로노박터 사카자키에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 CS4 유전자 시퀀싱 분석 결과로 얻은 유전자 맵을 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 CS4의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 CS4의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
이하, 본 발명에 대해 상세히 설명한다.
본 발명은 크로노박터 사카자키에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 CS4를 제공한다.
본 발명에서, 용어 박테리오파지(bacteriophage)는 특정 세균에 감염하여 해당 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.
본 발명에서 특이적인 사멸능을 보이는 크로노박터 사카자키(Cronobacter sakazakii)는 장내세균과에 속하는 그람 음성의 간균으로 포자를 형성하지 않는 통성혐기성균이다. 토양이나 물 등의 다양한 환경과 육류, 채소류, 유제품에 이르기까지 광범위한 식품군에서 검출되는 균주이다. 모든 연령대에서 질환을 일으킬 수 있으나, 특히 면역력이 약한 신생아 및 저체중아에 감염될 위험이 높은 균주로 장염, 패혈증, 수막염 등을 유발하는 고위험균을 말한다.
본 발명의 박테리오파지 CS4의 전체 유전자의 크기는 149,237 bp를 가지며, GC함량이 51%, 전체 ORFs의 수는 280개이다. 상기 박테리오파지 CS4는 약 190-210 nm의 크기이며, 머리 길이는 80-90 nm이고 꼬리 길이는 100-120 nm이다. 정이십면체의 머리를 가지며 꼬리가 있는 형태인 마이오비리대(Myoviridae)에 속한다. 상기 박테리오파지 CS4의 단백질 패턴 분석 결과 40 kDa, 34 kDa, 29 kDa, 28 kDa, 16 kDa 그리고 15 kDa 크기의 단백질을 포함함을 확인하였다. 또한 상기 박테리오파지 CS4는 크로노박터 사카자키에 대한 우수한 감수성을 통한 크로노박터 사카자키 사멸 능력을 가지고 있다.
본 발명의 박테리오파지 CS4는 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 CS4는 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.
크로노박터 사카자키 특이적 용균활성은 본 발명의 박테리오파지 CS4를 크로노박터 사카자키에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 CS4를 유효성분으로 포함하는 다양한 제품에 적용이 가능하게 한다.
본 발명의 박테리오파지 CS4는 도축장, 도계장 및 농장 부근의 하수로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자는 이를 박테리오파지 CS4로 명명하고 2017년 11월 28일에 한국미생물보존센터에 수탁번호 KFCC11751P로 기탁하였다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 항생용 조성물을 제공한다.
본 발명에서, 용어 항생용 조성물은 약제 형태로 개체에 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다.
본 발명의 박테리오파지 CS4는 기존 항생제에 비하여 크로노박터 사카자키에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 사료 첨가용 조성물을 제공한다.
축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞어 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 CS4를 이용할 수 있다.
또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조 상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.
본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 가축의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에 (Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.
본 발명의 박테리오파지 CS4를 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 광물성류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.
본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.
또한, 본 발명은 박테리오파지 CS4를 포함하는, 음용수 첨가제를 제공한다.
본 발명의 음용수 첨가제는 상기 박테리오파지 CS4 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 크로노박터 사카자키의 숫자를 감소시킬 수 있는 효과가 있다.
본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 소독제를 제공한다.
크로노박터 사카자키에 특이적 사멸능을 갖는 본 발명의 박테리오파지 CS4를 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 세척제를 제공한다.
본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 특이적 사멸능을 가지므로, 크로노박터 사카자키에 노출되었거나 노출될 가능성이 있는 개체의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.
또한, 본 발명은 상기 박테리오파지 CS4를 포함하는, 식품 조성물을 제공한다.
본 명세서에서 식품이란 함은 영양소를 한 가지 또는 그 이상 함유하고 있는 천연물 또는 가공품을 의미하며, 바람직하게는 어느 정도의 가공 공정을 거쳐 직접 먹을 수 있는 상태가 된 것을 의미하며, 통상적인 의미이고, 상기 식품 조성물은 식품, 식품 첨가제, 건강 기능성 식품 및 음료를 모두 포함하는 의도이다.
본 발명의 조성물을 첨가할 수 있는 식품으로는 예를 들어, 각종 식품류, 음료, 껌, 캔디, 차, 비타민 복합제, 기능성 식품 등이 있다. 추가로, 본 발명에서 식품에는 특수영양식품(예, 조제유류, 조제분유, 영, 유아식 등), 식육가공품, 어육제품, 두부류, 묵류, 면류(예, 라면류, 국수류 등), 건강보조식품, 조미식품(예, 간장, 된장, 고추장, 혼합장 등), 소스류, 과자류(예, 스낵류), 유가공품(예, 발효유, 치즈 등), 기타 가공식품, 김치, 절임 식품(각종 김치류, 장아찌 등), 음료(예, 과실, 채소류 음료, 두유류, 발효음료류, 아이스크림류 등), 천연조미료(예, 라면 스프 등), 비타민 복합제, 알코올 음료, 주류 및 그 밖의 건강보조식품류를 포함하며, 바람직하게는 분유 또는 이유식에 포함될 수 있으나, 이에 한정되지 않는다. 상기 식품, 음료 또는 식품첨가제는 통상의 제조방법으로 제조될 수 있다.
또한, 본 발명은 상기 박테리오파지 CS4를 식품에 처리하는 단계를 포함하는 크로노박터 사카자키균이 제거된 식품 제조 방법을 제공한다.
본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 특이적인 사멸능을 가지므로, 본 발명의 박테리오파지를 사용하면 식품에 존재할 수 있는 크로노박터 사카자키균을 제거할 수 있어 분유 및 이유식을 포함한 식품의 제조공정에 이용될 수 있다.
또한, 본 발명은 상기 박테리오파지 CS4를 인간을 제외한 개체에 투여하는 단계를 포함하는, 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.
본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 특이적인 사멸능을 가지므로, 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료에 이용될 수 있다.
본 발명에서, 크로노박터 사카자키에 의한 감염성 질병은 그 증상으로 패혈증, 뇌수막염, 괴사성 장염을 포함하나, 이에 제한되는 것은 아니며, 크로노박터 사카자키에 의한 2차 감염을 포함한다.
본 발명에서, 용어 "개체"는 크로노박터 사카자키에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 제외한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.
상기 용어 "가금류"는, 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.
본 발명의 방법에서 상기 박테리오파지 CS4 또는 조성물은 약학적 제제의 형태로 동물에게 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.
본 발명의 방법에서 상기 박테리오파지 CS4 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.
본 발명의 방법에 투여되는 상기 박테리오파지 CS4의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.
본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술 분야에서 통상적으로 사용되는 의미를 갖는 것이다.
이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.
실시예 1: 신규한 박테리오파지의 분리 및 배양
1.1 박테리오파지의 스크리닝 및 분리
크로노박터 사카자키에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 양돈농장 부근의 하수와 토양 시료를 채취하였으며, 대상세균인 크로노박터 사카자키는 생물자원센터에서 분양(KCTC 2949)받은 것을 사용하였다.
구체적으로, 채취한 시료를 균질화 한 후 크로노박터 사카자키와 함께 35℃에서 하룻밤 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.2 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다. 상기 여과액을 이용하여 용균반 분석을 통해 대상 시료에 크로노박터 사카자키를 특이적으로 용균할 수 있는 박테리오파지를 선별하였다.
다음으로 크로노박터 사카자키를 특이적으로 용균할 수 있는 박테리오파지를 스크리닝하기 위하여, 크로노박터 사카자키 150 μL를 취해서 멸균된 튜브에 넣고 3 mL의 BHI 탑 아가(top agar) [뇌심장침출액(뇌 침출 솔리드(solids) 12.5 g, 소 심장 침출 솔리드 5.0 g, 프로테오스펩톤 10.0 g, 글루코스 2.0 g, 소듐클로라이드 5 g, 인산나트륨 2.5 g/L) + 0.6% 아가]를 첨가하여 잘 혼합한 후, 미리 만들어 둔 2% BHI 아가 플레이트에 중층하였다. 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다.
박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(크로노박터 사카자키) 배양액 150 μL에 혼합한 후 0.6% BHI 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% BHI 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액(NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1M Tris-HCl(pH7.5) 50 mL)에 현탁하고, 실온에서 4시간 동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% BHI 탑 아가와 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 BHI 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, BHI 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 3,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 1에 나타내었다.
도 1에 나타낸 바와 같이, 2-3 mm의 크기를 가지는 용균반을 형성하는 박테리오파지를 확인하였고, 상기 박테리오파지는 크로노박터 사카자키에 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.
1.2 박테리오파지의 대량 배양 및 정제
상기 실시예　1.1에서 확인한 크로노박터 사카자키 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0×109 PFU/mL로 희석한 후 전배양된 크로노박터 사카자키 1.0×109 CFU/mL와 혼합하여 MOI(Multiplicity of infection)가 1이 되도록 하여 35℃에서 100 rpm으로 18시간 동안 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 박테리오파지 CS4(Bacteriophage CS4)로 명명하고, 2017년 11월 28일 한국미생물보존센터(Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고 수탁번호 KFCC11751P를 부여받았다.
실시예 2: 박테리오파지 CS4의 전체 유전자 분석
박테리오파지 CS4의 전체 유전자를 분석하기 위해, 박테리오파지 CS4 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 2시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올(25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 2시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL가 되도록 TE 완충액(Tris-EDTA, pH8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII 를 이용하여 유전자 시퀀싱을 수행하였다(마크로젠, 한국). 상기 시퀀싱 분석을 수행한 결과로 얻은 박테리오파지 CS4의 유전자 맵을 도 2에 나타내었다.
도 2에 나타낸 바와 같이, 박테리오파지 CS4의 전체 유전자의 크기는 149,237 bp를 가지며, GC함량이 51%, 전체 ORFs의 수는 280개임을 확인하였다. 상기 분석한 박테리오파지 CS4의 전체 유전자 서열을 서열번호 1로 나타내었다.
실시예 3: 박테리오파지 CS4의 형태학적 특성
박테리오파지 CS4의 형태학적 특성을 알아보기 위해, 배양액을 0.01% 젤라틴 용액에 희석하여 2.5% 글루타르알데하이드(glutaraldehyde) 용액으로 고정하였다. 이를 Carbon-coated mica plate(ca. 2.5 x 2.5 mm)에 적가한 후, 10분간 적응시켜 멸균증류수로 세척하였다. 이를 구리 격자(copper grid)에 끼워 2% 우라닐 아세테이트(Uranyl acetate)에서 30-60초간 염색하고 건조시킨 후, 투과전자현미경(Tecnai G2 Spirit Twin, Bio-Transmission electron microscope, 120 kV, 120,000~400,000)으로 관찰하였다. 그 결과를 도 3에 나타내었다.
도 3에 나타낸 바와 같이, 박테리오파지 CS4는 약 크기는 190-210 nm이며 머리 길이는 80-90 nm이고 꼬리 길이는 100-120 nm인 것을 확인하였다. 또한, 상기 박테리오파지는 정이십면체의 머리를 가지며 꼬리가 있는 형태인 마이오비리대(Myoviridae)에 속함을 확인하였다.
실시예 4: 박테리오파지 CS4의 단백질 패턴 분석
박테리오파지 CS4의 단백질 패턴을 분석하기 위해, 1.0×1010 PFU/mL로 준비된 박테리오파지 CS4 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.
도 4에 나타낸 바와 같이, 박테리오파지 CS4는 40 kDa, 34 kDa, 29 kDa, 28 kDa, 16 kDa 그리고 15 kDa 크기의 주요 단백질을 포함함을 확인하였다.
실시예 5: 박테리오파지 CS4의 다양한 세균에 대한 감염성 조사
크로노박터 사카자키를 포함한 다른 다양한 세균에 대해서 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였으며, 그 결과를 표 1에 나타내었다.
Figure pat00001
(+; 용균활성 있음, -; 용균활성 없음)
상기 표 1에 나타낸 바와 같이, 본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 대해 높은 감수성을 가지는 것을 확인하였다. 또한, 크로노박터 사카자키 외에 다른 속인 Salmonella, Bacillus, Listeria 종 등의 균주에 대해서는 용균활성이 없는 것을 확인하였다.
따라서, 본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.
상기 실험으로부터 박테리오파지 CS4는 크로노박터 사카자키에 대한 특이성이 매우 높고, 크로노박터 사카자키 내에서 증식함으로써 용균 활성이 우수하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 CS4는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 의한 감염성 질병의 인간을 제외한 개체의 예방 또는 치료방법, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물 분야에서 다양하게 사용될 수 있다.
비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.
이하 본 발명의 박테리오파지 CS4를 포함하는, 감염성 질병의 예방 또는 치료용 약학적 조성물 및 식품 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.
제제예 1: 의약품의 제조
1.1 주사제의 제조
박테리오파지 CS4 1 × 106 PFU/mL
주사용 멸균 증류수 적량
pH 조절제 적량
통상의 주사제의 제조방법에 따라 1앰플당(2 mL) 상기의 성분 함량으로 제조한다.
1.2 액제의 제조
박테리오파지 CS4 1 × 106 PFU/mL
설탕 20 g
이성화당 20 g
레몬향 적량
정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.
1.3 정제의 제조
박테리오파지 CS4 1 × 106 PFU/mL
옥수수전분 100 mg
유당 100 mg
스테아린산 마그네슘 2 mg
상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.
제제예 2. 식품 제제의 제조
1. 건강식품의 제조
박테리오파지 CS4 100 ml
비타민 혼합물 적량
비타민 A 아세테이트 70 g
비타민 E 1.0 mg
비타민 B1 0.13 mg
비타민 B2 0.15 mg
비타민 B6 0.5 mg
비타민 B12 0.2 g
비타민 C 10 mg
비오틴 10 g
니코틴산아미드 1.7 mg
엽산 50 g
판토텐산 칼슘 0.5 mg
무기질 혼합물 적량
황산제1철 1.75 mg
산화아연 0.82 mg
탄산마그네슘 25.3 mg
제1인산칼륨 15 mg
제2인산칼슘 55 mg
구연산칼륨 90 mg
탄산칼슘 100 mg
염화마그네슘 24.8 mg
상기의 비타민 및 미네랄 혼합물의 조성비는 비교적 건강식품에 적합한 성분을 바람직한 실시예로 혼합 조성하였지만, 그 배합비를 임의로 변형 실시하여도 무방하며, 통상의 건강식품 제조방법에 따라 상기의 성분을 혼합한 다음, 과립을 제조하고, 통상의 방법에 따라 건강식품 조성물 제조에 사용할 수 있다.
2. 건강음료의 제조
박테리오파지 CS4 100 ml
비타민 C 15 g
비타민 E(분말) 100 g
젖산철 19.75 g
산화아연 3.5 g
니코틴산아미드 3.5 g
비타민 A 0.2 g
비타민 B1 0.25 g
비타민 B2 0.3g
물 정량
통상의 건강음료 제조방법에 따라 상기의 성분을 혼합한 다음, 약 1시간 동안 85℃에서 교반 가열한 후, 만들어진 용액을 여과하여 멸균된 2 리터 용기에 취득하여 밀봉 멸균한 뒤 냉장 보관한 다음 본 발명의 건강음료 조성물 제조에 사용한다.
상기 조성비는 비교적 기호음료에 적합한 성분을 바람직한 실시예로 혼합 조성하였지만 수요계층이나, 수요국가, 사용용도 등 지역적, 민족적 기호도에 따라서 그 배합비를 임의로 변형 실시하여도 무방하다.
한국미생물보존센터(국내) KFCC11751P 20171128
SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel Cronobacter sakazakii specific bacteriophage CS4 and antibacterial composition comprising the same <130> 1-63P <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 149237 <212> DNA <213> direct input <400> 1 gactcacccg gcctgatgtg cattcgtccc acaataccta tttaacataa tacaccttat 60 acgcactcgg gataatgata atcattccca acacgtggag aggcccgcca gcactggcgt 120 agatgagaat gagtctcact caccttgtgg catgataatg agaatgattt gcattcgccc 180 tttgagaatg gttgtcggat gagaaccatt atcgtttacg caaaaagaaa aaaaaaatta 240 tttttcgctt gacacgaaga gcgaattttg ccaggcaaaa gtcctgtaga tgattacttt 300 tcgcacaata aaggccctcc cctctcaggc cctccggccc gtaccgggtc cgcctgttta 360 cgtaactatg cagataaaac acgattttat gcagatgaga ataattcgta tttgtgcctg 420 taggcactaa aaagcccttg acaatggcga ttttattact acgtaatgac caatagaaaa 480 caggtgatag cggtcatccc ttgaccgtgg gaacgtgagc acaatccttt gcgagctagc 540 aaagggggtg atccgttacc tgttttctat tggtcgcgcc tacggcgcgc cctcccttga 600 tccgtgggaa cgtaaaaccg tgttttgtca gaagtcaata aaaagttaag ttattgatag 660 taaatgagaa tcattatcgc attatgcaga taaatgaata aatagtgtca agttatgtaa 720 agaaaatgga tgattcgccg attcggcctg atacacgttt gcagatagaa gtcaataggg 780 gctaaaacgc gctgtaaggc cctatgcggg ccgctaccct caaccctggt tagtgggtta 840 ggggcgctgt tattcaatta tgcacttttg agggtgaaaa ttaatggttg atttccacaa 900 tgttaaatga taaggggcta taggctgggg gagtcggacc gataccgggt cgggcctgct 960 ggcttgccac gtttgggaca aaagaaaagc ccgccggggt ggcgggcctg tttggctgaa 1020 tggtgttagt taaggcaggt aaccagggca ggcagtgcca gcgccagatc ataacggttt 1080 aaggatttac gacgataagc caggcgggcc gttgccagtg tagcgccgaa agcgtttaaa 1140 aatgttgtga ccatttgatc gggtccgagt acagcggata aaatccagtt gtttacggta 1200 tcgccagaaa acgcgatgat gaccgccgcc agggtccaaa gtggaagatt gattttaaaa 1260 aggcggttca ttatggctta atctcgtttt gttgggtgag atcgcattat ggggcctttc 1320 ggcccctgag tcaatattat tttttgtttt tgtactcttc gatccagcgg gtgaagattt 1380 cagcttgctt ttctgccgct gccgctgttt tgtgttgcat cacttcaaca tgccaacaat 1440 cggcaagggt gaagcctgaa gcgtgagcaa cccacggata agacggatca gattctttgt 1500 aagacgccaa acgggccgga tcttcgtgga atacgtagcc ctctagctgt gcggcggtgt 1560 attcgttgcc gccgttgcct aacttcgccc attcgttatg gcttgacagg tagcgatcca 1620 gcatttcgaa aaatttagat ttggtcattt tttacggtct ccagtgtttt tagtggtttg 1680 ttgcttgagt gggtattatg gggcctttcg gcccccttgt caacgattaa tttaaatcca 1740 gattcagggc cagatctacc agggcggcga tctcctcttc tgttgcgatg cggcccacta 1800 cccagcggat atagatttta atcaataatg ctttgttgct tgcgtagccc ggatgtgata 1860 acagatcttt acggcgtaat ttgtcatctg ttgcgagggt catcacgccg cctttgtact 1920 caatggagat ctgcaaaccg ctttcaaagg tcgccataaa atagttttca aaggtaacag 1980 tttcaacgtg taactttgcg ccgtttacgt gctgttgcat ttcgaacgaa cgatcatacc 2040 cgaaagcatt tgcctgttcg tcgcggatgt agtagcggtt gaaattgttc aggttcattt 2100 tacggtctcc tctctgtggg ccgtcgcatc attgccgccc tacgtgataa ataatagcac 2160 aatggcggat cgatgcaata gggagaattg taaagttttg tcaacgtaaa cccggctttc 2220 agcccttcag gtctaacata aaaattttac gtttgcaagg gcaaaaagtg cgaaagtccg 2280 atttcgggag atctatattt ttatgatgta ggataccggg taaggggaaa acggcttaaa 2340 acgcgattta gagcgtttgg cgggcatgta catttataca ggagtaagaa ataaatttga 2400 caacggtttg aaagtatgta tttgattttg ttggaaatga taaccattct catttgcccg 2460 gttcggccca ggtccggtcc gcctccctga atagcgggca ggtccggtgt ttgtctcccc 2520 ctgcatcagg tgccatcgca tgacataaga ataacaaaaa aggggcgaac aagtcaaccc 2580 ctgtaaacac tgttaattca tccagccttt cgactgtttg cccggttcca tgccctggcg 2640 atccgatccc cggtgacctg gtgcggctgt cccatcatgc ggagtgattc aagggttagg 2700 cgttgacgct tgcggcgtaa actcaaaagc gataacgtgt tgcccatatg ggaccgggaa 2760 acattcattt tctgcccggc gttcagggta atgatctcat gaatggagat ccggcgctgt 2820 ttgctttcag cctctttgaa gatagccagc ggcggcgcga tctgctggcg ataccattct 2880 aaaaccattg gcgataaagc gatcatattt cacccccgat aaagtcggat cggtcgctgt 2940 ctctcatgcg gtcgtttaat tctttcagtg tggcgatccc gttttcggca tctttcgcca 3000 ggcatgaccc ggcataggtt ggatcactcc ccaagcgcaa gcggtgaagg taacgcaagg 3060 cggctaacgt ttggcggatc tcggattctg cgatcatggt tcggccctca attgtggcgg 3120 atgtcgtggc gcttttcggc gacggctaaa aagtcgtgaa gcgctttaat gttggcggtg 3180 tgggcgtcgt gttcggcccg gcccttttgg gcgtccagtt tggtgacctg gtaagcctcc 3240 agcaaggccc gatattgtgg atcatctgcc agcatatagc agaccccgaa acggcgtgtt 3300 atgccgtagc ggttgcgagt gttggccccc attttatgcg gtcctctcaa caatgatcac 3360 tgtttgcggg atctgcccct caatcactag cagcgctttc ttttgggtaa tgctgatttt 3420 aacacgggtt aacgtggctg taaaatcttt catttcatca tgcgccagct ttttacaaaa 3480 ccaggtttgc ggcttgccga tctccagcga gcgcagaaaa tcagttttgc ctaaagtgtt 3540 tttgataatc attctcgttt gtcctatatt ggcccctttc ggggccgggc cgggttacat 3600 tgctttttca atgtcgttta agatgtcttt tgcgagagtg tagccgattt gcaagcccct 3660 tgcaatgtcc tctcccaaaa ctttccggcc catgttgcca aaggataaga tccgcgccac 3720 ttctgatttt tccatctgcc aggaggcaaa acattgattg ccgttccact tgctaaagtg 3780 tgcgccgcct aactcctcaa ccgcaccaat aacggcaacg tttacagaaa tgacgtgttt 3840 gatgatttcc atttgactga ctccaggaca ttgggccggg gaccattccc cgccctatga 3900 gagacattat cggccctatt gcgccgggtg tcaaccccgg atcatgaaaa actttatttt 3960 gtggtgcata cgatagagcc aatcatgaaa ggcaggcccc cgcccgttaa cgtcaatgta 4020 aggcgttcta agctcttttt gctgttcggc ggtgggtatg tactcccggc cctctttaat 4080 catcccaaaa gccgttacat agtacacata cgccccacac tcagtaaaga tcatcctgtt 4140 tgagcggatg aatcggattg tgtaggcgtc accctcctgg cggatcttac ggcccgccgc 4200 gccgccgttg taaagtttgc ggatgtgata agggtcattg atcgccttgt tcgggtccgc 4260 tttaaaacgt tgccgggcct cttctatgtg ctttttccgg tggatcgcct cgctggctat 4320 tgcgttgcgc cgggcttgcg cctgcgctgc tggcgtcaat tcgtcgtagt atttcagatc 4380 tgtaaggttc atcattctac cccgatcaat ccgtcatcgt cgatgaatac atgtttttca 4440 ccaaaggatc gggcggcgtc gctcaggtca tcgccaacca tccccaaccc acgatcccag 4500 aatccgacgc cgtgcccctg gcgggtaaac caaaaatcgc ggcccgcttg cgtgtggtcg 4560 tagtcatccg atccggcaat ggctaaattt acctttgcgc cgtgccagtc caggaagcgg 4620 gcgcaagcct gttcgccctc atctttcgcc gtggcgctca actcataccc ggcgaggttg 4680 tcgatctctt cgccatcgtt cccggtggcg gattctgcaa aatacagcgc ctcaaagtaa 4740 ccagcgataa aggcgcggag gtgtaaagcg ttgaaagtag tcatttttac cagcccattt 4800 tgatgcaaat tgcggttgtg gatgcgatag ctacgaaaac agataccagg aagattacgc 4860 tcattttgtt tctctctttg tttgttgtgg tctgttgtga cccgatgaaa agagtataac 4920 ccgtaacgct tcccggcgtc aactttattt ttagcattta gtgctgatca ttgtttccag 4980 ttcggcccgg cgggccttcg ctgcatcgcg tagcgttttc atctctttaa tggtggcggc 5040 aatggtccgg cccacggcgc aagctaaaag ccacacgtgc ggccctttca ggtcgtgatc 5100 cttgtaaagc ccttgcgagg ttacagtaag acccaagcgg gaagcggcct tgtgatccgg 5160 catctcgaaa atctgtttca cttctttgaa tctcaggtgt ttgaagttaa gaccacggat 5220 cacggcggta gcggtgcgga caattgcatc cagttcgttt ttgctgcact caaccaggct 5280 gattttatac attggttccc acggggtgta cttgctcatt ttacgatctc tcttctgttt 5340 gtgggcggcg ttgtgtcgcc ctatgtgatg aattataggc cgggacggtt cccggcgtca 5400 acaaaagttt tgtaaagatt aaacgcctaa agtgtaggac gtgaaaaaga tcacgccggg 5460 cgcggctggc ttttgttctg ccagcttcca ggctggcaac gtgtgcgccg cgacatactc 5520 ccctaacatc tgccaggctt gcgcctcatc gctggcaagg atcacaacct cttcacactc 5580 ccccaacggg gggcggtgtc cggcaggcgc tcaaaggtaa acgcgatcat tttgcaccaa 5640 ccatacagca tacagaatca aaatgatttc gggcgcggtg ttcaccgtag cggacacggc 5700 tggaacctgt ttttgtgtag cggcccattt cgatgatttc gtaacagtca ccgccattgt 5760 gaaccaatga aatgataaac agttctgaga ctttgcgagc gatcacgcct tgcgcctcca 5820 gcggtggcaa cttgcaagcc ggggcggtgc gggtgaaaag tgatttgatg aattttaaca 5880 ttttgtgaat cctatttcgt ttggtgtggg ggtattatgg ggcctatcgg ccccgccgtc 5940 aactactttt tattttattt cttccggccc tttccacttc gaataggtca aaaatgcctc 6000 atgtagcgca ggggtcgctt cagagagaag gatcgcgccg ttatcgctta cagcggtgac 6060 ctggtaatga tcggcccggc gggatgattc accgcaagcg gacagggtaa cagtaacatc 6120 aatcaggcgg gacttttgca gaatcattgt aatcattttt acggtctctc tcttttgttg 6180 gtgtgggtca ttatcggccc tttcgggccg gatgtcaatc atttaaattc gtacattaca 6240 acattgtttt cgtcgatgat ttgggcttta tagtaaccgc cttgcgccag gcgataagcg 6300 gcgcataggt cttcaaaagt gcggcggatc ggggagcttg tttcgtgttc ccaagtcatc 6360 aaagtaaaca tattcataac ctcttagata atgcggggac cattccccgc cctatgtgag 6420 agattataag ccgggacggt tcccggcgtc aagctaattt ttaccaaatc gcaaacgctt 6480 tttagccagg gcgcgggcgg ttgtcttatt gtgcccggcc tcctgatagt agcgcgttaa 6540 gcggtccaaa gtttcacggc gatccgcctt gctggggtaa ctggtgatta agagtttatg 6600 cggattcata cagcgccccc gctgggatcg tgtcgtttac gatttcggcg atcacttgct 6660 ggataaaatc ggcggggatc ggttggcttt tggcttgcgt gatccggttg ccattataga 6720 tagcgtcata agagatcaca aattctttcc cgtcgcggtc tacgttgatt tgtaagcggt 6780 tcggcgcttt gtcatccata tggcgacaaa tgatctggac ggtgcccgct acgttggaca 6840 gcgacgccac gacgtgatcc gctacgtttg ccagaatgaa aagagtgtta gcctgttgca 6900 tgtttaaagc ctcgtttgtt tgtgtggggt cattgtaagc cgggacggtg cccggcgtca 6960 acaattattt tgcattcttt gccgggtgtg gttcccgaaa gtagcggcgg atctgcgccg 7020 ctgttagtcg ggcgtcagcc tgcaatgact ttagcggata ggggcggtta gcaataaatg 7080 tatgttgccc gcaaccattg ccgatcacga tgtcaaccag ggcgaaaagt aaagatgatt 7140 tcattttgca ccgcctttta acaattcaga gatccggcgg tttgcttcct cttctgatac 7200 ctcaaccgcg ccgatcacgg tcccatcggt gagatctgaa ggggtaaagc cgtcacggtg 7260 caaccagcca ccacgcgccc cactccagcg gtaaacgttg ccattttcta agcggtaaac 7320 attgcgagta acaaaataac gtgtcatgat ttgcggcctc atttgcctgt ttggtatgtc 7380 tgagattata agccgggacg gttcccggcg tcaagcgctt ttaatattct ttttgcgccg 7440 ggtttacgtt caggtgatta gccgccggga taggttctaa cagcggttca ccttccggca 7500 ttgcttcaac ttccggccct gggatacaag ccggattaat ccagcgcggg tcctggcggt 7560 agccattggc gacgatctcg caagttaact gatcgtcgta tgcttcaacg gtgtaatcat 7620 cacactgctt taaagcggca gcggcataaa aacacattcc ggcgaatact tcaaacataa 7680 ttttaaccct cgtttggttg tctggtgttg ctttcgtttg tctatgccgt cattgtaggc 7740 gacggcataa ccacacgtca agcgttttgc aaataaaatt ttgtgccacg tgggaggcgt 7800 gatccgaaac cttcccgatc acgtaggcgc tttcttgcgt cctgctcatc atagccataa 7860 actttcaacg ggccagccac gccagggatg tttacaagat agtgtttcat tggtctaact 7920 ccggtttgtt tgtctggggg tattatgggg cctaacccgg ccccggtcaa caattatttt 7980 tgataatttt tcattctttc ggcgttgtgt tcggcggctt ttacccatgc gccggggatt 8040 gtgtcggccc ggcttacaaa ttccccacaa aaacgggtaa catacaaggc cccgcaaggg 8100 tcgccggaaa attcacgggt cacggtgtag cgcttatctt ttttgattgt gcggataact 8160 tccccgaaaa gctgattaac aagcgctttc cattgtgtgc gggcgtcgcc gatctgatct 8220 tcaacaaccc actcgatccg gcccacgtca tcaaaatcgt gtgctttgac gtgaaaagcg 8280 ccgtgttcca ttaaaagctg tacccggata tttttcccgg tgatctttgt gtcgatctcc 8340 tggatatagc cgcaagccag tgcgtaaacg gataaacctg atttgatacg gaaaattggg 8400 gaagtcataa cggtctctct tctgttagtg cggcgcggtg tgcgtcgcta tgggttagat 8460 tatgggggaa ccggggccgg acgtcaagcc ccaaagatga aaatatttta aattatttta 8520 cagtgacccg gatcgcctcc accgttgcca gtgtcgccgg gtcaactacc agggcttgac 8580 ccgtggagat cttgacccct tcgcgggccg caacggcggc aagcgctttg caggtggcgc 8640 ggtatccttt gccatcggct accaggtaaa gggcgctaaa ccccatcgga cgggacccca 8700 tagcccggat aaaatctgtt aaggttaaaa ggttttgcat tgtgtacccc atagataaaa 8760 aataaggggc ctaagcggcc ccctgtgcgg tttaaactgt ttggcctggt gtttccatgc 8820 cggggcgctt actcccagtt atagcgcgtt ttacggcgct gttgtttgtt ggccttctca 8880 cgttgcaggc gctcacctgc ttcagcgtat gagagacggg cgcggcgcgg ttgtttatcg 8940 cggttaatgt tagtgtgaat cattctcatc ttctccggcg tttgttttgc tgctgttcca 9000 tgtagtaacg ttgatcaatt atttctccga tcttctcttc tgaggagtcg taaacctcat 9060 aagtgatcac cgcgcctaac tcctggcggt agttcatagc gccaaccata tcgatctcgc 9120 acattgcgcc atagtcccgg cttgatccct tctccccttt gtactcatat tcaaaataac 9180 cgtacatttt ttgacccttt cgccatagtg cggccttgtg agtggcgacg cagtaaagcg 9240 ccgccagtgc taaacaaatc agagttacga ttgtcattat acaccgtcaa gcatgggatt 9300 caataacaga gtatacaaca acccccagat atttagcaag ggcctcgaaa aaatcgcggg 9360 gcgtatggta tccgttaccc ttgatcccca tcttgcggat cgcctcctga aatgcggcat 9420 cctcgcgatt atagccatag ccgccagcct tgccaaactc agaaccatac agacccagga 9480 tcggggagtg aatccaaaga atcgccgtgt tagttttccc ggtgccgtag aagcggacct 9540 ccgccagatc tttgatctca ttgtctacca gcccgaccag gtgaacggcc ttgtaaaaat 9600 tgttttgctt acgggccttg cccaggtcgc cagaagttac aaccatgttg gaaaaatcgt 9660 aagtagcgtt cataatgttt tctctcttag tttggtttgt ggtgtttctc ttaatcagtc 9720 ccgctattat gccagcggga cggggtaaga gtcaacaact attttaaact ttttgccagc 9780 ttatcgatcc cggcgcttaa tttggtgtgc tttgttgctt ccagtaatac ggaaacctgc 9840 attaaaatat tttccgcctg ttcagggtac aactcaataa ccagattgaa ggcggcgcgg 9900 gaaccactac ggatcgccac ctggtaagcc tcatgtttaa cgtcgtttac ttgctgttcg 9960 ttgatcatgc tgtcaatctc tttctgttgg tgtacgggta ttatggggcc taacccggcc 10020 ccgtgtcaac ataaattata aatctttttt gcggctaaca tcataaacgc tttcggtgta 10080 gacaaccccg agatccgccg ccgcctggca agcgtaggac ataccacgcc acgccgccgg 10140 ggcatccttc accgcctcga tcatcgtgct taatgcggtt tgttcgaacc cgcgatcata 10200 accataggcg aaaccaacat aagccaggtc gatccacacg tcgccgcttt tgttgccgta 10260 cttgttagcg cctaagcggt ccgccacttc aacggatacc agcgccccca ggcttacgct 10320 gtgataagtg ttgccgtagc tacgctggaa ccaacgtttg ccagttacgg aaatttcttt 10380 gatgtcagcg gcgtttacag tgttgataat gttcattgtg tgatcctttc ggtttggttg 10440 tttgctttcg cttgtctatg ccgggtatta tggacccggc agaaaccaac gtcaagcggt 10500 ttttactaaa tcatcaaaga aactttgcgg acgggtggcg caacctttgc ccgcccattt 10560 gttaacgtgc tttgaggttg tcgcgctgtg ctttttgtca gtcacgacat agcccacgcc 10620 aggcaggcaa gccgcaaccg gggtattgta ggaaaagaaa acttgcgccc cggtggaggt 10680 agtgatcatg gtttggttag cgccgatagt agtcagattc attttgtaag cctcgtttgc 10740 ttgtctgttt gatatgtctg gtattatggg gcctaacccg gccccggtca acaattattt 10800 attacagaac cgtaattttt tcgcctttga tcattatgta agtgtgcccg gcgttgctgt 10860 actggtcaac atagatccgg cggcgcttgc cttgataatc caacatatag gacgtgggga 10920 tcttggtgcc atagcccgtg gcggtttttt gcaggccctg gcgttgccat tcaagcgggg 10980 cgtagatcgg tgcgtagaaa tctgaagcgt gatccgggtg gctaatcatt acggtttgca 11040 tactgttacc ttttggtttt ttggcggcgg gttattccgt cgccctatgt gatacattat 11100 ggacccatcc tggccggggg tcaataccca aaagcaaaat aatttaaata tttattccgt 11160 tgtcttttgg ttcgacgatc ccgccattgt ccaagatgca acggatcacg gcgtcgccca 11220 tcgctttaca tagcgcccac gtcggcgcgg tgatctcaat ataaggaaag caagcggccc 11280 cgccggggaa gtgttccacg tccgccaggt tatcaggatc ggcattgtgt gcggcgttgc 11340 ttactcgcct gtttaattcg tcccattccg ggaaatcata ttgatcatcg gtatcgccga 11400 tccattgtcc cgcaagatca ttacaatcat aaaagatatg gcaacggaaa agcggcgtga 11460 tctggacagc ggggatctgt ttggtcatgg tactgactcc acacgaaagg cccccgccgg 11520 gggcctgcaa ttggttagcg gtgagtgttg cgggaaagtg tgccgccgtt atgctttgcg 11580 gtaactcgcc agccgtccgc cgttttggtt ggcgttgtcg gggtcacgcc agcggcgcgg 11640 atcttactgg caacggcgcg ggcctcgtca cgggtacggt atgcgggcag ggttacaacc 11700 gccgccaggt taacagagga aacgccacgt gattttttat aggttacttt agccatttga 11760 tttactctct cattttgccg ggcaccattt gccgggcttg tcgtgaatta tggggccagg 11820 tggccccgat gtcaatagtc tttttaaatt attttgcgta gcgctcgcca ttcataaagg 11880 cgatccagcg ggccgcttgc cctggctttt tgaattgtgc gatcaattcg tcgccaccgt 11940 gacgggctac cgcctcaaca taatcggcgc tgtttggcgc acattgtacc aggttacccg 12000 tgttaaaatt tgggtgttta taaagtgtgc ggcggctgtt aatactatca atacggatga 12060 ttgaagagtc caaaagcgcc ccgccgccat agcttcggct attcttaacc agcaggggga 12120 tcttttgctc gcccatgctg cggcctatct tcccagtaac atcatattca tctaaccatg 12180 attcgcccgt ttcggtgttg ccgtaccata cacggacacg atcgccacgg ttataagcac 12240 ccatgatagc tttttgaact gcttcggaag ttttagcatt gaatgtaaac attttacgga 12300 ctctcttttg tttatgcggc gcggtgtgcg tcgctatgtg gtgaattatg gggcctatcg 12360 ctggccccgt caagcattat tttaaatctt tttgtaattt aattttgtgc tttcctggta 12420 cggcttgccc gttgtcatat catagatcac atattgcccg gcgcggtccg cctgttgcag 12480 tgtgacggcg cgatcctggc attgcttgac gccaccaata taaaccgggt ccaggtccgc 12540 cagcttaaca gcgccgggac caggcaggat cttaaacacg gcgaaaccac gatccacact 12600 atcgaacccg gcgaaccatt cgcggcggtt ctcttcttta ttgtagcggc aggcgcggat 12660 ctgcccggcg tgggcggcgg cgttaccttc aataaaatat ttcgtctgtt gcatcggtcg 12720 atctcctttg ttggtgtgcc tgcattgtgg cccggcttgc ctggcaggtc aagaaaaatt 12780 tattttcgtt ttggtattga cggcccggcg gggctagttc ataatgtaca catacaggag 12840 aggagacgcc accccacggc gaaaaggcgg ggctaacgta ccgggcaccg gggccaggtc 12900 ggaaggtgga tcgccggtag ttcgtccaaa atagttttgt aaagaactgt aaagacgctt 12960 gcaaccgggc cggggttggg ttatattata cacatagcgg ggagaaatga cccggagaca 13020 atcaccgggg gtgcccgcta ttctggagat gagaatgatt ctcattcaac tacgtaaatg 13080 cgaataatta tcatttcaat ttgcaaatga gaacgattct catttcgcct cgggcctaac 13140 gtgaatgata aaaattctca tttcgatttt cacctctgta tagattttga gaatacgttt 13200 ttgaaaatga aatctcgatc gagaccccgg gcggagacct gtacctgtat cgagaatacg 13260 atctcgaaat tgagttttcg atcgagaccc tgctttctgt accgagaccc cagtccggcc 13320 cggcgggcag agaatacgat cggcaaaacg aaaaaccgat cgagaccctc aaattttttg 13380 accagagata actcccgtat tgtaacgtat atgtgccgtt agtggtgcat aagcccctta 13440 atgtaacatt tatggtacat tagcccttga ccggggccgg gtgtgctggt acattgttga 13500 gtaaatctga aaaaggaatc tgatctgagt cccggcccgg cgggccatct caaataaaat 13560 ctcaaattga atttcgaatt gaaatctgat ttcaaatatc ggcgcaaata tcacaggcaa 13620 atatcaaatc gaaatccgat ctgaaaactg agccgtcctt ggcccacaaa tatcacagct 13680 tggtgctaac cgacacctgc aatgtgatcg gtttcacgtt cgagatgtag ttcttccctt 13740 cgtaatccct caagtatctg aacacagacc agttggcccc agggttgagg acatcaaaca 13800 gggcaatctc ttcttccgtt ggtcgcttcc agtcatcaaa gaaagtcctg aactcttcca 13860 ccttcatggc gagactttcc ttgccattcc ccaagacgat cttattatca ctggtgaagt 13920 acaggtagcc tggcacccac tgggtggata atcggaggat gccgttcgaa cacgccttga 13980 tggtcaagtc tccaagtttg gaatcttcca gatcccccat gtacgtatca tcgtgggtat 14040 atgacaacca ggcttgaccc agtgcatggt aatcctgaac aaaccgggct acattgtacc 14100 cgtaccaacc cataaccaca tctttcatta tgtgggattg tgggaggtac tcttcaagtt 14160 ggtccttcaa gttttcgaca aaggtcacca tctggtcacg ggtcattcca tccgggtccc 14220 agttcatctt cagatcgtaa cacgaatcac gcacagcgcg gtgcaaagta tctatctttt 14280 cgttggccct gtaaacaaaa tcctcaagag aagaatcaaa gtcaaaatca ctggctatgt 14340 ctttgatatc cgaagctaca gaatcattgc tctgccattc cttccgcaaa gtatcttgga 14400 catcagacag ccgccgctgt aaatttttcc aatcggggat ctctggcgtt ggactggtgc 14460 ccttggaata atcagcgaca ccgtgtagaa aagctgcatc aaatgaggac atgctctaaa 14520 agctcctgta acgcaacagg agaggcgcaa gcctctcccg gtatgattta tcaaagaccc 14580 tttacgaggc ccatgtgcca ctcaggagag cctctgtggg gcacttcctt cttattgtct 14640 tcgacgaaga cctctgcgct tgcaacaaca cagccgcact cgatggcttt ggtcattgta 14700 tcccgcattg cattaggaca aacaccgctg gcaatggctt gcttcgtcag ttgcccggca 14760 atggcccgca gcttgtccca agcctcttgt tggtaagcct ggaactcagg tgtcatctta 14820 ccgtatttgt cgtagcagat catacgatac cctcgtgcat tttcataccc atgacttggg 14880 cctccaagcc ccggctgcgg aagtagataa ccgccttgcg gaacccgtct tcattgtcaa 14940 cctgatttac atatacgtaa tcaaggacaa cttcccctgc atgaccgaac agcttatgcc 15000 accaacgaac ccggcggata gccgtgctgt tgtacatgat gttggacaag aaaacgtact 15060 ttgtcatgat acgaagtcca gtgtggtgcc cagttcttcc atacgcttca gaagccactg 15120 gcacactttg tggaactctt cttcatcctc gatgtcggca gtcaggtaat actggcagaa 15180 ctcggcatcg tcggtgtgaa gcgcgacaga cccgcaatcc aagtcgatga actcattcag 15240 gatcgtggtt tcaatttcgt cataacggtc ttcgtcatgg gggacgaaga acattacccc 15300 ggtgctgata gtgcgtgtga tcttcaggtc tttcatgtca tttctccacg taatgagtaa 15360 ggaaagtttc taccgccaat gcggcgttgg tttgataaaa gaaatcgttc accgtcccgt 15420 ggaacatatt agccacgtca ggaaaatctt cgttgacgta gttccacagg ttctggccta 15480 ctcgtaactg agggtgtgcc cggttaagag cataggccct gtcaatgagt ttacacgcat 15540 tcttctggct aatcaacttc attcgtgtgc ctccgcagtg atacggttta cccatgactc 15600 cagacccagg tttacccagt tggagaactc ttggccctct tggatgcgct ccagtgcttc 15660 aacggcaccg agggccttga tggccttgat gaagcgaacc atctgcgccg ggttgtcgag 15720 actcagttcc cgcaccgttt gggtgaagtg gtggtcgtta tcatccatgc gggggatgaa 15780 cgcatccagt tcccagcgct ccgcaccacc ggaacgcatc gccatgtact ggcgctgatc 15840 tttctcgcag atctctgctt gggcttcgat gttgcggata ttgtcgaaaa tgtggctcat 15900 ttgttcttct ccagttcggc aatcacggcg gacgcctgtt ttgtatttcg gaagttgatt 15960 gtagcactct gtcccatcat gtcaagacgt tccagcagag tttctgccgc atcatcctca 16020 cccattgccc agaaacccgg aaggccgagg aactcacacc agtacgcctt gcctccgtcg 16080 tcgatatccg ccgggcaagt atcgtcggtg tatgtccaat gacccacacc gaacccggac 16140 aggccgttac gggtcaggat cagttccggc atacagtcac aggaatcgtt gatgtggcac 16200 tcgcagtcac cgagaccctg gcggaccata aactgcggga cgattttacg aatatccatt 16260 acagatcctc catctcgaac agtgcgttgt catactcgcc gccgatcttg tcttcgtaga 16320 acccgatgtt ggcattgatg attgccagtg ccttgttcac ttcctcgccc ttcacacctg 16380 cggcgcggag ttccagttcg aaagcctgct gcaagcgacg aactgcctcg atgtggcctt 16440 tctgtactgc gacacgagcc aggtcatttg cttttttctt catgctcatc ttgtcgttcc 16500 ttttctctgt ttcgtttcga tggactaaga atagcaaaag gggttgaccg aagtcaaccc 16560 ctttgattaa ataaattcaa attttacgaa catccccagc aaagcggcgt ttttgtcgtc 16620 gagacgctcc gcataccacc gctctttatc ctccccaaca acgatcatgg agttaggatc 16680 tgccgctgac tcgtcaacct tgcaggcata ttctttacct acggtgaagt ggcattccat 16740 atcctcttcg acatacgtac agcgtacctt attcattgtt tcctccgggt tttataactt 16800 cacgaacgag atcaagaata cgctccaggt atgcgtattg gtggcttggc attttaggcc 16860 agtcaatgtg ccacggctca cacatccctt cgatgacccg caactcctcc ggcacatgac 16920 cgtaacacaa agagttacgg tccgggctgt agctatcaac gtagtaccac gcctgtttgg 16980 cttggtcttt ggtgatgtct ccggaacggc ggtgtttcag aattaaagac ttcaggtagt 17040 ccgggtctct gtccgggtcc ggttcagtgg ctcggtaatc agacatcttg tcgatcaggt 17100 agtcattgga cacacgctgg aagaactcct ccactgtgcc gcccatgctg ccccagaagc 17160 ctgtccagac ctgcccgtag caagagatgg taatcttgcc agtgcccggt tcaaagtttt 17220 ccacaataac ctcaaccggg tcgagacggt gggaatcctg aatgtcttcg atacggatct 17280 tttcgattgt ggaacgttta atctgcacgg cgggcctcca gttcacgggc aatttccccg 17340 ccctctgtgg tgagtaccca gccaaacggc gggagataac ggatcagtcc ttgggaagcc 17400 aggttgtcct gaacctttcc cttcaggtca cgattgtggt caccaccgag tgcagccagc 17460 agaaattttt gctggggttt agttagttta gccattattt attcctttat caataagatt 17520 gtgctgttat ctgccgagaa tatacacttc cccggtgcgg gagatggtat attgagggta 17580 agttttaccc tcttcggttg tatatgtccc tttctccacc agaccctttt tgacaagggt 17640 ctcaaggata ttgatggttc cctggcgtgt gttccacacc cacccacagc cccaggggaa 17700 ggcgatatag ccgtaacgac cttcgctgag acacttcagg accccgattt ggttttccca 17760 aggttcatac ccgttccttg tagaaagcgt aggcaaagta tgctttattg cgactatttt 17820 tcacgccgta ataggtatca tgcccgtaac cgaacaacca cccggtaaag acaagggtat 17880 gctcccagaa ccgccactta tacttcaggt acgttttctt cacgtgtctt ctccttacgt 17940 ttattgtgca ggtgctcaac aacacggacc agcggccccc ggcggcgctt acggatttgg 18000 cgttggatct tccacgtcac gtaacgaggg gactctctga acttatcgat cttcctgccg 18060 acccagaaca tcaactctac gaacagcagc acgggtgtca tcaaaaagca agccggggta 18120 agcataaaaa ggagcattac ccggtcatca ttacctacac gaccagaaac cgacatcagg 18180 gacaacatac gccagatgcc gaccactgag aacagtgccc agaggagata gaagtaaatg 18240 tgctccatca tgcccccggc tgaatgttgg aaggccacca gaaatactgc tgtgccgggg 18300 cacgtttacc atcgccaccc ttatcttcgt tcgccgcagg cataagtgcc caccatttga 18360 tattacccat tataacctcc acagatttgg ataacaaaca caatgatctt tccgatcacg 18420 cctaacagta gcatagaccc accgaggatt acaagaccct tatagatctt atccccaagt 18480 tccatacgga ttccttcgat attttgaata gaagaaatcc acaacaagtg tcaaagcaat 18540 accagcaatc agcacggtca tttgacctcc tcatcacaat atccaaacac acccagacct 18600 gcaaccgtga tcatataggt cttccaaccg atacgatcat caacaccttg gtagatcagg 18660 ctgatcgaac ctggtccaaa cttcaccggg aagtccatca ccatattgat atgatctgcc 18720 agagcctctt tggtggcggg gatctgtttc acagtcttca ggctttccac cagtgaaccg 18780 cgatgctgtc gaactctcat atgtctctcc ttcatgttgt ttgttgtgtg tgggagttct 18840 ctcccttgaa cacaaagata catgagagaa atgttggtgt caatacaatt tcgaagaaat 18900 ttaataaaac tgactccgaa cgaatgtgag tggggaagtt ttattataag atcagatcaa 18960 caccccgtag gcccggatgg gtgagcgtag cgaaggtgtt agatctatta ttacttcgtg 19020 tgcctttcag ggctacatac tatgttgtct tttctgccca ctttttcaga gtcgggcgaa 19080 tagcatcatg caacatctct tcgttatgtc ccgctgccca tttggcaacc aagaaagagc 19140 acagcataat gaaatcatga tcctctttta ccggagacat cgacagaaga tccacaaagg 19200 caagttcatc ctcgtccaca cgatccgggt aaaggaatgt ctcaaaatgg gcaagttctg 19260 tctcgatacc ctcggcattg gccctgacaa cttccatacc tcggctgttg aacatcgatc 19320 gccaagtgta ttctacctgc ccagccttat ccaaacggaa cacagagagg gtcgcccccc 19380 ggcgaccaca ctctaattga taaccatact gtgacataat tctccttaca gatatttgtc 19440 gaagtcgatg gcagtgccga acggaggggt ccattccggt ccgtgacggc ccaggatgat 19500 ccacaacgtc ttcttgccat acttctcggc ccagttttta acattggaca catcagagaa 19560 gtaaccatct gtatagatta caatctgatc gggttctttg tcaagattat caagacattc 19620 gaacacgcac tgcacatcgg tcccgtaggt agtcttgatc ttgtagttat caatctcctt 19680 caggttcttc ttcgtgtaag tacagatatt accaaccttt gtggaccatg ccgccatagt 19740 gacctcaaag tcctcgtact ggttgcacag acccttgatc tcacgtttgg tcggggccag 19800 caaatcatca gtaaaagatc cagacacgtc gaagaatacg tgagcacgga ttgtcttagc 19860 cttagtgtac gaaggaaggc cgatcgtctg ccgggaagta agatgccctg cttgacgtaa 19920 agatcgcgtc agggagtagc tacggcggtt taaacgacgg tatgaaacgt tgtctttgaa 19980 cagccgctca attgtccgac gtaacagtcg caggtagtta accttcggct ttcctgcctc 20040 ctccacaaac ttacgagcat ccgctggcgc tcccttgccc gctgcctgaa cagcgttctc 20100 gattgcccgg cgcattaccg tgtcattata gttcttctgc tcctgggtca gcggcttcat 20160 cgcccccggg tcagtaccca ttgctttgga taagtcatcc tcgccatctt gctcactgaa 20220 agtgccgtca gcattggggt gctggtcagt acccatcggc ccattgccct gctgcgattg 20280 gtcacctttt tggtcaccct tctcaccatc tcccggggcg ctgccgcctc caccaggtgg 20340 tgggggtgga gtatttttaa ccaagagttc gtaaatctgc tccgcgtaca tgtcggcata 20400 ctggaaatca caatacgccc acttcatgaa accaaactct ttgtccggat cgaacactgt 20460 cttggcaccc attgggaacc aagccgtacc catctcactg tttgtcgtat gattcaggac 20520 agcgttggtg ttgatacggt ggtcggcagc aatgttgaac agggcgaaat tgtaaccctt 20580 tccacggtac atgtgctcag aaaccacgtg atcgcactcg tgctccaaca ccaaggccac 20640 ctcacgggca gtcttgcgac gatagaacac atcgatcatc aacttcatct cagcattctt 20700 cttcttgtcg gtgatttgct ggtcaatgcg ctgttttacc agcgccttgc gcttatcgca 20760 catcccggca acaaattccg gagaatagaa caggtcgcgc ccattggtag ccatcgtgtt 20820 gatggtctct gtggcacgga taatcggcat tgacgccaac ataacaccat agaaaggttt 20880 gtagcgcatc agttgaagac ttgcagcctc aaggagtttc tctgcctctt ctgtattggc 20940 gttggcaagc tcaagctcct cggcactcat gatattgtcg aacatatttc ctccaaaaga 21000 aaaaggggcc atctcgaaag atgaccccat tctatcagct tatattgtga tgtcaacctt 21060 taacgttgaa atcctccatg attttaccat aacgagtctg atactccatt acgatagtca 21120 taacagcttc gcagttctta cgcagcgccg ggatcatctt ggtacgtttc gggttcaggc 21180 tcaggatcgc ctgttgatcc gtattggatg cacggaagat accaatcatc agcgcgatca 21240 tggtgtcttt gttcgccttg taatagttgt tgaacatgaa gttcaggaag ttagaagcac 21300 gttcgatgaa gatctcatca ttcatgccat tgtccatcac ttctttctcc agttgacgta 21360 agcaggtctg tgccagtacg taaaccaggt cgttcttctc acgagacagt tcgtgctttt 21420 tcaccttgcc ggagaagatg tcttcaactt tcggcagttc agcggcacgt aagtggtacg 21480 caagaaccgc agtttccaga ccttcaccaa cagaacccgc gatagcgatc tcggtgatgt 21540 actcattctt ctgtacttcg taatcgtaca gaatgtcaga aacagttttc cactgacgag 21600 gtgatgcgaa caccggagta gagcgcttct ctacgtcacc agtgtagaaa tgctccggga 21660 actgcttcag gaagccgatt acgtgtgggt gcagtttgaa tgggactgcg aagtcctcaa 21720 tccacacatc cagattgtat tcaacctctg ccatgatcat acggttaacc agcggccccg 21780 gcatttcggt ggtgcctgcg ttatcggtgt cacggttacc tgcaccaacg aacacacaac 21840 ctttcgggaa gcggtggtca cctgcaacgt gatccagaat aacctgatac gcagagtgct 21900 gagtgcccag cattgcgttc ggcagttcat ccaggaatac gataccttcc cagttcggat 21960 ctgtaggcca gaagctcgga catgcgtaca cagtacgggt aacttctttg ccctgaaccg 22020 gatcgaaata ggttaccggg accgggatac ctgcaatatc ctgcggctct ttgtcagaca 22080 ggcgaacgtc acacaggttg tccccgatgc ggtgggggaa catgttgttg gctacctgca 22140 acactttttg ggacttaccg agacctgcac cgccgaagaa gaaggtggtt ttaccgatac 22200 gggcaccaag gcggatcaga tcttccatct gtcggatact gattcgtttc ttaaacatgg 22260 tttggtcagt gcgtttgtaa gtctgctgca ttgaatttct cctctttgtt gtcaatgagg 22320 cccattatat atgggccatc tgataagtca acacttttat ccaccaaaag aactgctact 22380 gcgccccaca gaagaaccga acccgccacg ggtggttgtc tttgacgagg agaagctgga 22440 tttggaaccg gaccaagtgg atcgcggtgc ctcaaccttt ggcttaatgg cagacttcgt 22500 tactttgaac gatttccccg gcttcacgtc gtaagaccgg gccttgttgt caacccactg 22560 accagagcgg ctctggtaca tcggtgctgc gtgataggag ttacttgacc ccatcatatt 22620 acccagcatg taacccatca tcaggggcat ccacggggat tctccgcccg tactggcagc 22680 agccgccgag ttatgttggc acatactgcc aaactcttcg taacactcgg catacgtccc 22740 aaatttcggt gccgtttctg cggcaacctt ctgggcctct ttctccgcag tttggcactg 22800 ttcgagcgta tttccgcttt ctttggcaca ctgctcagag ttcatgtaca gtttcaccgt 22860 ttcgtcagct tgctcacagc cggacagggt gaaggttaca acagccgcga cagcaaaccc 22920 cagaaaggat ttacggaatc gcgccttgtt gattactttg gtacgcttca ttctcaaccc 22980 catgctttca ggccgtaacg cccggtaaag aagatttcgt tatcctggaa gatgccatcc 23040 gggttcttgc ggaacaggtc catgtagtaa tcacggaccg catcccactc cttcttatcg 23100 aagtacacca cggcctcccc agtgcccacc acgccgtttt tataaccgtc ggatacctta 23160 cccatgaccc ggacggtggc ctttttacgg tggatacgga cgttctcgtg atacccggcg 23220 caaccgccgt gaccgcagga acaggtaaag aacgtgttcc acgtccaacc gtcctgataa 23280 tcgcccttat agccgggctt cattgcctgg aggaagtagt acatgcagta cgtctcctcc 23340 ggctccacct tgttgattcg gcaaccgata cgtgtaatca ggtgtttgga atcctcttcg 23400 agttccaacc aaccaccatc atccatcacc tcggtactgc cgtaacgatc cggtgtcccc 23460 atgtaggagg aaatgactgg ctcaatgctc agggtctttt tcattctgcc tccaccagga 23520 cttcaatgaa gtcgtcagcg ccggacatgg cgcggtagta atagtggttc acttcacgga 23580 cgaaatattt gttgccctgt gcgtggatca cttcgttctt gcggggaacg ataataggcc 23640 cgttgtcgga gctacgtgtc gccaggatta cgtccacacc acgttcaatg atttcaagtt 23700 tcaattgtca cttcctccca ttccatatcg ctcaaaaagc aagattcgca atcgtcatca 23760 aaaacgaagg catatccgtg agtcccgtgg actaaataat gtttgtccgg gtcgaattta 23820 tgccccaagg gggcatctaa aactttaatc cgcatcgtat tccttctcca tgattgattt 23880 aacctgctca tcacgggcag aaaaataatc gcccgggaaa gagaacatgc tcaaatggtt 23940 gtcttcgtac catgcgatca tgtctttaat ctgcatgtgc attttatgat acttctggat 24000 tcgctgcaag tcttttttac gcagtccttt cagacggcgg atatcggtgt tgtgacgcag 24060 gtctgccagc ttaacacggc aggcgtcata actctccagg atacccttga gatattcgtc 24120 gggggtctga ccttctacct tggtgagtcg agcgatcccg gagataaccc tgttggacat 24180 acccaaccgt tctaaatcac agggttgtac cggggtatct tcaacgatgt cgtgacccac 24240 ggcaatacag ttcagctcgt cgtcatcctt tactttaagg tagtgcatta ccttcaggac 24300 gtgcagaaca taaggacgcc cgcccttatc aaactgtcgc atgtggtgtg tcgcagccaa 24360 cttaatcatc atggcaagct gctctgccgg ggataatact ttgttcatgg tagtctcctg 24420 ttcatgttta gtgaacaata aggtagcatg aacaaaaata cgatgcaagg gttgatttct 24480 tgatcgagac ccggtatatt gccttcatca aacacaaacg aggaacgaaa atatgttcga 24540 acgcaccaac aaccgtgacg aagagcacgt cgatgaacga gcctacaaat tcttctctta 24600 tatgtacgga agagagggtc atcattacgg ctggaacagc actaaggaag ggattcgtcc 24660 gacgaccgtg ctgtctgaca aatctaccca cgtctgtgct tactgtgggc gtatggccct 24720 acctatccaa ggtgagcgtt gggaccactt caaggatagc cgggagtatt tctccaaagg 24780 tcattgctgc gtgtgtaaag aggcaatgga cgaactggaa atgatggatc agttgaagat 24840 tatcgaggac cagtttgaaa atgcccgcag cgctgtgtac cgggcaatgc cgaagacaaa 24900 tcctgacatc gttgcggctt tcgtggaccg aaaggcggag caggtgaaaa aagacttgaa 24960 gttctggaac aataacggca gtatatcccc acattcactg gataagacgg gccttgaact 25020 tcgtggccca cgttatgcga aaggggacta tgatgaataa gctgaagatg tggctgaaaa 25080 gattcgcagg tattgacacc acgcccgatg agttcaacgc ctggttccag cataagctgg 25140 gccaagggtt gcgtggcggt gatgtgtact ttgcgataaa gatggttggg tctgacaccc 25200 ttccggtcat caacaagaag ttccaagttt tctccaaact gaaaaatgca gaaaggaaaa 25260 aagaagcctt gacaagagac aatccaggta ttaaccttga gattgtggtt gtgagaacct 25320 tttattcgtt tccggaggca tcatgaaaga agacctgact ggacagatta acctgcgcct 25380 gtcgaatgca ccaaagacta acgaaccgga caaacgcctc attggctttg tggtgggtgt 25440 ggatgaactg gagcacggga tgggctggtt ctccccgctg ctggagcaat actgtgccct 25500 gtacctgaaa actaaagggt acgatgtgat caagaaacct gttaacgacc gcctaacctt 25560 ggaggaaaga gcatgaaacg tacacgactg attctgatgg ctgcactgat gggcttcgtc 25620 ctggctggtt gcgacgccag cacccgtgaa tccactgaca gctatgtcct cccgaaggac 25680 ctgctggaaa agggctgcaa gatctaccac atggaaggga agtatgagaa ctccctcgat 25740 gtggtgtact gcccgaacgc acaggtgaca tcccgcacta aggcaggtaa gtcaccgcag 25800 cggtctgtta ccactattga cggggtgtat catgggtgag atcgtagaga ctgggccaga 25860 cctcttggaa aagttctttg gtcgtgaact gtacgggcat gaccgccaga gcatctcctt 25920 gtacggaatg ccgaagtatt gctgtgggga catcctgcgg cttgatggga gttcaggtgc 25980 cgggtacgcc gggcatcagt tcgtagttga agggatgttt tggtcggact tactgcactc 26040 ttgggtgtat tacgtcccgg cttttaattt ttaccaatgt gaatccaatc ttgaggagat 26100 taaataatgg aagctgtaat cgcgtttttc accgctgaac ctgctggcgc actgattacc 26160 ctactgacct tcggactgat cgggctatta tggctgttct gtgtggaagt gtcttgcatc 26220 tatgagcgcg tccgcgccct gttcaataag ggcctgcgac aaggttacac gtggaaaact 26280 gtggcttgga tgccaatccg aatctatgtt gtgatcctca tcccgcagat cgtgtacatt 26340 ttgtttaccg aaatcattaa attcggttga cagtaataaa tggggcctgt attatggccc 26400 cataccaaca caaatgagga aacaccgatg aacaattaca aatcccaagg tcagactttc 26460 gaagaagctc ttgttaacct gtctgaagac ggcatctttg tcgaagaccc attcttcaag 26520 cagcacatgg aaaacatccg taagcagcgt gagttgggct tgggatttga tatggagaag 26580 gcgaaaaagg ttgtcgaaga cgccgtgtct ggcatcgact attctgacct gccgaaggat 26640 atccgtaatc gcactttggt tatcgacatt gaccaggttt gtgcggcgca cggggtcgag 26700 accgccgagc agcgtgaagc tctcaaggac aagattgcca acatgccgga agttcgtgac 26760 atcaacttgg tctgttttga tgaggtcaat gcaccgaaag aggaatttgt aaccttcgag 26820 atcctcaagg gccgtagctc taccgggcgt ttcgattatc cgttcctgcc ggacatgcac 26880 cacatgccac gcctgaacaa gacgtacatg ccacctaaag atggtgatgc ctttatctgc 26940 atggagagtg agatggactg gtcccgcctg gaagaactct gcaaggccga ccttcctcgc 27000 ccggacctgc acatctccgg cgatgacccg gcactgaaga tccgtaagca cccgatgatc 27060 ttcaaggtca ctgacctggc cgaggacaaa gaagagtttc ctcgcctgaa gaagactttg 27120 gagcgtaacc aacaggtgga agccatgctg ggctggcctg cgccgccgat gttcatcgaa 27180 gccatcccag atgccaacgt tgtggcccgt gcgatggatg aagtgatgaa agagttgaca 27240 gcgctggcac gagagtataa agtgcaaatc tacttcggca ccaaacctgc attgaagact 27300 gccttgtact ctttgatgta tggtgccaag aaggaagacc tcgatatgtc ccagcttgac 27360 gagatctctg tggagaaagc catcgagatg tacgaaagca agctccgtaa ggtagccgtc 27420 atcggcgggc acgggcttgg gtttgggaag atggcaaaga tccttgctga tcattacagc 27480 accgagactg tctgtctgga ctctttcgac acgtggaact tcaaagactt cgccaacatt 27540 gcgaagctgg acaagccagc acgtgactgg gaacaggggc gactccgccg tggcaagggc 27600 cacaacaaat ttaagcgtaa ggtgaagaaa tgagaaagta tattgatggt gatcgtgagg 27660 ataaatactc ttcgaccacg gcggtggttg aaccacgggg gtatcgccaa atagttttgg 27720 ctgtccgccg gactggcggg ccttgttgcc tcggggagga gtttatgtac ctttctcggg 27780 agaaggcccg tgaactggcc caagtcctta acgacctggc agatgaactg tttttcgagg 27840 agcaacgtgc gaatggaaat gaatgatttt gtaggaaacc cactcgcaat cggtgatgaa 27900 gtggtgttta ctgagtataa ccgtcacggg atgtctcgtg gcaagattat cggcttctcg 27960 aaggctttga atatggcgag cattgagtac accaccgatg gtggctccgt tcgcaagaca 28020 aagaaaactt cgggatatgt ggtgaaggtg gtgaaatgag cagagaagaa ggcaaaccgt 28080 acccaaaaga gcgaccaacg atccgttctg aaatgacggg ttcaggttgt gatcgtatta 28140 tccaagaaca cccggcgtat ggtcgaatca cactgaccca cccgtcaggt ggcaatactg 28200 agatgtttgg ttcagacatc atccataatg agcgcatagc gcttcgtatt gacctggcgt 28260 atgaagaaac ggcctacggt attccaaact accgcagcca gccacagagc cgtggagggc 28320 gtgtgctgga actggaactg acagcttacc agtgggcagg tttggttgca tcccacagtg 28380 ggaatggtgt accgtgtacc ttgcgttaca ttactcctca tgggcagggc aaccttcccc 28440 tgattgatgg gcagaacacc agtaccgagc aggccaaccg tgagattgag gcatctctca 28500 agatcatgat gaaacgccat gcggagggcc ttgaagccct gtcagcgttg attgccaaag 28560 gcaaggccaa caagggtgag ttgcaggcgg cgatggagaa gttccagacc attcatgcca 28620 agctgccaga agtgacggcc tatgcactcc ataccttcac tgagcactca gagacggtca 28680 tggcccgggc aaacgcagag atcgaagcgt ccctgaacag cctgatccag cgtaccggga 28740 tcaaggctct gggcatgaag cctctggagt tggaggataa agaatgacag attgggcgac 28800 agtagaggac ctgctgaccc gtattgatgc caagatccac gggatcggta acgacgaaga 28860 ggacgtggag ttcgagcttc gtgaggttat ggatctgcgt ggggcgttcg agggagttcg 28920 tcatgagctt tatcacgttc gtaagtgtgg catcccgggc tttacccgtg gcgactttgt 28980 tcgtgacaag ttcaacggca agtcgtttta tgtgagcgat gccgaagtac aggaaggtag 29040 cgacgggtac gaatggttct atcgcagcgg gttctacttc atcccgcaat cagatctgga 29100 actggtaaaa ccgaggggtg ttgtatgaca gtaaaatctg tgaagcagca aaattgtgag 29160 cataagttca ttaccaaggg cagcgtacac gcttttgttc gtgaatgcac aaaatgcggc 29220 tggtacgaag tctgcgtggg gtaatcggat gcaagtgttg gcacaagaca tcaaggctgg 29280 cgacacgttc aaatacgtgt gtgattgcga cctgttcggc aagccgatca tgagccagcc 29340 gatcctggca agtgatgatg caattatcat cggcgggacc gtgatgatcc cgttcggtgg 29400 agacgagggc cgttgtttta tggcctcttt tggtagcaaa gtggagaaaa ttgatggaac 29460 tgactaataa cgttggcggc accaccctga tgtatgcaat cgacgacacc gccgccgggc 29520 acaatgtgcc gtccatgagc ctcgggcaga ccgatgacgg tcatccgatt gtggtgaaag 29580 ctgtgtttgc tgacgaagac agcgccaaac tgatggctaa ccacatggac aaacaaccgg 29640 gtgcccacat tggtcgattc caggttgtcg ctgttgaact gtggcgtccg acggacatcg 29700 aggtatacgt tcgtgagcgt atccgtgaat ctaagaaggg cgagggtcct aaactggtac 29760 tgccggggag cctgtaatgc acaaggttga agtgacgaaa gaagactttg cggccctgtt 29820 gaagcagttc acgggagcat ctggctggcg tcgttctaat ggtaagggtt cattcaacct 29880 gaaccaagag caggacgaag acaaacgtcg taaattgaag tatggcgaca ttgtgtttat 29940 cgaaaaggtt gacaccgacc agtaagtcat gtaatctgcc ctcattggaa acagagaggg 30000 ctttttagat gaaatttacg attgaagatt ttgaggtgac agttctggcg ggcaagcccg 30060 agatcgttta ccacaatgac ggtaacggca attaccgtga agtgacgatt acggcccctg 30120 aagaattgat tcacccggcg ttcaaagtgg agttcgaaga gtacacaaaa cgctgcatta 30180 agttgcacca gaataaggtc cgtctgcacg gtggattctg tgatacgatg cgttatgtac 30240 cgcccagaaa aatcaagtcg aagttctctg catacaaatt ccgtaagcag gtcgaaactc 30300 gggttggtga tatcgaggag gcgaaggaca cttgggacta caaccgagcg ccagcgggag 30360 cggtggcgac agggaagttt ggggacctga aggcattttt ggagatgcgt acaggccgag 30420 aactgaattg catggggact ggagaaggca aacatgtcaa gacgtcctga atacaaaccg 30480 accgattatc gctatcagga agagatcgac aaaagttgga acccgcaact gaaacggggt 30540 gatgacttct gggtctttaa ccaaaagacg gggaaggtgt gggggccgta caaattcagc 30600 cactacacta accttggggc ggtcggttgg tgtgatgttc catacaacag cactgtgaaa 30660 gttcgttaca gcaagggtga aattgtgtgc gccactgagg cgctcgctat tggtcgccaa 30720 ctcatggaga aagcccgaga gtggtcccgg acaacgctgt tggctgagga cctcaagagg 30780 gaagttgaag ctctgtctct caaactgaag gagattgaaa gtggaaaatg aaattgatat 30840 tatggatcag ttcaatgaag ttgctgaccg tgtggaaaaa gaactccaca atgaggttca 30900 ggtaattatc gaccagaacg gggacggcac ttggcacgtt gaggttcaag aacgtgctga 30960 ggaagaggat gaagaggact gggcgtgtca ttgtgttgac ggctggttca ccatcaacga 31020 aaagcgagac tgcaagtccc ctgatgaggc ggcgcagtgg cttgaaaatc aatacctgta 31080 ggagggttta tgttcgtata cctgaaccaa ctagcgtctg aagaaccaat ctgcctcgat 31140 gttgcaaata tccgggagtt tcacccgcag gtgaccgaag tagaagggaa agaccgcaag 31200 ggaaccctga ttaccctgta ccgtggcgag ccgtggatcg tcaagcagtc ttgctatgac 31260 gttctccaga tgtgccagaa ggcgaagcgg ggtgaacttt aatatgcctt gtggtaaaat 31320 gacataccgt gtgggcgatc tgatctctgc ggcgcaggct ggagaggtaa acgtgatagc 31380 ccactgctgt aactgcatga ataccatgaa gtctggtatt gccccaaaga ttgcgtcagc 31440 ttttccggaa gcgtggacgg cagaccaaat gaccacccgt ggtgatcggg ctaaactggg 31500 aactttgtcc tcggccttct gcaaaaatgg tttactggtt tacaatctgt acggtcaata 31560 caccttcacc gggcgcagag agggtaagat ggacctcgat tactgggcat tgcgttcggc 31620 cctgtctgca atggcagtat ctctccatgc caagtgtcgt actctggata tgagcaccca 31680 cgaccttcgt atcggactac caaaaatagg ggctggactc gcaggcggcg attggggtat 31740 catatctcgg atgattgaag gtcgcctgag agacttcgat gtgaccattt atgttctgaa 31800 ggagagtgaa attgtccacg atcaaaatgg ctgagtttgc ccgtaagtac gggaagaagt 31860 acggcggaaa tctgtgcctg gagggatgta aatctgggaa tcaggtcctt agccacgaaa 31920 aactcccgga ccttcaggtc ccggagaaga ttgtcacatt gacaggttat atcgagttca 31980 atgaggcgaa gcgccggaag acaggtaagg atgggaccca agtgcgtact ggctacgtga 32040 ctggccttgc cgtccattct gggcatttgt atgcgatcac cgtcgattcc gtgtaccgta 32100 tctacggccc ttggtatgcc gacgtgatca ccaacgaccc tttcctcaat tctctttggg 32160 aagatgttaa gaagggagtt ctcgctcaag cctccaaaaa ggcttgactt ctaaaggctc 32220 agtgataaac tgggcctttc tcatttagga gtttggatga aaaagagcac cgctgcatta 32280 ttcgcagcca gcgctttatc tttcgcctca gtacctgcct tggcaaaaga taacgcaccg 32340 aagaaaaagc tcgcccccat tgtccatgtt tgcaagaaga atgactcgtc ggtcaatgcc 32400 ttggcctgca atatttattt cgagtcacgc ggggagaata ttagtggaca aatggcagtt 32460 gggtttgtta cgctgaatag gctgaagcac gacagctacc cggggtcagt gaggaaggtt 32520 gtgtatcaat cctcacaatt ctcttggaca atggcgagga gtgggtatgc cgtaagggac 32580 cgggaatctt ggatggttgc tcaagatgtt gcaaaattcc tttacaagat ccggaacaat 32640 gatgtattgt acaacaagct ggacccaaca catggtgcga cgcacttcca cacgaagaag 32700 gtcaagccat actggagaaa gttctttacg aagacagcca ctatcggcta ccatgtgttt 32760 tataaaccaa aagaggaaaa ggcgacatga gaaatcttat cattctgttc attactttta 32820 tgcttgtttg gatattcccg gcccgctggg gcgcacagtt ctttttccct gagatgatgg 32880 cacagttctc atcccaggtt ccgtatttga tgggatgggg agccttgatg ttcctcttgg 32940 caactgtaat cactgcttgt ttggctcacg attaagggga gtgtatggaa gagaagtctg 33000 tttttctggt atcgtccgat gcgggttatg gtcaaagcgt tcgcgccaaa gttgacgatc 33060 cgcaggcggc aacactgaag gccagccgtt tggcaaagaa aggccacacg aatattgaaa 33120 tcagtgaggc caaaatcatt ggcaccacca aatttgaggc agaggcgtaa tgggcaaaac 33180 agtaattggt aacgaagaag caatgcgagc catcatggcg ggtgataacg tgttcatcac 33240 cgggccgggt ggctctggca agagcttgat gattgccact ctgcgtgagt tcttcgctga 33300 cagtttcctg ttcgttgcac cgacagggat tgcggcgctg aacatttcag ggatcaccgc 33360 tcacaaggct tttggcctga cgtttggtgt taccaccaag gaagattaca aagcgaagtc 33420 caagaagcct gcgatgctga tggcatctaa tgcgctggac gctatcgtgt tcgacgaaat 33480 ctccatgatt cgtagcgaca agctgcggga gatcgacatg aagctgcgtt atcaccgcaa 33540 ggtaaacaag cctttcggtg gccttcaggt catcatgttt ggcgacggtt tccagatcaa 33600 gcctgttctg aagcgcgaag agacggcgat gttccgtgaa ctgcacggca atgaaatccc 33660 gttcggttcg gatatttgga accaactgga tttcaccaat gcgtatcttc cgaaggtaca 33720 ccgccagtct gatcctgtgt tcgctcaaca cctgaacaac atccgtgtgg gtaataacgt 33780 cggcgcggcg gttgattact tcaaccaaca ctgtttcggt ccggccctgc caggggcggt 33840 gactttaacg accaccaaca aactcgcaga ggaaatcaac cagcgggagt ttgagaagat 33900 caaggcccag cctcatgtgt ttgaagccaa gatctcgggt gagttcccgg agcgtccggt 33960 caacgaagtt ctgaacctga aagaaggtct gaaggtcatg attgttgtta acgacaacga 34020 ccagaagaaa aaggagccag attacgttaa cggtacggtg gggatcatca agaaaatcgc 34080 caagactttt gtcatcgtgg acattgacgg aaagccgatc cacatcggca agtacgagtg 34140 gaccaacgtg acacaggtcc cggaagaaaa gatggttcag gttgaaaagg aaatcgaact 34200 ggaagacggc accaagcaga ctgtcaaggt gatggagaag cagaccgtac tggttgacaa 34260 agagatcggg aaatacttgc agttcccgtt caaattgggc tatgctatca ccggacacaa 34320 agcacagggc ctcacgctgg gcaaagtgaa cattgattta ggtttcggca cctttacgcc 34380 gggccaagcc tatgttatgc tgtcccgggc tacgagcacc gaaggtcttc gcctgatgaa 34440 gcgcctgcgt gtgaaggaca ttattgttga ccaagctgtc cgtaagtttt accatgagac 34500 attccctgag atttttggag gagaagcatg aaaaaattcc aagagggtca gagggtaagg 34560 tttacccctc gtgatttgaa aaattggact gacttctaca cgccggatgg tgttgtaccc 34620 ggtgcggagg gtgttgtcac cagcaacaag tttgatgatg atgtccttgt tgactttaca 34680 cgcccagacg gcactgtatg taaagggttc ttggcattta ccgccgacgt ggaggcactg 34740 aatgattaag gactgtttcg gaatcgaggc gcgtgtgggt gaccacatcg ccttttcccg 34800 gggtaacgcc ggggccaagc cattcgagat ggcggtgatt acgaagatga cggagaaatc 34860 cgttttcttc tccggtaaaa ccgggtccat gtaccgttct gcttccgacg agcttcgccg 34920 gggagagggt tgtttcgtaa ttgacacgac gaaacgagac cccggcaaag agggccgggc 34980 caacgcttgg gagtcgtttg acaaacacgt ccgcaatatt gttggtcctg cggcagaact 35040 tcgtagagaa atctccgaag agcttcacaa agacggatgt gcatctgcgt gggttcacca 35100 tgcgtacttt gttgatgctc tggtggaaaa atatgaggag tctctcaatg actaaagacc 35160 tgagcaatct gtccatgagt caccttctgg ccctgcgtga tctgggccgt gatgatcttc 35220 gccgtgtgga gaagaacaaa gcagaactgg aagaaatgtt ggcggcaatt aagctggaga 35280 tcgaagtccg tggaaaccga gcagcagaat agggtcagaa tgaccgcaga acgccactgg 35340 gagcgttttg acgaggcatg tcatggaaac gcacagcaaa tggcagaaat cgccgagagc 35400 gcgattgagg agcttttaca gcgtgagcgt gaaacccctc gaatccgccc ggatttgttc 35460 aacaagctgg tgatcgacat catggatacc gttaagacct atggtgcgac ccagcagtgc 35520 cggaccaagc tggtcggagt tatctccaag tacgttgtgc cggaccattc acatacgagg 35580 ccaagatgaa agatgtccgt tgtttggtga agaagggtga aggggatttt gatcgggccg 35640 cagggctggg gtatgccatc aacctgaact gtgctgaggg ttatatgtgg ctcatctatc 35700 ccggaagtgc ctgcacgacc cctgaacgtt tactgaagct gttcgaaaag cacctcgcag 35760 aggatggttt cgaaaaggta tctgcggtgg agttccgatg aaacctgttt ttgcttatga 35820 gatcaacgac gttgttctct ttgaccaggg caatcagcgc tgggattatc gcggggaagg 35880 taaggtcctg cttcaacagg aatacctgac ctgcaatgct tatctggtcg aaatgccgga 35940 tggagtcaag acacaggtca gagaagacca aatttccggt aagaagtaac agatcagtta 36000 agaaatcatc aataaggagt tatcatgcgt agcacaactg tagagttccc atattttcac 36060 aaggatttcg gacaggaagt tgtagtcgaa gccgaagtga tgctgtataa gggcattcct 36120 aacgccgcaa gcgactggga tgcagaggat tacctcgaca tcatttcggt ttccgtctac 36180 ttcgaaggtg atgtgctgga cattgacatt ccccgtcaag tgatctatgc tgagatctcg 36240 gctcagattc gtgacgccga aatgtcacgt gcgtttttgg aagaagacgg gggtttctga 36300 tggttgaagt aaagattttg gtttacacca accccgcaga gttgcagacc aacatcaaga 36360 aatggatcaa tgagtttgac tattcactca aaggtccggt cactgttggt gtcaacatgc 36420 acggcaatac gatttacgtt gcaacgttga ctaaggggga agtgtgagca catttggtga 36480 aggattgttc ggtggctaca agacggggta caccaacccg aaggcgtcaa ccacacgggg 36540 ttttggaggc ggagtgcagc gagttgaaga aacagttgaa gatgtaaaga cgtatccctt 36600 caaggcgatc ccggagcgcg ggattgatga gaagacggct gaacgcttcg gtattcgcac 36660 aaaactgtct gctaaggacg gtatgacgcc ggaagcgcat tattttccat atactttgga 36720 aggaaagatc gttggcttta agaagcgcga cctgaccatc cctaagcagc agaagggcca 36780 tttcagcact atcggcttcc aatcggtagc ctgtgatctg tttggcctgg agggtgccaa 36840 caaatcgtcc aaacgtatga tcttcatcac agaaggtgaa tacgacgcag cgattctgtg 36900 gcaggttctc cgcgagaact acaaatcgaa ggacggcaat gcccgtaagc ctaacttcac 36960 ggttgtgtcg atctccaacg gcacatccaa cgcagtacag aacctgtctc agaagaacaa 37020 ctataagctc ctgagcaagt tcgaagagat cattgtggct ttcgacgccg accgggcgaa 37080 cgaaactgag aaagccaagg gtatcatgaa gggcaaagat gccgtggcgg cagtgtattc 37140 tgtcatccca cagatgaaag tcgtcgatat ccctgaagac atggaccctt gcgacatgta 37200 caataagggc ttggcgcagc agcttttctg ggcagcgatg aagccgaaag agtacgtgcc 37260 ggacggcttt gcgacctact ctcagttccg tgagaaggca cacgagatcc ctaaactcgg 37320 gaagaaatgg ccttggccta caatgacgcg cctgacgttg ggccgtcgtc tcggggaagg 37380 tatgttcgtc ggtgccgggg ttaagatggg caagtccgag tggcttaacc agcttgtgga 37440 acacatcatc ggcacagagg gccgtaaggc cgcagtgttc aagttcgagg aagagaacga 37500 gatcacgtgt aagaaggtcg ctggtaagct gtatcacaag gatttcgtga acgcagagaa 37560 ggtgatgatc ccacaagagg acggaactta tcgggacatc tggggtgagg aagtcttcga 37620 gggccagcgt ggttacttca aacaggaaga actgattgag gctaccgaca aggtaggtga 37680 caacatcatc tactacaaca actacggtcg tgcagtatgg gacgaggtta agggcgctat 37740 ccgccatgcg gttatcgtag agggttgtga ggacatcttc attgacccga tcactcgtct 37800 ggtgcagggt atgtctgcat ccgaagcgaa cgtggagttg gagcgtttct ctgatgaaat 37860 ctccaaactt gcgaaggaac tgggcttctg gtattgttgc ttctgtcacc tgaacaagcc 37920 ggagacgggt aagcctcacg agttcggtgg tcaggttcag tcggcacagt ttgctggttc 37980 ccgtgcaatg atgcgtaaca cctactacat ggtaggcatt gagcgtaata aggacccaga 38040 gcttccaatg aagcagcgca acacctcttg gtttgtgctg ttggatgacc gtaagcacgg 38100 tcgtgctggt aagttcccgg tgttctacga catcgacaca ggtgattatc tggaaccgcc 38160 agaggggttc ttggacagtc catacgaaac tctccgtgag tggtatgcgg tccacccgga 38220 acatgatccg agcaacgatt cttatcagga gccgacggga agtgcagcac aacctctgtc 38280 tccggagaac caagataaga ccggatctga cctgacggat gatgacatcc ctccggcgga 38340 cgagcagttc ctggcagcac aggaagaggc caaggaacag caggttgagc agcaggatct 38400 gggcctggaa gttccagaag ttccggaaga ggaacagacg aaggaggaaa ctccggagcc 38460 tgttcaaaca acacctgtcg ttatcccaga catcccggaa gtcccggaca tgcctgatga 38520 aatggatgat gactgcccat tttaattaac ggggcttcgg ccccatttac ttcgaggtga 38580 ttatgattat tgaacgtcaa cgtggtggtg aacgtaacga ttttgacatc ccaccgatga 38640 aaaatggtgc ggttgtggac atcactgata ttgtgacaac cgcttttgag aatgcgatct 38700 tgcagaatct tggtaactcg gtgaaggtga ccttctcgac gtctgtgccg aacgactcgc 38760 agttctaccc gctggatcgg aatgtgccac aatatctcta tccgcatctg tcggagtttg 38820 ttcgtaccgg agtatcatcg actgaactgc gtaactttat cgcccaagta atcactgttc 38880 aggcaaacaa cgttattcag cgtgtgcagg cgtcaggtca ctcctgtttg gagttccatc 38940 cggcagatat ggtcatgtac gcaaacacgc aggcccgttc ggtatacgca ttcctgcgtc 39000 ggcacaatga ccgtttctct atcgagacag aaacctcttt ccgtgtattc actccggagc 39060 cggaagttgc tgacgcaatg ccggaagcgg cggcagaata ataaaaaggt cccttcgggg 39120 gccttttttc gtttgacacc ccgcaataac ttctgtagac ttcgaatatt actcaagagg 39180 aggatatcat ggtaaaatta atggcccctg tagttcgtga cattgttgca gaacgtgaag 39240 ggatcgaatc tctggttggc aagcaggttg aagtcgtcaa gaagatccct aagcacagcc 39300 gtatcacggt ggcaactccg ggcatgggtc agccaaagac cttcccggtg aacaaagacg 39360 tttacctggt gaatgccgag aagtcccgct ttatgtccac caagggccgc tgtggcccag 39420 tgatggtact gttccgtggt tatgagggca atgacattta ttctgcggag gaacttggat 39480 tatgatcaca tttttcatga cgctgctggc acactgtttt ggtcgccgcc ctgtggatga 39540 ggtgatttgg gtgattgcaa tgatggttgg tatgctggag cttctgatcg ccgggctggc 39600 gataggggag ttgctgaagt gattgacaag aacttcgaaa cacattacag tgtcaagtgc 39660 cggatgtcga tcggtgacaa ctatcatgtg tgcggttggg ccagggacga agagaacctg 39720 aaggaactgg tcgagcactt gaagaagact tggcggtatg ttgagtacag cggctaccgg 39780 gcgcgggtct gtgaaccaca accttcaaag aggaaaccac gtaaatgatt gacgattcac 39840 gcaaggaccc ttgcaacctg cacgagggga cgttgttctc tggcgggtat gccttggtct 39900 acgccggacc aaaagagttc cacgggaaga tggtcttcct gagcaaggcc gacgagttcg 39960 gttggtggga gtccttcgac cgcaaagggg atatgctgat cctcaacgta gattggctga 40020 tgcctgtctc cgagccgggc tgggacaaca aaacagattt ggacactttc ctttatgaag 40080 cgaggtatgg atcgtgattg acagaattat tgggctgatg acggcggcac aggattggtg 40140 gtggggaatc ctgaaaccca tcacttcacc gacaacccta attatttacc tcatagcctt 40200 ctcggcagtg gcgctgttct ttatcttacg ggatcagtac aagaaatgtg aagccatgtt 40260 catcttggag ggtattgagg tgattgtggc tgggtttatc ggtggctgcg tcttggcatc 40320 ggtatacggt ttaccgttca tattctttgc caccatcgcg gggttattct tgatgggcgt 40380 cttgacggta ttccagttct tggttgttgt atctgtgaaa ggagttaaac gatgagttgc 40440 cgagatattt tggacctgat cttcctgatt accaatgggt ttttcatgtt aactgcggtg 40500 tactggccca agatttatgg cgacggcatc tggagccggg tggtgtttac caccaacttt 40560 atcgccgttc tgatgtcttt tggtggactt attgcgaggg gtgcgctatg atgggtggta 40620 cagtaagagt ggtcagcaca actcgcaagg ttccggcgtt gacggttaac ggacgctacc 40680 aaatcttcgt gcgccagggc aaggagttca tccttgactg gtatggcggc tatgtacctg 40740 tgaaagaggc caaagaggca gggatcattt tggagagaat gcaatgaaat attgggtccg 40800 tctggataag cagcgcatca tggcagatta cgacgaagag gatctgctgg actcttccgg 40860 tatagattcc atctatctga tccggcagct tcgtttttac atcgaacatg gcgaaaacat 40920 gatcgcggca gatgaagacg acatcctatt cccttaccaa aaagttaaga tgcgcgatgg 40980 tttggggcgt gatgtgtttg tcccttgcac aattcacggc gaggttggtg atgtctaaag 41040 tcgtctggag cctgtttgat gggtctggtt tcatggggta tgagtacgcc ctgaatggtt 41100 ggaaggtgtt ctgctttaat gcagacaccg ctgatcatgg tcagtatgaa ctgcgccggg 41160 agcaccccaa catccagtat gtgaattgtt ggatcgatga agacttcgaa gccttcgttg 41220 cgaaagcggg tattccgaag ccggacatta tctttgcatt tccaagctgc accaacctgt 41280 ctgtagccgg ggcgaagcat actcggacga aatcggagtt gatggagtcg atagataatg 41340 ctaaaatggt agagcgtgtt gctaacgttt ttggctgtcc ttggatggtc gagaacccgg 41400 tgggcaagat gagtacgctg tggcgcaagc cggatcatta tttcgaccct tacgagtatg 41460 gagggtactt gagtcagatt gaaggctcgt accacccaaa aatgccgtac aggaacgcct 41520 acacaaagaa aacttgcctc tgggtaggga atggctttgt gatgcccgac aagaagcctg 41580 tgcctcatat aggctgcttc tggggctgga agtttttagg cggtaagtcg gagaggacca 41640 aacagctacg atcgctgacc ccggaggggt ttgcccgggc tgtttaccac ttcaatcatt 41700 aaggagtaaa aagtgcagga aatcctattg gcggctggtg caggcggcgg catgaaggga 41760 gataaaactc tccttctcct gcaagcagac aagggaggta ttgatgttgc caagcctacc 41820 cggcaatttt caaaagtagc aacagtaggc accggaagtt acggaaaatt caacaacaaa 41880 tactttgact gtactaccac tgccagctat tttgagatga tggcgacaga gaaaacagat 41940 ctcgtcttca aaccagagga cgagttcact atcgaatttt ggtcaagaaa ctcttcagtt 42000 gcctcttcct ggtggatgta ttttgggaca ggtactcaga gttgcctcaa ggtttaccaa 42060 agtgtggttt atcttcagga ccagaagaat tatttgagct ttagtaccaa ctactggcct 42120 ctttccaact ggacacatgt ggctattgtg agcaaagggg gagtcacgaa gttatatctg 42180 aacggtaaag tggcaccaac caccacgtcc tttgcttccg gagggtggag tgacgtaagc 42240 cgttttgcaa gaatcggctt cggcgaacaa actatgtttg gtgggcttga ccaattccgt 42300 atcagcaagg tggcccgtta cgacggtaat ttctcggtgc cgacagcacc atttgttctt 42360 gattaatagg caaaaggtag gagtattcat gagcgaacaa cgtgtaactg taggcgttat 42420 tgcactgtta gaccctccac tgggcaatct acacacggat tcttggcaag aggtttccga 42480 caggcttgac gagatcgatt ccaagttgaa gatcacttac ggtggtgata tggtcgttta 42540 ccgtcatgaa gacggaccgt cgtatgatgc aggcctggtg atcttcgacc agaacgataa 42600 tatgttcggc aacctgcaag aggaattacg gcaggcgggc ctgttcatcg tggaagggtc 42660 cgagaaaatg tttgtcgata actggtatga cgggtgcgat cccccgcata tcgccataac 42720 ccgtgaacat gccggatacg acaaggaggg gtccgatgac tgatattaaa ccatgccctt 42780 tctgtggtaa gcaacctgat tactgggaag atacccatta tcaagataag cacgtaataa 42840 cctgcggctg gtgcggggca gaaaagagat ctgagtacgg gtacgattcc gtgctgaggg 42900 actggaacac tcggtacaac ggtgcaggcg agttggtgga ggaataatga tcgagctatt 42960 aatggcagga ggaaagaaag gggtgcctgt agacatggat gactttaatg ctgacgaggc 43020 attagtgtcg gcatcagccg ccatgatgcc gggtcaatcc cgtggcggga ctttgggagg 43080 ctcttctcct accagcacag cagccgtcgc gatcgggtat tggaatggaa aaatctacgt 43140 tctgaaagca gatggtttgc acaccttcaa tgtgagcgac atggcatact caggcatggt 43200 ccctggtgtg gctggaagaa ccataccgtt aaatagcgcc agttatctcc ataagggagt 43260 tctttacttc ggacaaggca ggacaaagac aggggtaatc gaatccctga acttggagac 43320 gggtgtgtac aaaacttatc cctccttgcc ttatgattat ggggctattt acgtagatga 43380 cgattacgtg tactctattg ccaatgtcta caagtccacc gggttttcat cgaatgcgat 43440 ccgcagatgc cggatagatg gctcggcttg ggaagacgta attctttccg gtgctttttc 43500 tcacggggtc tctggtgggg acgccacttt gatgggcggg tttgtttata taaccggagg 43560 ggttcaataa agaacacaag cgagggcgac ggctctccat atgtggatgt cctccgtgtg 43620 gatttgacaa accttcagat ctcaacagta caaattacaa gcccgggatt taccccttac 43680 gatatgccgt cttgcgtatg gaaaggggtt atatatacag tccaacaaag cagtacggta 43740 cttaaccagt tcgatatctt gacaggtagt aaaacaacag cttctgtccc aacaaaccgg 43800 ttccactgcc catgtttaag ggtgggcgac ttgttcttct ggctatctgg ttatagttca 43860 aagacgatct atcaatacaa attaccggga ggtttgtgat gggaaaactt cgtaaacgtt 43920 cataccctgc cttggcggaa gccgggtcag gcgggaagtg gttcacagga tgggagggat 43980 ttgcttttac accaagagca gaagaggtgt atgctgcccg attcccactc tgtgactttg 44040 ttcatatgtt ccggcccggt tcggaaaaca aacgtgtaga ggagatagag cacgaaaccc 44100 gcaagatgtc tctccagttt tctcacacag agaaaggaag gagttctgcg gtggcggtct 44160 ttgaagacaa agagggattt gaatacaaga tctccttcag tagtctggag ttgattctcc 44220 aactccttca cagaaaacgt gatccaaaca cgaagtatga catctcggaa acacgtattc 44280 aaggttcggg gacttgggta gaggggacct tcatgcaagt caagaagggc cagaactact 44340 tcatcgagcc tgttgaggtg gactgatgcc ggattggttt ggtttagctt tcttgggggc 44400 cgtgggcctc ctttgtgttg tcatgtatat tctcgaagag agggcgcaac atgcttgaat 44460 tgttagccgc aggcgatcaa ggaaagatgg gtacaggggg gttcaagtat ttggacagcg 44520 tgactggacc aacatacacc caagtgaacg atgcgatggg attcgtgggc ggaacaagat 44580 tagctggcga tacctacatg agctttcttg aggaagatac tggagacatt tggctggttg 44640 caaaggcaca gacgatttat aatcttgccc acaacacgct ggatgacgcc ggggcctttt 44700 ctggcaaagt catcacaatc gccggggagc agtatttttg cagaactgta aaaatgacaa 44760 cccgtggatt caccaattcc gacttgccaa atggggggag tgtggtgtac acggcaactt 44820 caacttttgc acattctgag ttcaacaata tcttttacca agttcttggg ctgaatggtc 44880 agtcggtgga aggcatagag tacggaactt ctgcaaaatt cagccctgcc caactgggtt 44940 ttcatgcggg acagggtggc gctctaatcg gcgcagaggt taatcctgat ggatacaggg 45000 tggttcaggc cgcagggtat acctcccgtt tgagtagaaa agttgtcagt gtttatcacg 45060 gctggcgacc aatgctgagg aaaatctaat gaatgactat cgaggaactc ccctcaagga 45120 gggggatagg gtagcaattt attggggcta caatgagctt cagggcggaa ttatccgcca 45180 aataaaaggc aggaaggcca aggtcgaggt cttgggcacc atcagtaagt ggaaagatgg 45240 aaattgcatg gtcaagctgc cggattgata ggttgatctt tacgaggcat tgggctatcc 45300 tgagtggagg tatgccaaaa aggagagagt atgaaagggt tgtttgtagg ggatgcggaa 45360 gccaacggtc tgctcgaaga agtagaccag cttcacgtga tcctgttcaa ggagtataag 45420 gtcgataact ggaatatctt cctcgacccc aaccgggaag ggtacgatca ggcgttgaaa 45480 tttattcaat cgaagggcaa gaatttcaaa attcgtacct ttgaggagtt gaatgattgg 45540 ttcaagacgg agcctaaatc catcgcgatc cacaacctgt tcggctacga cctgcgtctg 45600 tttaaaaaga tgttgggaac acagtatgat atgttcggcg acccgaagtg catgggcacc 45660 ctgaacggca agcaggttaa cctgttcgac actctgtcaa tgtctcgaac tctttatcca 45720 gaccgaccgc ttcctcgtgg gtgtccggag atggtaaaga acccggtcac cgggaagatg 45780 aaacctgtcg gccctcacgg cttggaagcg tggggtatgc gtgttgccaa ccagaaagtg 45840 gcaatcgaag attggcgcgg actaccgttg tggaagtatt gcgatcgtat tatcgaagac 45900 gtcatcatca acgaaatggt gtggacggcc ctcatggaag agattgcttg tgacggaaag 45960 ttggttgacg acaagcgctt catgtacaag gacgaagaga aggacaagga cgccaagaag 46020 tacaaactga tcaactggaa gaacgcgatg cgtcgcggta tgttgaccga ttacctgatg 46080 gttgagcaag agatccaagg cgtatccttc gacgaagaag ctgcacttaa acttcgtgat 46140 cgcatcgatc aaatgatgcg ggagatcgaa ggcgatgtcg agcctcacct tcctaaaaag 46200 gagatggcga agtctgcaca gcctacgttc ccatccaaac cgttcaaggg cgatggatct 46260 ttgtccggaa ctgggtggaa gtggctggag aagttggggt ataatgtcaa ctgggaggca 46320 ctcgacttta agggtccccc ggcgaagtct ttcaaggccg atggtagcct gacggcggca 46380 gcaatcaagt attgcaatga gcatggtgtc gaggatgagg cagcgatgcc gcagtttatc 46440 cgggaccaga acaacaagca aacgaccctg atccctctgt ccccagagga catggcacga 46500 gcaatgttgg atctgaagaa ccaaactatg ccggacatta tgatcccgat gcgtatcggt 46560 aaccaggatg acgtgaagaa gttcctgatc cgtgatgcag gctggaagcc aaccctgtgg 46620 cgcagtaagg atgtgacgaa ggaccagttt aagaagcaac gccccgataa cgaggtcgat 46680 ggacttgttc gtgagtacat tgagcagttg gaccaagttg aataccggga tcttattctg 46740 gaatacctcg gcatcaccct gaaggcgtgg caggacaaag agaagatgta caagctgttg 46800 cgacgtaagg cccgtggcct gcctacgtct ccgcagttga aagatatgag cggcctgtgt 46860 ccgaacctgg agaaggttga cggtcatatg gcaaagcaga tcgtgaagtg gctgtctctg 46920 cgtaaccgtc gttctgtact tgacccgctc aaggaagaca aggttgacac aggatggctg 46980 aaccacccac gactgcgtat tgacggtaaa ctcccggcgc gttattctgg gatcaccaac 47040 accgggcgac gtaagcacac aatcgtggct aacgtcccta aaccagacga gaaggttttg 47100 ctgggtaaag agatgcgtgg cttattccgg gcatctgaag ggaaatatca ggtcggtatc 47160 gacggctcaa acctcgaagg tatgatcgca gcatggggtg cctacgagtt cgacggcggg 47220 gcatatctcc ggatcatgga atcaggcgac gcccacagcc gaaacgccga agcgtatacc 47280 aaagcggcgg gcaagaaggt ttcccgtggt gagggtaagg gtgtgacata cggcatcatg 47340 tacggtgccc aggcagcgaa gatcgcctcc atgttgggta tttccctcga caaggctcag 47400 gcggtaatcg acgcattctg ggatagcaac atcggtctga aaggtcgtaa agaagcactt 47460 gagaagttct gggagttgac cgggaaacgg tttatctatg gcctcgatgg tcgtaagatt 47520 tacacccgct ccaaacactc cttgctgaac gcataccagc agaacggcgg tgctgcactg 47580 tttgacttgg ttggtatcct gctgcactgg cagttggtta agcgtggctg gtatgatgaa 47640 ggcgtccgcc gtatcatcta ctaccacgat gaataccagc ttgaagtgcc gcacaagttc 47700 aagaaagaat ggaaattcaa cgacgaggca accgcaaaag cctttgttga gcagtgcctg 47760 gcgaaaggtc tggttctgga tggtcactgt gtgaaagaag gtaagttcaa gtgtgatccg 47820 gacgagaacg gcgtgtacac gattattcat tgcccggtcg ggcagatggt cgttaagtgc 47880 gtggagcagg cggctaagat gatgaaatct ccagtccaca tcacaggtga atacctgacg 47940 ggcacaagct ggggagattg tcactaatgg ctatttttac acatttgtgg taaaatgctt 48000 gtattccggg gggcttcggc cccttttctt ttagggggca atatgcaaga gatgttggta 48060 ctgccgggag gcggagatcc taaaaagtac agcacttggt tcgagttgga cttcaccaag 48120 tatcccttgg ggacattctc aggattcact gatcgcggga taacgttcaa caggaccgcc 48180 ggaacatccg cgacggttct tgacgagggc ctgccagcga tggattttgt tggagatggg 48240 gcattgagcg gagggaccac cccagacaag ctgctaaaca atgactggaa gatcaccatg 48300 aatctgaagg ttaaggcggc ggcaacaaac ccaatgatct ttgtggggag gtctattcaa 48360 ggaaacggat ctggcacttg gatcgccaac atgctgaata acggatacct tgattggtgg 48420 tataattcca acagggtcaa tgcaggccca gccgtgacaa aaggtgttta tcacgagata 48480 atcttcgagt ctattaacaa gagcctcact gtaactgttg atggctctcc gacgataaac 48540 aacaaaacca ttccagatct tgcagacggg acaggtttta atctcatgat tggtggttct 48600 caagaccaag ctctgtatca ttcccggtgc ttgatgcgct caatcaagat tgaaaccaag 48660 aaaagataac cgcccttcgg ggcggttttt tattacctga agaaaagtgt tgacgtgcag 48720 aatcattctg gtaatatgca cacatcgaaa caaaggaggt catccgtgaa taagggggag 48780 tttcaggagt ggaaaaatga aaattcgttc gaataaatcg tttgacacgc tggaagaaat 48840 agtgcaatat cttggtgacc cggaacgagt tggcaaagac aacacgtggg tggcaaagaa 48900 ctattcgctg gcacaactga taaaagatct gacgaagata aaggagacgg attatgtcat 48960 ttaaagcact ggcccaagtg actgttcacc ctgacgggac catcactgga agagttatta 49020 atcacgaaat cccgggtgtt ggtctggttg agaacggggt ttatgaactc ggactcgaaa 49080 cattcagcag caagctggat atgacatata ttgggaaagt ggagggcaag gctgatgaat 49140 cctaatgatc tgctgccaac agtcacggca attgtgggct acgatatata ccctcattac 49200 ttggttacca agggtaaact tttgtcaggc ggcagggtta aaaccgaggc aggtacatat 49260 gctgcggatt ctattatccg aatcctgcca gagtgtgatt atgaatcaca acaggccgta 49320 cttcgcacag tgaaatcgga gtatactgca aaagaacgtc aattacgtgt tgacatcctg 49380 aagcagaacg gtgtaaactt cttaccggtt cgataacaac ctaattcatt aactgaggag 49440 attcaaatat gagcactaac aactatcata acttcgtact ggctatccag aaacaactga 49500 ccaaaatggc taaaactggc ctgtttgaag tggctgctga caaagacgtc gtgtggaacc 49560 attatctcga ttcattcccg gcgggcacca acctgatgtt ccgtgagcgc cgtgagtacg 49620 actgcaactg ctgtaagcaa ttcatccgtg atgttggtcg tgtggtgacc ttcgttgacg 49680 gtaagcgtgt ctccatctgg gacatcaaag tgccgggtta ctaccaggcg gtggttgact 49740 cgctgtccaa actgatccat gcagcaccga tcgctgacga gttcctgcac ttcaccacca 49800 aagtgggcac ggcacaaagc aacgttctgg aaaacgatca ggtcgtgacg tataaccact 49860 tccacgccgt tctgccgcag aacttcgtga agccaaactc agatatcgca actgccctga 49920 gccgctctcg tagcaacgtg caggttctgg agcgcagcct gattgaactg actgccgacg 49980 cagcagaaac gatcatcgaa ctgaacgcac agggttccct gtaccgtggt aacgagcaga 50040 tcgccagcgt caacctgttc ctcgacctga agaacaaata cgatgctctg gataccgcag 50100 gtaaagaagc gttcgtgtgg acaaacggcc tgaagctggg tgagcgcggc aagttccgta 50160 atactgcgat cggcaccctg ctggaagatc tgtccggcgg tatggatatc gaatctgcgg 50220 ttaagcgctg ggaaaaggtt atggccccgg caaactacaa gcgcccaacc gcgctggtta 50280 ctgaagcaat gatcaagaaa gcacaggaga aggttcagga actgggtctg atggactctc 50340 tgcctcgccg ctacgctgta ctggaagatc tgactgtgaa caacgtactg tttgctgacc 50400 gcaacaccca gaaggccaca gatgtgttcg gtgacctgct gaaaggcgcg aaaaagcctg 50460 ttaaaggccc ggctaacgtg gaagagatct ccatcgagaa attcatccgt gaagttctgc 50520 caacggcaac aagcatcgaa gcgctggttg agaaccgcca cactggcaac ctggtgtctc 50580 tggtggcccc ggtatatccg gacgctccaa acatgctgaa gtgggacaac aacttctcct 50640 ggtcttacaa tggtgaagtt actgactcta ttaaagagcg tgtgaaggca gcgggtggta 50700 aagtggaggg tgccctgcgt atctctctgg cgtggaacaa tggcgatgac ctggacctac 50760 atatgcgcac ccctcacggt gagcatctgt attacggtaa tcgtcgtggt ggcggtgcgt 50820 atctggacct ggatatgaac ggcatggata agcatgatga tctgaaccct gttgagaaca 50880 tcatcttcga acgcgagagt cagatcgaag aaggtattta caaggtgtgg gtgaaccagt 50940 acaatgttcg ttctcgtgac cgtgttggct tcactcttga actggagcat ggcaatacaa 51000 cgctggagtt tagtcgtcca caggcgatgt ctcgcggtag cgatgttgat gtgatcacct 51060 tccgttacac ccgtaaaggt ggcgtggagg ttattgaatc actgccacac agcaagcagt 51120 ctaaagatgt gtggggaatg gctaccgagc agttccagaa ggtgtctgtg atcatgaact 51180 ctccgaacca ctgggacggt caggcgattg gtaacaagca ttacttcttc atgctggaag 51240 gcgcaaaaca gccgggcact actcgcggtt tctacaacga gtatctgcgt aacgaactga 51300 acgagcaccg taaagtgttc gagcatctgg caggtaagat gaaggttccg gcctctgacg 51360 aacaactgtc tggtctgggc ttctctgata cccagcgcaa cgaactgacg gtgaaagtga 51420 ctggtgcatt cacccgcaca ctgaaagtga ttttttaatt gacagcgggg ccgaaaggcc 51480 ccataatgaa cccgaactta attactgagg agaaatacaa tgtccactac caatatcttt 51540 gaaattgcag cacgttccaa aatccgtttc gcttccccac gcttcgcgtc cctggcgacg 51600 gaagacctgt tcgacctgtc tctgacccaa ctggacgaag tggcgaaggg tatcaaccgc 51660 cagatcaatg cagagaagga agagtccttc ctgtcccaga acaaaaacgc tgtgcgtaaa 51720 gatctggaac tgaagctgga gatcgttaag cacgtgatcg gtgttaaaga gaccgaagcg 51780 gcagagcgcg ttgcagcgca gaacaaggcg gcgcagcgtc agaaactgat caacgccctg 51840 gcggaagccg aacagcgtga agttcagtcc aagaccccag aagagcttcg tgcggaactg 51900 gcggcgctgg acgctgaata agattaaggc caccttcggg tggccttttt atttgcacaa 51960 aattgttgac ttcctctctg atttcccgca taatcctctc atcgacaaca aagaggaaaa 52020 gacatgaaca acaccaaaat cacgcaggta agttctgcaa tcatccacga aagtgatttc 52080 atgaataagt cttcataccg tcgcttcatg aagggttttg accgggcctt tgagattcag 52140 caactaaagg acgaggggta tattatcttt attgacggga aaccgatgga caaggatgaa 52200 aactttatct tcggtgacct ccgggataag ccatgcttcg gcatcggcga tgagcgctgc 52260 atgtacgtat ggcttggaag tacgttctgt gcagagactg agaatgtgtg cgtaaccaca 52320 gaagagatga ctattttcaa cagcatctcc tatgtttcac ccaaaaacat caagaaaatg 52380 aggaagctat aagatgggat ggtgtttcat caaaaggaaa aacaaagagc gcaactgctc 52440 tcacacctgg gaaataaccc agaacctgca catcacccgg caccacgatg ccccggcata 52500 cgttgttccg gagtcgaagc agacgagtgt gtaccggatc tgctgcaagt gcctgaagaa 52560 agagacccac gttgtggaag ggcacattga tcacagcaag gcgtacaaga tcttcggggg 52620 ttcggatgcg taaaaatagt aacttttggt tcaagttgtg gtttactttc atcggcggtt 52680 tgattatact tggtctcgtt ggttacttga tgcaggaata ccaagacttc aaggacggat 52740 gtgtaaagac cggggagcag cggatggtca actccgtggt caacgccccg gacggtgcct 52800 tcagcggact ggttgttgaa gacaagtttg tatgcaagac cggacgaatt acctggaaag 52860 cccaatatca atgaggtgac atatgaaatt taatcgtggc gaagtacagt ttggcaacaa 52920 gatcgagaag ccgtcccaag acgacatcaa gaacacacag ggactgtgga acgcatcgtt 52980 cgatgatgct ttccgcttcg gtgggtacgt gacccgcgcc gccctgcaag cgatgaatat 53040 ccgtggcgac aaaaagcata tcgtggttga cgtgaagacc cacatgctaa tgccgggcat 53100 gatccctgca atccctggtt ggcacacgga cggcgttcct cgtggcggga agtctctgtc 53160 tccggcctca ggcgctccgc acatccacat gcaggaaggt actgagtctc ctcgttacca 53220 tctactggtt gtcggtggcg actgcccaac gaagttcatt gcctcacgaa acatcaacct 53280 cgtgacggag aacctaccga acctgtacgc cggaatctcc agtcaggtct gtgagatgga 53340 cgacaagggc ttcctcgaca cctacgacgc accggatggg caggtggtgg aatgggactg 53400 gtgggaactg cacaccgcac aacaggcccg tgcgccgggc tggcgatacc ttattcgtgt 53460 gaccgagact gactatcttg agccacaaaa agatctgcgg ctggttctgc gtaatcagca 53520 gcaagtttac ctcccaacgg agaaattcgg atggtgaaaa aggtagacaa gggccagaaa 53580 gaagagtacc attttgagcg tcaccacttc tatctggaca aacatgcagg caagcaagtg 53640 tgtgcgtggt gcggattggt ggcgctccgc aacaaagctt ccgattggtg tgttgaaaag 53700 gggtgcaatt acaaactgca cacctcctac caaagcacta tgcggaaatt aaccaagcaa 53760 tttgatttct aaggggaact atgaaagacc tgtttttgat ctgcattaag ctgtttggtc 53820 tgcttctgat gatggcgatt atcaccattc cggggatcag caaactgacc agtcaggagt 53880 ttaaggacaa gtaccacgcc aaatgtgaag aactcgcaaa agccgtggaa agtaaaatcg 53940 aagatgtaga aaaatctttt aaataggaga gtattatgat gggttacttt gagtttctgg 54000 caaacaattc tgtaacagtg ctggttttcg ttgtggcggg gattctcttc ggctttaccc 54060 aaggtcttgg tgactcttgg aaggataaga tggcttatgc cgggattggt gtggttttct 54120 gggggctgat tctgtccccg ctgattatcc gcatggacta cagtgactat aaacgtcatt 54180 acaccacctg tgaaaaatat gaggccaaac aggccgggta catcttctct gacaatcgct 54240 gttacaagcc gatcgccaag gatgtttacg tgaaagtgaa cgaaaccaca aaaaccaagc 54300 aggagctttt ggatgctaaa taacagcgaa ctcgttgaga agcagtctga agaagtcaat 54360 gcttttgtat ccggactggt aggcccggac taccaagcgg cgatgaccca aagattccct 54420 ctggcgcagt taaatttcat cccggcagag aaacttccgt atgtcgggga aggaaaagta 54480 tgggtctgcg actgcggttg cggggaaaga gatcctgtgt tggtccctta tctgacatac 54540 agccgcatcg gcgtagaggg acttatcgaa gcaaatgtcg aaggtatctg ggtgtctcca 54600 tgcacccgac cgggttacga gccagaggag ggtgttcgtc actttgggat ggacctctgg 54660 gattacgggt tggatgatct tgctgaccca catgttcgtt tggaggggaa ttaaatgttg 54720 aaggtactga ccaagtttgg taaagtaatt gttcttctca ccgtactgat cgtactaaac 54780 ccacatcgtg cggtactgat tccgttcagc ctgcttgctg cctttggcag tttcttggcg 54840 gggaagctgg aagacctttg tcagtggaca gccgacaagg tggactttgc gaaggataaa 54900 ttctggttgt ttgggaaacc tatcaacaag aagctggacg aagaaatgtc tgaactgaac 54960 cgtatggtgg cggaggttga caagaagtta aaggccgacc gataatggcg gtccttaact 55020 tttaccacct gcgtaaagta atcccggaaa atgctgtata cataggtcgc aggatgcccc 55080 acttcgggct acagcagtct aagtttgcaa accccttcaa gctgtcgaaa gacgagccga 55140 gaggggccac aattgaacgc tatcgtgttt ggttgtggga acagattcgt tccgggaaaa 55200 ttaccattga agatcttctt gctttggaag gtaaagatct ggtatgcttt tgtcatcccc 55260 acccatgtca cggagacgta cttgaagcgg ctgtgaaatg ggcgagggaa gtttacaata 55320 agaggaggaa gtgagatgtt tgagattttc tgcgaatggg atgttggtca ggagggcgtt 55380 ctgtttactt cagaggaagc cgccaataac tggatgctca acaacgacaa tctgaaggat 55440 tgtttcgaag acggccttac cgggcaggcg ggtattgatg atctgatctc cgctggcttg 55500 ctgggcacca attacctaac tgttctcaac gagaaaggag agaaagtatg atcaagaaat 55560 ttgtggcgtg gatcaaagcc ctgttcgccc cggcgaagat cgaagacgca aaggttgacg 55620 agtatatcgc caaacaatct caggcccaga ccgtaagtca ggtacgcttt accaaggctg 55680 aaacccgtcc gctggacgag cctctggaaa agaaccaagt cttggtaagt gcaaatgtag 55740 cagaaaacac caagcgcgtg gtgacagtgg aaactcgcca gactgttcgt gaggccccgg 55800 tggaaaagac cccaccaaag cctctgaacg agcagcttaa aggtgtggaa ctgccagcgt 55860 atgcgaaggg taagactcta ccgccgaagg cgaagcgtca gttcatcaag caggctaaga 55920 tgtccggttc tccggcccca ggccgacgtc ttgacgatac cccgcacagc acaggtggtc 55980 atgtcgtttc tcacggtatt gatcccgtaa acgcggcgat gtacggctat gcagccggag 56040 cgatcctgag tgacgacacc ccggcggcgc agcctgcccc ggtggaagag tgccgcagtt 56100 cctctgcgac ctcaacgtac agttcaagct actcgtcttc tgacgacagc tacagcagtt 56160 cgagctatgg ttcttcttcc agcagttctt acgactccag ttcgtatgac agcggttcaa 56220 gttcctcgtc ctgtgattaa gtaagtaata tcgggggctt cggcccccat cctgtggaat 56280 aacgttttac cttgaggagt gatgaaatga gcaatacaag aaaagtttat ccggcaaaac 56340 ccgagtgggc tggcaaaaag catccacgct atggcgaccc ggagttccca aaagtgactc 56400 ccgaggagct tgcaaaagcg cgtgaggtgt tctgggacat tttcatggtc aaacacgaca 56460 gcgactgctt caatgacttc tcccatgcac tgggttgcga tcgtaatcga gcaaagcagg 56520 tatactattt catcctgtac cagcgtggtt tcatgcagaa ccagcagatg caggagcgta 56580 agatccgtgg caagttggca gtgaggatca agaagtatac agagttcctc gacaatccag 56640 agacaatcta tcagatcttg gcccgggcag aagacgaggc tattgaagat gaagataaac 56700 gtcgcaaggg agcaacaaaa tgttgatcgc gcctgaaact tttgttatat tgttcattat 56760 ggtagcgatg gctgggaccc ggttcatgta ttggaccgtg gttttctcaa tgacttatgt 56820 cgtggggatc atgatctcca cagaactttc gaaatactgg gggtggatgt gaagaaactg 56880 attttattaa cggcgctcct gctttcagga tgcaatcctt tcgatgacgg gaaaccagat 56940 cattatgagt cgaagaaatc gctgatgccg accgaggtag tggcattaca caaggtgtgt 57000 aagagccaac ccaattatga cacaagctgg gtggtccagc gagacggcga ggccaaaggt 57060 gtgatgtgtc gataccggga tgcagattac acccgaacca gcaataccta ttcgatcgat 57120 gcggagatcc tccaaattaa aatccaagag gggctgatca aatgacagag tttgtcgatg 57180 tgatgtggtc gttgttctca ggctcggcct gggtattcgt actgttctgg ctggtgcctt 57240 acttcgtggc ccggaagaga gaacaccgga atacgatgtt gattctggcg ctgtcggtat 57300 tcttctcaat gtggcctgcc ctgtgggtaa atggcattgc ttgggcgata ctgctgttta 57360 ttgctgcact aactgaacct cagtatgtgt atgtaccagg ccccgccggg cctgctggac 57420 cagaaggcaa ggcaggtatc gacgggaagg atggcaagga cggtgaaaaa ggaaaggatg 57480 ccgatgagat cccactatca aaagcgggtg ttttgaaacc gaggagtcgt tgatgcaaga 57540 actacttacg gtcggggagg ttgggatgga cgtgcaaggg gcgaagtcct tcttgatata 57600 aacttttccc ggcagatggc gggagatact gtagtcatag accagtcagg gaagaatacc 57660 tttaccaaaa ccgggccggg cgtggctgtg gtggaaagca accctttggg gaattgtatt 57720 aatttttcct cgggggccag cttcttttcc acaggtaaga cagtggatgt tgcgagcgag 57780 gctgttgaga tacgtattct gttagaatcg gcgttgaatg tcgggtcaag caacaaaatg 57840 gcatggtgta ccggggatta tcccgggagt agatttatcc cagggatcgc ccactactct 57900 ttgttggggt cagcgtctcc tcaattgttt tgtgtcgatt ctgacgccac atacaaaagg 57960 atctccactt tcgagcaggc gggggtgata aatgatttta ttttcacaac cgacccttca 58020 gcaagaacga tcaccgttga agaactgact cgtggagaaa aaagagttaa cccgattaac 58080 tcttggtttg ggccggggat ggacttctct tttgggggca gttactacgg tggtgtcacc 58140 tatgccccct tcacgggtaa gatctggaga ctcaaaatac agaaaatgat ttgacaacga 58200 attattttgc tgtaagatgt acccaacatt aactgacgag gaagacatga tgagcatttt 58260 cgataacact tttgttgagc cgggttgggt ttgtgttcag gcacagaaga acattacccg 58320 ttgcgacgaa tacaaatacg ttaacctgaa tctgatgtac gaactggacc accgtcaagt 58380 tgaagtaggg gctacatacg ccatcaacgt cggcgggcag atttctcgtg aggttccggt 58440 gaagatgatc atcaagatgt tcgatgtgtc gggagatgta actgaagatc cgaaagtcct 58500 cttcaaacgt tcactgcggg cattgcgccc ggatcagatg acggaggaga tgattaagga 58560 cattaatgct gcaaacttga tgtttgatca agcagacaaa gaggtgcagc gcgtctattt 58620 gtaaaaagga gaggaaatga acaagttact ggcaggttta ggtctgggtt ggctggcaat 58680 cgtaatcgca tccatcgtcg catggatcac ccacgttgtg gtgtgtatca aaactgcgtc 58740 gtggctgttc ctgattgcgg gcgctatctt cgccccggtc ggtgttatcc acggcgttgg 58800 tgtttggttt ggtgtctggt aagacacctt gcaattctga gtaaatgtgg taacctgttg 58860 tcctggcctc aattctgggg ccttgtttat cctcgaagga gaagtgaatg tctgatgtta 58920 aagtaattac cgaagtagtt aacccgatcg acaactctac ggtaagcctg gctgttggta 58980 ctatcgaacg tatcaacatt aaacgcatca acgaggacgg cagtccgaaa attaccccca 59040 ttaacaaggg tccgaacaag ggtaagacta tcgttgccac tcaccgtgca tctctgctgg 59100 ttaaaaacgg tgaagatcag gtgtggatca gcttcggcac tcacgaagtg aagaacatga 59160 aatacgaaag ccagtatcag gtaaaagaag gcgaagtatg ggttgacctg aagccgggta 59220 tggcaattcg tgttcctgtc cagatccgta agtggactga tagtgacggc aacgaacgct 59280 ctgccccgga gggtaagaaa tccaagatcg ttattaccga caaatccggt gcccgtgatg 59340 ccgccccggc aggcaatgca ggaggctctc agacgtcctc tgcgtcgtcc aacgccccag 59400 gtggcaaaac cactaaggtt tacggagaaa tcctctccct gagcgataca ggcgctgtgg 59460 tgaaggatga gaacggtaat gaagtctctg tggttctgaa caaagagcag atcgcccaag 59520 ttcaggtggg tggtcgcctg gcagggcaac gtgctgagga tggtacgctg tccggtttca 59580 aagcctatgg cccgaaaggt tctgctggcg caggcgcggg cggttccaaa ggtggtttca 59640 agaaggacaa ctccggtatg gaaacgggcc atgccctgaa cggtgccctg aacctgcgcc 59700 gtagcggtct gactatccct ccggtggtgg aagtagccaa ggttgttcat gatgtcacca 59760 aacatctgaa gctggacgct gcaaatgatc cggctaacaa gggtatgtct gattacgatc 59820 tgggcgcgat ggtgggccat gctgttctga acgccacccg tgatatccag gttggtgaga 59880 acgacaatcc agaagagatc actggtaagc tgttggctta tgctcgtggt ctcatgagcg 59940 aggttgtccc gggcgtatct gcatacgtca agggtgagca aagttctggt ggctctgtgg 60000 cacaaactgg acagtcccag cctgatccta aggtggaccc taaaccggag actccacaat 60060 cgactcctgc gacaagcagc aacggtcata tcgacatgac tccgccggaa gttgatttcg 60120 acgatgacat ccccttctga gttgtcatga taaaaagaaa ggcacccgtt agggtgcctt 60180 tttattatgc ctcgatcggc ggggttgcaa aacgtgccac atattcaagc cttgaaggtc 60240 cgggcattag gtatcccaca accggatatg cagaggagtt tcccgtatac ccccagtaca 60300 gaatctgcgt atcgttgtag gcagcaaccc aacccagtcc gaaggtcatt cccttgatag 60360 atgggatctc gtcacttgcc gcagcgacat tggtccagtt tgagagtgta ccgctggttt 60420 ggctggtccc ggaaattctc ccgcttgctt gaccagtaac tatgaatttc cctcccgtat 60480 ggtagaagaa aagaccacta tagttaggcc aagttccaga gaccgccacc cctcctgttt 60540 tgcttaccag aggctccgtt ccatcaccgg gggtgtatcc gtcaggaacg tccgtaaggg 60600 tattgtatgg acttgcatcc cctgaaggga gttgtccgat attgagacct ttggtacgat 60660 atttaccatt actatatctg atcaaaaacg cttggtcaga ggccagcgtg taatctgtta 60720 caacacctcc gtcagcgtgg gtggtgctaa acatccgggc aggggttgtg atactgctgc 60780 cagcagagga aatgatattt cgggaatttg atccgcagcc ccagaagtat ccgtctgttt 60840 tcacgaaaac aacagtgggt ccactggatg accaagatac cacaccatct gaaaccttca 60900 caaagcgtgt ggttaaggaa gttcccccgt ttccagcttg gcctttagag ttatttccca 60960 gataccacag cgaaccatcc tttttgagga tatatacgct ctctgtgtcg ctgtaaatct 61020 ccttgatatt atccccagac aaatccccaa tacttccagg cgctaccgtg tcgatttgcc 61080 aagtatatgc agttgtactg gatgaccgaa gatccggggt gtaaatggaa ccgtcgttct 61140 taattgccca cagcttctca cggttgcttg caatccagtt tacgtcctgc attaccaaaa 61200 cccattggtt atttcggtta gttgtgtccc caacaccaag ctcacccacc cggttgaatc 61260 ctgtaacata caggttcccc ttatcagtca ggaccatact gtcgtaagac gtaaccgaaa 61320 actgcttgat tttttccttg cctgaaagaa caaacggtgg aataatagca aaaggaaaca 61380 taatacctcc aaaataaaag ccgcccgaag gcggctgtat taacctcggt taagaatcac 61440 gtagtcgaag attgaacctt taccacggta gattacttgg accagagaga ttgcgtttgg 61500 cgctgtagcc acttctccat caccaatctt gaggtaagct gggtcaaagg tcacagtgtg 61560 gcccccaaca gcatcctgct cgatatagaa gaagtaagtc cccgcgcccg gcaactgagc 61620 aatggaaccg ataacggtat cggcggtaac cgtcacgtta taaacggact gaagcccgtc 61680 tggaatccaa gaccccgatc ctgaagtgat atcagtacca atgtcaacgg tgaacaactt 61740 ggacttaacc tggcctgcat tgaaaacgct gtctcccgca aaacttgtcg tcccggtgac 61800 cacaaggtcc ttcgtcgttg tcgtgccgga tgccgtgata tccacggccc cgattccggc 61860 tgacgccgcg acactccgtg gggtaatatc cttccctgtg aagtccatac ttccggtaat 61920 ggccccagtt acccgcaagt ttcctccaac atcgaggttt ttatccacct tagcgctgga 61980 aagagactgc aaaccgtact gggtggtggg ctgggaagac tggccgaaaa ttccattagc 62040 gccctgaacc gtgcctgacc ctgtaatatt ccttgcagaa agatcctcgg cgagcacaag 62100 gctgttcata cggatatctt gagccgtcag gtcaacaatc ccggtaatgg tccccgagac 62160 gttcaggtcc ccctggagat ctgaatcccc ctgcacaacc aagcgaggtg tatcttgacc 62220 agcaacgcgc ttcaggagca gagtttcgaa ctctgtggat tgccctgtta gcttcgcatt 62280 cacacgagtt tctgccaggt ttgtcaaccc ggaaacaccc aaggtccccg cagatacgtt 62340 attggtgatt gtcgcgctct ggcccaaaat atccccggtt gattggagac gaggggcctg 62400 tacagagacg gtagccacaa cggagcgtgg ttcaatgtcc ttgcctttaa tgctttcaac 62460 ggagccgatg acgttgccgt tggcatccgt caatgcacca ttgacctgta catcgttgaa 62520 cgttgccttc ccttggggtg acatgatgtc tccaagagtt actgtcagcc cgttacggaa 62580 ctcgacaggg ccacggaggg tagagccatc actgatgtcc aaggtttttc cgcgaataaa 62640 cgtcgcagat tgaacactgt tcggaagaat atctttgcct gtaacatcaa aggtgttgac 62700 aggattcccc gcagcatcca gaatatcacc cagaacttgg atgtcttgag tgatgatctt 62760 ctcgctgttg gtaagattat ctgttgtcac atccccaaat gcagaaggat ctacagcagc 62820 aattgactta actgtcacgt tcttttgaga aagatcaagt tcaagcccgg taacaacccc 62880 agtgaaatca acatctccga gggtagtctt tccagttacg tcgagggtgg ttccgacttt 62940 aacccccgct gtagtggtca cggagcgagg caaaatgtcg tcaccattga catcggctgt 63000 tacgccagtt gtcgttcctg tgacaaccag gttgactaca gaggttgttc ctgtcgtctg 63060 ggaaatgtta ccattaacaa ccagactatc tgcctcaact gcacctgttt ccatgctggc 63120 gggacggaac tctccagtca ccgtcaggtt acccccgata gaggcatttg cattggtaga 63180 caatgaacct gctgacacga ggcccgttgc ttgaacagaa gaaggcttga tcaaggttcc 63240 atcaacatca cctttgaccc cggttgtttt tccggtaacc accaagtcct ttattgtcgc 63300 agtttctgca acgttgatat tatcaacact cagatccgac ccggacaggt cgaggttagc 63360 tgtcagggtg ccaagcactt caagatcttg agtcgtgatc tttccggttg cagtggtcgt 63420 cccactgatc tgcacgttgc cagtagcaac caagttcccg gtgttcacag agcggggctt 63480 gatgtcttta ccgtcaacac tgatagcaac accagacagg gttccagtaa cctccaggtt 63540 attcaccttg gttgttccgc cgacagtcag cttccctgtc agggaggtat ctttgccaac 63600 cgtcaaacct tcgtcgatga taacactacg aggatgaata tccaagccat caacatcagc 63660 ttttacaccc tcaatggtcc cagtcacccg cagcgtattg atctctgcaa taccatcaac 63720 gatcaactga gggcgggttg tgctgtttcg gttgttacct tccagatgca ggtaatcccc 63780 acgcatgtac ccatcgacat tcagggaatc cgtggcaaca gcaacatcac caatctgggc 63840 agctttccct ttcaactggt caatcgtcaa gatgcctgtt gacatcgtgt acggcttgat 63900 gttagtcttt gtgctcgccc ctgctggagg tgcggtgttc tgctcaaaag cgatctcggt 63960 attgtctgcg gtgccgacca cacgaatacg acggaaggtt gcttcggcgc tggcagcgga 64020 caacttatca ctggtgacaa tgaactcacc gctgatatac gtgtctttga gaacggcatc 64080 gttacggacg gtgatgtttt cgaaatcacc cttcatagag gcaatgatct ggtcttccag 64140 gtcctgcatc tctgactgaa cccacccggt tgtcgggacg gtttggctgt tgtcgccagg 64200 ggccggggta ggcacacggg ggttaccgac gaagttcgga gagttcagag gggcatagat 64260 atcggcgatg ttggttttgt ccaagaaaac cttgaacttg ccgtcattga tcgggctgtc 64320 acgcatcaca accgggtttg ataccgtagc tccgggcgca taccaccaag tggtgttccc 64380 gcttacgtcg gtgaaggagt aaagctggtt gaactcgttg acagacccac cgtttctcca 64440 gggaagaggt ggggttttga aatacaggtt gtcgatcagc gctttgcgaa cagacgggag 64500 caagctccca tcctctgcaa cagcctgctc ggtgcccgtc ccgttgacca cgatgtgaag 64560 acgtttggag tcttcgatga tctggtcaac tgccttgtca gcatcgctgc tcaacagggc 64620 aatgatatca gtattggatg acacgcgaat ctcctcttat ttggattctt cgttgttgga 64680 aacttccgac tctttcttga caatacccca acgaagattg atgaggtcac tcagaaggtg 64740 aggtgctact actgtgggtg cataaaccca aacataccac tccgggaggg tgttgttgaa 64800 gccgtaccag aggaaaactg ccgtcatagc cgccataccc acgtttgacc agaacttcgt 64860 gtgggaagcc ttgtcaggtt cgatggggga agttacgagg tctttgaaga attttagcat 64920 agaacacctt cattatcaat gcgtcacacc agatgggcaa caataacaag tgccagaacg 64980 gttcctgttc tgagccactc ggagactgta ttgtccttcc aggaatagac gaagataaac 65040 acctcgatga aatacctgtg tgcatcctgt acggcgaagg aataaaccca atcggggaat 65100 aagattggat attggattgc gaatacttgt accagcatca gaggcagggc cagcgccaag 65160 acagcgacct gacgataccc tcggacaaag agtgccacgg caaataaaag tattgaatcc 65220 aatgcccaag ctgtggtaaa gtacagcgtg atgtcgaaga actcggcccc gctgaaaaac 65280 caaaacatca ggttttcgag aataagatag gcgaggccaa gccccgccat aatcttggcc 65340 ccggcatccg ggcgagttgc caggatgacg aagcagagtc caaaaataat ggacgtgatc 65400 atttgttgcg acgactctcc aacatgacgt taagtacgga gcggatgtcc ttctgaagag 65460 cgttagtctc ttctttggcc tctttccgca tgtcagtgat gtcggcacga atgtcgccaa 65520 tagtgtcggt gatatgcttg atcttacgat ccaggatgtc atcaatacta tctttgctga 65580 ccatctcacc acgaagccga atcagatctt tttcaagagc gtcctgcttc tcctgcattt 65640 tcttgaagtc ggaataaaag attttgagta cccccaacag aaggaaagtc accaaacccc 65700 aaagagactt cagaatcaac ataatatcaa gagccatgtg tgttctcctg gggccgggca 65760 aatacccggc ctgaaaggtt atgcagcggt gaactcagac caatcaattt cactcgcggg 65820 agtgtcatca gagatccgat ttagcttaac acgaagtttc agaagagcat tatatttctc 65880 aatctcctct tctgttgctt cacccagtcc cactgcatca gccaatggtg tgatctggct 65940 ggacagagac cccatgatgg ctttcttacg cttggcagtt ccgatagcca agtcgaagtc 66000 caccttggta attttcttcc catcgaacat ccaaggcccc ttcatgatgt cgaagtcctt 66060 tgggatgctg ttcaggtcgg aaatagacaa gcccaacgga taggtcatag aaatatccac 66120 ggacttgacc aagaagcgga ccattccgaa ctcgtcgaaa aggaccacat atttcttggt 66180 aaacaggtcg agactctcgt aaaaatcacg acccttgtca tcagaaaaat actgaacacc 66240 ttccccgaag gctttcgcct ccgggttgta gtgtttgaag ttgttcatac gcatgttaat 66300 taccccgtga tcgtgaccca gacgccgtta actttcttct ggatcggctt ataataaaca 66360 ccaccgatgt tgtcgccgga gtttgacccg gtgtcttgta cgatgatacc tgtcagagca 66420 caaccttgag gggcttggaa agtccaactg atttcgttgc cgggcgggat gtaagatcct 66480 accgcaccga gacggttgtc ctgtacgctc tcttcaacct gctcagggat aattgtcact 66540 gaacgtgtcg cagaaacacc agagagagta ccccgtaccg tgatggttgc attcccagca 66600 gaaacacctg ttacgtaacc tgcatcgttc acagtcgcaa caccggagtt atttgacagg 66660 aattgcagag gttcgttcgc accccctggg tttttgttaa caacaagcat cttcgactct 66720 gtgaccggaa tctggcctgg atcagcaatg gagatgctgg tcagaacaga gtagctcgta 66780 acacggatcg ctacgttcat ccccgtggag atggaagcga tgatgttggt ttcacccgga 66840 cctacaaggc ggatgttgcc agagccatca accgttgcca ccgcagcatt ttgagtagac 66900 caggatacag ggtattgacc tgcgatggaa gcagggagta cactcgcagt cgctttgacg 66960 gtgtatccta cacggttggt gattgtgtct ggagagacga cgatcgccgt tggtgagttg 67020 cctccggagg attgtgcctg gtcagtcttg ataatgtaca taaccgcgac gttcttcgga 67080 cggttttccg gggccgttgg aacttggcgg gaagcatcga agctatactt acgcacttca 67140 ccactacgag aaccttggtc accagaggtc agtgcgccat cgtcacggaa cacaccacca 67200 acgtaacgac cgatccagcc agactgaccg atgtccgcag ggaagtgacc cgtcatgttt 67260 cggatcgcgt caccctgcac agaaccaagg gcacggcctg catctggatc attagcgcca 67320 gagccgtgtg cccagccgcg caggaagaga ccacggtagt caggaacaac gttacggccc 67380 agaactccat acagcttagg gtttgtcccg gtattaaaca cctgaccgtt acactccaac 67440 cagccgttag ggactgtaga cccaggccaa gggataacgg caccgattgg aacaagacgt 67500 ggctcaaggt catcaattcg tccgttgact tgagcaatcg cagcatcaaa gtcttgacgc 67560 agtttgttca gatcgtttcg gacaccttgg atctcttgct tcagttcctg aaccttctga 67620 tcgacgtatc gacgaagatc tgcaacatct tgcttgagtt gggcaatatc ctgacggata 67680 acgttcaact gttggttgat tcggttttcc agttctgcca agagccgggc gatctccgcc 67740 tcaagttccg ggaacttctc gttgacgatc cagttcaccc aagcagagga catattcagg 67800 atatagttaa actcttctgc tgctggcttt tgtcctttat cataaccctt ggcgagcaag 67860 tcgtcaatag gctttgattt gttaggacga cccgtgcctg gaaggtttac gtcggcagca 67920 gcccaaacgt aaatagggtc ctttggttta gccatgaaaa tctcctcacg tgaacgacca 67980 gtcttcctcg tcgtccgata cataaattag ggtggacatg ccacctgccc cggtacgctc 68040 tgagtcataa accgatgcga acccaaatgc ctgtgcgtca ccattaaaac cgaatgggta 68100 accttggttc tcaaccacac ggaggtgggt taccaagggg agcatgtcga tgatctctgg 68160 gaggatgtca gtgacttcca tacaggtatt gaaaatgtta atatcgagac ggtagttgta 68220 acctttatag gttgtcactc cgtcttcccc gaagagttgc ttcagggtgg caatgatgtc 68280 ggcgcgggtc ccgctcttgg agttgttccc ggtcaagatc atgataacag cgcgatactc 68340 tgggtcattc aggccgttac ggtaaatgcc caactgtctg ccgatttcgt caaggatggc 68400 gtcttctgcg ttcaatgtgg tacgcagttc agcaagttca accatctttt ggtcgatata 68460 ctcaaggcgc tccaacaaga tccgaagggt cttctcgaag ttctctttgc ctgtgaaaat 68520 atcggaaggg acgtaatcaa aacctccctt cacgaaatcc ggcagagggt ggatgtggtt 68580 aacatccttc agtacaattt cctctgccat cttagctcct tacacgatct ggctgaaaat 68640 tacgtcttcc ggctccaagg agaatacctg cgtagtccct gcggtaacgt cagtgttaac 68700 gtatgctgaa tccggctcgc ccttgttttt gatgtccaca tagacctgtg tgaaacggtc 68760 cggagaggta gaactcatca cagtgcccac caagcgaacg ttgtacaggg tccctgcaat 68820 catcgtccca ttaacagcgg ttgccaagcc attggcaatg gcagtctctt ctgtaacaga 68880 cagtggacgt ccacggtatc gtacccgaat agccaactgg cgagcagtag ccttcgtatg 68940 ccaaatacgt tccacttggt catcttctgt ggtgatatcg tagaaggtgt caccatacgt 69000 gttgttagag gcagcgatcg tgtcgtaaag tacctgactg atctcggcgg tgcccccacc 69060 ataacagacg gtcatgaaac gatacggggg gattccaagg ctgtttgtct tgtccgtgtt 69120 gttgttaaag atacgaacct tctcgatacc ttccaccttg ttcagcaacg ctgcaaggat 69180 cgccgggcgg gttgctttgc cctcgttgat ggaggtcgct gcgcggatgc ggtattcgtt 69240 atccgactca acatcagagc cgtcgataaa cgcagacagg ttatcaatat caacaaatcc 69300 acccggggtc gggttgatgc tacggacaga atggacatca cgggaaatgt agcccggctc 69360 aattgagcga acatccatag agatgctgcg agtgccagcc atcgggttag tacggaagtc 69420 cacgcgactt gacaagccga tcatgttctt gttagtatca taaccgatgt acagcgcacc 69480 ctctgtggaa tcgatccaga tacgatcttg gttggacagg atcgtgttgt tcacgataaa 69540 gtccttgatc tgcccgaaga atgtcatcaa gggctgacca gaggtcgcgg tcaaattcag 69600 ggagagggtt tttacagact ggtcggttgt gttctgaatt tgcaggcggt aagttccgac 69660 tgacaaatca gtacccttaa taagctgggc cacaatatta cctgctacct gaacgtcaga 69720 agacagttca taatcggtgt cgattgtata ggtagcggcg gaataaatca tgttatacgg 69780 gactgaggag tcgatcgtca tcacgactgt cccggtactg cgggtctttc cgaggcggta 69840 gataccgcgc ttgcccaaga ggtcatccaa gtaaatgcct tcggcaccct gcatggtctg 69900 ggcgtagtaa acagaaccca tcaggagcca gagttgatac tctcgctcgt taaaaatctg 69960 aatcagcttg tcggcaacgg agttgctctc ggtgttgaaa tcttcaccaa aggcggactt 70020 gaaagtcttc ttcgtttcct gaacaaggtc gtccatcggc gggaggttaa atccgctgcc 70080 tgtcaaaccg taattctccg ccattactcc tcctgcgctt aaattaggcg ataagcgtat 70140 tttatcatat tccactgaga attaaaagaa aagggagcca gaggctccct ttgtcatttc 70200 caagtattaa cccacgtact gtcaccgtat ttcggcagtt ggaagttaat aaggtagtac 70260 agtttgtttt tgaaattgat gatgacgcct tcgtcaccac aaagttgcac gttgctctcc 70320 ggtggtgtag gatattggta ctggtcctca ccaacgaacg ccaagttgat ctcttcacct 70380 tcggcagtca ccacggtgaa gaagcactta tacgaacgac caaccacatc catcgttgac 70440 tggaagtcgg tgatttgaag aacatccggc tcttgccgaa cctccgactt gatccttccg 70500 tcgaggactg cctttaccgt tttcttgcca atgaaggtcc ggtaagggaa tccgaatgtt 70560 tcgtcaaagt accaatcccc tgcccaaatt gcgaaacgca aatacaggcg ctggcgcagg 70620 gacagttggt tcgtaagagc cagtctcatg ccccggtctc ccggggttcc gaagtccaga 70680 tccccggtca agggatcgag gagcaggtct ttaaactgag tagccatgat tctccttagt 70740 tcggcggatt ggtgttatca ccgccgcgct ctacgccgcc gtgggtgtgg gacatatact 70800 tctgatagaa gtcgtccatg tcaacaccat tggcagtaat gattcttcca gaggtggtga 70860 tccgtgctcc gttacacatc aactgcccag aggactgaag ggtgaatgat ccacctttgt 70920 ttccgccctt gatctccccg gaaggactca tggtgaactc cccggtgcca ttactgatct 70980 tgacgttgcc gtccgcaagg gcttccacag taactttagg gttctgaagg gaagtgtccc 71040 cgttaggctt cagggtgata atggccttat cgttctccaa gacaacgttg tctggatgaa 71100 tcgcctttga gttgccatcg gtgaagatct gggtgacggc ccacccggca aacagttggt 71160 gagtgttctg atcgttattg tccccctcgt tccgctcaga gaaggagaga cctaccacgt 71220 cgccgggctt aatcggcatg gtcaggcggg ccttaccccc tgcgcctgac ggcaacagga 71280 cggggacatc ataaataacc gggtatcggt ctgtggttcc agaagggaac tctgtgtagg 71340 ccatcggttg aacatcgaca gacggtccac tgtagttcac cccaaccacc ttcccacgaa 71400 tgttcgtgtg gacgttatta cgcaggaatc gggaaatgta aattccgaat gctgcatcat 71460 agcggtcagc gtatgccacg tcaactcctt atttgatcaa ttcgccacgt gtttccacca 71520 ggccaagttc ggtaatccaa tccccggttt cgtagccgcc tctgtgcgtc aactcggcaa 71580 ctttgtagaa gcctttgtgg tagcgagtgt tgagatagac cgtcgattca ggtaggatcg 71640 caccattcag gagggttgag actgtcatcc ccacgtcttc cttgatgtcg tgctcttttt 71700 tcttcttcga tggggctttg ggttttttac cctctgcctc gtctgacttg gccttagctt 71760 tagccttaat cagcttttta gaggacgatg gttgtttcgg tgtcggtgtg ccaaccatcc 71820 cgccctcttc ggaaatctca aacatcacgt tgttgaaacg agaaccttct ttcgtccaat 71880 acacagcgcc gtcttgcaca gagaacgtag atcccgtatt cttagccaaa ttggcaaggt 71940 tctgggaagc gttacctgta aaggccatag aggtttgcag agtctgatta ccaaagtcaa 72000 tcacacgacc ctttggcagt ttcaaatcag caatcaggtc attgagtacg ctgttgatag 72060 gagtcccttt gcggtaagac cgcgccgtgg tcgcagttgt caggttcaat gtaccgtcgc 72120 cgagaatgaa ctttgttgtt ctcgtttctt ctgggaagtc gtcctctacg tactccactg 72180 tccctgagaa gatcagcttt tcgtcaccgt tgtaacccgc atgaagcata accgcaagag 72240 attcacgctg gtttacagag agatagttga caacctcatc tgacaagttg tagactgtga 72300 cgtatccttt gttgggttcc ttcgagttat ccttcttcac attaaattca atgtggaggt 72360 ctttaatctc gtaggcatca cctttactgg tgttggcaaa cttctcgatg ttaacgggct 72420 tctcaccgat aaccaccgga cgaccaatca ccaaggtata agtcctctcc atagctcgca 72480 ttattcaatc tcctccacgt cctcaataag ggacgaatag gtcatctgga tacctttaag 72540 gggtccgatg ttaaaacgtc cggcccgggt tctgatgtcc ccaaggggcc agaggtaaag 72600 gttgccatta ggtacgttgt caagatagcg gtaaggggcc aagatgtcag agtagcaggt 72660 cagtttagag gtaatggttg ggcgctgggc accgacatcc cccaaagaca tgaaccatga 72720 gtcatctcgt tcattccaca tgaatcggag ttcgtaagtc acggagtcca ataccacacg 72780 gaatgtttcg tccgggtagc cactcaactc aaagtcaaag gtccgaacca cagtacgttc 72840 tgtaatgtta gccaaaatta cttcctcatc aggtcagatg ggtcaaacgg tagcttcgct 72900 cccggcttgc cgccgaaatc agtagtgccg atagctgcgt tttcccagcg ctcttttgtt 72960 tcagcattct tcccgatata cggtgtttga cgcttctgct tcgcactgtc atccaccgcg 73020 ccgccttcag ccgtttgctt cgtcccggtg ttggcgtttt tagccttctt cgggtcagaa 73080 gtacgagcca ttacggtttt gttaaccatc ttgaagcgga actcttccaa cgtaacctgc 73140 acgttgattg aagatcctgt ctctgaacta cgatccactt ggaagttggt gataacatag 73200 ttactaagga tattgtcctc ggtgacgaga gttacaagct ggtgtgagtc ggcaatcagt 73260 tcgaggatct cgatggcctt cgccgggcgg cgggcaagca tcgggttttc cttatctgtg 73320 tcccgatcaa tcatgttccg agggtcaatc aagtaagggg agtcagtaac tgtgccagag 73380 aacgtaaact tgccatcctg cgttgttacg tggtcagagg cttttgcctt tgactccacc 73440 gcatagcttg acttgttgta gtcctttgtg taactatggt tggtaactga gtcgaagagg 73500 attgccagat catctgtctg gtttttgctc tcgaactcgt tcagccgtcc acggcgcagg 73560 ccggaaacaa acatggtgta ctgaatgtct tcacgtgcct tggcgttaga aaccgccttt 73620 tccttccgat cggctccagc ccgccagtcg tcaacggcct ccttcatttt cttctcttgt 73680 tccgttgacg gaacgtaaac accgttttcg taacttgcca taaaagtcct cctgtgctag 73740 tattttagca tgaatgcagg caataaaaaa ggggccgaag ccccttgatt agttaggccc 73800 accctggatg agcatgttga agttgaactg gttgttctca tcaacaacgg cacgaatcat 73860 gttcttcaat tcgccagcct tgatctcgat ggtcacgttg ccctcaacct tttgaggagg 73920 ctgattgatt gggaacggcc ccggatatgg cccagaagcg ccagcggtaa ccaaacgttc 73980 aggatcgatg gtcgtgcttg gagcttcctt cttggaacca aacaaagagt agaacgctgt 74040 cttcatgaag agacccatgt cccccgtgag tgcttgctcg ataggggact gggttgcacg 74100 ggcaggtgcc atgaactcat ttacagcctg agctttggcg ttaacttcct catcgttcag 74160 ccagttccat ccaaggatac ctgccaccat aggccacggc ccaggaacaa caggcagctt 74220 gaatccacca cccccgcgag gagcacccca accatttcca cggcctccgc ccccacgtcc 74280 gcctctacca cctcttcctc cacggcctcc gcccatatcg ccacccattg taccacggat 74340 ctctttaaga gcaccacgca gtccagcgat tttgctaagg ataccgaaga ttttgtagag 74400 actgccgacg aagatcgcca tgccgactgc ataccctgcc cagttgaaaa catccttgag 74460 gagttcacct tggtaaccga gtttctcagc atagtagctg acgatacggt ccaacagaac 74520 gaagtcatcg tggatctctg taaccatgtc ccagaaccct tcgatcacat tgccgaagaa 74580 ggcaccgagg ttggtcgcca gttcaccgtt actgtcaagg attgttgcaa gatcacggaa 74640 cacacgcgtc atttgctcgc cgaaaccacc ttggaagatg gcgttctgga agttaaccca 74700 cgtttgctgc atctgttgca tcgccacacg gttgctctgc aatgccttgt ccaacgcgcc 74760 gccgttacgg gcagcttcag cgaagtattt ggctacgaac ggcagaactt tggcagcttt 74820 cagttcaccc ttctgcatca tatccatgag tttttcaacg tcgatggtgg tatcgttaaa 74880 cgcttcctga gatgccttca cgaatacctg caatgaaccc gggatacctt ctgccaactg 74940 acctttcaat tcttcagcca tgatctggcc tttacccatc atctgcccga tcgcggtgat 75000 accacgttgg aacttaactg ggtcaacctg aagggcggtt gcgtactctg agaaacctgt 75060 gaacagttca tcgttctggg ccttgttcag aatgccagcg gagttgacgg acatctgcac 75120 gtaaccctga gaggcaatct tcagatccag accgagacgg taagcctgat ccttcaggaa 75180 ctgaactcgt tttgccgctt cttcagatga atcagaaacc atcgtcatag ttgcatccat 75240 gccttcaaag aactggccct gacggataat gcttgcacca gatgcgaaca cactgtatgc 75300 tgcccctgct cccaaaagtt gagaccggat atcaccgagt gctgcaccaa acccacctgc 75360 gttagcctgt gcggaacgga actgacgttc gagtgcctgg atgctctggc gatactgccc 75420 ggcggacagc gccccggtac ggaactgacg gttcagatct tggatacctt gaccagcggc 75480 atttccaccg agacggcccg cgtagttgcg accatacttg gatgacaaac gaatacgctg 75540 ttgtgccata acatcttcga tgcgggctgc acgagccgct tcagccgcct tgcggcgtgt 75600 ctctgccttg gttctgcggt cttgggcctg agactgactg cggattcgac ctgccatcgc 75660 acggttctgg gcagcgatca attccgggtt gtaaactttg ttcggatcac caaccattcc 75720 cgttccggtt ccaccacgag gtggcaactg tagggagttg attcgagtga cgttcatagg 75780 acgagaagct gcattcattc cagtggtagc tttgcggtta gccttcttgg cttctcgctc 75840 ttgctgctgg tagaatttct tcatctcgct catcccggcc cgaggagcag tcatctgctg 75900 tacctgctgt ttgatacggg cagcggacac ctttgcgatc gcctctttgg ctttagcctc 75960 tcgacgggcc agcgcgatgc tgcgttcaga ggcgcgtttc tcttcacgag cgcgggtttc 76020 tgccaaacgc ttattcacca ggcgcatctg ctgggctgat ttgtcgtagg cttttgccgg 76080 gtctttcttt ggtttagaga ttgcatcaga tgccttctcc cactctttgc caacctgacg 76140 gatctgtttg accgcccggg catacgagga tttgtccacc tcaaacgttg tacggttgac 76200 tgttttggtg acaatcacgt ttccacttgc cattgatcct cctccggcaa ttataacgcc 76260 tcaaaaaaga aaaggccaga gtctttcgac tctagccctt atcctccctt aaacttcttc 76320 atgcgggcag cttgttcagc attcttctgt gcctgttcga tgtccttctg cttggcttcc 76380 tgtacgaaat cctggatatc caagtattcg tttttcttca ggagatcttc catatcgcca 76440 gcttcaatcg agatctcatt gacacccttg aaccgctcca ttaccctgaa gtaaaggtag 76500 tcataccatt ttagagaaga gttcttccgt gcatactcaa gtgctttctc tacggtactt 76560 agcgggatca ggtttccgtc tgggtcggat tctcgtccag ttgttccacc gctcgcgcca 76620 gccccagacg tttgaggaac gtgtcgatgg tcccgaaacc gctcttgccg aaaaaacagc 76680 catagttgac ttcaactacc ttaccgagca gagtaatcag gtcttcaacg tggtcttcga 76740 aaacttcgtc gatgttgatt ggaccaccca tgctgtctac ttctacaccc tcaagcagca 76800 tgttgatgat ctcttcacca ccgtcctcga tctggtcgag gatgtaaagg atcgcagtag 76860 ggatggcgtc actgaatcct tctccttttg agagggcaga gccagccacc gtgcccatcg 76920 ggaccgccac caggcgacca atcttaggca tattacgaat cacttggctt ggagaccagt 76980 gataaattgt gaaacgctta ccgccgcaca gaacaacttc tgtggacttc ttaaccttaa 77040 acatgataca ctcctgtgtc ttctgttgaa taatccatgc cgtgagaaaa ggccacatcc 77100 atgtggctca cgttgttatt ggtccagtcc aaccagacca gtgatcccgg cagcgacgcc 77160 ttgaatctgg tcaggagaca gccatgcgtc cagtacaccg atttcccagt ccatctgacc 77220 aacttcggag ccgtagctca ggtcaggctg cttctgaatc cagccgatgg tgttcaggga 77280 cagaccctga gaaccttcca cttggacagg cagataaatc aggccagtta cgttagcctg 77340 gcgctgccac tgggccagat agccgttcca ttgggccgtg ttctggaggg agagggtcat 77400 gaccccggtg ttatcacggg acagtgcgtt actgatctcg ccgtcaacac ccgcatgaac 77460 ggtgatgttg tcgttgttac gagtaataac gatcttcgta tccgctgcaa atccagagac 77520 acgctgtcca ccaataaaga cgaggacttt cgcagggtca tacgcctgca tcgtcaagat 77580 tttggattgg ttcagcatct attacactcc tacagcagag gaagacatcg gggcctgagc 77640 attagtgctc tggcccgccg gacgatccag tacaacggag gcgcggatct taacgtagtg 77700 cagagagttg ttgtacacaa gctctacctt cacgtcacgc aggatacgtg cagcaaggtc 77760 attcgtcggg atctgggcgc gtttcggaat agtgatcgtc gggtcgtagg acactttgtt 77820 ttcagcgtcg tagccagtca gaataccacc attacgaata ccgatgttga tcgggttgtt 77880 catcagaaca gacttcagta caggcaggtc ttcgtcgctc atcttcatgg acagacccat 77940 gtcagaacgg cgcttcatgt acgcgaacac ggattcttcc atacggaatt taacccaatg 78000 ggagaagcga atcacgtcaa cgtactgccc agaagaagtt ttaccttcga tgtagctacc 78060 accgccgtac agggaacggt agatgtttgc gttacgagac caagcgttgg aacgctgagt 78120 gtcggagcca gcaaacggaa ccatacccgg catcgttttc aggtgcaggg agtcgccgta 78180 agaaggatcg ttcgcagcca tcgcaccgat gacagagcct tcggtgaagt caacgtcagc 78240 acctgcgtcg gaggttccca gagagtcata actcagagcc ttcaacgtgt cgaacacgga 78300 ggcggctgag ttctcagggg cgtatgcgtc cacatcggtg gagttgtaaa cgtgcagttt 78360 gtagttcgct ttggagaact ctgcggcagc aacgatgtct gcatcagaac gggcttccgt 78420 tgacaggaag taccagttgt ggttctctgc aataacgaac ggcagtgcgg ttgcaacagt 78480 ctcgccagat tcgtttacga tcttgtaagt gcctgcgcct ttacccacgc tgaccacgtt 78540 cggcgatacc gctgcgatgg ttacgtaagt accattcgca atagcagtga ctttgccagt 78600 caaatctgca tctgcggtaa ctgcatcagc cagtgccgta gcaatctggg ctggagtgtt 78660 tccaggcagt acgttaattt taacagcctt gaccatcttg ttcaaggtaa tattaacgac 78720 aacctgttcg gtgtttgcgg tcccggtgaa gtccacacgt gtagattcca gagacatacg 78780 tccgattgcc acacgctgcg gggcgaagtt gcctgcgaat gcgttggtgg caaactgata 78840 tgccggggaa cctactgcaa atccatcagc aaccatccca gcagtggaca cgtagaaacg 78900 aatacgctct gggaagttac cgtgcattgc caggaacatc ggggtttcaa agccaacggt 78960 gtcgattggt tgagtgccaa ggctaacctc aacgtcaaca accttgtctt gatattcagc 79020 cattttgtgt cctctgcttc tgaacgatta ttgaccagca caaatgtgcc aatatgtggg 79080 ggattactcc cccgtcttgt cactgataag cgctggctta tcaataaccg gagttgccat 79140 acaaacctga gcgatggcgt catggtagac gatcggaggg ttaggctttg gtggcaggcc 79200 aggatcatca ccgccgggat tgacaccctt gtcatagtct gcttcaatac caacaggcgg 79260 accagaaggg ttgtcaatat cgatcccgat aatgatgtgc tcgacatcct cgaacgcccc 79320 aatatctttc tctacgaatg tcgcgttgaa agtgacaatg gttcgtgctc ggttctcaaa 79380 catttgctgg ttcagcggta cacgcattcg agcaatgttc gaggttgaag agtacgcata 79440 aggagacccc gttgggaagt atttctcacg aatgaacggc aggccgaaag cctgatgcac 79500 ccgggacaat gcccagtgag gtttcccacg gtaagcggtg agggtatagc tggcggtata 79560 gttgtgtgcc gtatgaacga caccttcttc atccaccact tcgtttgttg cccagtcgag 79620 aggggtaagc agagtaaggt ctacgaggat gtatggccct tccggttttg gaatggtctc 79680 atcagcttca acgacatcat aacccgttac gtccaaacag agacgaccga cagccttggt 79740 cagtgctccc atcacgacat ctgagtttgt aaaatcaaga gggagggcca ttagagtcct 79800 ccctcagtcc ctacagggac agcgatcagg tagtagcggt agcgaggcac accagaagag 79860 ggatacatgt ccgccttcat cactgtgaac catgtctgac cgccgccgga atccggcagc 79920 aacatctgat cggaaaggtg ttctgtgccc tctcgcgctc ggaacagcag agtttcagag 79980 taaacggtgt aggagtcata atcctcctcg ccgccgatca tcaactggtt gttctggtca 80040 cggatggctt tcccacgcat cggttgaata gtgcattcca cggcagtaaa cggggtgtac 80100 aacacttccc gcccgccgtt cagaaacgga ctatcagggt ccgtcttgac ccactcacgc 80160 ttccgacatt gcacttcgac acgagggatg agtctgtttc tgcttgagag caacgaataa 80220 gcccgtgcca tcggtcaccc cttatttccc ttggtacttg acgattttgt acgttgccgc 80280 actcgacaag tcaccgtaat gaatcattgc gtcatcaaac cccttgtaac tcgcccagtc 80340 ttttgatacc tttggattac tgaatgaacc cgtggagatc gtgaagcgaa tactgtcggc 80400 tgcatccttc ccgattttgg tcaggtagct tgagaagccc cggccctgaa tgatcccgtt 80460 gtgcatacgt ttaatatgtt tccggagacc ttcttggaag tgcatggagg ttgagaacat 80520 gaagttgcgc tcaggaaggt tattccagcc ttcttcatgg atggcggcaa gagtcgccat 80580 attcagccca gaatagtgtt tctcgtcgta aaaaccgtac tccacttctt tctcagctaa 80640 atcagagagt tggctgaaat accgcttcag ttcagagatg tcagtatatg acttctttgc 80700 cacggtattt ccccatgaaa gttattttac cacaataggt cagcaaaagc aacaaagtca 80760 acgctttagc ggaccatcca cggactgcgc cgaacacggt cacaaggcca cgcggattgc 80820 ttcgggatcg ccggggtagg gtagacgcct tgctccatga agccgttgta ggagttaggg 80880 ttattcttca cacggaagaa ctcatcttta cgaacaccac cgatgacgac aagggaggag 80940 ttgaagttca gagatgggtc aatgtaatca gggttcagtt ccagccaatc aaggaagtct 81000 ttccaggatt gccagcttga tccgcccttg atggagatag tctcatcacc gatcttttca 81060 aatctctcac gaattgatga atttccgctg gagacttctt gtacgatcaa ccaacgcaca 81120 cagtcaacaa cggtgttgta cagggccacc ggaattttct ccgggtggtt atccaaatca 81180 tacgtcagct tccacttggt ccagaagaag atgatcgtct ggtccgaaat ttcctcagtg 81240 gtgatcccac caaggaggac acggacaagc tcaattactt gttcgttggt cataatagtc 81300 tccatgcttt agccagtgca accattttat catgttggtc acaaaaagtc attgacaggt 81360 aaaaagaaag ccgcccggag gcggctttta attatgggat gggaatgatc acaagccagc 81420 cattatgggt tgtagacatt acctgtgagt aactcactgt ccccggagat ctgtactgca 81480 tgtacagcca aacgcccact tgtgtcgccc acagcagttt tttgggcaac ccctgccact 81540 gtcacttccc atgcttcaag ggtgtcgtgg caaaaaacaa caaggactac cttgtcgccg 81600 aaccccacgt tgatagtaga gtccgacgga taaactactg tatttgagat cgaggtgggg 81660 ccggttctcc cggtcttaat acgatttacg tccgtgtagg ttgttgttag tgcataagag 81720 aatccgatcc tcttcgccac tgacgaagtt cctgcggaga aaccaactcg ggtctgagag 81780 acattgttgt ttgcagagag aataagacga acattcccca agttgttacc ggggagttga 81840 atccaagagt tcgttttgtt gatcggggag gcataaatcc cagaaatggt cgggagggca 81900 ttgtcaccct tatctccctt agggccagtc tcccccggag gtccctgttc tccttgtgga 81960 cccgcagggc ctgccggacc tactggtcct tgatctccct tttccccttt ttcaccctga 82020 acaccttgaa tacctcgctg accttgtggt ccttgtagcc cttgaggtcc ttgctctcct 82080 tgtggtccgg cgggtccggc aggacctgtc gcaccggaag gccctgcggg tcctactggc 82140 ccttgcaaac cctgcgggcc tgttggtcct gctggaccta ctggtcccgg cgcaccttct 82200 gaggccatta gtgcccagtg gtcgttaacc cttgtaccag tagattccgg cgggatacct 82260 gtggatggct gagtagaaaa atatgtggca ccctgatacc caactgcatc gttaacgtcg 82320 taggagactg aatcatcata gtttcctctc catacaagac ctgtcgcacc ggaaggtcca 82380 acggggcctg ttgccccggc gggtccctgt tccccttgcg ggccagcagg gccttcagga 82440 ccttgagggc ctggttcacc cctctcccct ttctcgccct gagggcctgt tggtcctact 82500 ggcccctgag gtccttgagg accaatttcc cctgcctcgc cctgagggcc ttgttcccct 82560 tgaggtcctt tttcaccagg attgcccggc tctccttgga caccttgagg tccttgagga 82620 ccggggtctc ccttatcccc cttctcccct tgaggaccct gtgggccggg tacagaagat 82680 cccccctcgc caatttggtc aaaggggata agtttttcgt taacgagatc gtaaagtgca 82740 tacccgaagt atacaccgtt ctgctcccct gtgatacccc tcattgttcc catacagtct 82800 ccttatgtac aaaaaccgcc cctaagggcg gattaattat gcggctggaa ggtcgaaaga 82860 tgcagtcttc gttgtagagt cagacatggt gaaggttaga gttacagtat cgcctgagcg 82920 agccgctgcg atgtcagcga ttccaacacc gtctgcacct gctgcccccg ccgggcctgc 82980 tggacctgct ggtccagtgt ctcccgtatc acctttgtca cctttcgggc cgggagtacc 83040 gccaccacct gcaaaaagtt cagagatggt cttgctctct cctgttgctt ggtccatgat 83100 ctggtaacca gtcaggacac caagggatgc tccgccaatt gctgccatgt tattctccta 83160 cgaaagtttg aggaacttca gggatgtctg tgatgacttc ggtgtcatac acagttttta 83220 cgtatgccaa caggttctgg tggaccttgg cagttgcagc caggatttca tcaatcttga 83280 caacagcatc cgcagacggt agagtcaaaa ctgtgtaatc agctttgcga atcagaacat 83340 ccgattcaga gtttgcaaac gcaaacgctt tggacagttc aaggttcagg agttctcgtg 83400 gttcaacaga gaaaacgtcg ccgtcaacag ccacacccga ctgaaggtca gaggtatatt 83460 gctgatacgc acgggtacga taatcttcct tggcgcgggc caagttctct gcgatctctt 83520 ctggggagaa atcacgagca acccaagtct tgtaccacag atcatcttct tcgtttagtt 83580 ccggttttcc ttcggtgacc acatcaccaa taggaacttc agaatcatga accatgcaat 83640 aaccccacag gtctcgcatg tccttttccc aaacgtaaga accaatactt acgttagtat 83700 gttctttgag gaagtcgcta agatagacag gatatttcat gtcggacaaa cgaatcatcg 83760 gtgtccaagc ataaaccttg ctggtaggat ctacagccat ttgaatctcc ttgtgaaggg 83820 ggccgaagcc cccttgggta ttagtctaca gtcattgcct gaacaccagt caggtccgtg 83880 ccgtcccaga agaacgtcag gatggtacgg gtagtaccaa gtgctggctg ggtgccgtta 83940 gaccatgcca tcggagaagg ccaagtcatg gacccacctt taccgaggaa cttaacaacc 84000 acagtcatcg cacgacccgc tggcaggttg gagatggtga ttgccttaga cgtggttccg 84060 tcaacggtga acacgttgga tacagaagca tccagtgcgc cagttgcgga catgacacgc 84120 aggtcgtagc gatccagttt ctgccacgca ccgttcgcac ggacgtagta gccgttgtct 84180 tgaggcgctt ccagaacttc gaccagttcc caatctccgt cgatacgagc gtactgcttg 84240 ccgtctttcg gggaatcgta aacgttaccg ccacccatgt accccatcgg tgcccaagtg 84300 gttgcgttcg tcttgcggaa gaactgcaac gtcgaggagt tcaggaagta gtcacctaca 84360 cgaccatcag caggacccgg gtcatggtcg aacacgatcc acaaggaacc ttgatcaccc 84420 ttatcaccct tgacaccctg cggaccagta gggcctgggt caccagtagg accagtagga 84480 ccaaccgggc cttggatacg tccgaggttt tcgtaggcag agccagtcca tccccagaag 84540 tcgccgtcaa tcaggtaacc ctgacccagt tgcccggttg aaggcagttc tgaagtgctg 84600 ttgagtttac ccatgatctc aacgcccggg ccgatgtcac cttgcgggcc ttgagggcct 84660 gtagcaccag tgtcgccttt cacaccttgt gggccttggt ctccggtatc acctttgtcg 84720 ccctgcggtc cttgcggtcc acgcacaact cccaagtcaa cccaggttgt tccgttccaa 84780 gagtatccgg tcccagtatc ctcagtgacg tagtaatcac cgacggtgtt cccggtagga 84840 ggcagggtcg cagcagaggt tacagttccc ttcggaataa cacctgcgcc tgtggcacca 84900 gtatcccccg gatcaccttt atcccctttg tcgcccttgt cgcctttctc gccttgcggg 84960 ccgcgagtca ggccagtaac aacccactgc aacccatccc aagcgtaacc attgccatct 85020 tcctctacag cccagaaatc gcctttggtg ttgtcttggt caggaagatc tgccactgta 85080 ggaacagaac ctttcggcgt cagaccagta ccctgcggac cttctgggcc agccgggccg 85140 acatcacctt ggtcaccctt gtcgcctttc tcgccttggt cacccttgtc acccttagct 85200 ccagccgggc cagtggctcc ggtgtcacct ttcggaccac ggacagggcc tgcattctcc 85260 caagcagtgc cgttgaagat gtacaggtct tctccgatca gccatgcgtc accagttacc 85320 ggattggaag gcagttctga aggatcagct tttgatccga ggatcgcgag accttcccct 85380 acttcccctt tcgcaccctg cgggccagta agaccacgtg gaccagtcgg gcctgtgtcg 85440 cccttcgcac ctttgagaga tgccaggtag tcgctcaggg aaccttggaa cccgttctct 85500 accgccaatg cgtagttgtc tttgcctacg tcacctgcgt ctcccttgtc gccttttggg 85560 ccagcagggc ctacatcccc ctgatcacct ttagggcctt ggaaggcacc gaggttttcc 85620 cagttgtcat tcccagtgga tacccaaacg ttagttccga tcaggtaggc atcgcctgca 85680 tccgcgccag ccgggaggct cgcttcgtct gcgactttac ccaagaggtt gatggcgttg 85740 gcgttagtac cgtcagcacc cgtatcacct ttgtcgcctt tatcaccttt cggtccttgt 85800 gggccaatca gggagttcag gaagtcaacc tgagatccgg tgtgaccgtt agccagccat 85860 acctgatacg cagatttacc ctctgggcca atctgaccta cagtctgcca tccatcttca 85920 tcacctgtcc acacatacat catgtcttgg atgatgtagc agtcaccagg cttgttacct 85980 tcatcaggca gataggacgg gtcagggaag gaaccaagaa tttgcagacc gataccgtca 86040 gcccctttca gggattccag ccactcatca acagtaccaa cgaagcccgc gccttctgca 86100 acttcataag cagacagacc ttcaggcccc gcgaagttac cgatgtcctt ccactgcttc 86160 acgttgtttt cgttgacaac ggtccagaaa ttctgtccaa taacgtaagt gtcacccagt 86220 tccatttccg caacagccgg aagctgagaa acttcgtcaa gctgatcgat gacgttgata 86280 ccaataccag ccgggccttt cggaccttct gggccacgag caccctgtgc ccctgccggg 86340 ccagttgctc ccgctggtcc tacgtccccg gtgtcacctt tatcgccctt gtcgccctta 86400 tcgccctgcg gaccttgagg acccgggtct ccctgtgggc cttgagggcc tgccgggcca 86460 gttgccccgg tatccccttt atcacctttt acagtgtcaa cgtaaatccc gtcagacttg 86520 acttgaatct tgttgtttgg gtcttgggag attttagtct cttgtgggcg aacgtacaga 86580 gcaccctggc ggatttccag cgtgttgtct tgagccacag aaacaggaac gctcaggcca 86640 gcagtgccta ccttcagggc gttcatggaa tctggatcaa cgatcacgtc gatttgggtc 86700 ttggctttcc cggtaggatc agccttgatt tccagagtct tcttcggtga cgtggttgac 86760 acgttcaccg gatcagagta tacaccttcc agggccgggt tgccagcgtt agcagcttct 86820 tgggcggaga tgtaagttac ggtgttccca tccttagcag acaccttggt gtcggagcca 86880 gcaacataca gaccctgctc actggaggtg ctcaccactt ggaggcggtt tcctgaacga 86940 cgggagatgt tgatgtttgc ttgcagaggg gaggattgag taccatcacc aatcagcgtg 87000 gtggatacgg tgtcttgggt ttcgatgccc gtgaaaggcg caccagaacc accagaggtg 87060 ctcgcagacg gttccgggag agtcaccaga acttccacga ccttatcttc atattgtgcc 87120 attacttgct tctccggagg cgggattgga ggaggatggc cccgcacggg ggccggaggg 87180 aattacagtg cagctttcag gtcttccaac attgcgtcaa aagtcttagc cttgctcaga 87240 gagatctcca tagtcaaagc gtaggattcc agcgcagcct tagcagccgc ttttttggtg 87300 tcgtcacgca gggtttctgc atgagcgagg atctctgcct tttgttcgtc agtgcgggca 87360 gaagcgggtt tttcttcttc cttcacttct tccttgactt ccggcgcagg atcaattaca 87420 gttgtttgta ccagagagga cagtggtgat tccacctcgg tctcaacatc ttctgggatc 87480 acgttggcgc gagccgcctt gatctcaccg atgttagcca agaacttctc tggagactta 87540 ggggtctcgt cgaagaagac gaggaatgca gcgcctttct gaacagatgc gatcgtattg 87600 atgcccagtg cggtcatcgc ttcaatctgg ttcaggaact cataaaggtt tcggcccatc 87660 accagttcgt tgtcatagga atacaggaac ggtgccaggc gggcagatgc gtcaacgtcc 87720 agtttcggca ggtattgacc gaagaacttg agcatgtggt attcgctctg gaacacttcc 87780 agatgaggtt gtgccattat aggatactcc ttcgttgata atcaaaagcc tatcttacaa 87840 tggtacacta ttttgcttaa aatgtacagt tataccgcag tcaataaaaa aggccacccg 87900 agggtgacct tttccaatta tgcagtgaac ttgcctgtgg acttaacgac cagttccgga 87960 cggttgttca cagtcaggaa ggaagtctca gactcaatct tcgcttcacg caggtagttg 88020 gactctttga agaacacgta cagttcttga gccacctggt tagcgtcacg cagggtgtcg 88080 ctcggcgcgt agtagatctc gaacatacga gagataccac gtgggaagat gtacgcttca 88140 cccgccggga tgttcccgga aatgtcttcg atgaacagga tgttcttgtg ctcgaagata 88200 cggttgttag cgttaccgcc cagacgacga cgcagcattt cctgagttga cgggtactga 88260 gagtacgcac cagtcacctg cgggtgagcg atcagcgcgg agaaccactg acgggacgcc 88320 agaacgacga tctcgtagtt gtcaccgttg tcgccagccc agtcgatgat gtgagcacga 88380 gcttcagctt ccaggacttc aattgggtct acgcccagct tggtgaagtc aacgtcagca 88440 gtctgctgag ttgcgcccca aacttcgtag tagttgtagt cagaaaccgg gtcatccgga 88500 gaccaagagg tgcccttcag ggcagcatac atggccttgg acttcaggat cgcgtggcta 88560 cgacgaatac gtgccatgtg acgctgaact tccgcatcaa cagttgcagg ggcattctca 88620 gtcccgaact cacggaagtt ctgaatgtct gcacggtcga tggaacggtc cagagggaag 88680 aacgggatgt tcaggttgac gatcttttta cgatcgttag ccaggtgctg acgcacaccg 88740 ccacgctgaa cagccttgat gtcaccagcg ccgtcatcca gacgttcgat acgggcaaca 88800 gtggtacgac cgaaatgttc ggtgaacagg ttcatgctct gaagcagagt gtccacacgt 88860 ggcatggtag agatcaggcc agtgtagtcg agaatctgga aatcgccgtt ttgcatttaa 88920 atatctcctg ttaaattaca gtacggaacc gatgaactgg gtgccgacaa tcttatcagt 88980 tacctggtta ccttgggctt ccagagcttt aatgccagca gcatcaatgt cagagccgtc 89040 agcatacttc agtttcaact ggttcagggt caggccgcga acagcgagaa ccatagggac 89100 tttttcgccc ggttcgaaaa cgccgatgta gtggtcaacg cccggcagaa ccttacggtc 89160 aaccagaacg ccgaagacgt cagcagccgc agtagcaggg gtgccatctt cgccaaccag 89220 cataccagcg aacagagcag ttttggaatc tgcatccgca tcagatgcga tgaaggtcat 89280 gtccacttct ttgaagttcc aaccagtatc gccgaaagcg acaacacggc ccagaacgat 89340 gtcagagtag ttaccttcga gagtagcaac gtgtgcttta gccatttgtc aggttctcca 89400 gattaggcgt taataaattc agcggattta gcggctttcg ccagttccgc agcgcgttct 89460 ttgatcacac ggtccaggcg ggcctgtgca tcttcggaac ctttggctac ttcagtcaga 89520 gtgccatcag caccgacttc tttgccattt gcgaaggatt ttttaacttc ttcgatctcc 89580 agatctttag cagccagagc ttcgtctttc gctttcagat cagcagcagc tttttccagt 89640 acggatacca gaacagcctg cgccgggttt tcgataacgt cagcaacaac atcgcgctgg 89700 tcagcagcta cgaagctaaa gccagcggct ttctcaacgg cgattgcacg tttagcagca 89760 gcttgggact tgacgatctc ttgggcagcg gtaagagtgc cttccataga tttcatctgc 89820 gccaccagag cttcgttggc cttcatcagg tcaatgaact gctgggattt ggttacatca 89880 acttctttct ccacgggaat ctcctcgtcg ggtttgatag tcgctccagc ggagctttca 89940 gttggcgcta caggagtcac agacttttgc gtttccacaa caggcttgac ttcagcggcg 90000 ggtttgacta cagttgaatc atcaccgaag tcgatgccga ggtcacggca accttcttcg 90060 aagtccttac gggccttaat gagttcaaac tgttcaagca gtgacagttc atcgccagcc 90120 ttcgctttct tgataagggt gacagaggag agcttctgtt ccaagtattc ttggtggcgc 90180 tcattccatt ctgcttccca ggaatcatca tccggcgggt tgtcttcgat ggactgttcg 90240 aactcggtct tcatgcccag cactttggtg agcaactctg catctccact ccataggtgg 90300 aagaagcggc gcaggtactc ttccatagaa atggtgagtt ggacctgttc gagagatttg 90360 atgatgtcaa ccgtgagttt ctcagggtca acttcggatt tggtcaggag gctgacgtgg 90420 cggttattcg cgctgtagcc ctgatctcgg tgagtgagag caatgccgcg agatttaatc 90480 tggcgacctt tctcgatcca cgtcttgatc atttggcttc ctcttcttcg agtgaaatac 90540 tgaagtccag ttcggaaagt tcattcgtct cttcgttcag cattccgccg cactgaagtg 90600 acaggccacc gataagtccg gccttcttca actcccatgt ctcaggggtg tactgaactt 90660 ttgcaaccca agatccggcc ttgattactt cgccagtttg cgctacatta acgtcgaact 90720 ctggttgaat ccagtggtca acgattttcc aagagtcggt gtcgaaaagg tgatacaggt 90780 tctccgtgac agcaccgagt tcctgagcct ttttgaaatc ttgttgagcc tttgccaagg 90840 tctctttcga catccactgt ccgtgaaggt ccggggtgtc aggttcgtag atgatctcat 90900 aagaaatcat ctcttcttca ccagcggctt tctggacgag gacggagcca acggccccgt 90960 taacggcagc agctttatta aagccctgct tcaacaggtc gttggccttt ttcacaaacc 91020 gactcttttg gattcgagtc agattagttt gtgaaggaag gtcggaaagg gtaatgtttt 91080 ccatcattgc tcccgtgata attattttag cactgaactg actgttttgc aacaggttgt 91140 tttcacgact ggattaatta tccaaattag ccgctgaatt atctcttgaa gcagagattt 91200 tgccagtacc gttaccagaa gatcctttcg tcatgccgtc tccagcgcga ctggtatcct 91260 cacccaacag cttcatgagt tcttcctgag aaatgtcttc ctcaatcttc tcatcaatac 91320 ccagaacttc cagtacacgg ttgataacct tcggagtttt cggcaggtag ccaacggcac 91380 caatacgctg aatcgccttg gagaaacctt ccatatccac gtccacgatt tccccagcct 91440 tgacgtatgg catctccgtc tccgggaggc gcatatcgtt cagggccagc aattgtggca 91500 gcaggttttc gttcagagct tccagaatga tctcgtttac acgttgaaca aactgggtgt 91560 ggatagtctg cttggactca gacaggttgt aagaaccgcc tttgtcgtta cccacgttga 91620 tgaagccagc gcccagacga tcaaggattg acttcttacg gtcactgatc aactgtgcgg 91680 tgctgtactg cttacccatc ccgtcgatgc ccttgagggt cattgaatac tgaggggcgt 91740 tatcctttgt atcggacggc agcatgaaga atgactgctc accggagtgg gcatttgcag 91800 cgtcagacat caggccacgg accatttctg cttcaggaga agactggtcc attgcagctt 91860 tgttcaggat ctgggaaggg atcttcaatt cgatcacacc acccatgtcc ttggttgcgc 91920 caacaacctc aaggttctca atcagaatct tttcacgcca cgctcggtag caacctacca 91980 gaggagagac accgagagcc tgggatgaag agcctcccgt gttcatcagc atgacacgat 92040 tgattgggat aatgacatca ctcatgcggg tggatacgcc accaacacca atctcgctgg 92100 ctgtgtagtt ctggaacgca gatagggatt gtttaatacc gatgatggca gagccatcct 92160 cattgtaaac aatcgggttt gtccggctca aggacgcctg cggtcggaaa gcaaggttct 92220 ttaccttgta cttgccgatg tattccccaa cagtaacctg agtgtagact ttctccacaa 92280 ctgacaggcc atactcgttg aatgttgcgg cgtcacgggc gaactgacga agggtttgac 92340 cttccatgtt cttcaggcaa tactcaacaa acttagcagc ctttttggac tcctcagatt 92400 cgccagggat taccttgaaa tccttgaacg ccttctccac gaaagtgtac agcatgtcaa 92460 ggcccgtcgc aacggtggcg tcctgcttca ttgactcgac tgtaccgatc aggttgggcc 92520 agcgaatctc ttcggccttc atacgttcgg agtcaacctg aaccttagcc agagcaaagg 92580 tcccttgctc actcatacgc atacgggata cgttaatttg ctcgctggtg gccttagcca 92640 ctttaacgga gcggttacga ttacgttttc ttgacacggc atatcccctg tgatattaat 92700 aacgacgtga ggcgtacaga gtaggggcat ttggtcgagg gatagcgacg gcgcggacga 92760 cctcggtctt ctctaggaaa ttaattcctg atgccacggc atccgcccag tcatccttac 92820 gggacccggt agaacgttca ccgttgaaag actcaagttc tttcatcaat gcgttgtacg 92880 tgtccagagg gaatgacttc ttaacgatcc ggacaaatcc gttttgtgcc aactgggcaa 92940 acggggagaa gcgggttagc ttcgatttgt taccgggtgt cgggtctttc tctaccatat 93000 accctttcga gataagatca cgggatgacg tggtgaactc ggagatacct gcctgaccgg 93060 ggtcaacgga gaaaatgacg atcgtgtcgt caccgtccag cattgcctgc ttcgtgataa 93120 tcacgtcacg ttcgccagct ttcttacaga agcgcccggc ggtgccagtg gaccactcac 93180 cattgtcgat gaaatcgtca tggtagtttc cgtacaggta ataaaatccg tcgtcatcgc 93240 gggccacacc aatccccgcc gtaaagtcag gggttttgtt tgctgtggat cgctccgtac 93300 ctgccttatc gtaagcacgg actttcgtga cgttcatcgg gaggcaatcc acctctttca 93360 ggaactcacg tttgaaatag tttgcacctt ccgggcgagc gtcccagttg ccgtgaagca 93420 gacgggcgcg gtcaacatcg ttcagacctt ccaactgggc aaggtactcc gggttgttga 93480 tcagcatcgg agggttgtcg taaatggtgg aagagatgaa gctgaatgaa acaggcttac 93540 atttcttacc gaagcgttgc ttcagttctt ccttggtgga accccagatg tagttgtcat 93600 ccacacgaac aaaccaacgg ataactccgt cacgttcagg gatcggcaga ccattctcat 93660 ccagatacca gtcaatcatt tcccggagct tatgatccgg gtcggggtta caagatacga 93720 ccatacggga agggtacttt gagtttgaac gcaaacgcga catcatgtac tcaagctgtt 93780 cccagtcaaa ctgggttcct tcatccacac caatgaaagt aaattccaga ccctggatgt 93840 tatacttatc gttgatgtgc tgcatggact gccacttcac cgtcgccccg ttcgggaagg 93900 tcgcaatcat ctcgttctct ttgaacttag gcttgacgac cggaggaagc tggttgtaaa 93960 tatctttcgc tttgtcgaac agaccgccct gaccacgaat ctgaggcact gtacggcgga 94020 acatgatgca agctgtacga ggatcatcaa tgatcaacag gggcatcaac tggagcaggt 94080 aagatttgcc ggagcctgct gcgccaccca tgatgaggat ctgtgcttta gattcgagaa 94140 ccatctgttg cttacgactc gcgggtgcga atgtagcgga cattaactct cctgaataaa 94200 taaattgaca tgcttcgata gtaggtatat tatcacaaag tcacctaaaa gaaaaggccc 94260 tccgcgtatg gagagccttt tggcacaatc acttaccctt ctcgcagact tccccaaccg 94320 ggtcttggaa gaggttgcag acgtattgct ggaggtcttc gagcctgcgc tcgactgtcg 94380 ctgcccgcaa gttgttgtta cttataacaa ccgcgccttc accgttgtct gtacctttct 94440 tgaggtactg ctttggtgga gccttacgca ttagctctcg gtccggcttg tctacaaggt 94500 cttctaccgt ggtgcccttg aaggccacct ctgggattct gtctttgttg ctacacgctg 94560 acagtgccag aaccatgaac attccgagaa taaatttcct catcagtccc ccaaggattc 94620 gttgtacaga tccacaaagt catcgtccaa ccctttcttc cgggcggctt cagtcttgtt 94680 gtactcgacc tgcttatcgc ttacgttgtg acgccgggct tcttccagct tgcgcttttc 94740 ttcagagacc cgggccagtt cttcgttaag agccgtgttg tcagccttac ccttgtcgat 94800 aaggtccacg tactctttcc cctttttctc ccactgggta ttggcagact ggaagccaag 94860 agcataggcc gcatcttctt tggtgccgac ataccagttg aaggagaaca gcagcaggac 94920 cgcgatcccg ataccgatca gatacttctt gtacttatca atgaaagtag ccataatacc 94980 tcctttgggt attttatcac cgaaaccaga aataaaaaag ccctccgcaa agggagggca 95040 ctgaggcgaa ggagaggaga tattttattg ttattggaat ttcgtaatcg tgatgttttt 95100 caacatcccg ttcatgttgt aagaatttgt tccgtagtga ccgccgatac ctacaggcag 95160 gccctcggag tgtaccctgg aggcagctat cgtcccgacg ttgacgtcgt ccatgaaaat 95220 ggtgatattc tttccgtcaa acttaacccg gacattcaca ggcgtcagaa gggggacatc 95280 tcgatctgca acgaccactt ggcgggaaga caagctgcca ttgaatgtga agaaaaaggc 95340 caatcttttc acgttcgtga cgcttgccat cgtcaggcca aaagttcctc caccactgga 95400 gggactcaac tgagagaata tagcaccttc ggtggaagga tatccccaca ggtacatgtc 95460 gagtttcaac tcgaacggct tggtcccgat tgcgaaatct acattactga ggttttcgaa 95520 gtgacctcct gcggattcca taccgaggac ttgatttccg aaagcatggc ccacaacacc 95580 tgcggaacct gtggcattga attgccgaag gcccgcaacg tccatgaccg ttttagaacc 95640 accaccttct accgggggaa tattaaaaag caaggtttct gtttcttggc gaccgatcaa 95700 aagtaattcg ttcattgggc acctgtgatt ggtggaactg aacggattcg aaccgccgac 95760 gcgctgctct tcaggcaacc gctctaccaa ctgagctaca gttccatgtt tggcagaaga 95820 ggagagactt gaactctcag gccccgaagg accccggatt agcagtccgg tgcggctacc 95880 tatttcgcca ctcttctaaa ttggcggaag ataatagagt cgaactatca ccgtggggtc 95940 gccacagcgg gccggggttc aaatccgggt gcgtaccact acgccctatc ttccattatt 96000 tgatgcttgt ccaagccgtt cttgtgcgga gaagttgacc tgctgccctg aacagcgtca 96060 gaggtgcggc tgaaactcca ccttgggcat tggaccaagt ttgaaattcg gtattactga 96120 ctgcccggaa caacacttct ttctcatcaa catacaaatg aacaccgtct gatttcattt 96180 cgtagctcaa gaggtgccag cccttgttga taggtactgt actgtcgagt tgcaccggat 96240 tggagccgtt ccatacatag aagcaaagaa cagtggcccc atttaagaat ttgacaccga 96300 aggaccaata atccaaggtg tctatgcctg cgaaacctac catagtgggg tagaagccgg 96360 aggggtaaaa atccacagcg gggtcaagat acaccatagt gtctatcctg gctccacgtc 96420 tgatagcaga caggttcaat ccataattgt attggatgaa cccaccttgg gtgttctgta 96480 taacagcgtg accgtccaca acatccttgc ttactccgct cctgttggtg gagcttttgt 96540 tccctgcaag gtcgggagtc atagagttgt cggcaactgc caaaaactga tacccggtcg 96600 ggtctggagg gggaagatac ttgcctcctt gcggggcaga gacgatcatc atttcgttca 96660 taaacacctc agattggggt gacctgtggg actcgaaccc acgactgccc ggttcacaac 96720 cggggattct acctgctgaa ttaaggccac attgatgctc actaaaacac acgtctgtgt 96780 cgcctgctct aagggttcga gttccactga caagagctaa tgagcattaa tgtggcgggg 96840 gatggaggat tcgaacctca cgatgtcggg atcaaaaccc gatgttttac caattaaact 96900 aatcccctac actgggtgag ataacccgat caccacgggc aattgaattg gagcggacat 96960 ccgggatcga accggactca ttagcttgga aggctaaggc acaaccacta taccatgccc 97020 gctgggcgct caggtccgaa gaaatctgag ccttgtgttt ggtcagagtg gagaggatcg 97080 aactcccgaa gacctgttcc caaaacaggt ggcataccgc ttgcctacac tctgcgtatt 97140 cctgcatgga cttctttatg gcagcaggag caaagcagga cgcatttaga gacctctgag 97200 aggtatgctg cccaactcct gtggataacg tctgccacgt tgtcgtcctt gttatcgtcg 97260 gggtggtgcc actcaagagc accgccgtat gcgttgtatc cgcaaccgag acaacctatt 97320 gattctttat gttccctcat ccgcttagag tacaagtcat ttctggtctt gtttctatcg 97380 taacgggaaa ggccgtttgg gaggcaggag aagcagaata gtctgttctt tccgccggag 97440 cctttcttag ggatttcaaa ctctgccgtg caataatcac aaatcatatt tcctcctttt 97500 atggaagatt accatctgtg gttgcaggtg tcaagaaaat ggttggggat ggtggtttcg 97560 aaccaccgac ctcacaatta tcagttgtgc gctctacccc tgagctaatc cccatttgaa 97620 gtggcggtcc taacgggatt cgaacccgtg actctcgcgt gacaggcgag tatgtttacc 97680 gctaatacca taggacctga atttggcagg aaggtgacga atcgaacgcc ttgaactggg 97740 gttggaatcc agcgagcggc ctttgctcat taatctaccg acctataata attggttacc 97800 cggacaggga tcgaacctgt gtctccacgt tcattcgagc ggtggacgac ttaccgcttg 97860 tcgcaccggg taattgtatg gcgtcctgag aggggatcga accctcaaac tccaccttga 97920 aagggtggtg actttatcca gtttgtctac caggacttaa cgaatagtca tcgcaatgac 97980 tattgattaa gtattggctg gtcctccggg actcgaaccc ggataaacgg attaacagtc 98040 cgccgtaata accgattata cgaaagacca ataattgggt gcgccccttc cggtgtgact 98100 gagaactgta cccgacaggc ggggaagtat tactcaatca gggaccttcg gttggacgac 98160 tttagggtgg cctccatctg ggctttggtc tgaggactcg cctctcgcat taccagcttg 98220 gaccctcttc ctttctggtg gaccgtcagg gactcgaacc ccgaacctcg ggattaaaag 98280 tcccttgctc taaccaattg agctaacgat ccgaattgga ggtaggagag agatttgaac 98340 tctcgggccg tggggttacc acgaccgaca cctttccaag atgctgcttt aagccactca 98400 gccatcctac cttaaatttg gtgccgaggg acgggatcga accgcccgag tcgcaatgac 98460 agcagattta cagtctgccc cgctaccttc tacggtctac ctcggcaaaa ttctcttttg 98520 tacggctcac ctgacatcca aggatctgcg ctgatcccta tagaccttcc tcgccatcaa 98580 acgccgttgt acaccgtcgt cattctgcgg gtcgttaaca agtgcccgtc aaaagagaac 98640 ttctaataaa ggctccttcg ggagccttcc agttaatcat cttcgcctac tgctttatac 98700 tcacgaatct gggttgtcaa cgggatggca tttttcatct cgtcagaaga accagcgtga 98760 gtttcagaag aggcagatgt tgtgccgcct gctgcgtcgt cttcgttatc ctcttcagta 98820 tagaggttgt taacctcttt cgcctgctca aggatatact tcgccgtggt ttccttcact 98880 ttctctgtgc ctgttgtgag caggttttcg agagtatgaa tagccttcgg cgtcagacgg 98940 gccaattcgc ctcggagatc aagcattgcc ttttcaaggg cgattgctgt gctctcttct 99000 ttgcttgggc gaccacgctt acgagttaca atcgcagcct tgctcataat gcccccattg 99060 aattagtgta tccatattag cagtataatt acactatgtc aataggttac ataaattttg 99120 gtgcgccttc ccagattcga actgggaacc cctacatttt gaatgtagtg cctctaccaa 99180 ttggaccaaa ggcgcttgga gcaacgtact ggattcgaac cagtgctcat ctcgtttgca 99240 gcgagagccg ttaccagact ccggcaacgt tgcatgatct ggtgctggat gcaggattcg 99300 aacctcgcga catcctcatt acaagtgagg cgctctacct actgagctaa tccagcaagt 99360 ctcccagcaa gtccggtagt tgttacgctc cgggggaggg agaaatgggc agaggacgta 99420 tgcccgtggg gttgacttcc ccttctcgtc cagcaaaagc gtgtttcacg taacgggtgg 99480 tcgtgagacc tgaagcaacc gtcgctattc cagaggccgt cgatggagcc gctgtttatc 99540 cggctgaact caacccgaac cgcaatggca ctttggtcgt ttaacagacc gggttgactt 99600 atccatccac ctacttgatt gtcatctcgt tcgggacata ttcagattac ctgtagccct 99660 actctttgtc aacaggcttt ttaccgtttg cacaaagatt gcacataatt gtgcgttttg 99720 ggccgaggta cttgtttccg cacacgtaac aaaggcagat gtatcccttg tattcgtggt 99780 tccgggggtc atccgccccc ggcaggtgat taaaagtccg ggtgctcatc ttcgttacac 99840 ccagagccaa taccttcacc ccaacctacg aaaccgtcga actcatcaaa catcccagtt 99900 ctcctctcca aggccccagt cctcttcgct acgaatgcct tctccgtagc cgatcactaa 99960 ttcggtgctg ttcatttgca ttctcctgcg aaaacagttt taactttgct gttgccagcg 100020 tcaccgagac cttcttgtaa agcctcgtca ataccttcgg tcatcttctc tgcgaaaaca 100080 cttacgaagt tttccggggc tactccttcg aacgtctcgc agtcgataag gtccggctgg 100140 tccttaatca tctgctcaag gtggtcatca tccagatcga tggtgactaa gtaatggaac 100200 tttctcaaac ttcctccttc aggattgcca gcttatagcg agaggtttta tcaacctcat 100260 tcgggtaaaa cgagtatagg tgattacctt caccaaagtc aacattttgc caaccctcaa 100320 gagggaatcc gacggtactg aaagctaaat cgtcggcgtc atcgagagcg tcttgaaggg 100380 tggggtaatg ctcacaatgt tcttcagaag tgtaatcggg ggtgataaag ctgagagtga 100440 gtttataggg attcataagt ccaacagtaa gttaatcaag tgatatggtc attttactgg 100500 aggacttgat gatagtcaac gcccgggtgg aaggggagca ccgggggcat ttgtggaggc 100560 acgttcatat tcgctgtatg cgacgttctc agcgttttct gcgtagtagt caagcaaacc 100620 ctcatctacg gtctgtcgtg gctccttgga gcgatccagg tgggttgctg cacggttcct 100680 gtcatgtttt gcgacaaggt ttctcattta tcctccggat agtgaaaaaa ccgccccgaa 100740 gggcggctga aattatttca ggtttgctgt gacacgctca cggatttcag tcagcgtttc 100800 gtcaaccaac agcttgccat cacgaaacac gacacgaagt tcgttatcgg catcgttgac 100860 ttgctccagt tggaggttat caaccagctt cagttcgccg tcttcaccac gaacaacctt 100920 caggaagccc tgtgcagact tcttgccgag gtcggtcttc ggctctttga cgaccatgat 100980 ctgctgaccg tcgataaccg caccagtagc cttcacggcc tgacccagag aatcacgggt 101040 gttgaactgg gtggtgaagg aaccgacccc gaacacaacg ttgttcgatg caaagccttt 101100 tgcttcaagg cgctcgaaga tctctttcgc acgggccacg gtgatggagt caccgtaaat 101160 caggccgacg tgagtatcga gtgtacgata gcctttggag ttcaggtcgc cgccgaacac 101220 atcgtacagc agttcaacag agcctttctg ctcgttggtc agttccgctt tttcgtaaga 101280 cagaacacga ctaccgtcga tgtagtaata ctgcttgtca taacggttcc agtcaagctc 101340 acccttcatc aggtacaggt caccatcgaa caggaagtaa cgttcaacag tctcatcacc 101400 acattcaccg tgcggtgtgt cttggcgaac ttcttcttcc gcactttcca gcgcccactc 101460 tgcggcacgt tcgagagtgc ccgcagcgtc cagttcttca atctttctcc agtcgagtgt 101520 tccgcagatg atgtcttctg gaactccgga gtccggacgg aataccacac gaccgtcacg 101580 ggccatgatt tcgtctttca ggatgcgaac accctcggtg atcagacgga accagtcgta 101640 gctgtcgccg acgtatgaca cgaaaccttt cgggaagatt tcagtgatgt atcggcgcag 101700 gaactcgact tctgcgtgga aacgcaggtc atccagcgac atttccggat gctcagaacg 101760 gaggcgtccg atgatgaacc cgatgttcgt tgttgcaacg ctgtgctcgg atgccgggat 101820 ggagccggat acgaacttgc ctttcatacc gtaataacgg tttgcataca ggatcgccgg 101880 gatggtgtcg gtgccctgag agttcatcag ttgtcccagt tcagactgtg ccgcatcgtg 101940 agtaccagcc tggccgcgat aagcgaagca gtgaatctgg aacggaacat gcaggttgtt 102000 gtcgcaggtt ttctgcgccc acagttcagc cagcttgcga tactgccaga aaatcgttgc 102060 cgtggttacg gttttccagt tttcagagga gatcactgac tccagatagt ttgggagcca 102120 gtagaagtcc gggtgcgtgt tctgaattgt gaacagaggc acttgtaccg gagaaagagt 102180 accttccggc agggcgcgga tttcaacagg cagatagccc aggtcatgca gcttttcgaa 102240 gccccacgtt tcaaccatgt ctggaccgat cgccaggtca cagatctctt tgaactcccc 102300 gataacttct tccttcggac gaccgaagaa ctcacggttg aagtgttcaa tcaggaacca 102360 cttaataaag ccttgcaggc cagcagacat gacgcgctgg tcactgtcag aaaagtgctg 102420 aaagtgtttg cttgagcgtg gtgtcatgtt gtcttgtacg atctcagact gtttgctgta 102480 catggagata tggctcggtt tgtaccagtc agcaaacagg ataggcaggt cgttatgtaa 102540 catataaatc tcctcagtta aattggggca atgtgccccg gaacgttgtg aatattactt 102600 gaactcaacc atcttgtcaa cagatttgaa aatattattt tcgtttcggc cttccaggtt 102660 cttcatccac ggataggcgg agtaaacctc atcaataacg tccttaaaca catccgcgcc 102720 gtaggaataa atcccgtgcg tggtgtacag aacaacctct ttcgcaccat tggcacggag 102780 aaccttacca agctcgataa atgtacgacc tccgtcgcaa atgtcatcaa ccatgatgac 102840 acgcttacca ttaacatccg gcccggcata agtcgtgtca gtaatgttat tggtcataag 102900 gtcacggtgc ttggtcccaa ccccgatttc acggtggttg accttctgag ccaacttcgt 102960 gaccttcttg attgccccgg cgtccggagc tacgataacg gcatcgtcga agaagcccgg 103020 gccaagaata tccaaggcca gttcatattg ttcgaaaatg gcaacgttct tgatgtgtga 103080 cggggacaca tctgagtgtg ggtcgtcaac aatgatacgg tcaaatccac acaggttgat 103140 aagtgttcca aacactgccg acgacagcgg ttcgccagga accatcactc ggtcttgacg 103200 ggcatacggg aggtatggca cataacagac cttcttcact tggttgcctg tgccgcgacc 103260 catacggttg aatgcgtcgg taaacagcag caggtccatg atggcatcgg aactgtcgat 103320 gtgggcgtag acaacgaggt ctttgccttc cggcatcttc tctttcaggt caaccccgta 103380 tgcaggggaa tgctggaagc ctttgatgcg gacgttacgt tcaccgccag cgaagccagt 103440 gaactcaatg tcgagggcta caccgcccag aaatgcacga atcatatttc tctcctctca 103500 gttaaagtac agcgatctta caaaaagaaa aaggccccgt caagggcctt ttgttagagt 103560 ggtgtaattt taagactttt caggcgtccc ttccaagagg caccgtatgt gtacgacccg 103620 ccaaccgaca gcttgcttcc attgccgatc gggcttggac ccaaggcaac cctggagaac 103680 tcggcaccgt cgcgataaac aaccattggt cccgttccat catttgaccg ttggaaggtt 103740 acagtctccc attccccggt gaaggttgta gctggaggta ggccacggcc ccaagacccg 103800 ttggtataca tcatgaaata ctggatgtac gtagcagggt attgaccaac actaaggcaa 103860 atgccgggtg ttggtggtcg tccactgggg tagttcccag tctcccagac agaccctcct 103920 gcggcaccgt cccacttaaa taccgcctcg atcatgacag gtactccagc gagttgaagg 103980 tcctttacca taggggtttc gaagtatccc gtaccgggga agtagaagca cttccctacc 104040 tcggggtctt cgactacccc accaccagtc gcgatagtac caacgagtgt gaaaggatgt 104100 ccgttcttgt ccacaatcgt ggtgctgcca atctcggcgt cttcaaaatc aatatccagg 104160 ccagctttag ctttggcctg cccaagcata agcatttcgt tcatgagttc ctccgccccc 104220 attttatcaa gattcagtca gatagtctaa gaaagaccat acctttccaa taacacaggg 104280 tcattgacca caatgtagtg ccgtggcttc attgaaccgt acagcattac tttctcacgt 104340 atgatggaaa tgtggcccga tgcctccatt cgcttgagaa actttccaac cttcgtcctt 104400 gatgcttcag acataccaaa caggcgacac atggtctcct gtgactcata gtaacaacgc 104460 ctaacgtctt caccactctg aaacgcttgc tctgcaaaat acttgaatcg gaaatgtaac 104520 aagaacatcc gcttcaggtc ttcagcaggc aagtcgaagc cccacttagt agggaggctt 104580 acaaaagaac cctctggaac aacaaaatcc ttcacatacc ctcctttgaa accctaacca 104640 gtgtttcatt aatcaaatcg gttgtcaacc atgtagccct gaaaggcaca cgaagtaata 104700 atagaatcta taaacctcgc tacgctcgcc ctccgggcta cggttttatt aatcttataa 104760 tttattcgtt ccactcataa attattgatc ttataattat tattcatata cattcataat 104820 aattattaaa aacaagaaaa caataggaga ttcctgttga tctttaggat ctttatatag 104880 atcttacatg aaaaatttaa aatttaaagt attgacaaga gggtcattgg atcatagaat 104940 gcacacatcg aaacgagaca accatacgag ggttatagaa tgttaagtaa taagcaacgt 105000 aataaaattg atgaactgga attagcccat ctggaagctg tgcgtgaggc atggcactca 105060 gcaaaagctg gcctgaaagt ctgcatggtg tctgtttacg agtgtggatg ggacacccta 105120 ttggggaaat attacgatgt gatgatcaaa tatgtggaaa aggggttgat ttatcatcgt 105180 gtggaggata gtatgaagtc tgaactccag cttactgctg atgacctcga caatgtactg 105240 attacgatgg agatgatctg atgaaacagt gtgtgaatga tattgtggct ttcggtatga 105300 acgataccga actccgtgtg gttgccactg tggttgccac tgtggctgcg tccgctgcca 105360 ttgtgtacct attcaaactt atccacaaat actcataagg atcaggtcat ggaacagtgc 105420 gtaaacaatg tcgttgcctt cggtctgaat ggtctggagt tctgcaccgt tatcggtgtg 105480 gctttggtgg cccttgcggt tgtcctgatt cgttacttga atcatggtat cggggagacc 105540 aaggaggagc gctgggcgcg gaagaacccg tttctggcgg tggacttgga catgcaccct 105600 cgtgggaaga aacgtgatgt gtggtaactg ttctgatggt tcataccctt actacggcgt 105660 agggccgcat atctgcttct acaagatacc gggtgcggtg atagggcaat caataacttt 105720 gtccacagca cctccgaatt acgtggagga ttctgactgc cccggactgg gtgtatggta 105780 ttgcccggag tgtcgggcag gcatgaagga gacataatgg ctttacattt caaagatggc 105840 gtcgttgatc ggatggaaga gatctaccgg gcacaagaga agcctcgctt ctacaagtgg 105900 acgatagacc tgaatgacca gtgggcgtac ctcgaagagc ggatacaccg cgccgggatt 105960 gacttcactg tgacgagagt ccggcagaac tgtgacaata tgcacgtcac gatcgatggt 106020 gacccggatc aggttgcatg gatggacatg gcccttctgg tctgggcaaa caacaagcgg 106080 tgcaaacacc tgctggtact ggagcacaag ggatgatgga aactattgtt gcatataagt 106140 tgtttcgtgt gcgaaaggat ggtacgatag gacccctatt catcaacagg aagctcgtgg 106200 tggcccctgg tgaatggatg gaggcagagt gccacccaac gaaaggtttc gccctacggc 106260 ccggctggca ctgcacactg gcccctgtgg cccctcacct tagcaccaac ctgaaatccg 106320 gtgaagtgcg taagtggttt aaggtggagg ttcagggaat tacgaccttc cagcgcccgg 106380 agtcccaagg tgggacgtgg gtcctggcag aaagactccg tgtcgtggag gaagtgaatg 106440 tgtgattgcg aaaggtgcaa actcggacgc cgagtgaagg cgctccggga aaggctgatc 106500 gaaaccgatt ctggtcgcca tgtcgagaca ctcgacgatc tgtactcgga atacgtacac 106560 gacagcatgg accatgacca tctgaaggcg atcgtggaca accaatggcc ctctgcggag 106620 gcgtatatga aatcgaaggg gtgggttcgt gggtaagagt ttatctgaaa agtggcttga 106680 cgccgggatc gataagtgcc ttaatcctcc ggtagaggag accgaggata tgctggtcat 106740 ggttgacgaa gagccggaat atgactcccc acacgggagt gtgtggatcg tggcggtgga 106800 ttatgctggg agggttaccg tgctggaccc accaaacctg catcccggta tcatggacaa 106860 cggcccggag gcggagtatc ttggcctgcc gccggacgta gatgacatgg accctggtgt 106920 ttatcgctgg acgtgcagtt accacaccca tattgaccgg gagtctggtc atgtggaaga 106980 ctacgacttt gaggtcgggg agtctgtttt gctctggtca ccagataatg cttgacgcga 107040 tccgatttct tgcggtattc ttaattctcg gcggggcaat gctcgccggg cttacaattg 107100 tggcgttaat gaggagacca aatgtcaaac gtaacgagta ttctcgcaga gttgtctgca 107160 acccgatctc tcaaggagaa ggaagcgatc ctgcgggcta atgccgataa cgatggccta 107220 aaacaagcct tcgctgttgc atattccaaa gaactgaact ttttcgtccg aggactgcgg 107280 gttccattct tcacgactgg tcttaccccg ctgtctgaaa gcgtgggtct gctggtgaag 107340 aacatcgcag ggcgagttta cacaggtgat gatgctaagt cgtacatgac tcaactggta 107400 cagacctgcg aggagccagg cacacttctg aagatcatca accgagatct ggagtgtggc 107460 atccagacca ctcttaccaa taaggtgtgg aaagacctga tcacggagcc tccgtaccag 107520 agctacaccc tgttcaaaga ggatctgctg cgtaagttca actacaaggg cgctttctcc 107580 gacgagaaaa tggacggcct gtatgcggac atcatggtgt ggcctgagca ggtgatctac 107640 cgttcccgct ccgggaagga actgaacttc cgtgcgccgg aagagatcga gcagcgcctg 107700 atgcaggcgg cagaaaaccg tggggccttt gtggcacacg gcgaaggtct ggttatcgac 107760 gatgacggcc tgcatggtgt gatggaacgt gccgagggca acggctacct gaaccaagac 107820 ccggcagaca tcgatcgtga tctggtgcgc ttggtgatct gggacatcgt gacgatggaa 107880 gagtacatcg cacgtaagtc gaagaccgac tacgctgatc gtcgtatcga ggcggatctg 107940 ctggtgcagg aagtcgatcg ccgttacaac ttccgtatgg tcacgggccg taagatcaac 108000 agcctgaagg aagcgatcga ccacttcatc gaaatgcgcc tccagaagaa agagggcacc 108060 gtcctcaaag aggcgaagat gccgtggggc gacaacaaga cgaagaaagg cgtcaagttg 108120 aagaacgagt tcgatgttga tctggaagtc gtggctacaa cgccgcacaa gaaagatcct 108180 ggtctcgtcg gcgcactgat ctgtcgtact cgtgacggct tgctggaagt tggcgtcggc 108240 tccggcttga cggacgcgct tcgtaagaag ccagcggact tcttcatcgg gcagatcatc 108300 acgatcaagg ccaacgacat cacgaagtcg gaaaccaaag agcttcagtc tctgttcctg 108360 cctcgtctga actacaagtt cgtcgagatc cgtatggaca agaccaaggc taacagcctg 108420 gaagaggtga tcgaggcatc tgactccctg ctggatctgc tgcgggctat tgcggaggat 108480 ctggaatgac gggattctgg gtctgcacaa gtttgtttat tcttctggtc ctcgtatggg 108540 catgggataa gtacgtgaca ccaaggcgca tgacccggcc cccggtcaat cggattctcg 108600 aattgatcgc tgccaaaaag ctggaagtgt acgacaaccc atcgcaagct gaccgagacc 108660 gctgtagcca ctttgtggac tatgtgatcc tcgaccacga acggaaggtg aagacgtacc 108720 tttaccgtga caacttccac ggctcccctg ttgtctccgg ggatctcgac tggatgaacc 108780 gttgggagca ggatcgtgtt ctgcgtctgg tcgaaggtat ctgcggtgcc cggcggaaag 108840 cctaccggga agcgtgtgcc atcgaaagga aggcccgtga cgaacgtcgc cgggaagaag 108900 cagaaaagat ttacaaaagt cgttgacagt gtaacggggt catgtataat ggccccactg 108960 aaacagaaaa ggagaagttg atgtcgcagt ttattaaaga tgctatccgt accgagtccc 109020 acaactttta tctggacgcg gttggcccgc gcctgattca cgcttcaatg ggtctggtga 109080 ccgaggcggc agagttccag gatgccctga agaagtccct gttctacggc aaacctctgg 109140 ataccaccaa cctgaaagag gaaatgggtg acctgctgtg gtatctggca ctggcgatgg 109200 atgcactgga aacagacttc gatgcagagc aggaccgtgt gatccgcaag ctgaaggcgc 109260 gatacccgag caagttcgat aatgaactgg cagagaaccg tgatctggct actgagcgta 109320 agatcctgga gacagacaag taatgcctac gtattcttac aaatgccccg ggtgcggggc 109380 agtatttgac aagaatcaaa agattgcaga gcgcgaaact gccccttgca attgcggagc 109440 tactgcggta aagtccctgt ctgctccccg tggtattaaa aacggatact acgagcaagg 109500 acgaatgttc gtccgatagt ttcaaaaagt tgttgacaca ctgagttaaa acgagcataa 109560 tgctcacaca ttcactgaag aggagtaaca caaatggcta aagtaaaagt tgaactgctg 109620 aacaccctgc cttctgaccc ggctgtacgc aagcgccttg caaatatcgt tcaggaaggt 109680 gttgatgcga ttcgtaagca gaaggacgcc gcagaagacc tgaaaagcat cctggcgatc 109740 accaaagaag atctgaacat cgatccgaaa ttcctgcgca ccctgatcaa cggtgagtac 109800 gacaagcagg acgccgccga gaagaaacgt gcggcgctgg aaggccaaat cgagcagctt 109860 aacgaactgg acatcctgat gggccgcgct tctgaagaag acggcgagta ataccccgct 109920 gtgcagtacc ccgcccctac gggggcggtt aacccaaaca taattcagaa aggagattta 109980 caatatgaac attaacttca acgatgcaac cttcgaaaaa ctgcgtttcc tggctgaccg 110040 tgaaggtcgt tccgtcgccg ccttcgtttc catgcgtatg gatgaactgg ctggacaact 110100 ggtcaacacc acgttcacca tcaacgaaat tccgccgggt gttaagctgg cccatctgga 110160 cccgacaccg cgcccggccc cagtccgtag cgagcagtac aactttacgc taaaggacgt 110220 ggataacaca gaaaatcagc gccgctacgc tgaagatcaa tactaaaaga accgcccttc 110280 ggggcggttt ttctctatct gcctcttgac tcctgcctcc catcctgtat actactccca 110340 tcaaacaacg aaagaggaaa tatcatgagc aacagtatca acctggcctt cattgaaaag 110400 tggatcaaca acgtatctat ctaccctccg gcagagatct tcttccaggc tccaaagagc 110460 caagagaaga aggagaagcg ctgcaaggaa atctgtgagt ctctttaccg cttcaactgg 110520 gaaaacgccc cggtagccaa cccgatcggc accgttcgtg agatggtccg cgagatggtt 110580 attctggata agatgttcga gtacaacccg tttccaccga agtacgaaaa tattgtgaaa 110640 ttggttgcaa agttcctgaa tcatgcgtat tatcttattg accagttgga cagtatgcac 110700 aaagagcacg acaaactgag tgcatggtac ggtgaatggc ggcgcgggcc gctgcacatc 110760 atgatgaacg ccaaccgctg gggtgccgac atcctccgcc tgccgggcga tgacaagacg 110820 cagactcagt atttggacga catagcgaaa gagatggggg caaagtgagt acagaaatga 110880 aatggcgaga ccttgcgctt cagttcgatg ggcaccgtat gcaggctttg tgttttctga 110940 aacagatcct gaatgcactt ccggagactg aatttccaga ggcccgtgaa tttattaagg 111000 ccgggccaat accaggcgaa gagatccttc gcgaacgaat cgaaaatatc gcaaaagggg 111060 tgacgaaatg aaagaagtat tcttagggtt tatgctggga gttctgatta caggtgtctt 111120 aaatttctct gcggcacatg cggctcaaac gctggacctg gaggattact acaccgacgg 111180 tagtgacaag gtgtgcattt atagcaacgg acgcaccacc gtggcgataa ctcacgaagg 111240 tggcggttct tgcccttcaa aatacgttaa gcactaaggg gacaccatgc taatcaaatt 111300 caaccgagag cagatcgcag cactcctgaa aaaccagtct gtccagtctg gtatcgacaa 111360 ggcaagccga gacataaaac tgccagagat gaacaccacg gcggctgtgc tggagcacat 111420 aggggcgaag atcctcagta agttggagaa ttgccagtga aatatttcaa actgcactcc 111480 gcacacgaac cttggctccg tgctgaaatt gccaaaggga ccatctttta cgacatgcac 111540 aacggttttc gtggtattga gggccggaga atgatctcca cggctgctta ccgtgaatca 111600 ggtcggtcat atgacgacat gcctgtgaga gaggttgtgc gcctcatcaa gctgtacaaa 111660 aatgtttact ggaggaactg atggaaaacc aaatcaaaga cgacctgccg gacgtgtgct 111720 acaagattgc tgactggtgg gacggacgta aactccaacg ccggatcgtt tgtgccgcca 111780 accgattcca gttgaaagat ggcggggaac tggtaatccc tggtgttcgc cactattcga 111840 aagatatggc cttggttctg gaccaacttc gtgataaagt ggtcagcgac cacgtaacgg 111900 gagacgacca agggttcgtt gaccagtggg gcgattacca cacccgggag gtggcagtta 111960 ttatcgccga acatgcaggc cagcttaata cggtctgcaa gaagtccggt ccggtggacg 112020 aactctttag cgaggatctt tactgatgga aactgtaacc attgaggtgt ttgctgtgga 112080 tatgtcaaaa gcggttggtt tccgtaagat ggagccgact ggcccggctg ggctgcgctt 112140 tggtctttac ctcccgtcga aaggtgagcc gctgattacc ttcgggcagt tgatggacat 112200 cgtggagacc cacatcgtga acagtgcgct gttcccgtgg aagatctctt acatccacat 112260 caatgccggg cagtatagca acaattcaag catcctgttg gcgcaatacc tccaggagtt 112320 cccgttagca aaagactgcc ggatcagttg cccggcgtcc ctgatttttg gagatggatt 112380 atgagagctt taatttgggg tggtgtgtac gttctgtttg tcatcttcgt ggcctgcctg 112440 atcccggcag tgatgattcc ggtattccaa gacttcggcc tgtacgcccg cgatgttgta 112500 gggttcaccc tgaccatcac actggtcgct gttctgcttt tgatggcatt cggggcactg 112560 atatggagcg ttctgtcatg aaagtgatcc acccaatcaa gaatggcatg ttcccgatcc 112620 agactgtcct gcgggacctt gcgagtcagg agaactgcga cggcgatccg tatgaccaga 112680 tgattcaggc tgcggatcat atcgacgacc tggaggtccg ccttgagttc ttccgggaaa 112740 agtacaatcg actggcaggg gagttctgcg tatgagagtg accgacaagc acgtgttctt 112800 ctattcgtgg aaggacatgt tcagtaatca ttaccgaaat gaccgggctt tcgctctgcc 112860 gcgccatgag caggaaggtg tgaagttcta caccggggag cacatgatga tgtacgagaa 112920 ggccatgctg tttgccgatc acaatatcgc ccgtcagatc accgaggtct tccacccgca 112980 ggaagccaag atgcttggtc gtaaggtgaa gggtttcaac aatgagttgt gggagaagtc 113040 ccgggagaac attgttgaga atgtgtgcta ttgtcgcctt gtgtacgacc tggatcttcg 113100 gggcgctgcc atcattcaca gactagctgg caggagtttc gtagaggctt caccacgtga 113160 ccgcatctgg gggatcggga tggatgagtt tcacccgatg attaacgaag agcagaattg 113220 gctgggcctt aacctactgg gtaaggcttg ggaccgggcg actgacgccc ttattgaccg 113280 ttgcggcggt tatgaccgag tgagaggtga ctttgcagat caagcataaa atttgtctaa 113340 tcccacagac tgcctgggat aacaatcttc gctcctacct gactcaagcc gggtgggata 113400 aagttcgccg caaatgctat gcagagcata actataagtg ccagatctgt ggcggtcagg 113460 gcggcaacgg aagaaaacat ccagttgagt gccatgaaag ctggacattc gaaaatggag 113520 aggttaaact ggtcggcctc atgagcctgt gtccgccgtg ccatgagttc caccacccgg 113580 gcctcgccga gaagaacggg aaactggaaa gggcgatcaa gcaattcatg aaggttaatg 113640 ggatcactcg tgatcaggcc attgcctatc tgaaaagtga gtttgccaca tggcggcagc 113700 gcagccagca ggagtggtcg cttaatatcg actacctgag tgagtacatg gggccggact 113760 ttaagttcaa gcgccccgtc aaggaagaag aggactttgg tgatgcgttt taagaggagt 113820 gagtaatggg ttatcccgtt gtagaaaacc tgaaggatat cgttacggat gatgttacta 113880 ttgttcttga tttggatcag acgtgttatg ttgcggcggc gggcgcggaa aagcgtacca 113940 ttatcgcaac ccacaacaaa tccggtcgtc agatggagtt caagaacaag acggagtttt 114000 ggggccgaca gaaaacagta gtcggcgggt ggctgaagga ccagaacacc aacatggagg 114060 cgaagatggc ggcagcgggc cgggagttca ctccttggac ccgcgatgat ttcacgatta 114120 cggacaagca gtacccggaa cccgtggaaa actgcctgca tctgttgaag attaagatca 114180 acgcgatcct tgagcatatg gggaccacca acggccttgg tgtcttgggt gggagcggaa 114240 acttccggtt ggcactgcct acgccggaaa tctacaaagg caaccgtgag gacactgttc 114300 gcccgttgtt gctgtcggat acccgtgaat atgttcaacg gaaatacggc gcgatcgtga 114360 ttgacgggat cgaggcggat gattatctga ccatgaaaca gtatgagggc tggttgcatt 114420 acaaaaagac tggcaagttc aactatatcg tggcatcatt cgacaaagat caagtccagt 114480 gccctggcct tatcttcaat accatgcgtg actcaacaga gcgcgactgg aagcatccgc 114540 ttccgtggct tattgatgag tcgatggggg agatctggat ggagaagggt aaggtaaaag 114600 gctggggcca gaagttcttt ggttaccaaa tgttgttcgg tgatcaatcg gataacgtga 114660 agccatacca aaacttcgac aagatcaagt ttggcgagac ctctgccttc caagtcatct 114720 ctccgtgtca ggatgagaag gccatgtggg aagcgatcgt aaatcagtac aaggagtggt 114780 tccctgacgg ggtggcattc actgatcaca tgggcgtgga tcgtaagttc agcgccgggc 114840 agtgggcctc tgttatcttc caagcggtgt acatgaagcg caccccggat gataagacca 114900 ctctgggaca tgttcttcgt aaagtggggg ttgtgtaatg agtcaaaacg acgctggcgg 114960 tttggatgtt cgcgtcgagg agatgattaa ggcagatgaa ctccgggcgg cattcgtgcc 115020 cggggcttca aagaccttct atctcatcga ggagccgtgg accatgctgg aagaaccttg 115080 gcgaatccag tggtacgacc cacgggtgcg tagtctgtgc gaagtatacc cggtgggtgt 115140 tccttacccg ggggacaagt acgccatgtt cacggtgtac gacgaagttc aaaaggtcat 115200 caagaactat gtgtttttga tgaacgagta ccattttatt gctaaggatg aagatgcgct 115260 tattgacgat tgaccaaagt ttgtcttcat gtgcctatgt ggtgttggaa gacgggattc 115320 cgatctttaa ggaggtactc cacaccacgg ggtcagagaa gaaggccaag gactccaaag 115380 gttggtgcat gtacttcgag cacactgctg aacagattgc ctacatcacc gggcagattg 115440 ccggggtgtg tgattcgttc gatgtggatc acatcgtgct tgaatcgttg agtttaggtt 115500 ctgttggtga tgccacaagg gatttggctg gattatttta cagtatccag ttgactcttc 115560 ttcgtgacgg atatactatg gaccaaattc acgtcatcgc accgacatct gttaagtctt 115620 gggcacgtaa gtggttgccg ggggaagagc aggaaaccct gaacgactcc gggaccaaga 115680 tggtgaaggt gaagatgggc aaaaacgaaa tgatgcgtgt ttgtgagatc ctgcacccgg 115740 ggttcctgaa gggctataac aagtccggaa agaatggcgg ggctaccgac ctcgccgacg 115800 ccatcctgat cggagggtgt ttccttgaga gaaacggaga aagactggga ttcaatctta 115860 aagaaagcaa cacgtaagat tatcctgtgt tacgaccgga gtgataagca ggactggagg 115920 ttttctttgc aggggactct ttcccgcgat aaaacatacg agtctgtaga caggaaacac 115980 ttcgacgaga tcattgttcg tgacaaggtg ctgaatgttg atttcctgat caacttttac 116040 tgcactaatc aatggtcttg ggcagagaag acaaggggcc tcatctatga tgaggtcctc 116100 gtcaccgggc gggggtttga gaggatggag tatcctgaaa acctagcgga ggtgatgtct 116160 cgttgcaaaa ggtcagaata cataccgggc atggctatgt tcctcttaac gcaaaacgac 116220 gagaggatca ggaacgggct gggttcagat attgccctga ccagtacagg tgtcggtaca 116280 aatgtcggat cactgtcgga taagtttgac tttcctgtta cgctgttccg ccggaccatg 116340 ctgggatatt ttgaggactt caaaaacccg acccgggagg agttcctttt cgctctgacg 116400 atggagggta ttagtggcaa tacggacagg gagaagaagg cgatcgagga agcccagctt 116460 cactgctaaa gtgaaagcta caacgccgat tcgtgtacct ttgagcaagg acaagtgggt 116520 gtctgggtcg aagagtattg cggcctacag ggatcaactc cttttggagc agggtggcct 116580 ttgtgctatc ctgcgggagc cgatgacgga cccatgtttg gaccatgacc attacgacgg 116640 aaaatgccgt ggggtcatcg ggtcaactct taatcttttc gagggcggag tccagaagtt 116700 gtggtctaag cacatggaag gaaaaacagg gttgacaatg agtgaaactc tgcgtagact 116760 ggcagactat cttgaaaggg actatctcca ccataagttc cacggagaga ttgtcgccga 116820 cttgaagaag tcactcaaga ggtggacaaa ggaaactatc gcccgtaacg cctacctgaa 116880 cttcggtatc gttattgacg agaacctgga caagggcgtg atgatcacca tctacgtcac 116940 tgagtttgtc cggaaattgg aggaagacta tctttatgag taagatcgat cgaagtctgt 117000 atgcggggtt ggatgccccg aacattcggt tcttctaccg taactggaga ggtgaatgcg 117060 gttatcgaac catcaagggt gccccaatgt tctggtacgg ggaaagtgag taccataaag 117120 gcgctcagtg gttcatcaag gcgcacgatg tcgataaaga cgatgttcgt gacttcgccg 117180 tggtagacat tatcgaattt tgtaagtaat cgggagatta attttggcta atgtgacttt 117240 tactgttgaa caggttatgg ctctgatgaa gggtgggttg tcccagcgcg aggtagcccg 117300 tcaactgggc aaggaatctc aagagtcaac tgtacgcaac atgctgaagc gtgaactgga 117360 agcacgtaat ctggaaactg tccaacagtt gattgacagt atcccaacac cagacgagta 117420 cgctgatttt atgcagcagg aagtcaatgg tggtaaaacg ctggcagaga tccagaaaac 117480 cttcatcgaa aaggtgaagg aaaataaccc gggtgccaaa gtgttccttg gtgatgtcga 117540 gacctctcca agcatcgcct attcgtttgg tcgcttcaag caattcatcg ctccgaagca 117600 ggttattcaa gagccgtaca tgctgacgtt cgccgggaag tggctgcaca acccttcaat 117660 cttcagccgt aagctgaccg actacccgga agagttcaaa agggatcatc agtcggatcg 117720 taaattgatc gaagacctct ggcaggttct ggacgagtgt gatatcttca ttgcacataa 117780 cgcccgcttc gaccgtggtt gggcgaatca gcgcttcgca tattacggta tgcaaccgcc 117840 aagtccgtat atcacgattg ataccctggc ggcactgaag gagtcgttct ctctgccttc 117900 caatgcactg gaagcggcgt gtaactactt cgaactggac agccgtaagt tgtcccacga 117960 aggattcggt ctgtggcgtc gctgtgtgga aggtgatccc acggcgttcg atgaaatgga 118020 agaatacaac atcggggata ttccgacgct ggaagaactg tacctgactg ttcgaccgtt 118080 tatgcgtaag cacccgaaca tcgccctgtt ccacccggat cagtctgtga tgcgctgtgt 118140 acgctgcggc tctgacgatt tggaggaaga aaaaggcaaa tctgcccaca ccttcctgtc 118200 caagttcaag gtgtaccgtt gtcaggaatg cgggtcttgt gcccgtgacc gccagaacgt 118260 tcgtgagaag gcagcgatga agaaaacgct ggcgaacatt ctgtaaccca agccgccctt 118320 cggggcggtt tttctttttg aaacaggagg ataatgatgt tcatctccca agaaatgaaa 118380 aaggcccttg acaaaaagca ggcgcatcgg gataatggcg atcagttcaa atatcgaatc 118440 cagtacgacc cgagagctta tttctttaag taccgggttc aagagttcag gtattgcgaa 118500 ggctcttatg agtgttttga actcccggtt cattacaagg ggtggaagac actccgccgc 118560 tttacaaaat taagttcggc agagaagatc ctgaacgaac ttgagcgtgt gaatggttac 118620 ttggcaccta tgccaaaatg gtacagagag gagtgggagc actaatgatt ctgattaatt 118680 tgaatgcccc ggcgggcgcg ggaaaagatg cactgtgcga aggtctccac agttatatca 118740 acaccccggg gtttgaagtc gtccacatgg agttcaagga acttctgttc gatatcgctg 118800 tccgggcatc cggcctgagc cgtaagctgt ggttcgctct gtatgagcgt gagtacaaag 118860 agaagccgtg cccgtatctc cagatcaacg gcgtaaacgt cagccctcgt gactggatga 118920 tccactgctc cgagaacatc atgaagccca catttgggaa tgatgtcttt ggcaaggcat 118980 ttgccgccaa gttgcaaaag ctgaaggatg aaaccccggc agacgtgcaa ctggtggttg 119040 tggtcagcga cgggggcttc ttagaggagt cgattccggt tgtgaatgtg gttggcccgg 119100 acaactattt ccttgtccga atccaccgtc tgaaaaaaga tggctcggag tacaatttcg 119160 atggggattc tcgccgatat atctatgcga aagagtttcc tgaacatctc cggatgtacg 119220 agactgatat tctgaacgaa gaaggtgatc ttaacggcac ggtccgtaag atttgtgatt 119280 ttgtgcaaga ctgtaaaggg agcgacctgt atgtcattca ctaagacccc gatcctggta 119340 gatgtagatc tgacgttcgt tgattcaggg tggccttggc tttactggat ggaaagtgtc 119400 tatcaaatcc ctgcggacgt tgatttgatg gacaaggatt atgaggaaaa ggggttgttc 119460 aattacaacc tctccaaata cttcccgact cgttgcaaag aggcgattga gccgtatgag 119520 ttttgggaag atcctcatct gtacgacaag atgacgccga ttgccggggc agtggatgca 119580 attcgtcgtt tgcacgaggc cgggcacccg attcgtttcg tatcttactg caagaagggg 119640 cacttcagca gcaaggtacg attcctgaag cgtcattgtc cgttccttga tctcgacaac 119700 gggacagacg gcagcggttt ttatgccaca aaggttaaag ctggcgtcgc tggaggggta 119760 atcattgacg atcggaacca gttcctgaat caattcccgg acgacgtgat taagatcaag 119820 ttcgacacgc ctttcagtca ggatgttgag ccacgcatca attacgactt aacttcagcg 119880 gactggaaag aaatcgctga ttggttgctg gaaaacctgt aatgcgttgc ggaaaaggtc 119940 gatatgttgt ccgctacggg gagcatattg aggtaagaac ggagcaggga gacctgctca 120000 cttctttcag ggtgacgcag gatatgtgca aggagatgct tgacttgtac cttgccgtca 120060 ggcatgatgt tgttgttcct tacaaaattc gtaagttgaa gtaataaaag gagattttat 120120 gggtcaggta tttagtcgtg gcaatatcga agttcagatc atcgccgatt ctgtggggca 120180 gcgcagtggt cgtatcacga cttttgaatt gacttaccct cgcatcatcc acagtgagtt 120240 catgactcac cgactgttca gccgtaacgc gatgtcatct cgcgctgtac cgatcaagac 120300 gatggtgaag ctgattcgtg aaaacatggc aatgccagtc cgattcggtt ccaaccagcc 120360 gggtatgcag gacaagggtg ttgagcatga tgcgttggtt tacctgccgc agtacgagca 120420 gggaatgact gggcgcgacg catgggccga ggcggctgat cgcgcctgtg aagtggcact 120480 ggcttttgaa gaggccaaat tccacaaaca gatcgccaat cgcctgatcg aaccgttcca 120540 gatgatgaag acggtcatga ccacaacgga aatggaaaac ttcctgtggc ttcgtgtaga 120600 tgctgatgca gacccaacga tcgaggttct ggctaatctc atgaaggagg cgatggataa 120660 ctccgagccg gagtggctcc cggcgggcgt atggcacacc ccgtatgttg accacgtgta 120720 cggtttcggg ccggagggtg acgcacacat cttcgaaggc tattgcgttc tggatgaaaa 120780 tgaccgcccg gtaatgctga cagaagaaga ggcgctccgc atctctgcct cttgttgtgg 120840 tcaggtgagc taccgccgtc tggacagcac caaggacaag gcgctggaca tctacacccg 120900 actggttgcc gggaagaagg tccatgcttc tcctttcgag catcaggcgc gtgagatcga 120960 agagactttg gatgacgtcg agtacggcca gcagcaagtg aacgtcttct ggtgtattga 121020 gacatgggaa gaggggatta ctcatgttga tcgtgaaggt aacttctggt cgggtaactt 121080 caaggggttc atccagcacc gtcagttaat cccgggccat gttgcaaaat aaagtttgac 121140 aaagaagtaa ccttacccta ttctgttatg accggggcat tggccccgga atttgtgtac 121200 gaggagatgt agaatggctt tcggtaaaaa tattaaatat ggctctgtga ctctggattt 121260 cattgtcgag tgtgcaaagt ttcttggaaa ggacatgaag aaaaaggaaa ctcttcgcca 121320 agtgttgcac ctgatcggat ttgaggtctc tgtcctgaat gaagagactg gtctgtacgt 121380 cccatgcaag attgaccgca tggacggcgt aaatgtccga tgtgctgata agccttacat 121440 gttccgcacg acaaccattt tctcaggtcg tctgcgtgat gaacgtgact tcccgttcgt 121500 ggggatttat gataaagtag atgtcctcga tgtaaacagc gccgtgggtg ctgcactggt 121560 gaactccctg gcgttcgaca tcccatctgt ggaaaaggtc aacacccgca agtacaccaa 121620 acgcgaggat cgtagcgacg ttgttgtcat ggacctgcca gagttcgacg acatggatga 121680 tatcttcaac ctggtgaaag gagcgtaatc atggcaaaga aaaacaatgc tgttccggac 121740 gagcagacta agtggttcaa acgtggcttc caaagcaaag ccgagtacat tggctggttg 121800 cagttcaacg acctgtgtga tgagtcgatg ggttacgacg atacgtacca cgacccgtac 121860 tccggtaaaa caatccgcct cggtgcggct tccgaggaag atgttgagca gtacgaagtc 121920 aaaaagcctg aagctaagta attcaataag gagatccgct tgaccagcat taatgttgta 121980 aaaaattccg gcgcgacaga gaagttcgat gccgagaagg ctaaccgtgt ggtagagtgg 122040 gcatgtgaag gtctcgatgt gtgtgcatca gagatcctta tgaaagccca gattcaaatg 122100 ttcgatggag taacaacaaa ggccatccac gaaaccctga ttaaggcggc atccgacctg 122160 attagtgttc agaatccgga ttaccagtac gctgctgcac gactgctgct gttcaagatc 122220 cgcaaagagg catatggtga tttccagccg ttcgatctgt tccaccagat ttatctgaac 122280 gtgggcaacg gcaagtacga ccgccacctg ctggacgatt acacccgtga tgagattgct 122340 ttcctgaatg acaagatcgt tcacgaccgc gacttcgatt acacttatgc agcaatgcgt 122400 cagtacgaag acaagtacct ggtcaagcac cgcgtcaccg gggagattta tgaatcccct 122460 cagatggcgc tgatgctgat tgcaatgggc ctgttgtcac aggaagacaa aaagacccgt 122520 ctggaacgta ttgttgacct gtacgagaac gtatcgctga tgaaggtgtc tttaccgacc 122580 ccgatcatgg cgggtgttcg taccccgacc cgtcagttta gctcttgcgt actgattgag 122640 tctggtgata atatcgacca gatctttaac gccaacacgg cgcagggtaa atatgcggct 122700 caacgagccg ggatcggcct gaacttcggc atgattcgtg gtcaggattc tgccattcgt 122760 ggtggtgagg ttaaacacgc aggcaccgtg ccgattgtcc gcatgtacca agagtctctt 122820 gggtggacct ctcagggcgg cgtccgtaag gcatcggcta actatttcta cccgatgtgg 122880 cactgggatt ttgagagcct gatcgttctg aagaacaacc gtggcaccga gagcactcgt 122940 gctcgccatg tggactacgg cctccagatc aacaagctgc tttatacccg cctccagcag 123000 ggcaagaaca tcacgttgtt ccatccgaac gtggctggcg gtaagctgta cgaatatttc 123060 ttctctgacc aggagaaatt ccaacagctt tacgaggaac tggaagcaga tccttccgtg 123120 gcgaagaagt ctatccctgc ggcggacgca ttctctgtct ttgggcagga gcgttcacaa 123180 actggtcgta tttatgttca gcacgttgac cactgtaata ccaacagccc gtttgaccct 123240 aaacaggccc cggtgaagca gtccaacctg tgtatggaga tcgcgctgcc gacgcatccg 123300 atcaacgaca ttaacgatcc agaagacccg ggcgaggtag ccctgtgtac tctgtctgcc 123360 attaaccttg gcaagatcga gaagctggaa gacatgcgtg agcctgtccg tacactggtt 123420 cgtgctctgg accgactgct ggactatcag aactacccgg ttctggcggc agagaagacc 123480 aagctgcgcc gtacactggg gattggctgg accaacctcg cgtactacct ggcgaagcgc 123540 gggatgaagt acagcgaccc tcgtgcagct aacgctgttc acgaactggc tgaagcattc 123600 cagtattacc tactggaagc gtcggttgac ctggcaaaag aactgggcaa atgtgatctc 123660 ttccacgaga ccacttactc tcagggcatt ctgccgatcg accgttacaa aaaagaggtg 123720 gatgctctcc acactgcgga actgaagatg gactgggaaa agctgcgtgt cgatatcgcg 123780 attcatggcc tgcgtaactc cacactgtcc acgatgatgc cttgcgagac atccagccag 123840 atcactaact ccacgaatgg ttttgagcca cctcgtgatg cgatttcctt caagaaatcc 123900 ggagcgggta tgctgccagt gttggtgccg ggggtaggtg acccaagtgt ggtttacgag 123960 tacaagtggg acatggcttc gcctattcct tacctgactc tcgtggcaat catgcagaag 124020 ttcatcgacc aggcggcatc ggcgaatacg ttctacaagc cgtgggactt cccgggcgga 124080 aagctgccga tcaaggtcgt gctgcgtgac attatgtggg cgtataaaca cggactgaag 124140 actctgtatt accaagagac caaagacggc aacgatcagg aagacgatgg ttgcggcggc 124200 ggggcttgca aactgtaagg ggcagtatga ctgtgttatg gtggttcatc tatcgccgct 124260 ggcggatgat cagttggacc aagacgtatg ggccgttgga gaagaagact ctcatcaaca 124320 acgcatacaa ggtgaatctg tgctcgtgtc gtgaccacaa agcgatctac cgtgacatgc 124380 agaagatcct caaatagtaa accgcccttc ggggcggttt ttctgtctta gggtattgac 124440 acttggtccg gcatccgtat aatggaccac aagtttagag aaaaggagaa aacaatgtct 124500 tacagcactt tcaaccagaa caaattcgat ttcctgactc agccgatgtt cctcggcgag 124560 acaccgaacg tttctcgcta tgaccagcag aaacacgcca agttcgagaa gctgatcgag 124620 aagcaactgg cgttcttctg gcgtccggaa gaagttaacg tgacccgtga ccgtatcgac 124680 tacatgaatc tgccggatca cgagaagcac atcttcatca gcaacctgaa gtaccagatc 124740 cttctggatt ctgtacaggg ccgtgggccg aacgcagttc tgctcccgat cgtgtccgac 124800 acaaccctgg aaacatgggt cgagacttgg gcgttcagtg agactatcca ctctcgctca 124860 tacacccata tcatccgtaa catcctggca gatccgtcga tcgtctttga cgacatcatg 124920 aagtcgccgg agattatcgc ccgcgccgag gcggtgacga agatgtatga tgacctgtac 124980 gaactgaact gccgcaaggc cctgaacctt ccggttgacc cgtacactca tgcccgtgcg 125040 ctgtacctgt gcctgcacaa tatcaacgca ctggaagcga tccgcttcta cgtgagcttc 125100 gcctgctcat ttgcgttcgg cgagcgcggg gtaatgctgg gcaacaccaa cattattgaa 125160 ctgattgccc gtgatgaagc cttgcatttg tccggcactc agtatatgct gaaagaaatg 125220 cagaacggta acgaaggtga tctgtttgct cgtgtggcag aggattgcta cgaagaggca 125280 cgacagggct ttatcgacgc atcggtgcag gagaaagact ggggcagctt cctgttcaaa 125340 gacggttcga tgatcggtct gaacaaaggt atgctggacg gttacatcga ctacatcaca 125400 gatcaacgta tgcgggcggt tggccttggt gaactgatcg ggaaaccgac caagaaccca 125460 atcccttgga tcaacagcca cctgaatacc gggaatgtgc aggtaacacc gcaggaaacc 125520 gagaacggtc agtatctgtc cggccaggtt gattcctcta tgtctgccga agatttcaat 125580 atggacctgt aaggaggttt tatggcaaag ctgaaatgta agaccgttgg taatgggtat 125640 ggaaagttct tcaccatcgg aaaggtgtac ggggcagatt tggagtatgg tgttgctgac 125700 aacgactcca tcgacgagac tgatcacaac tgggaattgg agccggatgg ggttacggtc 125760 cgtgccgctt gttgcgatga agacagcgcc attgtggcaa cttttgaaat tgtggaggaa 125820 tgatggaaga cctgcaagat ttgtattgca aggtggttgc caaatctatg aacaacccgt 125880 tcaaggctgg ctcggtgtac aaatacagca aagatctgaa tctggtgtat gatgctgagg 125940 gtatacctca tacgctgggc acttttgaaa atcacggccc gctggaggca cacgtcgatt 126000 atttcgacgc caagtctccg gtactggcta tgtttgtgga ggtttgatgt actttacggt 126060 cttcggtaag gaaaactgtc cgtactgtgt acgggccaag gagcttctcc agtcaaaact 126120 gttggagttt acatacaagg atgttttaga ggacgaagtg ttctttatgc aaatgaacgc 126180 ttgggtgaaa gatgcgaccg gacgacctgc tgcaactgtg ccgcagattt tccttgacga 126240 tcggtacatc ggtgggtaca ctgacttagt ggctcatttt gagtctcaaa aagaggtcgt 126300 taaagctgac gacttcgata ttggcgaact gtaaggagaa gggaatgaca gcactggctg 126360 agaacatcgt ggtttccccg gaagaggcgg aactggacat tctccatgac gtggctattc 126420 gcctcgcgga gatcaacatc gaaccgcaga ttgccgtagc tgtcgatact ctggagtttc 126480 tccaggatat tgaagacaaa acggctgatg accttcgccg catcaaagat caagagaaac 126540 ttattgatca gttgtcaggc gaagattatc gtaaccgtct ccagaatctg ttcgctgaac 126600 acttggcgac actggagcca gagcacctga agcaatatca cgcagatatc gtctatcaag 126660 atgcgattgc agaaatgaac ctgcaactcg tcccggcgct tcaagaagtg cagcaggagc 126720 ttctttatgg cgtcgtcagt aagccgaccc tgcaataagg agttgtagtg ccagcacgat 126780 ttagtaaaga aggcattatc cgcgccaagg tgaatatcga ggcagggtat gtcaacaaca 126840 agaacgacct tggtggtgaa accaatcatg ggatcaccat tgcaacggca agggagttcg 126900 ggtataaagg cgcgatgaaa gacttgacag tggcccaagc cttggacatt tatgaccgtg 126960 gttggtggca gcgtatgtgg ttggatgata tcttggctat cagcccggct atcgccgacc 127020 gcctgtttga cttcgggatc aactccggac gtgcaaacgc agtcaagact cttcagcgta 127080 tgttgaacgt actgaatcgc cagggcaaac tctacggaga tattgccacg gatggaggca 127140 tgggtaaaaa tacccttgct gccctgaagg cgttccagaa ggcgcgtgga gacaagggca 127200 tcaacgttct tgcattcgca ctgacctgtc atcaggtgtc ttattacaca gacatcagtg 127260 agaagcgtca ggccaacgag gagttcacct acgggtggta cgaccgtgtg ttccgggaaa 127320 tgccggagta caacgttgaa ctgggccttt gccagaagta actgacggcc cccgccgggg 127380 gccataaaca gctttcggag gtactatgcg tcataacaat cgtcaagagc gtcaatctcg 127440 tcgtgagaag aaggcaagtc gtgagcgtgt ggtaacaccc cgcgcccgcg aggaagttga 127500 actggctaag gctatccaga cccggaccca cttccagaaa agccttttga gcgcggtaaa 127560 ccagaaggat gccgttttcg taaacggccc cgctggcact ggtaagactt tcgttgtgat 127620 gagtaccgtc attgactggc tcaaatctgg gaagattaaa aagatcgtcc tgtcccgccc 127680 aaccgtgggt atggggaaca gtttgggcct gctgccgggt gatatcagag agaaatttga 127740 accgtacctc gcggcactgg ttcaggtgat caaagatcgc tacggggcga actactacga 127800 gacccagttg aacaacaaga acatcgagtt cgttcctctg gagtacgtgc gtggtcgatc 127860 ctttgaggat tctgtggtta ttatcgacga gtttcagaac acggacgaag agaccgcata 127920 tacgatcatg acacgactgg gtgaaggttc caagatgttc tgcctgggtg acattaccca 127980 gaacgacatg aagggccgtg aatccgggct ggactgggcg attgagttta tcgatcgtca 128040 caacctcttc catctggcag agtttgtcga aggttccagt gacgatatcg tccgtagccc 128100 gttctgtaag gcagtggtta aggcgcgtga gcgtgacttg aaggagcagt aatgacggca 128160 tacaccggga ttggttcccg tgaaaccccg gctgaagtcg taggcgtcat ggaagacgcc 128220 gcttaccgac tagcccgtat ggggtttgtt ttgcgttccg gtaaagctgc cggggcggat 128280 gcggcgttcc aacgtggagc gcagagattt gaaggtgcaa aatgtgagat cttcatccct 128340 tggagaggtt tcacaggtgg tgatggcctt gtcaatacgt gggacatcac tttggacgct 128400 gtggacagac agttcccgga acacgcagag atgcgctggg agtgggtgaa ggaagtgcat 128460 ggtggctggg agaggttgtc ccaaggtgct cgtaagttgc atgaacggaa cgtccaccag 128520 ttgtttggtg cggatctggg caatgcgtac ttgaaccaga gtaaatttgt gctatattac 128580 gccctcgaaa ccaagaaggg tgacccgaaa ggtgggacgg cgacggcagt gaatcttgcg 128640 aagaagcagg gtattcgtac cttgaacctc cttcatgaga aaaaccacga agtccttgag 128700 aagtttttgg taagtatgga ggaaaagcgt ggccttaaat cgtaataacc ttaacagcgc 128760 ttttgcactg ggtaaggata agaagaccgg gaagtggtcg gtaggtcagt gggccaacca 128820 agcgctctgg accgtggatg ggtccaacaa gcgtatctgt gctttcaagg agatgaccca 128880 ttggcgttat ttccgagagg caattgagca catttctgat gtgcagttgt cccctggtga 128940 tcgggttggc attgctgtta agcgaggtat caatgagtgg tactacgtta ttgacaaaat 129000 tacgtcagat gacggaaaat ttcactacct cgtcggtatc taagggagag tttatggata 129060 agggtatttt tgccacagtt gaacatcgca aactgatgga acttaaaaac tgtggtgctg 129120 tcgatgccgc tcgcctggaa gatctggcgg aactcctttt cttggacatg aaagaggaaa 129180 tcatcaacgt ccgtaagcta cgggttaagc ccggcttttg ggccaaacta ttcgacctgt 129240 cgatgccagt tgagcaagag gtccacctca tgttctcaaa gcgtcaagaa ctggttgacc 129300 atttggcaga tatcgaggtg ccaagtgaac tgtgtccggt gacaggcgat gcaaaagagc 129360 gcctgctgtt tatcgaccgg gcggcgcggt atgcggtcga ggctcaaaag atcctcgata 129420 tgttcaagcg ccatcatgaa gtgattgtgg attcggatcg gtctcaggtt attgagtgga 129480 ttctgcaaaa ccacatccgt gtccgtactg aactgagcaa gggggcctga tggaagagca 129540 attcgatacc gttgatcaaa cttaccgtgg gaatctgtgg tgtactcccc aagagcgtcg 129600 tgactggcgt ctctatgtga ccgaactgga caatgatcca cgaaaccact tcgagggttt 129660 ggacatgatt cggaccgcag aggaagagga tgttattgaa atcctgatca catcaccggg 129720 cgggcgagta gacattgccg acatgtacct cgctgctttc cgtgacagca aggcgaagat 129780 cattacccgg gccattggtg agtgtgccag tgcagcgacc acgatcttcc tggccgggga 129840 tgagcgtgtt tgtgaagacg gctgctattt catgttccac aacgttcagt tgggatctgg 129900 aggtgatagt gcccacgtga tttcccgcag caagttttat gaacgtctct ttaaagagaa 129960 gttctacggg atgatggcgg aggttctgac acctgtagaa ctgggtgagt tgttcgaacg 130020 tgcaggcgaa atctacctga cagcggagga gatgcgtgaa aggctggata aggccgcgcc 130080 taatcaacct gaaatcgcca ttgtcaatga gaatggaaag tccggggttt tgatgaagac 130140 ccctgacgga gggttggtag ggtatggcgc aactacctgc gaagaggctc gtggtgaact 130200 ctccccgggg agtggtggaa tttggtaacc aagggacaaa acaagccgac gaccgaggtt 130260 gtgtcgatgc ctttcccaga gaccaaggtt aagtcggcgg aagagttccc gcagggagac 130320 gagttcgaca tcactctgga cgacggctac aaaaaggtgt ttcgtcttag taccctgtgc 130380 cagaaggatt tcgatgagta caacatggac gagatcgagg agatcggcat tgcctttggc 130440 cttgatctcg atccctcgca gaatactcgt cagcaggcac tggagtgctt gattgaagaa 130500 atcctggcgg gaagtcagtt ctatgttgga gaggaagatt aatggcggca ctgaagccga 130560 agggcgaacg taaggcattc gatgtatacg aaactcctga gtgggcagta aaatgtctgt 130620 tcgacctgat tccaatccgc aagggctgga cttacatgga accttgtcgc gcctccgggc 130680 gcttttacaa cgaactgccg atcgggtcag cgtggggaga gatcagggac ggtgttgatt 130740 accttaatac ttcttacgat cgtgtggatt gcattatcac caatccgccc tactccttgg 130800 cccaagagtt tgtggagaag gcccataaag atgcagatgt cgtaatcatg ctgctgcgcc 130860 tggggttctt ggagagtatg cgtcgagagg agttctggaa acagtacccc cttgaccacc 130920 tgatcacgtt gtcgaagcga ccatccttca ccgaggatgg taaaacagac ggtgccgggt 130980 acgcatattt catctgggac ccactgaaaa agctgaatct ggggaagcct ttctactggg 131040 tctctcccaa ataacaaaaa ggtcaccttc gggtggcctt ttttattgca ttgcgaccag 131100 acatgtgtat aatgaccatc attgaagagg agataatcat gaaatacgac attttttacc 131160 gcccggtgtt tacaaagaaa gccaaaactc tgtcagggta tgaaatggtc gtgtaccctc 131220 atgatcctgc tcgtccacac gatgattttg acgtaatgac cattgaggca aaggccgaca 131280 atgagttcac tcgattcgaa aacatgcttc gtggtgagta tgacccgttc agcgacattt 131340 cttttgttga caagcacccg ctgaatatca taagatacct gcgtggtgag aaagagatgc 131400 ccaaacgaac gatggattgg gaaaaggata ttgaccgctg gtctgtcaac ttacgaggag 131460 aaagagtatg agcggatacg tagaaagaac ctacctgttt gaaggcggga cggtgccggg 131520 caagtttttc gatgatgtgt acaacccatc atggggtgcc aagcacctca aggttgttga 131580 gtctggagtc accaactggg gtgatgatac ggaagtagtg gtctctgccg attgcgaaga 131640 gacattcgat gattatctgc acaactggga agggaacatc aaaaaatgaa aatctatctg 131700 gtcggcggcg cggtccgcga tgaactgatg ggtgttgaga gcaaagaccg tgactacgtt 131760 gtggtcggct ccacccacga ggagatgatg gcactcggct tcgagcaagt cggtgccgca 131820 ttcccagttt acctgcaccc tgagaccaag gaagagtacg ccctagcccg taccgagcgt 131880 tcaactggcg caggatacca cgatttcgag gtgatgttca gcccagatgt gaccatcgaa 131940 gaggatttgg cccgccggga cttgaccatt aatgcgatcg caaaggatct ggagaccggg 132000 gaatacatcg acccatacgg cggtatccgt gacatccaaa aaggtgttct gaggaacgta 132060 tcagcggcag ctatgcgtga agacccgctc cgtatctacc gcctggctcg gttcttggcc 132120 cgctttggcg gcaagtttgt ggtggaccac tcaacgatgt tcatttgtga gagtgcaaaa 132180 gcgacactgg ctgcgctccc gaaagagcgc aagatggcgg agatccgcaa atgcttcgag 132240 gaccagagta atgacaaccg accctcgttg atgatcgata tgctctgcaa tcttggggaa 132300 atgccggagg tggcaaacct gcggggtgca ttgcagccga aagcccacca ccccgagggt 132360 gacgcatacg tccacacgct actgtgtttg gactatgccc agcgcatcat gtcatcaccg 132420 gaggtgaaat gggcagtcct gtgtcacgac ttgggaaagg tccagtattt tgagtacggg 132480 aacctgcacg gacacgaaga gtttggcctt gggttggttg cacaactgag cgagcgattc 132540 ggcgtaccaa acaaatgggc agacctcgcc catcgcgttt gtgccgacca cacacgactg 132600 caccggatca tggatctgaa gcctcgcaag gtattcgacc tgattgaacg catcaaggcg 132660 cacaaaccgc aggaaaatca gttcgcactg aagttcattg aggcttgtat gtgcgacgca 132720 cggggccgtg ggccggagaa aatgtttgac atctacgacc agcctcatgt actatgggcc 132780 tgtgctgttg agttgcacaa gaaccgactg gaaatctccg agaagagtaa agagatctcc 132840 acgagattgg caggtcgtcg tgaattaatc tcttctgaga tccgagcgat gaaagttaaa 132900 tacgttgccc gcgctctatc acgagtaaag gcagaaatca aaaaattaag aggggaggaa 132960 gggtatgacg attccaattt acctacttgg cgtctgtatt agtgcagcag tgtggttcgg 133020 gattatcaag tggcggcaga ctggccgggg gataaagatg ccggacgcct tcgatgggtg 133080 gtatctttgc cctttggaca agggtaaaac cgtggattgg tccatgctaa tgctggggtg 133140 ggtcttgatc gcagtggttt ggcccattgc atggtttatc ctgatcagcg gttacgctat 133200 cgcgtgggca attgaaataa tccgatgggt ttggaaccac acgatcggcg atgaggaatt 133260 ggcccgtaag attttcggag gtaaagagtg aagactcgta tgtatttctt ggtcaaccag 133320 tatatcatgg gtatccaggc aggtatccag ccgggacatg ctgcttgcga actgctggct 133380 gactactggg acgaaccgcg agacaatccg aaggtaaagc tgatcgagca atggctcaag 133440 aaggataaaa cctttatcgt gctggacggc ggatatcagc aacggatgta tgaatttgcg 133500 gataagatcc caagttccat tccgtttgcc tacttccacg aggaagaaga tgcactgaac 133560 ggagcattga ccgcagtggc ctttgttctc ccggatcact tctacgacgt gaagttggat 133620 gaggacggga aggccccggc ggggtacttt gccgagggcg attactgccg ctgggtagac 133680 tttacggaaa cagaacgtaa tttcatcgtc gaactgaaaa agttccatct taaaaggggt 133740 taatatgttt gatttaatgg ttgcggcctc gaacgccatc ggtagtgtcg tgatgatcgg 133800 gtgggtatgg gcgataatcg gtgtcctggt gtggttaggg gtggtactct tggccctcgc 133860 cggggaaccg agttacaatc gtgaaaatgg ggccgtactg gggtcattgg ttggtgccgt 133920 tcttggcttc atcaccccgg tactcctgac aatactaccg ttctttttac ctttcatctt 133980 ggcggcggca attctgtccc tgattgggct ggccttggca catttctgta aggttggcaa 134040 atgataaaag ttaaagagtt gattgagcag ttgcagaagt gcaacccgga agacaaagtg 134100 gcggtacaga tcgacaaagg tttcgtgacc attggcggaa caccccgtgt cggtgtagac 134160 tctgcccaca gcggattcga ctgggaccac gggactgtct ttctgaaact ggaagacgga 134220 aagatgttga cagacatcac ccgggaagag tattatgagc acatccggta caagcagttg 134280 gtcagtggga tgcgtggcaa gcaggacatt gcccacttgt cggatgtgtt tgtgaagaag 134340 gacttcgtta tcgagcgact gaagcggttg attaacgttg aagagttaga acctttcgag 134400 gtctctgacc tcatcactga tatttacgag gagaaattat aatgttggca ccaacttggc 134460 agtacatcgt tcttatggta atcttctgct tgggcgcgag cctgaatgta atcagcttgg 134520 gcctgatgct cttcttggaa agcattaagc cggaggcgtt gaagttcgaa cagcgaacgt 134580 taggtcccgg gtctcttctc ttcaagactt tgatgggtat ctttgcagcg tacctttcgt 134640 actcgctgta catttggtcc cctggcgcac tgagcctcgg catcatgatt gtacactggg 134700 catcgatcat cgttagctat atcttgggca ttgccaatgc aggcaaggcg aaaacgtaca 134760 cttacggtca gcacgtcttc ggtgcaatct acacaaccgg gatggtgatc gctctgattt 134820 tctacggggt aaaatgtctg taacaaaaga ctgtactaac tgtgacagtt tcatccgggt 134880 gaaaaagccc ggatgggttg gtctctgtga tttgcacgac tggaggatta atggaaaata 134940 ccattgtgac aaatggaagg gtaaaaagca tcgtcgagaa gctggaaagt cacaaagacg 135000 tatcgaaggt gctgatgcta tgtctcgcag gatctcatgc gtatgggacg gcgacgccga 135060 ctagcgacac tgatattcgt ggcatcatcg ttgcccgccc gggagtaatc cgggcacctt 135120 tccgaaccct ccgtgagatg gggatcgagg acgaggaaga tggaaaggtt tacgaactga 135180 acaacttcat ggagttgttc tgcgacatga acccaaatat cattgaactg ggcttcactg 135240 atgatcaggc gactctgtac aagcatccgg cgtgggacta tttgaagtcc ttcctgccgc 135300 aactgctgaa caaaaacgtg gcctaccgct tcggcggtta tgcgatggcg cagttgaaac 135360 gcatcaaggg tcacaacaag cacatcaaca acccgatgcc ggaagaaaag ccgactcaac 135420 ttgagttctt ccgtttggta cagagctacc tcgacgtgaa ggtgctgaag cacgaagact 135480 tcatgcgtaa gctgaacaat atgcagggtg tctgcacgtt ggtgccgttc ggggcggaca 135540 tctatggcgt agtaccggac caccgtgaag atgttgggcc gatgttcaac cccgacgggt 135600 cgatccgtaa attgcagtac gatgagatcc cagagtctgt gaaaaagcag ccgccgttgt 135660 tcatagttaa atatcttcgt caggatcaca cggttgccaa ggataagcac cacaactact 135720 ggcagtgggt gaagaaccgt aacgccgccc ggcatgagct ggaggagaag ttcggttacg 135780 acaccaaaca cgccatgcac ttggtgcgcc tgctccgtat gggacaggaa atccttgaaa 135840 cggggcaggt catcgttcgc cgcccggacg cagaggaact gctgggcatt cgtaacggaa 135900 cccacagtta cgaggacatc gttgagtggg catcggacaa ggacaaactg atccgtgaag 135960 ttctctacca cgagagtaag ctgccgaaga acagcaacaa gcgattggcg gaagaactga 136020 tcctcaatgt acaggattct gcatggtcac aatgactaac gggagaatgg cgcatctcct 136080 gtctgtcgat acacaccggg ccaaaagccc ggttatctct tggatagagg aaaacattcg 136140 cacagggaag gcaaatcctg attacggatc aagttgcaca gaggtaatcc aagaggtttc 136200 gatcaggctg gttgagagcg tggattatga ggtaaaggac ggtaaggtta tccatgtcat 136260 tactggatgg aaatcatacc cgtattttga gaatccggca aaaccgacaa aacaagagat 136320 tgacttgttg gaggtatgcg agcataatca ctttatatgg ttgagaggac tttgttttga 136380 gatcctcgat atgctggacc atccacactc atgttccatc gactaccaca ttatggaaga 136440 ggggtgcagc gggtcagggt gtgagagagc agggccagta aactaccacg ggggtagaag 136500 ctggcaatat tattgtggtg gagggccgcg ctgctgccca taggaggaga aagtgcaaga 136560 taaacctggt tatcatctgg acaaaataga aaagcgccgt ttcggatctc tcggcaagat 136620 tcaagaggag gtcgaggaac tggtcgatgc acaccgtcag ggcagtcacg tcatgattct 136680 tgtcgagatg tctgatcttt acggggccat gcaaggattc ttggaggaaa actacccggg 136740 gttcaagatg gaagacctga aaaagttctc cggcattacc cgccgagcat tcgaaaacgg 136800 gcacaggggg taatatgaaa tatcctatga acttggcact ggtacgtgac gcgactaact 136860 ggtgggggct ttggtttgag accaaaaagg tcccggccct tgtagacccg gatgttatgt 136920 ctcacacctg cccgccgggc gtacatgatt cccgcctgta cggtaaatat ccggatactg 136980 ttgttgcctc ggcggagcaa tcttttctcc agttggagaa agagggcaaa cttaaaccgg 137040 ggcgttggat ggctttgact ccgtgctacc gggatgaacc aattcttgat gaaactcacc 137100 tgcctgtgtt cctgaaactg gaactcatga agctgagtga cgacagcaac ttctacaccc 137160 ggacggatgc actgtggatc gctgggaaga tgcagaagtt tctgagggag ttttatgcac 137220 tgcctacaga ggtgatcgag acagaggacg ggttcgacgt catgtacgaa gatctggaac 137280 tcggatcata cggtgtgcgt aaaaccatga ccggaaaatc gtatgtttac gggaccggat 137340 tggcggagcc aaggacctcg atcgcattgg aacgtttcca gcataaatgt gaaacgactt 137400 ttgactaaaa attcattgca aggttatgcc tattgaccag atcccgacga taggcatttt 137460 cgatgtatta aaatagattt tagcaattta aatgtgaagc ggagaatttg ttgtgtaaaa 137520 tgacaacatg gcaactttgt caagagtctt ctgttgtatt tttgcataac atggtaaaat 137580 ggttgtgcgg aatcttacaa cgggaggaag gctatgtttt acgcatacgt tcgtcaactt 137640 ccgatggtag agggtaacct cgatctgatc cgaggggatc ggttggatta ctcgtgcgga 137700 tctatccgcc gggccaaggc cgatctttgg ggattcaggg catacgtcct tgaagataag 137760 gtccgagggg ttacttaccg ggtaaatcag cgcggcatgg ttgtggaaac accatctggg 137820 tcgattgcag tcccgaaccc cggagagttg aagcacactc cattcgctat gacaggcgac 137880 gccggagaga tcaatgcttt cctgacactc tgcaagaatc ttgttgtgga gcataagaaa 137940 agaaactccc tgttcgctcg tctaaagcgc ttcacacgca agccattcgg aatgattctc 138000 attgccgggg cggcggtata cgccattgtg acagtcatcg tgctgttctt tggataatcg 138060 ggtcgatcgt cgaaagacgg tcggcctttt cttttggagg gtgcatggca aattttaaca 138120 ctggtaatgt atctaacccg tattcaacgt ctcccggcct tttccccgct tcgacacaaa 138180 atatggtgat acaagggtca ttgcaatcag tgaccaatct acctttgacg gcaaaccacg 138240 gcgacaccta tatcatcggg ggtgttctgt atatgtggat gcacgggagt tgggcaaact 138300 taggtgcgcc gggaggaccg atgggtcaca gcggatcata cgaaccgccg aaagaaatta 138360 tcgaatccaa gttgatctgg aagggtattt cggttacatt gtattcggaa gaggacataa 138420 aggctctctt ctttaaccag tatgccctca ccagggacga tatggcattc ttccagatga 138480 cgtatccgga tgaatttaaa gcgtttaggg agcagtgggc ggaaaagtgg gccatcgaaa 138540 gggccaaaga agaatttgac gaatgggagt tagactacta tgagaaaaag ccaagaagaa 138600 attacccgtg aggtatttgg acggggtgct cgctggatcg ggtggaacca ctggctgaag 138660 caccaagttt tcttcaagtt ccttgaacat cgggtggaga gagggataga tatagacagt 138720 cgggcgtcgt tctacctcaa aaccaagatg gattcttctt gggagacgga caagatggta 138780 aaggcgaata tcgatcctga gacaggagat ctggcgagca tagagatccc tggtattggg 138840 ataaaaggtc tccgggccag attggtagtc actgaaaact cctgcactta cgagtgtgac 138900 ggtgtaaaga ctcatttatc ggagatgttt gacgaccctt ggcgtccgac atttgaagag 138960 ttggatatgt tccagatgct ttacggcgac gagcaaatgc tcatagatat gaatcgggag 139020 ttcttcggcg tcacccgaaa actcgataag gcggcgggtt ccaataccct gtctgtattt 139080 ttcccaatga aggataaata atgagtgaaa tcaaagatgt aattgagaga ctggctcggg 139140 attggagttg gaaggccgtt atggatgacc ctgttcgacg tcagatagtt actaagttgg 139200 aaggtaagtt ccgaggtttg actatcgaag tccccaccgg gccgaacact gtccgggaat 139260 ttaccatgcg ccacgaaatg aagaacgggg acctgcgtct gtggaccaag agcatgagtg 139320 ggcttcttca gtggagaacc tgccctgaga agggtgatcg tttggtttat catgcctttg 139380 ggcgaggaga taccgaacgt ctgtctattg aagaaatctt cttagacacg cacaacgtgg 139440 acgaaggaga ggtggcgatg ttcgagatgc tgtacgcaga tctttcccca atggtgcctc 139500 tctttgctgg ggctttggac gaagccgata aactgttgct ggagaaattc aatgggccaa 139560 aagcgaagcg ctaatgatgc actgagggcg gcgcagttga acgaactgcg ttacgacgca 139620 actaccgggg ttgtgatggg ggtaaatggg atgttgggac caagagggga tatgggggtg 139680 tccggggtgt gcgggacacc tgggcctatg ggtatctgca cagagcttta tgttttatcg 139740 tatgcggggc ttccctttaa ggtccggttg aaaccagaaa cctttgccat gattgaggat 139800 gctacccaat tgaacgggga cgaactttct tttatcaagg tggtggatga gtccgagtgg 139860 aaatcgatca gggaggcttg ggcagaagag tggaacaaac gccaagcgta ccgggccttt 139920 gatttggggg agatgatgcc tgatgaataa cttaaataat catatcgacg cagcactgat 139980 gggtagcgaa acaacagggg tcaacgtgaa cccgtggaga attggagatg gctacaccac 140040 gccgaacatt caccaacctt ggactccctc cccgtccgat attaaggccc gggagtggga 140100 aaggattatg agggagatcg tgaacgcccc gacaccaacc accacttcga ccgggaccaa 140160 ggttatcgta gaccctccta cgtcgagaaa caggacgatt aagttcaaag agatcgtctt 140220 tacggcttac ctttctgatg aggctatgga gttcttcgag gacgacaggc acgtaactcg 140280 ggacgagctt cgattactgg aagttgctca tcctaaagag tacgccaaga taaagcaggc 140340 atggattgcc gcctggaaag agcttcaggc actaaatgct tttgaaaacg attgacattg 140400 acacaggacc ctgtatgatg ggtcctatca aacaacagag gagagaagag tgaaaaaggt 140460 atccaccatc gaaaaagcat ttatcattgg cgtgacatcc ctgattggcg ggtttggggc 140520 atacttgggc cagatgacca caccacaggc ggtagtgaat ggcatagtct ttgggatctt 140580 gggcgctgcc atcatcggcc ttctgcataa gagtcgtagc tgatgagcaa gaacacccga 140640 tactctcacc ttttgttcca catcatgtcg cctgaactcc gtgagcagtt cttcaccgac 140700 gatgaagaga acttcgatgc aggctgggac ctctttgaga ccctgcatcc ggaaaaggcc 140760 gaggtgctgg tcagtttact cgaaccgcat ctcgaatatg tgataaaaga gttgaagttc 140820 cagcgggacc ataatatatt gctgggcaaa ggcgacgaac tcggcgctgc acgactggca 140880 atctgccacc gcgctgataa actggactgg taaaggagat caatatgtta cagatgaaca 140940 aagaagttac cgctcaagcc gttacggcga tgtctgagcc tccggcggca accggactat 141000 ttctggtgtt cgcatcggaa aaatactacc cgcagggcgg gtttaacgac ttcctgtgtg 141060 tggcactgtc gttggaggaa gcccgccggg tgatccttga gactgacatc tacttgggga 141120 gctaccagat cgtgaactac aaaaatctgg aagtggtcga agctaaagaa atcaacaggt 141180 tgaactgata tgagcagatc tcgttttggt gttgtgtctc tgatggtggt tacgccgggg 141240 ttcatgtcct tccaaggctc aaactgcgga tttgcccaga actgcaagat gatgttgcag 141300 acagccttcc ccggcctgcc gtatgacgtg ttcaagcgtc cggacatcat gcagatgatg 141360 gatcaggtgg acaatgttac cgggacgctg tatatcatcg accctgtgga gggccagccg 141420 cttatggcta atgcgaccct tgagggtctg gaagaggagt accgccagtg ggaagagcgt 141480 cgttaatttt actggcactc ttggcctttg gggccagtgc cgaggaagac ctgaagaagt 141540 gtaccgtgca tgaccacggc ggtggtgcca ctatcatcgc ctgcccggat tacgtcatca 141600 cgaagacatc agataagacg atgatctgtc gtcttatgga aggtagtcca aatgtgagtt 141660 gcaccaaggt tccttaaaac gccctgtaac gcgctgtaag cgttttagag gtgaggtaag 141720 gtgatttatc atccttggcg agaaaacgcc tcagaatcgc tctggtgcgt cctgacgggc 141780 attcccgtct aaaactttac aggagaatac aaatgaaggt aaaaggtgcc ctttggaaac 141840 aattctacaa tgacgagggg ttctggggca gtcgttggca tgacgacacc ctgatcctat 141900 ttgacggtgt tgagcaagag gagtatgaca acccagcaga tgacgccgtg gttgacgtac 141960 aggccgggga tgtgtatttt gaagccgaag gcttccaact tgccgcccgt gatacttctc 142020 tggaggcttt ctatcgccgt tggctcaaaa tccaaactac cgaggtcctt atcgtaactg 142080 tggaaaaatc ccaagctgca tcggtaaagg cggaaattaa aaatattact ggcgtaaagg 142140 gggtcaaatg attgatttcc tgatccttgc tacactctgg ttctttggta ttatcgtacc 142200 gctgggtggt ctgatcctga tcgtaaggaa ggtcatcgtc ccgtattggg taaagggttg 142260 gtccggtcag tgggtattct ggtacatact gggggctgtt cccctgtatt actacatctt 142320 ctgcaaggtc ttggtatgga taggggtgga gagtggagca ggagcttaaa agaacaactg 142380 acttgattgg tgccttgcag gctgctatcc gtgtcgccgg gtatgatatg gactgcggag 142440 atatctggtc ccacataaag ggtatcgctg ctgcggaaat aaagaaccac cctggcccta 142500 tggggcctat gggcatggct ggtgccccgg gagagccggg gaaggatgcg tgggataagt 142560 atgcctatga ccctcagacc gaaagaaaag cccagttctt ctggaagggt attgagtttt 142620 ggtctccggt gccgcgccac ttctacgacg ccttgcctgt agggaaggag ttgacatatg 142680 gcgatattgg cttcatccgt acaatgtacg ggaaccaaat cgtcgaaact atggctgtct 142740 tttggcgtcg tgaatacgac ctgaagacag atatgtcttt gtttattaac gaggaagata 142800 aatgtcattt agcgaatatc aacaaatccg attcatctcc ggcccatttg aaggtctgat 142860 gggaaaaact ctcgctccgg ttgctgacac cgaaaactgg tacgttgagg tgaagatcgg 142920 tggtcggcct gttgttcagg aagttcctga gtcggacatc gcccctcttt aaaaacaacc 142980 gccttcgggc ggttttttat tgcttgcaat ccgatgatgt tcgtgtatac tggccctgga 143040 ggtgacttat gaagacaacg ccgtggagaa aacccgtcgc ggagtgcggt gggataacgg 143100 atctgattaa aagggagatt aagttcagat tccccagcgg catggagagg tatagggcag 143160 atatccgtat ccatgcttac cgggaggtag ggacgagctt ggaggccagt tatgaggttg 143220 aggttgatgg accgtttggt aaatttttca agtgggagac catagttata tgatacacgt 143280 ggacgatatg cactggcacc tgtgggaggc cattgttctt caggcccggg atatgtatta 143340 caaaggtttc gtgagtaagg aactgaacgc agaggtcaca gctatcagtt gtgagactgt 143400 tgctacaggg aagttttctg aagacctgcg gaccagagcc tgccttgtgg ctcaggcact 143460 ggaaccaaac gcagaagaat ggcaaaaagc cgtggctatt gaatacgagg ggatgaatcg 143520 tgaagctgaa atgtatgaac gtgatcacag acttcaacaa ggtgtttccg aagggacagg 143580 tcttcaccgc ttcagagctt aaaaacgggt tctgtgatgt tgaagggacc cggcccaagc 143640 gtgacggctc tccgtggaca ggtgtcctgt ctctgggtca cgtggtggta ctgggtgttg 143700 ccaaattcga gatccttccg gaggaggaaa gtgatgattc cacggatgac taagaccact 143760 ctgcacaaac tgtttaaaga gtggacatgg cgagacctga ctcggcgtaa atacgtcggg 143820 aacctgatct ttacaggaaa tggcggctac cgcaaggaca atcgtgtggt tcagaacgtc 143880 ggcaaacctg ccattaagtt tcgtttcgat attggtccat accttggtgg gacagtcacc 143940 tccactccga gacacttcag tatttccaca accggaaagc tggatcgggt ctcttggatg 144000 gcaatgcctg acggggatgt tttcttgaag cgtcgtgtcg gaaaggtatg gcaatccccg 144060 gtgaagatga cagacttctt cttggattgc cgtgacatcc agaacgaaga actggagatg 144120 ctggagtttc tgtatccggg cataacggct caggtagtgg agttgctgcc cggcttgcac 144180 gggatagact ctgcactttg ggaaaaattc tgtggaaagg ggccatatca tggaatgtct 144240 gcctaagtgt tacgattctc cacgggtgcc gtcccagtgg aaaaaggatc agcgtgtacg 144300 tatcttgcgc gggaagaata agggccgcac ggccctcgtt tcctacgaga cagagccgca 144360 tcctctgtca agtaagcgtc ggttctacct gtggcttgag tccaggcaca atttctgggc 144420 accgaaccac gtactgatga acgaggatgg gtttgtcgca gtctaacaaa agacctccgt 144480 acaatgggct acttgagtat ggcgaatttg agtacggagg tcacaaagtg agtctcaggt 144540 tgcccaaaga tgtgtgggat tatataaaac aggttggaga aaaggacttt ttatggtccc 144600 cggaggaaga ggtgttcttc gaaatgctct accctggctg gattggatac attcggcatc 144660 aggttgaggt tcaatattcg tttttggtgt ttcaaaccag caccttcgga gaatccctgc 144720 ttggggccag agaaatcaag gattacgtcc ctgacgaaat ttcaaccaca agatatggtt 144780 gatttctacc ctattttcat gtattctgca caaatcgggt gaaaatgtgc cgtttttgca 144840 tgtaaaagtc aaaattctgg cacttttctg cacaaaaccg caaaataatt gcactcagga 144900 ggcaaaatga tcgaaaaatc tgcaattgaa ttgttgcttg aaatggcaaa gactaacgaa 144960 accctccgcc ggaatatcgg caatttgatg atgttcgggt attgggagtc gaaatattac 145020 aattttgagg acatgatcaa ggacgagttc cccgaactcc tccggctgta cacaccttgg 145080 gagtacgaca tgcactgcat gggtgttttt agggccgcag ccaacaaggc gcagcttgct 145140 ggtcttccgg ggaaggtgga catgttcaag actcttatca atgcccacaa ggacagcatc 145200 aaggctaccg cagaggctat ccgggatcac atctacgaaa atgatatgga ggggatgttt 145260 gaatgaagat ccttatcgag aaaaacgtga agacctatgc caacgggcgt gtgattgagt 145320 attaccgggt gaagtacaat cgtggcttct ggtggccctt ctggcaatat gtccagcagc 145380 attactccca cggcgacccc gacatcaagg attttgaaac cttggaggaa gcaaaaaggg 145440 ttgcaaagaa actggcagag gactatactg gccctcagca cataatcacc gaccttgata 145500 tcaacggtga accagttaac aaatactgtg ggggatgata tggctggcgg ttaccatgat 145560 gcttttgcga taaagcagaa aggaaatgac gggattgttt gtatcgacgg gcacttccac 145620 atttataact ccatgcaggc tgctgcactc aacctgacgg ttttggctgc tgagtatcct 145680 ggcagggagt ttacaatcgg gcagttacgt attccactgc cttggacaaa acaggggttc 145740 taatgtacac aattatttct taccgtgaaa acgatgccgt ctaccgtggc ggctactgtg 145800 aaggccgcac tgacagtgac atgacgcttc agtcaactca ggatcgtgaa caggctattg 145860 agttgctggc ccacgccatc tatctggaca ctgtggccca ggatcgtagc ctgaataagg 145920 attacgagtt cactgctggg gcagacatca ctttgggcat caacgggtac ttcggcacat 145980 cttatgcggt tgacgaaatc tccgacgagg agtatgagaa atactcggct gaacgtcagt 146040 tgatgctgga agatgcagag atcctcgcca agcgtaagta tgatgcccgt ctggtagact 146100 accgcgaggc acagcgcctc cgggccgaga aggcagagca gcaggcggct gaacgtcgtg 146160 aggccgagga acgtgcccag ttggcccgcc tgaaagcaaa atacggggag tgagatgaaa 146220 gcatacgttt accagttatt ccacgtaagt atgcgtggag agatgggaca gaccgatgtg 146280 gactggggtt tgtttaccag cctgccgctg gttcgtgaag tgatcttgaa gtctaacgac 146340 aacccggagg atttcgattg ctatcgccac cctctgaacc cgcaggggca ttacgtgccg 146400 accccggtac aaatcttccg caaataaccg ccgaaccgcc ctccgggcgg ttttcatgtt 146460 tatgaaatga acttttttcg acaaataccc cgaaacatgt ttacagcgta aacatatggg 146520 tgtatattga ccttaccgac tgaagaggag aagactatgg agccgactat tgaacaaatt 146580 cgtgagacta tcagccgcct ggaggaccct gttatcctgt ccacgctacc gctgatgcgt 146640 aagatggccc tgtgcctcgg caaggatagc tccgctgccc tggtggttgt ggaactgtgc 146700 cgtgaaggcg tgaagcgggg tattctggaa tgatgggctt ttgtttgttc atggcctgcg 146760 ttgctggcgc ggtattcctg tacggggaac tgtgcctggg gcacggtagt cactgagggg 146820 aggacaaatg atcaacaacc ctaacgctga atgggagaac tgcgattatc ttttgtggcc 146880 tgcatggtac gcatatgtgt catgggccat cgtggccctg atattcgccc cttgtgcctt 146940 tgcgatctgg atgggcctat gagcaagaac cgtgacccgt gggaccaggg cgtccgtata 147000 atccagtacc cgaacgggca ccgtacagaa ctgcgcctgt cctcgacagg attcgtgcat 147060 gagttcccga tagaaacgcc tgaagaggct cgtgtccggg aaatctgtac tctgcaacgc 147120 cgaattaaat ctgacaccgc ccggctggcg gaactgcaag gagattggta cgatgaacat 147180 tgaagaaatg aacgcaccac atatcatcga ggacatcaac ggcaacccgt tggccttagt 147240 gcataacatc gttatggccc gctcagtggc ccgctactgg gacagattcc tgatggtgtc 147300 cactcatatc cgtctggcaa atgaggacga catagcggcg tttggacgcc gactggtgga 147360 cgcatgactc ccggcattgt aatcgtcggc gggttcctgc tgataatcgc cgccggggtg 147420 gcggggtatt acttcgagcg ttacctggac aggcgctggg ctgaacaagc cgcagaacgc 147480 atctgggaaa accgtgataa atggctgaag agaggttagt gtgggcgtac cgtatgcaat 147540 cgtagaccgg aacggcatgg tagccgccat tgtgccggag cgcatcgtag cggaggtcat 147600 ggcctctgcg ctcgttccca acatgggtta ccggatggaa tgccgcccgg caacggaaga 147660 ggaaatctac caactaatct accaactgga acagaaccgc cctcccctgc cggagcgctc 147720 cgtgcgctac aagaccctga agggtgtggg ccaacaattg gtggtggtag cattaccaag 147780 ggagcctgtc gagtcccatc agtaccctgc ctgaagtggc gaacctgttg ataactaagg 147840 agtttctgtg gaaaataccg aagaccgaag cccgtatgcc gggtacaatc cgattatccc 147900 gaacagtgac gaagaggcag cgctggagca gcgtgtcttt gacatgctgt acaacggcag 147960 gaacaacctg tatagccgct gccagcggga gcacgtcgcc atcatccaag acctgtggag 148020 agagttcgta ttccgcgaat cctggtactc gaaagaggac aagcccaagg actggtacat 148080 cgggtatgtg gacgcactga agcactttga gggtgagtgc ccgccgggcg gctacaaggg 148140 cgcgaacggt gatcccaaaa ctgattacga cttcggctgg aacgccgggt ttaaggcatc 148200 ctcatgatta aggtccctcc ggagatcaag gtctcggaat ggtatccgac gtatggcttc 148260 acacagaaag aactgcggta tctgtatgtg gactgcgacg tccgcatctt cgaggaccag 148320 agagacggcg ttatctacca gatcatggat agcggtccag tggataaacg acgccgggac 148380 ctgtctggtt tctggctcaa aaagttggag gactacttat gagtcgaacc ccatgcaggc 148440 tcgctacccg ctggaacctg aaggcccgcc ccaagaagcc tgtgtggagg caactctact 148500 tcccggtgcc ggagtccggc atggctgtat gccttgagca caatggcttc ggcttcgtga 148560 agggtaaggc gtatcgcttc cacacacagg taagggctga ccagtacccg ccatacgatg 148620 tggtcacggt caccagagat gactactctg aggaccaccc catcaccacg tgggtgttcc 148680 tcaacaatca ggatgacctt ttccgtaagt cattccaaat catctgaccg ccacacactc 148740 ttgacctcct tcgggaggtc tttttgtttc ccacagaggg taacccagag agcctaaaga 148800 ggcagacctg tgcataactc atgtgccaca ggctggcgca ccaccccgtc cgggaggctc 148860 tctcccgccg ggtagtaacc gtcccacaga gacgtacccg tctgtattcc cacattgccc 148920 aaatatcaag ggagccggag aggctcacct accctgactt tttggtgttt ttaccctccc 148980 gccaaaattt ttagaacgcg atcaggggta gcccttcttg cccaaaaacc agaaaaatat 149040 ctcagcgtat ggatatagct gccaggcatg gcgaatcggg ggtggggagg ggcctcgtta 149100 ttttccccaa atatccttat gaatcaatga cttagcccct ctcaactttt cttcaatcgg 149160 accgggtagg tcctcgcttt acgtgatcat ctccacaaaa tgtctaccat cttgcccatc 149220 tttacacttg tcctatt 149237

Claims (11)

  1. 크로노박터 사카자키(Cronobacter sakazakii)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 CS4.
  2. 제1항에 있어서, 상기 박테리오파지는 수탁번호 KFCC11751P인, 박테리오파지 CS4.
  3. 제1항의 박테리오파지 CS4를 포함하는, 항생용 조성물.
  4. 제1항의 박테리오파지 CS4를 포함하는, 사료 첨가용 조성물.
  5. 제4항의 사료 첨가용 조성물을 포함하는, 사료.
  6. 제1항의 박테리오파지 CS4를 포함하는, 소독제.
  7. 제1항의 박테리오파지 CS4를 포함하는, 세척제.
  8. 제1항의 박테리오파지 CS4를 포함하는, 식품 조성물.
  9. 제8항에 있어서, 상기 식품은 분유 또는 이유식인 것을 특징으로 하는, 식품 조성물.
  10. 제1항의 박테리오파지 CS4를 식품에 처리하는 단계를 포함하는, 크로노박터 사카자키균이 제거된 식품 제조 방법.
  11. 제1항의 박테리오파지 CS4를 인간을 제외한 개체에 투여하는 단계를 포함하는, 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법.
KR1020170180928A 2017-12-27 2017-12-27 신규한 크로노박터 사카자키 특이 박테리오파지 cs4 및 이를 포함하는 항균 조성물 KR102037394B1 (ko)

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CN115011564A (zh) * 2022-01-19 2022-09-06 华中农业大学 一株能够裂解阪崎肠杆菌的广谱噬菌体lpcs28及应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114540314A (zh) * 2020-11-24 2022-05-27 广东省微生物研究所（广东省微生物分析检测中心） 一种宽宿主谱克罗诺杆菌噬菌体及其应用
CN114540314B (zh) * 2020-11-24 2023-12-05 广东省微生物研究所（广东省微生物分析检测中心） 一种宽宿主谱克罗诺杆菌噬菌体及其应用
CN115011564A (zh) * 2022-01-19 2022-09-06 华中农业大学 一株能够裂解阪崎肠杆菌的广谱噬菌体lpcs28及应用
CN115011564B (zh) * 2022-01-19 2023-06-20 华中农业大学 一株能够裂解阪崎肠杆菌的广谱噬菌体lpcs28及应用

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