KR20190068521A - 혈액암을 치료하기 위한 항-cd20 항체, pi3 키나아제-델타 억제제, 및 항-pd-1 또는 항-pd-l1 항체의 조합 - Google Patents

혈액암을 치료하기 위한 항-cd20 항체, pi3 키나아제-델타 억제제, 및 항-pd-1 또는 항-pd-l1 항체의 조합 Download PDF

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KR20190068521A
KR20190068521A KR1020197008508A KR20197008508A KR20190068521A KR 20190068521 A KR20190068521 A KR 20190068521A KR 1020197008508 A KR1020197008508 A KR 1020197008508A KR 20197008508 A KR20197008508 A KR 20197008508A KR 20190068521 A KR20190068521 A KR 20190068521A
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delta inhibitor
weeks
antibody
kinase
kinase delta
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Korean (ko)
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마이클 에스. 웨이스
하리 피. 미스킨
피터 스포텔리
Original Assignee
티지 쎄라퓨틱스, 인코포레이티드
라보라토이레 프란카이스 듀 프락티온네멘트 에트 데스 바이오테크놀로지스
리젠 파마슈티컬스 소시에떼 아노님
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Publication of KR20190068521A publication Critical patent/KR20190068521A/ko
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A—HUMAN NECESSITIES
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020197008508A 2016-09-09 2017-09-08 혈액암을 치료하기 위한 항-cd20 항체, pi3 키나아제-델타 억제제, 및 항-pd-1 또는 항-pd-l1 항체의 조합 Ceased KR20190068521A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662385723P 2016-09-09 2016-09-09
US62/385,723 2016-09-09
PCT/US2017/050825 WO2018049263A1 (en) 2016-09-09 2017-09-08 Combination of an anti-cd20 antibody, pi3 kinase-delta inhibitor, and anti-pd-1 or anti-pd-l1 antibody for treating hematological cancers

Publications (1)

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KR20190068521A true KR20190068521A (ko) 2019-06-18

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KR1020197008508A Ceased KR20190068521A (ko) 2016-09-09 2017-09-08 혈액암을 치료하기 위한 항-cd20 항체, pi3 키나아제-델타 억제제, 및 항-pd-1 또는 항-pd-l1 항체의 조합

Country Status (13)

Country Link
US (1) US20190247399A1 (https=)
EP (1) EP3509634A1 (https=)
JP (1) JP2019526595A (https=)
KR (1) KR20190068521A (https=)
CN (1) CN110191720A (https=)
AU (1) AU2017322501A1 (https=)
BR (1) BR112019004185A2 (https=)
CA (1) CA3035976A1 (https=)
CL (1) CL2019000585A1 (https=)
EA (1) EA201990374A1 (https=)
IL (1) IL265194A (https=)
MX (1) MX2019002728A (https=)
WO (1) WO2018049263A1 (https=)

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WO2020191022A1 (en) * 2019-03-18 2020-09-24 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
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US20220378756A1 (en) 2019-09-19 2022-12-01 Forma Therapeutics, Inc. Activating pyruvate kinase r
WO2022171121A1 (zh) * 2021-02-10 2022-08-18 同润生物医药(上海)有限公司 治疗肿瘤的方法和组合
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN118922208A (zh) * 2022-02-28 2024-11-08 贾斯帕医疗公司 用于消耗患病造血干细胞的组合物和方法
CN115141092A (zh) * 2022-07-27 2022-10-04 诚达药业股份有限公司 一种抗淋巴瘤药物相关化合物的合成方法

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CA3035976A1 (en) 2018-03-15
WO2018049263A1 (en) 2018-03-15
CL2019000585A1 (es) 2020-05-29
CN110191720A (zh) 2019-08-30
US20190247399A1 (en) 2019-08-15
EP3509634A1 (en) 2019-07-17
EA201990374A1 (ru) 2019-09-30
MX2019002728A (es) 2019-08-16
JP2019526595A (ja) 2019-09-19
BR112019004185A2 (pt) 2019-09-03
AU2017322501A1 (en) 2019-03-28
IL265194A (en) 2019-05-30

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