KR20190053905A - 리포솜 안티센스 올리고뉴클레오타이드와의 병용 요법 - Google Patents

리포솜 안티센스 올리고뉴클레오타이드와의 병용 요법 Download PDF

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KR20190053905A
KR20190053905A KR1020197010647A KR20197010647A KR20190053905A KR 20190053905 A KR20190053905 A KR 20190053905A KR 1020197010647 A KR1020197010647 A KR 1020197010647A KR 20197010647 A KR20197010647 A KR 20197010647A KR 20190053905 A KR20190053905 A KR 20190053905A
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cancer
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아나 타리 아시자와
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바이오-패쓰 홀딩스 인크.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/30—Special therapeutic applications
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  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197010647A 2016-09-16 2017-09-15 리포솜 안티센스 올리고뉴클레오타이드와의 병용 요법 Ceased KR20190053905A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662395680P 2016-09-16 2016-09-16
US62/395,680 2016-09-16
US201762487277P 2017-04-19 2017-04-19
US62/487,277 2017-04-19
PCT/US2017/051723 WO2018053232A1 (en) 2016-09-16 2017-09-15 Combination therapy with liposomal antisense oligonucleotides

Publications (1)

Publication Number Publication Date
KR20190053905A true KR20190053905A (ko) 2019-05-20

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KR1020197010647A Ceased KR20190053905A (ko) 2016-09-16 2017-09-15 리포솜 안티센스 올리고뉴클레오타이드와의 병용 요법

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Country Link
US (2) US10927379B2 (enExample)
EP (1) EP3512525B1 (enExample)
JP (1) JP7132911B2 (enExample)
KR (1) KR20190053905A (enExample)
CN (1) CN109963571A (enExample)
AU (2) AU2017325971A1 (enExample)
BR (1) BR112019005166A2 (enExample)
CA (1) CA3034637A1 (enExample)
ES (1) ES2928654T3 (enExample)
MX (1) MX2019003070A (enExample)
SG (2) SG10202008771WA (enExample)
WO (1) WO2018053232A1 (enExample)
ZA (1) ZA201902079B (enExample)

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EA038277B1 (ru) 2015-10-14 2021-08-04 Байо-Пат Холдингз, Инк. P-этокси нуклеиновые кислоты для липосомальной лекарственной формы
MX2019003070A (es) 2016-09-16 2019-10-14 Bio Path Holdings Inc Terapia de combinacion con oligonucleotidos antisentido liposomales.
SG11201909336VA (en) 2017-04-19 2019-11-28 Bio Path Holdings Inc P-ethoxy nucleic acids for stat3 inhibition
US12234457B2 (en) 2017-04-19 2025-02-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for BCL2 inhibition
WO2022060477A1 (en) * 2020-09-16 2022-03-24 Board Of Regents, The University Of Texas System Methods for treating cancers with inhibitors targeting the role of grb2 in dna repair
CN112891376B (zh) * 2021-03-09 2023-02-03 阜阳天祥食品科技有限公司 羊油在制备治疗肺癌药品中的应用

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US20210261972A1 (en) 2021-08-26
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US12012601B2 (en) 2024-06-18
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