KR20190043648A - 단백질 키나제 저해제 - Google Patents
단백질 키나제 저해제 Download PDFInfo
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- KR20190043648A KR20190043648A KR1020197011438A KR20197011438A KR20190043648A KR 20190043648 A KR20190043648 A KR 20190043648A KR 1020197011438 A KR1020197011438 A KR 1020197011438A KR 20197011438 A KR20197011438 A KR 20197011438A KR 20190043648 A KR20190043648 A KR 20190043648A
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- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 150000003871 sulfonates Chemical group 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- UIJXHKXIOCDSEB-QMMMGPOBSA-N tert-butyl (3s)-3-hydroxypiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H](O)C1 UIJXHKXIOCDSEB-QMMMGPOBSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- DDPWVABNMBRBFI-UHFFFAOYSA-N tert-butylhydrazine;hydron;chloride Chemical compound Cl.CC(C)(C)NN DDPWVABNMBRBFI-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- YUKQRDCYNOVPGJ-UHFFFAOYSA-N thioacetamide Chemical compound CC(N)=S YUKQRDCYNOVPGJ-UHFFFAOYSA-N 0.000 description 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
- DUYAAUVXQSMXQP-UHFFFAOYSA-M thioacetate Chemical compound CC([S-])=O DUYAAUVXQSMXQP-UHFFFAOYSA-M 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical class CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2779184A CA2779184A1 (en) | 2012-05-31 | 2012-05-31 | Protein kinase inhibitors |
| CA2,779,184 | 2012-05-31 | ||
| CA2813299A CA2813299A1 (en) | 2013-04-17 | 2013-04-17 | Protein kinase inhibitors |
| CA2,813,299 | 2013-04-17 | ||
| PCT/CA2013/000513 WO2013177668A1 (en) | 2012-05-31 | 2013-05-28 | Protein kinase inhibitors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147036372A Division KR101972990B1 (ko) | 2012-05-31 | 2013-05-28 | 단백질 키나제 저해제 |
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| Publication Number | Publication Date |
|---|---|
| KR20190043648A true KR20190043648A (ko) | 2019-04-26 |
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| KR1020147036372A Expired - Fee Related KR101972990B1 (ko) | 2012-05-31 | 2013-05-28 | 단백질 키나제 저해제 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020147036372A Expired - Fee Related KR101972990B1 (ko) | 2012-05-31 | 2013-05-28 | 단백질 키나제 저해제 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9796716B2 (enExample) |
| EP (1) | EP2855484A4 (enExample) |
| JP (1) | JP6175495B2 (enExample) |
| KR (2) | KR20190043648A (enExample) |
| CN (1) | CN104379586B (enExample) |
| BR (1) | BR112014029718A2 (enExample) |
| CA (1) | CA2874211A1 (enExample) |
| HK (1) | HK1208460A1 (enExample) |
| IN (1) | IN2014MN02338A (enExample) |
| RU (1) | RU2678767C2 (enExample) |
| WO (1) | WO2013177668A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2833867A1 (en) * | 2013-11-21 | 2015-05-21 | Pharmascience Inc. | Protein kinase inhibitors |
| CA2834528A1 (en) * | 2013-11-26 | 2015-05-26 | Pharmascience Inc. | Protein kinase inhibitors |
| CA2953798C (en) * | 2014-07-07 | 2019-06-11 | Eternity Bioscience Inc. | Aminopyridazinone compounds as protein kinase inhibitors |
| GB201508747D0 (en) | 2015-05-21 | 2015-07-01 | Univ Edinburgh | Compounds |
| HK1257555A1 (zh) * | 2015-05-27 | 2019-10-25 | Gb005, Inc. | Tec激酶家族之抑制剂 |
| US10927087B2 (en) | 2015-12-07 | 2021-02-23 | Dic Corporation | Method for producing polymerizable compound |
| WO2017134685A2 (en) * | 2016-02-02 | 2017-08-10 | Sun Pharma Advanced Research Company Limited | Novel hydrazino compounds as btk inhibitors |
| CN109369654A (zh) * | 2018-11-20 | 2019-02-22 | 山东大学 | 1，3-二取代-4-氨基吡唑并嘧啶类化合物及其制备方法和应用 |
| CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药（上海）有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| US20250042904A1 (en) * | 2021-11-15 | 2025-02-06 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Compounds used as src inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0014073A (pt) * | 1999-09-17 | 2002-07-16 | Abbott Gmbh & Co Kg | Pirazolopirimidinas como agentes terapêuticos |
| HUP0303363A2 (hu) | 1999-09-17 | 2004-07-28 | Abbott Gmbh & Co., Kg | Kináz-inhibitor hatású heterociklusos vegyületek alkalmazása gyógyszerkészítmények előállítására |
| US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| CA2363274A1 (en) * | 1999-12-27 | 2001-07-05 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs for hepatitis c |
| AUPR392301A0 (en) | 2001-03-23 | 2001-04-26 | University Of Newcastle Research Associates Limited, The | Protein phosphatase inhibitors |
| CA2810339A1 (en) * | 2001-08-10 | 2003-02-20 | Novartis Ag | Use of c-src inhibitors alone or in combination with sti571 for the treatment of leukaemia |
| EP2529621B1 (en) | 2006-09-22 | 2016-10-05 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| CA3001152A1 (en) * | 2007-03-28 | 2008-10-09 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| US7718662B1 (en) * | 2009-10-12 | 2010-05-18 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase |
| PL2488486T3 (pl) * | 2009-10-13 | 2020-01-31 | Ligand Pharmaceuticals Inc. | Małocząsteczkowe związki mimetyczne hematopoetycznego czynnika wzrostu i ich zastosowania |
| CN105408334B (zh) * | 2013-05-21 | 2017-10-10 | 江苏迈度药物研发有限公司 | 作为激酶抑制剂的取代的吡唑并嘧啶类化合物 |
| CN103787839B (zh) | 2014-01-21 | 2015-12-02 | 苏州昊帆生物科技有限公司 | 合成2,3,4,5,6-五氟苯酚的方法 |
-
2013
- 2013-05-28 HK HK15109229.7A patent/HK1208460A1/xx unknown
- 2013-05-28 US US14/404,497 patent/US9796716B2/en not_active Expired - Fee Related
- 2013-05-28 RU RU2014145285A patent/RU2678767C2/ru not_active IP Right Cessation
- 2013-05-28 KR KR1020197011438A patent/KR20190043648A/ko not_active Ceased
- 2013-05-28 WO PCT/CA2013/000513 patent/WO2013177668A1/en not_active Ceased
- 2013-05-28 CA CA2874211A patent/CA2874211A1/en not_active Abandoned
- 2013-05-28 KR KR1020147036372A patent/KR101972990B1/ko not_active Expired - Fee Related
- 2013-05-28 JP JP2015514295A patent/JP6175495B2/ja not_active Expired - Fee Related
- 2013-05-28 EP EP13796590.1A patent/EP2855484A4/en not_active Withdrawn
- 2013-05-28 CN CN201380028248.2A patent/CN104379586B/zh not_active Expired - Fee Related
- 2013-05-28 BR BR112014029718A patent/BR112014029718A2/pt not_active Application Discontinuation
- 2013-05-28 IN IN2338MUN2014 patent/IN2014MN02338A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013177668A1 (en) | 2013-12-05 |
| EP2855484A4 (en) | 2015-12-16 |
| HK1208460A1 (en) | 2016-03-04 |
| EP2855484A1 (en) | 2015-04-08 |
| JP6175495B2 (ja) | 2017-08-02 |
| CA2874211A1 (en) | 2013-12-05 |
| KR20150015527A (ko) | 2015-02-10 |
| IN2014MN02338A (enExample) | 2015-08-14 |
| US20150191473A1 (en) | 2015-07-09 |
| KR101972990B1 (ko) | 2019-04-26 |
| JP2015518009A (ja) | 2015-06-25 |
| BR112014029718A2 (pt) | 2017-06-27 |
| US9796716B2 (en) | 2017-10-24 |
| CN104379586A (zh) | 2015-02-25 |
| RU2014145285A (ru) | 2016-07-20 |
| CN104379586B (zh) | 2018-01-16 |
| RU2678767C2 (ru) | 2019-02-01 |
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