KR20190043147A - 상처의 상태를 결정하는 방법 - Google Patents
상처의 상태를 결정하는 방법 Download PDFInfo
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- KR20190043147A KR20190043147A KR1020197007448A KR20197007448A KR20190043147A KR 20190043147 A KR20190043147 A KR 20190043147A KR 1020197007448 A KR1020197007448 A KR 1020197007448A KR 20197007448 A KR20197007448 A KR 20197007448A KR 20190043147 A KR20190043147 A KR 20190043147A
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/0094—Plasters containing means for sensing physical parameters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
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- Wood Science & Technology (AREA)
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- Sustainable Development (AREA)
- Materials For Medical Uses (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
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| GB1614053.5 | 2016-08-17 | ||
| GBGB1614053.5A GB201614053D0 (en) | 2016-08-17 | 2016-08-17 | Determining the condition of a wound |
| PCT/GB2017/052435 WO2018033739A1 (en) | 2016-08-17 | 2017-08-17 | Determining the condition of a wound |
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| EP (1) | EP3490514B1 (https=) |
| JP (1) | JP7089294B2 (https=) |
| KR (1) | KR20190043147A (https=) |
| CN (1) | CN109561993B (https=) |
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| WO (1) | WO2018033739A1 (https=) |
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| EP3806790B1 (en) * | 2018-06-15 | 2023-06-07 | Coloplast A/S | Data collection schemes for a wound dressing and related methods |
| US20220072217A1 (en) * | 2018-12-21 | 2022-03-10 | Systagenix Wound Management, Limited | Wound dressing material for visual indication of wound protease activity |
| CN113660899B (zh) * | 2019-04-01 | 2024-05-14 | 吉温成象有限公司 | 体内免疫测定系统 |
| BE1028324B1 (nl) * | 2020-05-19 | 2021-12-22 | Rousselot | Ge(meth)acryleerd gelatine laag in endotoxines |
| CN112779777A (zh) * | 2021-01-04 | 2021-05-11 | 陕西科技大学 | 乙烯基胶原蛋白微球/聚酰胺纤维复合材料的制备方法 |
| CN117131941B (zh) * | 2023-08-29 | 2026-01-27 | 山东新一代信息产业技术研究院有限公司 | 一种基于ChatGLM2的关怀机器人对话方法、装置和介质 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5936035A (en) * | 1988-11-21 | 1999-08-10 | Cohesion Technologies, Inc. | Biocompatible adhesive compositions |
| US5466567A (en) * | 1994-10-28 | 1995-11-14 | Eastman Kodak Company | Imaging element comprising an electrically-conductive layer containing conductive fine particles, a film-forming hydrophilic colloid and pre-crosslinked gelatin particles |
| GB2323166B (en) * | 1997-03-12 | 2001-04-11 | Johnson & Johnson Medical | Method and apparatus for mapping the condition of a wound |
| GB0025084D0 (en) * | 2000-10-13 | 2000-11-29 | Cambridge Meditech | Improvements in detection |
| US6474235B2 (en) * | 2001-01-02 | 2002-11-05 | Eastman Kodak Company | Method of preparing a lithographic plate |
| US20030119073A1 (en) * | 2001-12-21 | 2003-06-26 | Stephen Quirk | Sensors and methods of detection for proteinase enzymes |
| JP2005528887A (ja) * | 2002-01-31 | 2005-09-29 | エクスプレッシブ コンストラクツ，インコーポレイテッド | 微生物の検出方法 |
| US20040126897A1 (en) * | 2002-12-19 | 2004-07-01 | 3M Innovative Properties Company | Colorimetric sensors constructed of diacetylene materials |
| CN1525173A (zh) * | 2003-02-27 | 2004-09-01 | 重庆金标生物技术有限公司 | 杀虫晶体蛋白BT-Cry1Ab/1Ac快速检测试条 |
| CN1902494B (zh) | 2003-11-03 | 2010-10-27 | 伊西康公司 | 用于检测广谱细菌的方法、肽和生物传感器 |
| GB2418145A (en) * | 2004-09-17 | 2006-03-22 | Ethicon Inc | Wound treatment system |
| GB2437311A (en) * | 2006-04-07 | 2007-10-24 | Mologic Ltd | A protease detection product |
| CA2671872A1 (en) * | 2006-12-07 | 2008-06-12 | University Of Florida Research Foundation, Inc. | Materials and methods for efficient and accurate detection of analytes |
| BRPI0718328A2 (pt) * | 2006-12-15 | 2011-10-11 | Lifebond Ltd | composição, curativo hemostático e dispositivo médico para a inserção em um corpo de um ser humano ou de um mamìfero inferior |
| US7935538B2 (en) * | 2006-12-15 | 2011-05-03 | Kimberly-Clark Worldwide, Inc. | Indicator immobilization on assay devices |
| US7897360B2 (en) * | 2006-12-15 | 2011-03-01 | Kimberly-Clark Worldwide, Inc. | Enzyme detection techniques |
| GB2452076A (en) * | 2007-08-23 | 2009-02-25 | Mologic Ltd | Detection of enzymes by detecting binding of substrate recognition molecules to modified substrates |
| GB2454672A (en) * | 2007-11-13 | 2009-05-20 | Mologic Ltd | Chromogenic protease substrates |
| CN101452000A (zh) * | 2008-12-30 | 2009-06-10 | 扬州大学 | 快速检测牛γ干扰素的试剂条及其制备方法 |
| US20110171749A1 (en) * | 2009-03-02 | 2011-07-14 | Board Of Trustees Of Michigan State University | Nanoparticle tracer-based electrochemical dna sensor for detection of pathogens-amplification by a universal nano-tracer (aunt) |
| US9046518B2 (en) * | 2009-04-09 | 2015-06-02 | Hitachi Chemical Company, Ltd. | Detector and detection method |
| CA2897844A1 (en) * | 2009-12-04 | 2011-06-09 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with sample compressor |
| FR2954911A1 (fr) * | 2010-01-04 | 2011-07-08 | Commissariat Energie Atomique | Procede de detection d'un analyte dans un fluide corporel |
| JP2013544361A (ja) * | 2010-11-23 | 2013-12-12 | ケーシーアイ ライセンシング インク | バイオマーカーを用いた創傷の診断及び治療用の装置及び方法 |
| EP2671081A2 (en) * | 2011-01-31 | 2013-12-11 | Systagenix Wound Management IP Co. BV. | Wound prognosis |
| WO2012171922A1 (en) * | 2011-06-14 | 2012-12-20 | Lantor (Uk) Limited | Diagnostic device |
| WO2013016114A2 (en) * | 2011-07-22 | 2013-01-31 | Rapid Pathogen Screening, Inc. | Enzymatic cleavage based lateral flow assays |
| US20140322722A1 (en) * | 2011-09-30 | 2014-10-30 | The Research Institute At Nationwide Children's Hospital | Compositions and methods for detection of defensins in a patient sample |
| GB201206976D0 (en) * | 2012-04-20 | 2012-06-06 | Mologic Ltd | An enzyme detection device |
| WO2014005138A1 (en) * | 2012-06-29 | 2014-01-03 | Kerschensteiner Daniel A | Colorimetric gelatinase assay |
| CN102879583B (zh) * | 2012-09-21 | 2014-11-19 | 任建东 | 一种快速诊断胰腺创伤和急性胰腺炎的测试卡 |
| WO2014125237A1 (en) * | 2013-02-12 | 2014-08-21 | Microarray Limited | Novel biosensor |
| JP6080164B2 (ja) * | 2013-10-02 | 2017-02-15 | 古河電気工業株式会社 | 蛍光標識粒子 |
| CA2955420A1 (en) * | 2014-07-17 | 2016-01-21 | Daniel A. Kerschensteiner | Preparation of stabilizer-free gold sols and their configuration into a gelatin-coated protease-indicating homogeneous (one step) assay |
| US20160069884A1 (en) * | 2014-09-09 | 2016-03-10 | The Johns Hopkins University | Biomarkers for distinguishing between aggressive prostate cancer and non-aggressive prostate cancer |
| GB201502350D0 (en) * | 2015-02-12 | 2015-04-01 | Microarray Ltd | Determining the condition of a wound |
| RU160017U1 (ru) * | 2015-10-01 | 2016-02-27 | Федеральное государственное бюджетное учреждение "Российской научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Минздрава России ФГБУ "РНЦ "ВТО" им. акад. Г.А. Илизарова" Минздрава России | Термочувствительный пластырь |
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2017
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| Publication number | Publication date |
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| GB201614053D0 (en) | 2016-09-28 |
| JP7089294B2 (ja) | 2022-06-22 |
| EP3490514A1 (en) | 2019-06-05 |
| ES2847158T3 (es) | 2021-08-02 |
| AU2017313387A1 (en) | 2019-02-07 |
| JP2019526326A (ja) | 2019-09-19 |
| RU2019107481A3 (https=) | 2020-11-23 |
| CN109561993A (zh) | 2019-04-02 |
| AU2017313387B2 (en) | 2022-01-20 |
| US20200397619A1 (en) | 2020-12-24 |
| CN109561993B (zh) | 2022-05-10 |
| EP3490514B1 (en) | 2021-01-06 |
| DK3490514T3 (da) | 2021-04-06 |
| CA3031310A1 (en) | 2018-02-22 |
| WO2018033739A1 (en) | 2018-02-22 |
| RU2749326C2 (ru) | 2021-06-08 |
| RU2019107481A (ru) | 2020-09-21 |
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