KR20180122397A - TGFβ1-결합 이뮤노글로불린 및 그의 용도 - Google Patents

TGFβ1-결합 이뮤노글로불린 및 그의 용도 Download PDF

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KR20180122397A
KR20180122397A KR1020187028835A KR20187028835A KR20180122397A KR 20180122397 A KR20180122397 A KR 20180122397A KR 1020187028835 A KR1020187028835 A KR 1020187028835A KR 20187028835 A KR20187028835 A KR 20187028835A KR 20180122397 A KR20180122397 A KR 20180122397A
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antibody
tgf
beta
complex
antigen
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Korean (ko)
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토마스 슈르프
그레고리 제이. 카르벤
아비셰크 다타
킴벌리 롱
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스칼러 락, 인크.
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Application filed by 스칼러 락, 인크. filed Critical 스칼러 락, 인크.
Priority to KR1020237018780A priority Critical patent/KR20230088508A/ko
Publication of KR20180122397A publication Critical patent/KR20180122397A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020187028835A 2016-03-11 2017-03-10 TGFβ1-결합 이뮤노글로불린 및 그의 용도 Ceased KR20180122397A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237018780A KR20230088508A (ko) 2016-03-11 2017-03-10 TGFβ1-결합 이뮤노글로불린 및 그의 용도

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662307353P 2016-03-11 2016-03-11
US62/307,353 2016-03-11
US201762443615P 2017-01-06 2017-01-06
US62/443,615 2017-01-06
US201762452866P 2017-01-31 2017-01-31
US62/452,866 2017-01-31
PCT/US2017/021972 WO2017156500A1 (en) 2016-03-11 2017-03-10 Tgfb1-binding immunoglobulins and use thereof

Related Child Applications (1)

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KR1020237018780A Division KR20230088508A (ko) 2016-03-11 2017-03-10 TGFβ1-결합 이뮤노글로불린 및 그의 용도

Publications (1)

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KR20180122397A true KR20180122397A (ko) 2018-11-12

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KR1020187028835A Ceased KR20180122397A (ko) 2016-03-11 2017-03-10 TGFβ1-결합 이뮤노글로불린 및 그의 용도
KR1020257001174A Pending KR20250011248A (ko) 2016-03-11 2017-03-10 TGFβ1-결합 이뮤노글로불린 및 그의 용도
KR1020237018780A Ceased KR20230088508A (ko) 2016-03-11 2017-03-10 TGFβ1-결합 이뮤노글로불린 및 그의 용도

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KR1020257001174A Pending KR20250011248A (ko) 2016-03-11 2017-03-10 TGFβ1-결합 이뮤노글로불린 및 그의 용도
KR1020237018780A Ceased KR20230088508A (ko) 2016-03-11 2017-03-10 TGFβ1-결합 이뮤노글로불린 및 그의 용도

Country Status (19)

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US (2) US11643459B2 (https=)
EP (2) EP3365368B1 (https=)
JP (4) JP2019509737A (https=)
KR (3) KR20180122397A (https=)
CN (1) CN109071646A (https=)
AU (2) AU2017230103A1 (https=)
BR (1) BR112018068340A2 (https=)
CA (1) CA3055555A1 (https=)
DK (1) DK3365368T3 (https=)
EA (1) EA201891909A1 (https=)
ES (1) ES2951648T3 (https=)
FI (1) FI3365368T3 (https=)
HU (1) HUE062976T2 (https=)
IL (2) IL307835A (https=)
MX (2) MX2018010948A (https=)
PL (1) PL3365368T3 (https=)
PT (1) PT3365368T (https=)
SG (1) SG11201807176XA (https=)
WO (1) WO2017156500A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210039328A (ko) * 2019-08-28 2021-04-09 추가이 세이야쿠 가부시키가이샤 종교차성 항잠재형 TGF-β1 항체 및 사용 방법
KR20220007118A (ko) * 2019-06-10 2022-01-18 샨동 보안 바이오테크놀로지 컴퍼니, 리미티드 PDL1 및 TGFβ에 대한 2기능성 융합 단백질 및 이의 용도

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
KR20220007118A (ko) * 2019-06-10 2022-01-18 샨동 보안 바이오테크놀로지 컴퍼니, 리미티드 PDL1 및 TGFβ에 대한 2기능성 융합 단백질 및 이의 용도
KR20210039328A (ko) * 2019-08-28 2021-04-09 추가이 세이야쿠 가부시키가이샤 종교차성 항잠재형 TGF-β1 항체 및 사용 방법
KR20220043930A (ko) * 2019-08-28 2022-04-05 추가이 세이야쿠 가부시키가이샤 종교차성 항잠재형 TGF-β1 항체 및 사용 방법

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