KR20180119582A - 라이실 옥시다제의 인돌 및 아자인돌 할로알릴아민 유도체 억제제 및 이의 용도 - Google Patents

라이실 옥시다제의 인돌 및 아자인돌 할로알릴아민 유도체 억제제 및 이의 용도 Download PDF

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KR20180119582A
KR20180119582A KR1020187024804A KR20187024804A KR20180119582A KR 20180119582 A KR20180119582 A KR 20180119582A KR 1020187024804 A KR1020187024804 A KR 1020187024804A KR 20187024804 A KR20187024804 A KR 20187024804A KR 20180119582 A KR20180119582 A KR 20180119582A
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cycloalkyl
halogen
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앨리슨 도로시 핀드레이
크레이그 이반 터너
만다르 데오드하
조나단 스튜어트 풋
울프강 자로리맥
웬빈 조우
알란 던컨 로버트슨
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파맥시스 엘티디
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KR1020187024804A 2016-02-12 2017-02-10 라이실 옥시다제의 인돌 및 아자인돌 할로알릴아민 유도체 억제제 및 이의 용도 Withdrawn KR20180119582A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2016900478A AU2016900478A0 (en) 2016-02-12 Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
AU2016900478 2016-02-12
AU2016902593 2016-07-01
AU2016902593A AU2016902593A0 (en) 2016-07-01 Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
PCT/AU2017/000040 WO2017136871A1 (en) 2016-02-12 2017-02-10 Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof

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KR1020187024805A Active KR102742235B1 (ko) 2016-02-12 2017-02-10 라이실 옥시다제의 할로알릴아민 인돌 및 아자인돌 유도체 억제제 및 이의 용도

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201806700RA (en) * 2016-02-12 2018-09-27 Pharmaxis Ltd Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
CN110709385A (zh) * 2017-03-02 2020-01-17 法玛西斯有限公司 赖氨酰氧化酶的卤代烯丙胺吡唑衍生物抑制剂及其用途
GB201716871D0 (en) 2017-10-13 2017-11-29 Inst Of Cancer Research: Royal Cancer Hospital Compounds
CN110605143B (zh) * 2017-10-27 2022-07-19 苏州大学 有机铁盐作为催化剂在合成烷基硼酯化合物中的应用
TW201940483A (zh) 2018-03-12 2019-10-16 美商艾伯維有限公司 酪胺酸激酶2介導的傳訊之抑制劑
KR20190110740A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR20190110736A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
AR115906A1 (es) 2018-08-03 2021-03-10 Pharmaxis Ltd Derivados de haloalilamina sulfona como inhibidores de lisil oxidasas
TWI835945B (zh) 2018-12-14 2024-03-21 南韓商柳韓洋行股份有限公司 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物
TW202039486A (zh) 2018-12-14 2020-11-01 南韓商柳韓洋行股份有限公司 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物
WO2020146639A2 (en) * 2019-01-11 2020-07-16 Viscient Biosciences, Inc. Compositions and methods for the diagnosis and treatment of diseases of the liver
WO2020161209A1 (en) 2019-02-06 2020-08-13 Syngenta Crop Protection Ag Herbicidal fused pyridazine compounds
WO2020161208A1 (en) 2019-02-06 2020-08-13 Syngenta Crop Protection Ag Herbicidal fused pyridazine compounds
MX2022001031A (es) * 2019-07-25 2022-02-23 Pharmaxis Ltd Inhibidores derivados de difluorohaloalilamina-sulfona de lisil-oxidasas, metodos de preparacion y usos de los mismos.
JP7629442B2 (ja) 2019-07-29 2025-02-13 ヘパリジェニックス ゲーエムベーハー 肝臓再生を促進または肝細胞死を縮減もしくは防止するためのヘテロアリール置換ピラゾロ-ピリジンタンパク質キナーゼ阻害剤
CA3164361A1 (en) 2020-01-15 2021-07-22 Heparegenix Gmbh 3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as mkk4 inhibitors for treating liver diseases
WO2021155439A1 (en) * 2020-02-05 2021-08-12 Pharmaxis Ltd. Bioprobes for lysyl oxidases and uses thereof
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
EP4173639A4 (en) 2020-06-26 2024-03-13 RaQualia Pharma Inc. METHOD FOR SELECTING A CANCER PATIENT FOR WHICH COMBINATION THERAPY OF A RETINOID AND A CANCER TREATMENT AGENT WILL BE EFFECTIVE, AND COMBINATION DRUG OF A RETINOID AND A CANCER TREATMENT AGENT
JP7384138B2 (ja) * 2020-09-30 2023-11-21 株式会社島津製作所 電気泳動装置
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
US12686665B2 (en) 2021-10-01 2026-07-21 Yuhan Corporation Bicyclic fused ring derivative or salt thereof and pharmaceutical composition comprising same
US12233056B2 (en) 2022-04-06 2025-02-25 Syntara Limited Lysyl oxidase inhibitors for treating myeloid malignancies
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
IL321907A (en) * 2023-01-09 2025-09-01 Univ Florida pparg modulators
CN117069611A (zh) * 2023-07-12 2023-11-17 浙江工业大学 一种1-(2,4,6-三氯苯基)丙-2-酮o-甲基肟的制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4454158A (en) 1981-06-01 1984-06-12 Merrell Toraude Et Compagnie Allyl amine MAO inhibitors
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4699928A (en) 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
US5182297A (en) 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5059714A (en) 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4943593A (en) 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5021456A (en) 1988-02-25 1991-06-04 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4965288A (en) 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5252608A (en) 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4997854A (en) 1989-08-25 1991-03-05 Trustees Of Boston University Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates
AU2003259965A1 (en) 2002-08-20 2004-03-11 Neurogenetics, Inc. Methods and compositions for modulating amyloid beta
WO2007005737A2 (en) * 2005-07-01 2007-01-11 Case Western Reserve University Amine oxidase inhibitors
US20070293548A1 (en) 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
US20080293936A1 (en) * 2007-05-23 2008-11-27 Elmar Reinhold Burchardt Novel inhibitors of lysyl oxidase
AU2014200520A1 (en) * 2007-08-02 2014-02-20 Gilead Biologics, Inc. Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
CA2693310C (en) 2007-08-02 2018-11-27 Arresto Biosciences, Inc. Lox and loxl2 inhibitors, antibodies and uses thereof
WO2009062118A2 (en) * 2007-11-07 2009-05-14 Foldrx Pharmaceuticals, Inc. Modulation of protein trafficking
US8426587B2 (en) * 2007-11-21 2013-04-23 Pharmaxis Ltd. Haloallylamine inhibitors of SSAO/VAP-1 and uses therefor
JP2012521429A (ja) * 2009-03-23 2012-09-13 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛治療用のp2x3受容体アンタゴニスト
WO2011022670A1 (en) 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vivo screening assays
US8841463B2 (en) 2011-02-11 2014-09-23 Glaxosmithkline Intellectual Property Development Limited Cathepsin C inhibitors
CA2871793C (en) * 2012-05-02 2020-09-15 Pharmaxis Ltd. Substituted 3-haloallylamine inhibitors of ssao and uses thereof
RU2732416C2 (ru) * 2014-07-31 2020-09-16 Институт Пастер Корея Производные 2-амино-бензимидазола и их использование в качестве ингибиторов 5-липоксигеназы и/или простагландин е-синтазы
SG11201806700RA (en) 2016-02-12 2018-09-27 Pharmaxis Ltd Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof

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