KR20180091311A - Composition for Respiratory Symptoms Containing Red Ginseng Extract - Google Patents

Abstract

The present invention relates to a composition for alleviating respiratory symptoms containing a red ginseng extract and a plant mixed extract. The composition comprising a red ginseng extract, an Angelica gigas extract, a Liriope muscari extract, an Astragalus membranaceus extract, a Xanthium strumarium extract and a Ulmus davidiana extract has the effect of alleviating the symptoms of respiratory symptoms such as stuffiness, dryness, and thirstiness. Therefore, the composition of the present invention can be used for preparation of a health food composition for alleviating respiratory symptoms.

Description

Technical Field [0001] The present invention relates to a composition for reducing respiratory symptoms containing red ginseng extract,

The present invention relates to a composition for improving respiratory symptoms containing red ginseng extract.

The respiratory tract is collectively referred to the respiratory organs and includes the nasal cavity, pharynx, larynx, trachea, bronchus and lung. Throat and bronchial pains appear to be ugly or stingy for a variety of reasons. Major causes include overwork, fatigue, yellow dust, and sudden weather changes such as the season of change. In the case of bronchial diseases, it is desirable to improve early when symptoms appear because it interferes with sleeping and becomes more severe as an allergic disease depending on the living environment. In general, neck pain is accompanied by nose and general fatigue, so it is necessary to study the raw materials that can alleviate the pain of the neck while relieving fatigue.

As an example of treating respiratory diseases, Patent Document 1 discloses a method for treating respiratory diseases such as Staphylococcus, Moraxella, Klebsiella, Streptococcus, and Haemophilus Techniques using bacterial strains derived extracts have been disclosed. In addition, to relieve the pain of the neck, traditional treatments were to boil muna and boats. However, there was a difference in the degree of improvement in treatment for each person, and research was needed on the raw materials showing the same effect on many people, although the improvement on the neck pain was excellent.

Ginseng is a herb medicine in ginseng and ginseng, and red ginseng is produced by steaming and drying ginseng roots. Ginseng contains amino acids, vitamins, organic acids, carbohydrates and various minerals. It is known as an excellent herb to prevent and cure tonic effects, relieve thirst, strengthen immune function, blood pressure, diabetes and various diseases.

The present inventors have studied whether compositions containing red ginseng and herbal medicines can improve the frigidity of the neck, dryness, chalking, and the like. The composition containing red ginseng, angelica gigantis, mangmundong, hwanggi, It was confirmed that the effect of restoring fatigue was improved while improving neck pain in all.

Korea Patent No. 1527483

It is an object of the present invention to provide a composition for improving respiratory symptoms.

In order to solve the above problems, the present invention provides a pharmaceutical composition for preventing or treating respiratory symptoms, which comprises a mixed extract of red ginseng extract, angelica gigantis extract, mungumun dong extract, hwanggi extract, ganoderma extract and rhizome extract.

In addition, the present invention provides a health food composition for improving respiratory symptoms, comprising a mixed extract of red ginseng extract, angelica guinea extract, mungumun dong extract, hwanggi extract, chrysanthemum extract and rhizome extract.

The composition for improving respiratory symptoms of the present invention has the effect of improving symptoms such as dryness, dryness, and chalking of the neck.

Fig. 1 shows the overall neck condition after ingestion of the composition for improving respiratory symptoms of the present invention.
Fig. 2 shows the degree of improvement of the neck / bronchial related symptoms after ingesting the composition for improving respiratory symptoms of the present invention.
FIG. 3 shows the improvement rate of neck / bronchial-related symptoms after ingesting the composition for improving respiratory symptoms of the present invention.
FIG. 4 shows the degree of improvement and the degree of improvement according to the symptoms of the non-smokers after ingesting the composition for improving respiratory symptoms of the present invention.
FIG. 5 shows the degree of improvement and the degree of improvement according to symptoms of smokers after intake of the composition for improving respiratory symptoms of the present invention.
FIG. 6 shows the degree of improvement and the degree of improvement of symptoms for the elderly group after ingestion of the composition for improving respiratory symptoms of the present invention.

First, terms used in the present invention will be described.

As used herein, the term " prevention " means prevention of respiratory symptoms and can be understood as a broad concept including prevention, treatment, mitigation and the like.

"Improvement ", as used herein, can be understood as a broad concept which means treating respiratory symptoms and restoring them to their original state.

The term " respiratory symptom "used herein refers to a pain or foreign body sensation appearing in the respiratory tract and can be understood as including all the abnormal symptoms appearing in the nose, throat, sinus, bronchus and lung included in the respiratory system.

Hereinafter, the present invention will be described in detail.

The present invention provides a pharmaceutical composition for preventing or treating respiratory symptoms, which comprises a mixed extract of red ginseng extract, angelica gigantis extract, mungmun dong extract, hwanggi extract, chrysanthemum extract and rhizome extract.

The extract may be obtained by extracting from a raw material or a dried product thereof, and the raw material may be cultivated or commercially available.

When the extract is obtained by extracting from the raw material, any conventional extraction methods known in the art such as a solvent extraction method, an ultrasonic extraction method, a filtration method and a reflux extraction method may be used as the extraction method. Preferably, the extraction method or the reflux extraction method can do. The extraction process can be repeated several times, and then the step such as concentration or freeze-drying can be further roughened. Specifically, the obtained extract is concentrated under reduced pressure to obtain a concentrated liquid, the concentrated liquid is lyophilized, and a concentrated powder can be produced using a pulverizer.

The extract can be extracted with water, an organic solvent or a mixture thereof as an extraction solvent. The organic solvent may be at least one selected from the group consisting of alcohols, preferably C 1 -C 4 alcohols, hexane (n-hexane), ether, glycerol, propylene glycol, butylene glycol, ethyl acetate, methyl acetate, dichloromethane, chloroform, ethyl acetate, Lt; / RTI >

The above-mentioned mixed extract may be a mixture of red ginseng, angelica gingiva, ginseng, mulberry, hwanggi, ganja, and yugi, or may be mixed after obtaining an extract from each raw material.

The extract of Angelica keiskei koidz. Extract is used in an amount of 0.6 to 0.1 parts by weight, the extract of Angelica keiskei koidzaiensis extract is used in an amount of 0.6 to 0.1 parts by weight, 0.6 to 0.1 part by weight. If it is contained below the lower limit value, the respiratory symptoms may not be improved. If it exceeds the upper limit value, the taste of the composition changes, for example, the bitter taste becomes stronger or the neck turn is not smooth.

In one embodiment of the present invention, the red ginseng concentrate is contained in an amount of 6 parts by weight, the Angelica gigantis concentrate is 0.36 parts by weight, the Mukumundong concentrate is 0.36 parts by weight, the Hwanggak concentrate is 0.6 part by weight, the Chrysantia concentrate is 0.34 part by weight, (1) to (6) of the present invention, the symptoms such as dryness, dryness, chalking and tingling of the neck, which is respiratory symptom, were remarkably improved as a result of ingesting 50 ml / .

Respiratory symptoms may include, but are not limited to, one or more selected from the group consisting of stiffness of the neck, dryness of the neck, sagging of the neck, throat and neck tingling. Examples of respiratory symptoms that can be improved by applying the composition of the present invention include one-shot (throat), cough (sneezing), boiling of the sputum, sore throat, vomiting and rhinitis.

The composition of the present invention may be ingested in combination with a known compound or extract having an effect of improving or treating respiratory symptoms.

The amount of the composition according to the present invention may be 10 ml / day to 200 ml / day, 20 ml / day to 170 ml / day, 30 ml / day to 150 ml / have. In case of ingesting below the lower limit value, respiratory symptoms may not be improved. If ingested in excess of the upper limit value, the herbal medicines contained in the composition of the present invention are consumed in an excessive amount, which may cause side effects.

The composition according to the present invention may be ingested for 1 to 3 months, preferably 15 to 1 month, but is not limited thereto and can be taken for a long term to improve symptoms.

In one embodiment of the present invention, the composition of the present invention was ingested at a dose of 50 ml / day for 1 month, and it was found that symptoms such as stiffness, dryness, dryness, and tingling of the neck of the bronchial symptom were remarkably improved 1 to 6).

The pharmaceutical composition of the present invention may further contain, in addition to the above-mentioned mixed extract, other ingredients which can give a synergistic effect to the effect of the above-mentioned mixed extract within a range that does not impair the objective effect of the present invention have. For example, conventional adjuvants such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavoring agents, or carriers.

The route of administration of the pharmaceutical composition may be oral, intravenous, intramuscular, intraarterial, transdermal, subcutaneous, intraperitoneal, intranasal, intestinal, topical, sublingual or rectal, for example topical application by application, . ≪ / RTI > The parenteral route includes subcutaneous, intradermal, intravenous, intramuscular, intralesional injection or infusion techniques.

The pharmaceutical composition may contain at least one active ingredient which exhibits the same or similar function in addition to the mixed extract. The compositions may be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, oral preparations, external preparations, suppositories and sterilized injection solutions according to a conventional method.

Solid form preparations for oral administration include powders, granules, tablets, capsules, soft capsules, and the like. Liquid preparations for oral administration include suspensions, solutions, emulsions, syrups and the like. Various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included in addition to water and liquid paraffin, which are simple diluents commonly used. have. As the agent for parenteral administration, the external preparation such as powders, granules, tablets, capsules, sterilized aqueous solutions, liquid preparations, non-aqueous solutions, suspensions, emulsions, syrups, suppositories and aerosols, The composition may be formulated in the form of a cream, a gel, a patch, a spray, an ointment, a warning agent, a lotion, a liniment, a pasta or a cataplasma, , But is not limited thereto. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. As a base for suppositories, witepsol, macrogol, tween 61, cacao paper, laurin, glycerogelatin and the like can be used.

Such compositions may additionally contain preservatives, stabilizers, wettable or emulsifying accelerators, adjuvants such as salts and / or buffers for the control of osmotic pressure, and other therapeutically useful substances and may be prepared by conventional methods of mixing, It can be formulated according to the coating method.

The dosage of the pharmaceutical composition may vary depending on various factors including the age, body weight, general health, sex, administration time, route of administration, rate of excretion, drug combination and severity of the specific disease. In addition, the pharmaceutical composition of the present invention can be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, and biological response modifiers. The pharmaceutical composition may be administered at a dose within the range of 0.001 to 100 mg / kg on an adult basis. When the pharmaceutical composition is an external preparation, it may be administered once to 5 It is preferable to apply it for one month or longer, but the dose does not limit the scope of the present invention.

When the pharmaceutical composition is formulated in a unit dose form, it is preferable that the mixed extract of the present invention is contained as an active ingredient in a unit dose of about 0.01 to 1,500 mg, And a range of about (1 to 500) mg per day, depending on the strength, but is not limited thereto, and in some patients a higher daily dose may be desirable.

In addition, the present invention provides a health food composition for improving respiratory symptoms, comprising a mixed extract of red ginseng extract, angelica guinea extract, mungumun dong extract, hwanggi extract, chrysanthemum extract and rhizome extract.

The health food composition of the present invention may further include known natural substances or compounds known to have health improving effects in addition to those enumerated above.

For example, the composition of the present invention may contain a sweetener, a flavoring agent, a physiologically active ingredient, a mineral, a processing aid, and the like in addition to the mixed extract.

Sweeteners may be used in an amount such that the sweetness of the food is adequate and may be natural or synthetic. Preferably, natural sweeteners are used. Natural sweeteners include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.

Flavors may be used to improve taste or aroma, and may be used in combination with natural products. Preferably, a natural product is used. When natural products are used, nutritional fortification can be performed in addition to flavor. Natural flavors include those obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or those obtained from green tea leaves, Asiatica, Daegu, Cinnamon, Chrysanthemum leaves and Jasmine. Also, those obtained from bamboo shoots, aloe vera, banks and the like can be used. The natural flavoring agent may be a liquid concentrate or a solid form of extract. Synthetic flavoring agents may be used depending on the case, and synthetic flavoring agents such as esters, alcohols, aldehydes and terpenes may be used.

Examples of the physiologically active substance include catechins such as catechin, epicatechin, gallocatechin and epigallocatechin, and vitamins such as retinol, ascorbic acid, tocopherol, calciferol, thiamin, and riboflavin.

As the minerals, calcium, magnesium, chromium, cobalt, copper, fluoride, germanium, iodine, iron, lithium, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, .

In addition, the composition of the present invention may contain a preservative, an emulsifying agent, an acidifier, and the like in addition to the above sweetener.

Such preservatives, emulsifiers and the like are preferably added in a very small amount as long as they can attain an application to which they are added. The term " trace amount " means, when expressed numerically, in the range of 0.0005% by weight to about 0.5% by weight based on the total weight of the food composition.

Preservatives that can be used include calcium sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, and EDTA (ethylenediamine tetraacetic acid).

Examples of the emulsifying agent that can be used include acacia gum, carboxymethyl cellulose, xanthan gum, pectin and the like.

Examples of the acidulant that can be used include citric acid, malic acid (malic acid), fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, and phosphoric acid. Such an acidulant may be added so that the food composition has a proper acidity for the purpose of inhibiting the growth of microorganisms other than the purpose of enhancing the taste.

The health food composition of the present invention can be used as health food itself, or it can be contained in food or beverage. When the composition of the present invention is contained in other foods or beverages, it may be added in a form that is easily added by adding a concentration process or a powdering process separately. Foods to which the composition of the present invention can be added include various foods such as beverages, gums, tea, vitamin complexes and health supplements, and they are in the form of pills, powders, granules, infusions, tablets, Can be used.

Hereinafter, the present invention will be described in detail with reference to Production Examples and Examples.

However, the following Preparation Examples and Examples are for illustrating the present invention, and the content of the present invention is not limited by the following Production Examples and Examples.

Preparation Example 1: Preparation of Angelica gigas Daiwai extract

To 1 kg of Angelica gigas , purified water was added 5 to 10 times by weight and then extracted at 95 ° C for 2 to 3 hours. The mixture was centrifuged at low temperature and concentrated under reduced pressure to obtain 200 to 400 g of Angelica gigas concentrate.

≪ Preparation Example 2 >

To 1kg of Liriope muscari , purified water was added 5 ~ 10 times by weight and then extracted at 95 ℃ for 2 ~ 3 hours. Then, it was centrifuged at low temperature and concentrated under reduced pressure to obtain 200 ~ 400g of concentrated liquid.

≪ Preparation Example 3 > Preparation of Hwanggi extract

To 1kg of Astragalus membranaceus , purified water was added at a ratio of 5 to 10 times by weight, and then extracted at 95 ° C for 2 to 3 hours. The mixture was centrifuged at a low temperature and concentrated under reduced pressure to obtain 200~400 g of Hwanggi concentrate.

≪ Preparation Example 4 >

To 1 kg of Xanthium strumarium , purified water was added 5 to 10 times by weight, and then extracted at 95 ° C for 2 to 3 hours. Then, the mixture was centrifuged at low temperature and concentrated under reduced pressure to obtain 200 ~ 400g of concentrated concentrate.

≪ Preparation Example 5 >

1 kg of Ulmus davidiana was weighed 5 to 10 times as much as the weight of water and then extracted at 95 ° C for 2 to 3 hours. The mixture was centrifuged at a low temperature and then concentrated under reduced pressure to obtain 200 ~ 400 g was obtained.

≪ Preparation Example 6 > Preparation of red ginseng concentrate

To 1kg of red ginseng, purified water was added at a ratio of about 10 times by weight. The mixture was extracted 5 ~ 10 times at 70 ~ 90 ℃, centrifuged at low temperature and concentrated under reduced pressure to obtain 200 ~ 500g of red ginseng concentrate.

Preparation Example 7 Preparation of Plant Mixed Concentrate

Each of the extracts obtained in Production Examples 1 to 5 was blended in the ratio shown in Table 1 below to prepare a plant-mixed concentrate.

concentrate Content (% by weight) Angelica 18 McMundong 18 Hwanggi 30 Window 17 Yugunpi 17

<Preparation Example 8> Preparation of composition for improving bronchial health including red ginseng and plant mixed extract

The composition for improving bronchial health was prepared from the extract of Preparation Example 5 and the plant mixture extract of Preparation Example 7 at the ratios shown in Table 2 below.

Raw materials Content (% by weight) Red ginseng concentrate 6 Plant mixed concentrate 2 Agave syrup 9.3 Concentrate 3 Jujube concentrate 3 Fructooligosaccharide One Cyclodextrin syrup 0.8 Ginger syrup concentrate 0.5 Taurine 0.5 Cyclodextrin 0.35 pectin 0.35 Herbal extract 0.31 Bellflower concentrate 0.2 Elder extract 0.1 Glycine 0.03 Antler extract 0.03 Mushroom extract powder 0.03 Vitamin B6 hydrochloride 0.0005 Vitamin B1 hydrochloride 0.0003 Vitamin B2 Phosphate Ester Sodium 0.0003 Purified water Suitable amount

<Example 1> Confirmation of bronchodilating effect

The bronchial improvement effect of the composition prepared in Preparation Example 8 was confirmed. A total of 120 participants participated in the confirmation of efficacy. There were 40 non - smokers, 40 smokers and 40 elderly people. Before drinking the composition of Preparation Example 8, a questionnaire about the respiratory condition such as the neck and bronchus was prepared and it was drunk for 1 month in the amount of 1 capsule (50 ml) per day by the HUT (Home Usage Test) method. After one month, the same questionnaire was written to confirm the improvement of respiratory condition such as neck / bronchus. The items of the questionnaire were stiffness of the neck, dryness, chalkiness, sleeping symptoms, fatigue, throat, neck tingling, one way (neck) panting, coughing (sneezing), sputum boiling, immune depression, sore throat, . Each item was scored on a 9-point scale, and overall neck health was rated as '1 point: Not at all good' to '9 points: Very good', and the degree of improvement before and after taking was recorded Item of improvement in health status &quot; in FIGS. 4 to 6). The symptom improvement rate is the percentage of respondents who have risen more than one point on the 9 point scale after the Gap (after taking / taking) among the total respondents (the 'improvement rate' item in FIG. 1 and 3 to 6). The degree of neck / bronchial symptom improvement was evaluated as "1 point: no neck / bronchial related symptoms" to "9 points: very severe symptoms related to neck / bronchus" (FIG. 2, 'Improvement by symptom level' item).

As a result of ingestion of the composition of Preparation Example 8 for 1 month, all the symptoms of the questionnaire items tended to be alleviated (Fig. 1), and the difference before and after the administration was statistically significant (Fig. 2). As shown in FIG. 2, the items such as stiffness, dryness, dryness, and lockiness of the neck were significantly improved compared to other items, especially compared to other items. Figure 3 shows the percentage of respondents who answered that the symptom was alleviated by more than one point based on the 9 point scale among the total respondents. As can be seen from FIG. 3, the composition of Production Example 8 had a symptom-alleviating effect on the neck and bronchus, and it was found that the composition of the present invention had a particularly excellent improvement effect on the knitting, stiffness and dryness of the neck.

In addition, symptoms of each questionnaire were individually identified for 40 non-smokers, 40 smokers, and 40 elderly people participating in the efficacy confirmation. The non-smokers showed a higher improvement rate in the frustration of the throat than in the other items (Fig. 4), and the degree of improvement in the smoother, drier, chewy, tingling and boiling (Fig. 5). It was found that the bronchial symptoms such as the frigidity, dryness, and boiling of the throat, which frequently occur in smokers, are improved by ingesting the composition of Production Example 8. In addition, dryness and fatigue symptoms of the neck were improved in the elderly group (Fig. 6).

From these results, it was found that the composition for improving bronchial condition of the present invention is excellent in relieving symptoms of bronchial asthma including dryness, dryness, and chalking.

<Example 2> Evaluation of taste preference

The compositions for improving bronchial symptoms were evaluated for softness of neck turn, sweet taste (cool taste), bitter taste, concentration, sweet taste and red ginseng taste. The subject of evaluation was the same as the subject of Example 1, and the score of "softness of neck turnover" was given higher score when it felt smooth, and the score of other items was higher when the taste was stronger. The evaluation results are shown in Table 3 below.

Evaluation items score Tenderness of neck 4.11 Flavor (cool taste) 3.97 bitter 3.97 density 3.89 sweetness 3.82 Red ginseng taste 3.70

As a result, the overall taste sensitivity of the compositions for improving bronchial symptoms was very high. The reason for preference is that bitterness and sweetness are appropriate, red ginseng taste is great, taste is cool, taste is soft, and favorable bitterness, sweetness and preference for sweet feeling after taking the composition are favorable It was found that they acted positively in the high evaluation.

Through Examples 1 and 2, the composition for improving bronchopathy of the present invention can be used for improving bronchial symptoms by improving bronchial symptoms including dryness, dryness, and chalkiness while satisfying the taste. .

Claims (6)

A pharmaceutical composition for the prevention or treatment of respiratory symptoms, which comprises a mixed extract of red ginseng extract, angelica guinea extract, mangumun dong extract, hwanggi extract, chrysanthemum extract and rhizome extract. The method according to claim 1,
The extract of Angelica keiskei koidz. Extract is used in an amount of 0.6 to 0.1 parts by weight, the extract of Angelica keiskei koidzaiensis extract is used in an amount of 0.6 to 0.1 parts by weight, 0.6 to 0.1 part by weight. The method according to claim 1,
Wherein the respiratory symptoms are selected from the group consisting of tightness of the neck, dryness of the neck, chalkiness of the neck, throat and neck tingling. A composition for improving respiratory symptoms, comprising a mixed extract of red ginseng extract, angelica gigantis extract, mungmun dong extract, hwanggi extract, chrysanthemum extract and rhizome extract. The method of claim 4,
The extract of Angelica keiskei koidz. Extract is used in an amount of 0.6 to 0.1 parts by weight, the extract of Angelica keiskei koidzaiensis extract is used in an amount of 0.6 to 0.1 parts by weight, 0.6 to 0.1 part by weight. The method of claim 4,
Wherein the respiratory symptoms are selected from the group consisting of stiffness of the neck, dryness of the neck, chalkiness of the neck, throat and neck tingling.

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