KR102134385B1 - Composition for Respiratory Symptoms Containing Red Ginseng Extract - Google Patents

Abstract

The present invention relates to a composition for improving respiratory symptoms containing a red ginseng extract and a mixed plant extract, wherein the composition comprising red ginseng extract, Angelica extract, Macmundong extract, Hwanggi extract, Changija extract, and Yugeunpi extract is a frustrating throat of the respiratory tract, Since it has an effect of alleviating the symptoms of dryness and deterioration, the composition of the present invention can be used to prepare a health food composition for improving respiratory symptoms.

Description

Composition for Respiratory Symptoms Containing Red Ginseng Extract containing red ginseng extract

The present invention relates to a composition for improving respiratory symptoms containing red ginseng extract.

The respiratory system refers to the organs related to breathing, and includes the nasal cavity, pharynx, larynx, trachea, bronchi, and lungs. The neck and bronchi become stuffy or stinging for a variety of reasons. The main causes include sudden weather changes such as overwork, fatigue, yellow dust, and seasonal changes. In the case of bronchial disease, it is desirable to improve early when symptoms appear because it often interferes with sleep and deepens into an allergic disease depending on the living environment. Normally, the pain in the neck is a situation in which the fatigue of the nose and the whole body is parallel, so it is necessary to study raw materials that can relieve the pain while reducing the pain in the neck.

As an example of treating respiratory diseases, Patent Document 1 includes Staphylococcus, Moraxella, Klebsiella, Streptococcus, and Haemophilus to treat respiratory diseases. Techniques using extracts derived from bacterial strains have been disclosed. In addition, in order to relieve the sore throat, there was a traditional treatment regimen for boiling radish, pear, etc. However, because there is a difference in the degree of improvement in treatment for each person, it is necessary to study raw materials that have excellent effects on neck pain and have the same effect in many people.

Ginseng is an herbal medicine of the genus Gapi and ginseng, and red ginseng is produced by steaming and drying the roots of ginseng. Since ginseng contains amino acids, vitamins, organic acids, carbohydrates, and various minerals, it is known as an herbal medicine with excellent effects in preventing and treating tonic, thirst quenching, strengthening immune function, blood pressure, diabetes, and various diseases.

The present inventors have studied whether the composition containing red ginseng and herbal medicines can improve the stuffiness, dryness, and knifeiness of the neck, and the composition containing red ginseng, Angelica, Macmundong, Hwanggi, Changgi and Yugeunpi is smoker, non-smoker, and elderly In all, it was confirmed that it exhibits an effect of restoring fatigue while improving neck pain.

Korean Registered Patent No. 1527483

An object of the present invention is to provide a composition for improving respiratory symptoms.

In order to solve the above problems, the present invention provides a pharmaceutical composition for preventing or treating respiratory symptoms, including a mixed extract consisting of red ginseng extract, Angelica extract, McMoondong extract, Hwanggi extract, Changija extract and Yugeunpi extract.

In addition, the present invention provides a health food composition for improving respiratory symptoms, including a mixed extract consisting of red ginseng extract, Angelica extract, Macmundong extract, Hwanggi extract, Changija extract, and Yugeunpi extract.

The composition for improving respiratory symptoms of the present invention has an effect of improving symptoms such as stuffiness of the neck, dryness, and knifeiness.

1 shows the overall state of neck health after ingestion of the composition for improving respiratory symptoms of the present invention.
Figure 2 shows the degree of improvement of symptoms related to the neck/bronchi after ingestion of the composition for improving respiratory symptoms of the present invention.
Figure 3 shows the rate of improvement of symptoms related to the neck/bronchi after ingestion of the composition for improving respiratory symptoms of the present invention.
Figure 4 shows the degree of improvement and the degree of improvement by symptoms for the non-smoker group after ingestion of the composition for improving respiratory symptoms of the present invention.
Figure 5 shows the degree of improvement and the degree of improvement by symptoms for the smoker group after ingestion of the composition for improving respiratory symptoms of the present invention.
Figure 6 shows the degree of improvement and rate of improvement for each symptom for the elderly group after ingestion of the composition for improving respiratory symptoms of the present invention.

First, terms used in the present invention will be described.

As used herein, "prevention" refers to preventing respiratory symptoms, and can be understood as a broad concept including prevention, treatment, and relief.

As used herein, "improvement" can be understood as a broad concept meaning to treat respiratory symptoms and restore them to their original condition.

As used herein, "respiratory symptoms" refers to pain or foreign body sensation appearing in the respiratory tract, and may be understood as a concept including all abnormal symptoms appearing in the nose, throat, sinuses, bronchi, and lungs included in the respiratory tract.

Hereinafter, the present invention will be described in detail.

The present invention provides a pharmaceutical composition for preventing or treating respiratory symptoms, including a mixed extract consisting of red ginseng extract, Angelica extract, McMundong extract, Hwanggi extract, Changija extract and Yugeunpi extract.

The extract may be obtained by extracting from a raw material or a dried product thereof, and the raw material may be grown or commercially available without limitation.

When the extract is obtained by extracting from a raw material, as the extraction method, any of conventionally known conventional extraction methods such as a solvent extraction method, an ultrasonic extraction method, a filtration method, and a reflux extraction method can be used, and preferably produced by using a solvent extraction method or a reflux extraction method. can do. The extraction process may be repeated several times, after which it may be further subjected to steps such as concentration or lyophilization. Specifically, the obtained extract was concentrated under reduced pressure to obtain a concentrated solution, and the concentrated solution was lyophilized, and then a high-concentration extract powder could be prepared using a grinder.

The extract may be extracted using water, an organic solvent or a mixture thereof as an extraction solvent. The organic solvent is alcohol, preferably C1-C4 alcohol, hexane (n-hexane), ether, glycerol, propylene glycol, butylene glycol, ethyl acetate, methyl acetate, dichloromethane, chloroform, ethyl acetate, benzene and these It may be a mixed solvent of.

The mixed extract may extract a mixture of red ginseng, Angelica, Macmundong, Hwanggi, Changija and Yugeunpi, or may be mixed after obtaining an extract from each raw material, but is not limited thereto.

With respect to 1 to 20 parts by weight of the red ginseng extract, Angelica keiskei extract is 0.6 to 0.1 parts by weight, Magmundong extract is 0.6 to 0.1 parts by weight, astragalus extract is 1.0 to 0.3 parts by weight, Changja extract is 0.6 to 0.1 parts by weight, and root extract is It may be included in 0.6 to 0.1 parts by weight. When included below the lower limit, respiratory symptoms may not improve, and when it is included above the upper limit, the taste of the composition changes, for example, the bitter taste becomes stronger, or the throat is not soft, so it is not easy to ingest.

In one embodiment of the present invention, the red ginseng concentrate is contained in 6 parts by weight, the Angelica kerosene concentrate is 0.36 parts by weight, the Macmundong concentrate is 0.36 parts by weight, the astragalus concentrate is 0.6 parts by weight, the Changgi concentrate is 0.34 parts by weight, and the root muscle concentrate is 0.34 parts by weight As a result of preparing the containing composition, and ingesting 50 ml per day for 1 month, it was confirmed that symptoms such as stuffiness, dryness, sharpness, and tingling of the neck, which are respiratory symptoms, are significantly improved (FIGS. 1 to 6 ). .

Respiratory symptoms may be any one or more selected from the group consisting of stuffiness of the neck, dryness of the neck, sharpness of the neck, neck throat and tingling of the neck, but are not limited thereto. Respiratory symptoms that can be improved by applying the composition of the present invention include tonsil (throat) swelling, (cough) sneezing, sputum boiling, sore throat, cracking in the voice, rhinitis, and the like.

The composition of the present invention may be taken in combination with a known compound or extract having an effect of improving or treating respiratory symptoms.

The intake amount of the composition according to the present invention may be 10 ml/1 day to 200 ml/1 day, may be 20 ml/1 day to 170 ml/1 day, and 30 ml/1 day to 150 ml/1 day have. When ingested below the lower limit, respiratory symptoms may not be improved, and when ingested above the upper limit, side effects may occur because the herbal medicine contained in the composition of the present invention is consumed in excess.

The composition according to the present invention may be ingested for 1 day to 3 months, preferably 15 days to 1 month, but is not limited thereto, and may be ingested for a long period of time to improve symptoms.

In one embodiment of the present invention, as a result of ingesting the composition of the present invention for 50 ml per day for 1 month, it was confirmed that symptoms such as stiffness, dryness, sharpness, and tingling of the neck, which are bronchial symptoms, are significantly improved (FIG. 1 to 6).

The pharmaceutical composition of the present invention, in addition to the above-mentioned mixed extract, within the range not impairing the effect desired by the present invention, preferably may further contain other components and the like that can give a synergistic effect to the effect of the mixed extract. have. For example, antioxidants, stabilizers, solubilizers, vitamins, pigments and customary adjuvants such as fragrances, or carriers may be included.

The route of administration of the pharmaceutical composition includes oral, intravenous, intramuscular, intraarterial, transdermal, subcutaneous, intraperitoneal, intranasal, intestinal, topical, sublingual or rectal, for example, topical application by application. Can be applied in a manner. The parenteral includes subcutaneous, intradermal, intravenous, intramuscular, intralesional injection or infusion techniques.

The pharmaceutical composition may contain one or more active ingredients exhibiting the same or similar function in addition to the mixed extract. Each of the above compositions may be formulated and used in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, external preparations, suppositories, and sterile injectable solutions, according to a conventional method.

Solid preparations for oral administration include powders, granules, tablets, capsules, soft capsules, pills, and the like. Liquid preparations for oral administration include suspending agents, intravenous solutions, emulsions, syrups, etc. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, can be included. have. Preparations for parenteral administration include external preparations and sterile injections, such as powders, granules, tablets, capsules, sterilized aqueous solutions, liquids, non-aqueous solvents, suspensions, emulsions, syrups, suppositories, aerosols, etc. It can be used in the form of a formulation, preferably a cream, gel, patch, spray, ointment, warning agent, lotion agent, linen agent, pasta agent or cataplasma pharmaceutical composition for external use for the skin can be prepared and used. , But is not limited to this. Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As a base for suppositories, witepsol, macrogol, tween 61, cacao butter, laurin butter, and glycerogelatin may be used.

The composition may further contain preservatives, stabilizers, hydration or emulsification accelerators, adjuvants such as salts and/or buffers for osmotic pressure control, and other therapeutically useful substances, which are conventional methods of mixing, granulating or It can be formulated according to the coating method.

The dosage of the pharmaceutical composition may vary depending on a number of factors, including the individual's age, weight, general health, sex, time of administration, route of administration, release rate, drug combination, and severity of a particular disease. Further, the pharmaceutical composition of the present invention may be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, and biological response modifiers. In addition, the pharmaceutical composition may be administered in a dosage within the range of 0.001 to 100mg/kg on an adult basis, and when the pharmaceutical composition is an external preparation, it is 1 to 5 times a day in an amount of 1.0 to 3.0ml on an adult basis. It is recommended to apply once a month and continue for at least 1 month, but the dosage is not intended to limit the scope of the invention.

When the pharmaceutical composition is formulated in a unit dose form, it is preferable that the mixed extract of the present invention as an active ingredient is contained in a unit dose of about (0.01 to 1,500) mg, and the dosage required for adult treatment is the frequency of administration. Depending on the and intensity, the range of about (1 to 500) mg per day is usually, but not limited to, a higher daily dosage may be desirable for some patients.

In addition, the present invention provides a health food composition for improving respiratory symptoms, including a mixed extract consisting of red ginseng extract, Angelica extract, Macmundong extract, Hwanggi extract, Changija extract, and Yugeunpi extract.

The health food composition of the present invention may further include known natural products or compounds known to have an effect of improving health, in addition to including the extracts listed above.

For example, the composition of the present invention may include sweeteners, flavoring agents, bioactive ingredients, minerals, processing aids, etc. in addition to the mixed extract.

Sweeteners may be used in an amount to give the food a moderate sweetness, and may be natural or synthetic. Preferably, a natural sweetener is used, and natural sweeteners include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose, and maltose.

Flavoring agents may be used to enhance taste or aroma, and both natural and synthetic substances may be used. Preferably it is the case of using natural products. When using natural products, in addition to flavor, the purpose of enhancing nutrition can be combined. Natural flavoring agents may be obtained from apples, lemons, tangerines, grapes, strawberries, peaches, etc., or may be obtained from green tea leaves, perilla, large leaves, cinnamon, chrysanthemum leaves, jasmine, and the like. In addition, those obtained from bamboo shoots, aloe vera, and banks can be used. Natural flavoring agents may be liquid concentrates or solid extracts. In some cases, synthetic flavoring agents may be used, and synthetic flavoring agents may be used in the form of esters, alcohols, aldehydes, terpenes, and the like.

As the bioactive material, catechins such as catechin, epicatechin, gallocatechin, epigallocatechin, and vitamins such as retinol, ascorbic acid, tocopherol, calciferol, thiamine, riboflavin, and the like can be used.

As minerals, calcium, magnesium, chromium, cobalt, copper, fluoride, germanium, iodine, iron, lithium, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, silicon, sodium, sulfur, vanadium, zinc, etc. can be used. .

In addition, the composition of the present invention may include a preservative, an emulsifier, an acidulant, and the like, in addition to the sweetener.

It is preferable that such preservatives, emulsifiers, etc. are added and used in a very small amount as long as it can achieve the use to which they are added. The trace amount when expressed numerically refers to a range of 0.0005% by weight to about 0.5% by weight based on the total weight of the food composition.

Preservatives that can be used include sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, and EDTA (ethylenediaminetetraacetic acid).

Emulsifiers that can be used include acacia gum, carboxymethylcellulose, xanthan gum, pectin, and the like.

Acidulants that can be used include citric acid, malic acid (apple acid), fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid, and the like. The acidulant may be added so that the food composition has an appropriate acidity for the purpose of suppressing the growth of microorganisms in addition to the purpose of enhancing taste.

The health food composition of the present invention may be used as a health food by itself, or the composition may be included in a food or drink. When the composition of the present invention is included in other foods or beverages, a concentration process or a powdering process may be additionally added to make it easy to add. Foods to which the composition of the present invention can be added include various foods, for example, beverages, gums, teas, vitamin complexes, health supplements, etc., in the form of pills, powders, granules, needles, tablets, capsules or beverages Can be used.

Hereinafter, the present invention will be described in detail by production examples and examples.

However, the following manufacturing examples and examples are only for illustrating the present invention, and the contents of the present invention are not limited by the following manufacturing examples and examples.

<Production Example 1> Preparation of Angelica keiskei koidz

Angelica gigas 1 kg of purified water was added 5 to 10 times based on weight, extracted for 2 to 3 hours at 95°C, centrifuged at low temperature, and concentrated under reduced pressure to obtain Angelica gigas 200 to 400 g.

<Production Example 2> Preparation of extracts of Magmundong

Purified water was added 5 to 10 times based on 1 kg of weight of Liriope muscari , extracted at 95°C for 2 to 3 hours, then centrifuged at low temperature, and concentrated under reduced pressure to obtain 200 to 400 g of pulsed pulsed concentrate.

<Production Example 3> Preparation of astragalus extract

Astragalus membranaceus was added with 5 to 10 times purified water by weight based on 1 kg, extracted at 95°C for 2 to 3 hours, then centrifuged at low temperature, and concentrated under reduced pressure to obtain 200 to 400 g of astragalus concentrate.

<Production Example 4> Preparation of Changja extract

After adding purified water 5 to 10 times by weight based on 1 kg of Xanthium strumarium, extracted for 2 to 3 hours at 95°C, centrifuged at low temperature, and concentrated under reduced pressure to obtain 200 to 400 g of Changja concentrate.

<Production Example 5> Preparation of yugeunpi extract

After adding 5~10 times of purified water by weight based on 1kg of root root (root of elmus davidiana ), extract for 2~3 hours at 95℃, then centrifugation at low temperature and then concentrated under reduced pressure. 400g was obtained.

<Production Example 6> Preparation of red ginseng concentrate

After adding purified water to about 10 times by weight based on 1 kg of red ginseng, it was extracted 5 to 10 times at 70 to 90°C, centrifuged at low temperature, and then concentrated under reduced pressure to obtain 200 to 500 g of red ginseng concentrate.

<Production Example 7> Preparation of plant mixture concentrate

Each extract obtained in Preparation Examples 1 to 5 was blended in the ratio of Table 1 below to prepare a plant mixture concentrate.

concentrate Content (% by weight) Angelica 18 McMundong 18 Astragalus 30 Window 17 Yoo Keun Pyo 17

<Production Example 8> Preparation of composition for improving bronchial health including red ginseng and plant extract

The composition for improving bronchial health with the extract of Preparation Example 5 and the plant mixture extract of Preparation Example 7 was prepared in the ratio of Table 2 below.

Raw materials Content (% by weight) Red ginseng concentrate 6 Plant mix concentrate 2 Agave Syrup 9.3 Pear concentrate 3 Jujube concentrate 3 Fructooligosaccharide One Cyclodextrin syrup 0.8 Ginger syrup concentrate 0.5 Taurine 0.5 Cyclodextrin 0.35 pectin 0.35 Herb extract 0.31 Bellflower concentrate 0.2 Pine cone extract 0.1 Glycine 0.03 Deer Antler Extract 0.03 Pressed mushroom powder 0.03 Vitamin B6 hydrochloride 0.0005 Vitamin B1 hydrochloride 0.0003 Sodium vitamin B2 phosphate 0.0003 Purified water Proper

<Example 1> Check the effect of improving the bronchus

The effect of improving the bronchus of the composition prepared in Preparation Example 8 was confirmed. A total of 120 people participated in the effect check, 40 non-smokers, 40 smokers, and 40 elderly people, respectively. Before drinking the composition of Preparation Example 8, a questionnaire was prepared for respiratory conditions such as the neck and bronchi, and was ingested for 1 month in an amount of 1 packet (50 ml)/day by the HUT (Home Usage Test) method. After one month, the same questionnaire was prepared to confirm the degree of improvement in respiratory conditions such as the neck/bronchi. The questionnaire items were stuffiness of the neck, dryness, knifeiness, symptoms of tiredness, tiredness, sore throat, tingling of the throat, tonsils (throat), coughing (sneeze), sputum boiling, reduced immunity, sore throat, cracking of the voice, rhinitis . The scale for each item was set to a 9-point scale, and the overall neck health status was recorded as '1 point: not good at all' to '9 point: very good', and the degree of improvement before and after taking was recorded (Figure 1). 'Improvement degree' item,'overall neck health condition' item of FIGS. 4 to 6). The symptom improvement rate represents the percentage of respondents who increased Gap (after/before taking) by 1 or more points on a 9-point scale (item'Improvement rate' in FIGS. 1 and 3 to 6). The degree of improvement of symptoms related to the neck/bronchi was evaluated by presenting '1 point: no symptoms related to neck/bronchi' to '9 points: very many symptoms related to neck/bronchi' (FIGS. 2, 4 to 6). 'Improvement by symptoms' item).

As a result of ingesting the composition of Preparation Example 8 for 1 month, overall, all symptoms of the questionnaire tended to be alleviated (FIG. 1), and it was confirmed that the difference before/after taking was statistically significant (FIG. 2). As shown in FIG. 2, it was shown that the stuffiness, dryness, knifeiness, and lockedness of the neck compared to other items, the symptoms were significantly improved compared to the other items. In addition, the percentage of respondents who responded that symptoms were relieved by 1 or more points based on the 9-point scale among all respondents is shown in FIG. 3. As can be seen in Figure 3, it was found that the composition of Preparation Example 8 has a symptom relief effect on the neck and bronchi, and particularly, an improvement effect on the sharpness, tightness and dryness of the neck.

In addition, the symptoms for each questionnaire item were individually checked for 40 non-smokers, 40 smokers, and 40 elderly people, who were participating in the effect check. In the case of non-smokers, compared with other items, it showed a high improvement rate in the stuffiness and knuckleiness of the neck (FIG. 4), and in the case of the smoker group, the degree of improvement for the symptoms of suffocation, dryness, knifeiness, tingling, and swelling in the throat Excellent (FIG. 5). It was found that the symptoms of bronchial symptoms such as stuffiness, dryness, and sputum swelling, which frequently occur in smokers, were improved by ingesting the composition of Preparation Example 8. In addition, in the group of the elderly, symptoms of dryness of the neck and fatigue were improved (FIG. 6 ).

From these results, it was found that the composition for improving the bronchus of the present invention has an excellent effect of alleviating symptoms appearing on the bronchus including stuffiness, dryness, and knifeiness of the neck.

<Example 2> Taste preference evaluation

The composition for improving bronchial symptoms was evaluated for softness of throat, mild taste (cool taste), bitter taste, concentration, sweetness, and red ginseng taste. The evaluation object was the same as the object of Example 1, and on a 5-point scale, the softer the "throat smoothness" item was, the higher the score was, and the higher the taste was, the higher the score was. Table 3 shows the evaluation results.

Evaluation item score Softness of the neck 4.11 Angry taste (cool taste) 3.97 bitter 3.97 density 3.89 sweetness 3.82 Red ginseng 3.70

As a result, the overall taste preference for the composition for improving bronchial symptoms was very high. The preferred reason is that the bitterness and sweetness are moderate, the red ginseng taste is rich, the taste is cool, and the taste is soft, and the preference for the moderate bitterness, sweetness, and the mild (cool) feeling felt after taking the composition is favorable. It was found that it had a positive effect on high evaluation.

Through Examples 1 and 2, the composition for improving bronchial symptoms of the present invention can be usefully used to improve bronchial symptoms while improving bronchial symptoms including stiffness, dryness, and calcality of the neck, while having high satisfaction with taste. Can be seen.

Claims (6)

As a pharmaceutical composition for the prevention or treatment of respiratory symptoms, including a mixed extract consisting of red ginseng extract, Angelica extract, Macmundong extract, astragalus extract, Changija extract, and yugeunpi extract,
The respiratory symptoms are selected from the group consisting of tonsil swelling, swelling of the neck, coughing, sneezing, sputum, sore throat, cracking of the voice, and rhinitis,
With respect to 1 to 20 parts by weight of the red ginseng extract, Angelica keiskei extract is 0.6 to 0.1 parts by weight, Macmundong extract is 0.6 to 0.1 parts by weight, astragalus extract is 1.0 to 0.3 parts by weight, Changija extract is 0.6 to 0.1 parts by weight, and Yugeun Phi extract Is a pharmaceutical composition for preventing or treating respiratory symptoms contained in 0.6 to 0.1 parts by weight. The method according to claim 1,
A pharmaceutical composition comprising 6 parts by weight of red ginseng concentrate, 0.36 parts by weight of Angelica concentrate, 0.36 parts by weight of Magmundong concentrate, 0.6 parts by weight of astragalus concentrate, 0.34 parts by weight of Changja concentrate, and 0.34 parts by weight of dermal root concentrate. delete As a health food composition for improving respiratory symptoms, including a mixed extract consisting of red ginseng extract, Angelica extract, McMundong extract, Hwanggi extract, Changija extract and Yugeunpi extract,
The respiratory symptoms are selected from the group consisting of stuffiness of the neck, dryness of the neck, sharpness of the neck, locked neck, and tingling of the neck,
With respect to 1 to 20 parts by weight of the red ginseng extract, Angelica keiskei extract is 0.6 to 0.1 parts by weight, Macmundong extract is 0.6 to 0.1 parts by weight, astragalus extract is 1.0 to 0.3 parts by weight, Changija extract is 0.6 to 0.1 parts by weight, and Yugeun Phi extract Silver 0.6 to 0.1 parts by weight of health food composition for improving respiratory symptoms. The method according to claim 4,
A healthy food composition comprising 6 parts by weight of red ginseng concentrate, 0.36 parts by weight of Angelica concentrate, 0.36 parts by weight of Magmundong concentrate, 0.6 parts by weight of astragalus concentrate, 0.34 parts by weight of Changija concentrate, and 0.34 parts by weight of root extract. delete

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