KR20170138569A - 용해성 키메라 인터루킨-10 수용체 및 이의 치료학적 용도 - Google Patents

용해성 키메라 인터루킨-10 수용체 및 이의 치료학적 용도 Download PDF

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KR20170138569A
KR20170138569A KR1020177034625A KR20177034625A KR20170138569A KR 20170138569 A KR20170138569 A KR 20170138569A KR 1020177034625 A KR1020177034625 A KR 1020177034625A KR 20177034625 A KR20177034625 A KR 20177034625A KR 20170138569 A KR20170138569 A KR 20170138569A
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KR1020177034625A
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질베르토 필라시
다니엘라 페노글리오
프란체스카 페레라
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메디오라늄 파마세우티시 에스.피.에이.
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Publication of KR20170138569A publication Critical patent/KR20170138569A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
KR1020177034625A 2015-04-29 2016-04-26 용해성 키메라 인터루킨-10 수용체 및 이의 치료학적 용도 KR20170138569A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102015000013548 2015-04-29
ITUB20150391 2015-04-29
PCT/IB2016/052359 WO2016174575A1 (en) 2015-04-29 2016-04-26 A soluble chimeric interleukin-10 receptor and therapeutic use thereof

Publications (1)

Publication Number Publication Date
KR20170138569A true KR20170138569A (ko) 2017-12-15

Family

ID=53765409

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177034625A KR20170138569A (ko) 2015-04-29 2016-04-26 용해성 키메라 인터루킨-10 수용체 및 이의 치료학적 용도

Country Status (15)

Country Link
US (1) US20180086809A1 (pl)
EP (1) EP3288965B1 (pl)
JP (1) JP2018518945A (pl)
KR (1) KR20170138569A (pl)
CN (1) CN107531771A (pl)
CA (1) CA2979973A1 (pl)
CY (1) CY1122061T1 (pl)
DK (1) DK3288965T3 (pl)
ES (1) ES2744342T3 (pl)
HK (1) HK1245814B (pl)
HU (1) HUE046343T2 (pl)
PL (1) PL3288965T3 (pl)
PT (1) PT3288965T (pl)
SI (1) SI3288965T1 (pl)
WO (1) WO2016174575A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110546168B (zh) 2016-09-27 2024-03-15 埃皮辛特瑞柯斯公司 免疫调节性融合蛋白
JP2020536518A (ja) * 2017-09-27 2020-12-17 エピセントアールエックス，インコーポレイテッド 免疫調節融合タンパク質
CN116125074A (zh) * 2022-12-13 2023-05-16 北京东方百泰生物科技股份有限公司 一种IL-10-Fc融合蛋白与其受体结合活性的检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789192A (en) * 1992-12-10 1998-08-04 Schering Corporation Mammalian receptors for interleukin-10 (IL-10)
US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
JP2003531590A (ja) * 2000-04-12 2003-10-28 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
US20090111146A1 (en) * 2003-09-02 2009-04-30 National Institute Of Advanced Industrial Science Antibody Drug
KR100775343B1 (ko) * 2003-11-13 2007-11-08 한미약품 주식회사 면역글로불린 Ｆｃ 영역을 캐리어로 포함하는 약제학적조성물
DK2662449T3 (en) * 2007-05-30 2017-05-15 Postech Academy-Industry- Found immunoglobulin fusion proteins
PT2344540T (pt) * 2008-10-02 2018-02-02 Aptevo Res & Development Llc Proteínas de ligação multi-alvo antagonistas de cd86
MX355041B (es) * 2012-05-25 2018-03-28 Janssen Biotech Inc Dominios de union a albumina consenso no naturales.

Also Published As

Publication number Publication date
WO2016174575A1 (en) 2016-11-03
CA2979973A1 (en) 2016-11-03
SI3288965T1 (sl) 2019-10-30
EP3288965B1 (en) 2019-06-26
EP3288965A1 (en) 2018-03-07
PL3288965T3 (pl) 2019-11-29
CN107531771A (zh) 2018-01-02
PT3288965T (pt) 2019-10-15
JP2018518945A (ja) 2018-07-19
DK3288965T3 (da) 2019-09-23
CY1122061T1 (el) 2020-11-25
HUE046343T2 (hu) 2020-02-28
HK1245814B (zh) 2020-06-19
US20180086809A1 (en) 2018-03-29
ES2744342T3 (es) 2020-02-24

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