KR20170138569A - 용해성 키메라 인터루킨-10 수용체 및 이의 치료학적 용도 - Google Patents
용해성 키메라 인터루킨-10 수용체 및 이의 치료학적 용도 Download PDFInfo
- Publication number
- KR20170138569A KR20170138569A KR1020177034625A KR20177034625A KR20170138569A KR 20170138569 A KR20170138569 A KR 20170138569A KR 1020177034625 A KR1020177034625 A KR 1020177034625A KR 20177034625 A KR20177034625 A KR 20177034625A KR 20170138569 A KR20170138569 A KR 20170138569A
- Authority
- KR
- South Korea
- Prior art keywords
- leu
- glu
- ala
- lys
- thr
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102015000013548 | 2015-04-29 | ||
ITUB20150391 | 2015-04-29 | ||
PCT/IB2016/052359 WO2016174575A1 (en) | 2015-04-29 | 2016-04-26 | A soluble chimeric interleukin-10 receptor and therapeutic use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20170138569A true KR20170138569A (ko) | 2017-12-15 |
Family
ID=53765409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020177034625A KR20170138569A (ko) | 2015-04-29 | 2016-04-26 | 용해성 키메라 인터루킨-10 수용체 및 이의 치료학적 용도 |
Country Status (15)
Country | Link |
---|---|
US (1) | US20180086809A1 (pl) |
EP (1) | EP3288965B1 (pl) |
JP (1) | JP2018518945A (pl) |
KR (1) | KR20170138569A (pl) |
CN (1) | CN107531771A (pl) |
CA (1) | CA2979973A1 (pl) |
CY (1) | CY1122061T1 (pl) |
DK (1) | DK3288965T3 (pl) |
ES (1) | ES2744342T3 (pl) |
HK (1) | HK1245814B (pl) |
HU (1) | HUE046343T2 (pl) |
PL (1) | PL3288965T3 (pl) |
PT (1) | PT3288965T (pl) |
SI (1) | SI3288965T1 (pl) |
WO (1) | WO2016174575A1 (pl) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110546168B (zh) | 2016-09-27 | 2024-03-15 | 埃皮辛特瑞柯斯公司 | 免疫调节性融合蛋白 |
KR20200057070A (ko) * | 2017-09-27 | 2020-05-25 | 에피센트알엑스, 인코포레이티드 | 면역조절 융합 단백질 |
CN116125074A (zh) * | 2022-12-13 | 2023-05-16 | 北京东方百泰生物科技股份有限公司 | 一种IL-10-Fc融合蛋白与其受体结合活性的检测方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5789192A (en) * | 1992-12-10 | 1998-08-04 | Schering Corporation | Mammalian receptors for interleukin-10 (IL-10) |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
AU2001266557A1 (en) * | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2005024027A1 (ja) * | 2003-09-02 | 2005-03-17 | National Institute Of Advanced Industrial Science And Technology | 抗体医薬 |
KR100775343B1 (ko) * | 2003-11-13 | 2007-11-08 | 한미약품 주식회사 | 면역글로불린 Fc 영역을 캐리어로 포함하는 약제학적조성물 |
KR101380729B1 (ko) * | 2007-05-30 | 2014-04-10 | 포항공과대학교 산학협력단 | 면역글로불린 융합 단백질 |
EA024877B1 (ru) * | 2008-10-02 | 2016-10-31 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | Связывающие множество мишеней белки, обладающие антагонистическими свойствами по отношению к cd86 |
ES2670442T3 (es) * | 2012-05-25 | 2018-05-30 | Janssen Biotech, Inc. | Dominios de unión a albúmina de consenso no naturales |
-
2016
- 2016-04-26 JP JP2017556722A patent/JP2018518945A/ja active Pending
- 2016-04-26 ES ES16728097T patent/ES2744342T3/es active Active
- 2016-04-26 HU HUE16728097A patent/HUE046343T2/hu unknown
- 2016-04-26 PL PL16728097T patent/PL3288965T3/pl unknown
- 2016-04-26 CA CA2979973A patent/CA2979973A1/en not_active Abandoned
- 2016-04-26 KR KR1020177034625A patent/KR20170138569A/ko unknown
- 2016-04-26 DK DK16728097.3T patent/DK3288965T3/da active
- 2016-04-26 WO PCT/IB2016/052359 patent/WO2016174575A1/en active Application Filing
- 2016-04-26 US US15/562,557 patent/US20180086809A1/en not_active Abandoned
- 2016-04-26 SI SI201630348T patent/SI3288965T1/sl unknown
- 2016-04-26 CN CN201680024854.0A patent/CN107531771A/zh active Pending
- 2016-04-26 EP EP16728097.3A patent/EP3288965B1/en active Active
- 2016-04-26 PT PT167280973T patent/PT3288965T/pt unknown
-
2018
- 2018-04-26 HK HK18105461.9A patent/HK1245814B/zh unknown
-
2019
- 2019-09-23 CY CY20191100997T patent/CY1122061T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
SI3288965T1 (sl) | 2019-10-30 |
HK1245814B (zh) | 2020-06-19 |
EP3288965B1 (en) | 2019-06-26 |
JP2018518945A (ja) | 2018-07-19 |
PL3288965T3 (pl) | 2019-11-29 |
CA2979973A1 (en) | 2016-11-03 |
EP3288965A1 (en) | 2018-03-07 |
HUE046343T2 (hu) | 2020-02-28 |
CN107531771A (zh) | 2018-01-02 |
US20180086809A1 (en) | 2018-03-29 |
DK3288965T3 (da) | 2019-09-23 |
WO2016174575A1 (en) | 2016-11-03 |
CY1122061T1 (el) | 2020-11-25 |
PT3288965T (pt) | 2019-10-15 |
ES2744342T3 (es) | 2020-02-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7095078B2 (ja) | キメラポリペプチド及びその使用 | |
JP6644678B2 (ja) | Ctla−4およびcd40の両方に特異的に結合可能である二重特異性分子 | |
JP6929867B2 (ja) | がんに対する免疫療法で使用するための形質移入t細胞およびt細胞受容体 | |
ES2968802T3 (es) | Células T transfectadas y receptores de células T para su uso en inmunoterapia contra el cáncer | |
CN110582509A (zh) | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 | |
KR20170094341A (ko) | 인터류킨 15 단백질 복합체 및 그의 용도 | |
WO2017027392A1 (en) | Treatment of cancer using chimeric cd3 receptor proteins | |
CN110382539B (zh) | 用于cd16a定向的nk细胞结合的串联双抗体 | |
EP3990491A1 (en) | Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof | |
US20190119387A1 (en) | Inhibition of tgfbeta in immunotherapy | |
JP7355977B2 (ja) | Cd24に結合する抗体、その調製および使用 | |
EP2999485B1 (en) | Gastrin peptide immunogenic composition | |
JP2022528030A (ja) | 多機能性融合タンパク質及びその使用 | |
US20220133792A1 (en) | Signaling platforms for chimeric antigen receptor t cells | |
WO2000030680A1 (en) | Tumor antigen-specific antibody-gp39 chimeric protein constructs | |
KR20170138569A (ko) | 용해성 키메라 인터루킨-10 수용체 및 이의 치료학적 용도 | |
CN112533629A (zh) | 结合使用il-10药剂与嵌合抗原受体细胞疗法的组合物和方法 | |
JP2023520572A (ja) | オルソゴナルな受容体を発現するようにゲノムが改変されたヒト免疫細胞 | |
JP2022519713A (ja) | Car操作されたt細胞およびサイトカインを含む治療 | |
TW201206472A (en) | IL-18 Receptor as a novel target of regulatory T cells in cancer | |
US11613567B2 (en) | Modulators of notch signaling and methods of use thereof | |
Omabe et al. | HER2-specific vaccines for HER2-positive breast Cancer immunotherapy | |
KR20240099410A (ko) | 신규한 폴리펩티드 | |
EP4426738A2 (en) | Novel polypeptides | |
CN118043066A (zh) | 构建体和免疫刺激性化合物的共表达 |