KR20170133561A - A cosmetic composition for anti-dandruff comprising extract of Polygala tenuifolia or Lycium chinense - Google Patents

Abstract

The present invention relates to a cosmetic composition for suppressing the generation of dandruff, which comprises a Polygala tenuifolia extract, a Lycium chinense root extract, and a complex extract thereof as active ingredients. More specifically, the composition can be used not only as a cosmetic composition that suppresses dandruff generation and alleviates itching without side effects on the scalp, but also as an external preparation for the skin.

Description

A cosmetic composition for anti-dandruff comprising an extract of Aspergillus oryzae as an active ingredient. {A cosmetic composition for anti-dandruff comprising extracts of Polygala tenuifolia or Lycium chinense}

The present invention relates to a cosmetic composition for suppressing the production of dandruff by using an extract of green leaf, ganoderma lucidum or a complex extract thereof.

As scalp, new scalp is created and replaced like hair. It replaces new cells about once a month at a faster rate than hair. In a healthy scalp, the cells of the horny layer (or stratum corneum) are quickly replaced with new keratinocytes as they collapse to an invisible small size. However, it is called dandruff that the excess keratinocyte is formed so that the mass of keratinocyte clusters so that the keratinocyte clusters are visible and peeled off from the scalp.

There are many people who worry about itching, dandruff and alopecia due to increased stress, air and water pollution. Some consumers who use traditional soap or hair shampoo to clean their hair and scalp have a growing number of people with scalp troubles such as itching and dandruff caused by product use. One of the trials is to add shampoo products such as anti-dandruff, anti-bacterial, anti-irritant and anti-itch ingredients. Or various products used before or after shampooing are being studied.

If a lot of dandruff occurs, the scalp is rubbed excessively due to itching and the like, resulting in scarring, inflammation and hair loss in some cases. In particular, the itching is mainly mediated by histamine and arachidonic acid metabolites, and if itching is caused by histamine, a reaction similar to the action of antigen or compound 48/80 on mast cells in skin occurs, In addition to histamine already present in mast cells, cyclooxygenase or lipoxygenase is involved, and secretion of prostaglandin, leukotriene, or PAF (platelet activating factor) is secreted, resulting in complicated inflammatory reaction, It stimulates the cells and causes itching. So far, many drugs for the treatment of dandruff have been developed and are on the market. However, since most of the dandruff remedy developed and marketed is manufactured as a form of shampoo, the surfactant contained in the shampoo has a problem that the scalp stimulates much. In addition, many attempts have been made to inhibit the production of dandruff by applying or taking the plant extract to the scalp. When the extract is used (Korean Patent No. 0461098) and when the plant extract is used (Korean Patent No. 0521784) There is a drawback, however, it has no significant effect on itching.

 Therefore, there is a desperate need to develop a hair cosmetic composition which can effectively prevent dandruff by effectively keeping the scalp healthy and preventing itching without side effects on the scalp.

Under these circumstances, the present inventors have made extensive efforts to develop a cosmetic composition for inhibiting dandruff formation, which alleviates itching and has no adverse effects on the scalp. As a result, it has been found that the extracts of Aspergillus, But the scar of the scalp was scarcely found, and the present invention was completed.

It is an object of the present invention to provide a cosmetic composition for suppressing the production of dandruff which comprises as an active ingredient a crude extract, an extract of a bark bark or a complex extract of a bark and a bark.

Another object of the present invention is to provide a quasi-drug containing as an active ingredient a crude extract, a ganoderma extract or a combined extract of ganoderma and ganoderma.

As one embodiment for solving the above problems, the present invention provides a cosmetic composition for suppressing the production of dandruff, which contains as an active ingredient an extract of green leaf extract, extract of leaf extract or extract of leaf and leaf extract.

As used herein, the term "Polygala tenuifolia" refers to a plant belonging to the non-adherent tree. In the herb, the root portion is used for medicinal purposes and the efficacy of sedation, hypnotic action, have.

The term "Lycium chinense" as used in the present invention refers to a dried medicinal substance of the root bark of Gujuga tree, which is also referred to as a goitrous muscle, a famine, and a hungry famine, and includes blood pressure lowering action, Action, antibacterial effect and so on.

As used herein, the term "extract" refers to any conventional extraction solvent known in the art, such as (a) water, (b) C1-4 lower alcohols such as methanol, ethanol, c) a mixed solvent of the lower alcohol and water.

The extract may contain any one of the extract obtained by the extraction treatment, the diluted or concentrated liquid of the extract, the dried product obtained by drying the extract, or the adjusted product or the purified product.

The extraction may be carried out using any one selected from the group consisting of hot water extraction, cold extraction, reflux cooling extraction, ultrasonic extraction and steam extraction, but is not limited thereto.

The term "complex extract" used in the present invention refers to a composition comprising a mixture of a mixture of a mixture of a raw material and an extract of a fleshy crust in a weight ratio of 1 to 10: 1 to 10 (w / w), specifically 1 to 5: / w), more specifically from 1 to 3: 1 to 3 by weight (w / w).

The term "dandruff generation inhibition" used in the present invention means prevention of dermatosis on the skin surface of the head caused by sebum secretion, dandruff causing bacteria, and the like. The cause of the dandruff may include, but is not limited to, a natural phenomenon, an increase in sebum secretion, a causative agent of dandruff, and a schizophrenia caused by a metabolic disorder.

According to one specific embodiment, the present inventive antimicrobial test on dandruff causing bacteria of the present invention has shown that the extracts have an excellent effect on inhibiting the growth of dandruff growth not only in a single extract but also in a complex extract as compared with the control group (Table 1).

In addition, it was confirmed that dandruff prevention effect and itching reduction effect were excellent in shampoo containing single extract or compound extract as compared to conventional shampoo (Table 3).

The cosmetic composition for inhibiting dandruff formation according to the present invention contains 0.001 to 95% by weight (w / w) of the complex extract, specifically 0.001 to 50% by weight (w / w) 0.001 to 20% by weight (w / w). However, the composition is not limited thereto, and may vary depending on the condition and progress of the patient.

The cosmetic composition for inhibiting dandruff formation according to the present invention contains 0.001 to 40% by weight (w / w), specifically 0.001 to 30% by weight (w / w) Specifically 0.001 to 20% by weight (w / w). However, the composition is not limited thereto, and may vary depending on the condition and progress of the patient.

The term "moisturizing agent " as used in the present invention means a moisturizing agent used by a method conventional in the art.

The cosmetic composition may further comprise a moisturizing agent, and the composite composition may be contained in an amount of 0.01 to 0.5 times the amount of the moisturizing agent added. The moisturizing agent may include 0.01 to 20% by weight, specifically 0.001 to 10% by weight, based on the total weight of the cosmetic composition. The moisturizing agent may comprise glycerin, 1,3 butylene glycol, lyroylylglutamate lysine or a non-toxic salt thereof.

The cosmetic composition of the present invention can be used not only in the above extracts of Raw, Extract of Ganoderma lucidum and Composite Extract but also as auxiliary agents commonly used in cosmetic compositions such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, , Blocking agents, pigments, absorbers, dyes, and the like.

The cosmetic composition may be at least one selected from the group consisting of hair tonic, hair conditioner, hair essence, hair lotion, hair nourishing lotion, hair shampoo, hair conditioner, hair treatment, hair cream, hair nourishing cream, hair moisturizing cream, Hair shampoo, hair shampoo, hair shampoo, hair shampoo, hair shampoo, hair shampoo, hair soap, hair cleansing foam, hair oil, hair drying agent, hair preservative, hair dye, A hair mousse or a hair spray.

In another aspect, the present invention provides an external preparation for skin containing as an active ingredient an extract of green tea extract, extract of coriander oil and complex extract.

The term "external preparation for skin" used in the present invention refers to an external preparation for skin, which is effective for suppressing the production of dandruff that is contained as an effective ingredient of extracts of leaves, ganoderma phloem or complex extract, and is used as a cream, gel, patch, spray, ointment, , Liniment agent, pasta agent or cataplasma, or a quasi-drug, but is not limited thereto.

The extracts of the extracts of ground, bark bark, or complex extract according to the present invention can be used not only as a cosmetic composition but also as an unexpected drug by suppressing boiling without side effects.

Hereinafter, the present invention will be described in detail with reference to the following examples. However, the following examples are only for illustrating the present invention, and the scope of the present invention is not limited by the following examples.

Example 1. Preparation of extract

Dried Korean soils were purchased and used in the experiment. After finely ground, the dried weight of 100 g was placed in a flask and subjected to hot extraction with 1000 g of extraction solvent (distilled water) at 70 ° C for 3 hours. The extracted hot water extracts were filtered with a filter having a pore size of 0.2 μm to prepare respective extracts.

Example 2. GI  Preparation of extract

Dried Korean myofibers were purchased and used for the experiment. After finely chopping the scallops, 100 g of dry weight was placed in a flask, and extracted with 1000 g of extraction solvent (distilled water) at 70 ° C for 3 hours. The extracted hot water extracts were filtered with a filter having a pore size of 0.2 μm to prepare respective extracts.

Example 3. Mix  Preparation of extract

Mixed extracts of the extracts of the extracts of the leaves and the bark bones prepared in Examples 1 and 2 were mixed in an amount of 1 g per 3 g of dry weight of each extract.

Experimental Example  One. Antidote  effect

Antimicrobial effect of Pityrosporum ovale , a causative agent of dandruff, was tested. As a test sample, Magnolia was compared and evaluated as a control group in addition to the extract.

The minimum inhibitory concentration (MIC) assay was used for the experiment. Three strains of common bacteria, two strains of fungi, and pityrosporum ovalet were used as test strains. Bacterial-MHB2 and fungus-PDB medium were applied and serial dilution method was performed, and 10 ⁶ levels of bacteria were inoculated into each well. Three kinds of general bacteria, two kinds of fungi, and Pityrosporum ovalet were inoculated and cultured, and then the degree of growth of the cells was observed for each sample concentration to determine the minimum concentration for inhibiting the germ growth. The results are shown in Table 8.

Minimum inhibitory concentration ( % ) E. coli
Escherichia coli S. aureus
Fungus P. aeruginosa
P. aeruginosa A. niger       Black mold C. albicans     leaven Pityrosporum  ovale
Dandruff Zinc pyrichion 0.002 0.001 0.002 0.02 0.02 0.001 Example 1 0.01 0.01 0.01 0.2 0.2 0.01 Example 2 0.01 0.01 0.01 0.1 0.1 0.01 Example 3 0.01 0.01 0.01 0.01 0.01 0.01

As a result, as shown in Table 1, in the MIC assay, the inhibitory effect of the extract on dandruff growth was higher than that of the positive control group, zinc pyrithione, and showed excellent efficacy not only in the single extract but also in the mixed extract Respectively.

Experimental Example  2. Dandruff prevention and itching reduction effect evaluation

A shampoo was prepared in a usual manner according to the prescription of Table 2 below

Compounding ingredient practice
Formulation Example 1 practice
Formulation Example 2 practice
Formulation Example 3 compare
Formulation Example 1 Polyquaternium 0.5 0.5 0.5 0.5 Sodium lauryl sulfate (30%) 20 20 20 20 Sodium polyoxyethylene lauryl sulfate 30 30 30 30 Coconut oil fatty acid diethanolamide 3 3 3 3 Quaternary ammonium cationic surfactant 2 2 2 2 Carbopol-1342 0.3 0.3 0.3 0.3 Paraoxybenzoic acid ester 0.2 0.2 0.2 0.2 Example 1 0.5 - - - Example 2 - 0.5 - - Example 3 - 0.5 - Spices and Pigments Suitable amount Suitable amount Suitable amount Suitable amount Purified water Balance (100 total) Balance (100 total) Balance (100 total) Balance (100 total)

Ten men and women with a relatively large amount of dandruff were selected and shampoos of Examples and Comparative Examples were used for one month, respectively. Before the start of the test, the dandruff was sampled with a normal shampoo, and the dandruff accumulated for 3 days was sampled. The sampled dandruff was compared with the dandruff accumulated for 3 days after the test with the shampoo of each of the examples and the comparative example Respectively.

At this time, the collected dandruff was obtained by allowing the skilled tester to wash the scalp using about 5 g of the sample, then rinse with about 2 to 3 liters of water, and then rinsed with 800 micro-pore size filter The dry weight of the dandruff of the filtered state was measured, and the dandruff reduction rate was determined by the following equation.

After randomly selecting 10 men and women who feel a lot of itchiness and using the shampoo of Examples and Comparative Examples for 8 weeks for every 2 days for each product, the dandruff prevention effect and the reduction effect of itching were evaluated by the interview standard . The criteria for the anti-dandruff effect are as follows:

5 points - Dandruff prevention effect is very good,

4 points - Good anti-dandruff effect,

3 points - Dandruff prevention effect is normal,

2 points - little dandruff effect,

1 point - No dandruff effect at all.

In addition, the criteria for the evaluation of the itching reduction effect are as follows:

5 points - Very good itching effect,

4 points - good itching,

3 points - The itching effect is normal,

2 points - slight itching effect,

1 point - No itching effect.

The results according to the evaluation criteria are shown in Table 3.

practice
Formulation Example 1 practice
Formulation Example 2 practice
Formulation Example 3 compare
Formulation Example 1 Dandruff reduction rate (%) 29.7 31.2 32.9 19.7 Anti-dandruff effect 3.4 3.6 3.7 2.4 Itching reduction effect 3.2 3.4 3.5 2.5

As a result, referring to the results of dandruff reduction rate measurement as shown in Table 3, the shampoo containing the single extract (Example 1, Example 2) or the mixed extract (Example 3) according to the present invention had a dandruff reduction rate . Dandruff prevention effect and itching reduction effect evaluation results, it can be seen that when using the shampoo containing the mixed extract (Example 3) as well as the single extract according to the present invention (Examples 1 and 2) and the effect of reducing the itchiness Which is superior to ordinary shampoo.

From the above description, it will be understood by those skilled in the art that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. In this regard, it should be understood that the above-described embodiments are to be considered in all respects as illustrative and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention without departing from the scope of the present invention as defined by the appended claims.

Claims (8)

A cosmetic composition for suppressing the production of dandruff, which contains as an active ingredient, extracts of leaf extract, extract of leaf extract or extract of leaf and leaf extract.
The method according to claim 1,
Wherein the extract is extracted with water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof.
The method according to claim 1,
Wherein the combined extract of the raw paper and the femoral pulp has a weight ratio (w / w) of 1: 10: 1 to 10: 1.
The method according to claim 1,
Wherein the complex extract comprises 0.001 to 95% by weight, based on the total weight of the cosmetic composition.
The method according to claim 1,
Wherein the raw paper or the crustacean is contained in an amount of 0.01 to 40% by weight based on the total weight of the cosmetic composition.
The method according to claim 1,
Wherein the cosmetic composition further comprises a moisturizing agent.
The method according to claim 1,
The cosmetic composition may be at least one selected from the group consisting of hair tonic, hair conditioner, hair essence, hair lotion, hair nourishing lotion, hair shampoo, hair conditioner, hair treatment, hair cream, hair nourishing cream, hair moisturizing cream, Hair shampoo, hair shampoo, hair shampoo, hair shampoo, hair shampoo, hair shampoo, hair soap, hair cleansing foam, hair oil, hair drying agent, hair preservative, hair dye, Hair mousse or hair spray.
A dermatological preparation for inhibiting dandruff formation, comprising an extract of Aspergillus oryzae as an active ingredient.