KR20170095965A - 간 및 위장 질환의 치료에 사용하기 위한 fxr 효능제로서의 아자비시클로옥탄 유도체 - Google Patents
간 및 위장 질환의 치료에 사용하기 위한 fxr 효능제로서의 아자비시클로옥탄 유도체 Download PDFInfo
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- KR20170095965A KR20170095965A KR1020177019415A KR20177019415A KR20170095965A KR 20170095965 A KR20170095965 A KR 20170095965A KR 1020177019415 A KR1020177019415 A KR 1020177019415A KR 20177019415 A KR20177019415 A KR 20177019415A KR 20170095965 A KR20170095965 A KR 20170095965A
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- azabicyclo
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| PCT/IB2015/059450 WO2016097933A1 (en) | 2014-12-18 | 2015-12-08 | Azabicyclooctane derivatives as fxr agonists for use in the treatment of liver and gastrointestinal diseases |
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| KR20170095965A true KR20170095965A (ko) | 2017-08-23 |
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| US10144729B2 (en) | 2016-05-18 | 2018-12-04 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
| US10138228B2 (en) | 2016-05-18 | 2018-11-27 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use therof |
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| TW201808283A (zh) | 2016-08-05 | 2018-03-16 | 廣東東陽光藥業有限公司 | 含氮三環化合物及其在藥物中的應用 |
| JP7093341B2 (ja) * | 2016-08-23 | 2022-06-29 | アルデリックス， インコーポレイテッド | 代謝異常状態及び代謝障害を治療するためのホルモン受容体調節薬 |
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| JOP20190040A1 (ar) * | 2016-09-14 | 2019-03-10 | Novartis Ag | توليفة من ناهضات fxr |
| RU2019113066A (ru) | 2016-10-04 | 2020-11-09 | Энанта Фармасьютикалс, Инк. | Аналоги изоксазола как агонисты fxr и способы их применения |
| MX2019003889A (es) * | 2016-10-05 | 2019-08-12 | Novartis Ag | Composiciones de combinacion que comprenden agonistas de fxr para tratar o prevenir una enfermedad o trastorno fibrotico o cirrotico. |
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| WO2019089667A1 (en) * | 2017-11-01 | 2019-05-09 | Bristol-Myers Squibb Company | Bridged bicyclic compounds as farnesoid x receptor modulators |
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| CN110128432B (zh) | 2018-02-02 | 2021-03-02 | 广东东阳光药业有限公司 | 含氮三环化合物及其在药物中的应用 |
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| CN110357875B (zh) * | 2018-04-10 | 2022-06-21 | 浙江海正药业股份有限公司 | 氮杂双环辛烷类衍生物、其制备方法及其在医药上的用途 |
| CN110357876B (zh) * | 2018-04-10 | 2022-06-28 | 浙江海正药业股份有限公司 | 氮杂双环辛烷类衍生物及其制备方法和用途 |
| CN112334467B (zh) * | 2018-06-26 | 2023-06-20 | 轩竹生物科技股份有限公司 | Fxr受体激动剂 |
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| AR118050A1 (es) | 2019-02-15 | 2021-09-15 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x |
| AU2020221371A1 (en) | 2019-02-15 | 2021-10-07 | Bristol-Myers Squibb Company | Substituted amide compounds useful as farnesoid x receptor modulators |
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| CN111825701B (zh) * | 2019-04-19 | 2023-12-08 | 正大天晴药业集团股份有限公司 | 含苯并噻唑的三环类fxr调节剂化合物 |
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| CA3139291A1 (en) | 2019-07-18 | 2021-01-21 | Jacky Vonderscher | Method for decreasing adverse-effects of interferon |
| WO2021104021A1 (zh) * | 2019-11-29 | 2021-06-03 | 广东东阳光药业有限公司 | Tropifexor的新晶型及其制备方法 |
| CN114728954B (zh) * | 2019-11-29 | 2023-10-17 | 广东东阳光药业股份有限公司 | Tropifexor的新晶型及其制备方法 |
| WO2021144330A1 (en) | 2020-01-15 | 2021-07-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of fxr agonists for treating an infection by hepatitis d virus |
| EP4161925A4 (en) * | 2020-06-09 | 2024-09-04 | Viking Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES |
| US20230226143A1 (en) * | 2020-06-30 | 2023-07-20 | Ocvirk, Soren | Pharmaceutical composition comprising a combination of a guanylate cyclase c (gucy2c) agonist and a short-chain fatty acid or prodrug thereof |
| MX2023008365A (es) | 2021-01-14 | 2023-10-04 | Enyo Pharma | Efecto sinérgico de un agonista de fxr e ifn para el tratamiento de infección por hbv. |
| CN113292555B (zh) * | 2021-04-28 | 2022-03-18 | 武汉纽瑞斯医药科技有限公司 | 一种Tropifexor的制备方法 |
| US20240216364A1 (en) | 2021-04-28 | 2024-07-04 | Enyo Pharma | Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment |
| CN116987062A (zh) * | 2023-08-03 | 2023-11-03 | 中国热带农业科学院分析测试中心 | 一种氨基酸键联槟榔碱衍生物的制备方法 |
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| JP2009511450A (ja) * | 2005-10-07 | 2009-03-19 | ノバルティス アクチエンゲゼルシャフト | ニロチニブとファルネシルトランスフェラーゼ阻害剤の組合せ |
| US20130261108A1 (en) * | 2010-12-20 | 2013-10-03 | Irm Llc | Compositions and methods for modulating farnesoid x receptors |
| CU24152B1 (es) * | 2010-12-20 | 2016-02-29 | Irm Llc | 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr |
| EP2545964A1 (en) * | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
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- 2015-12-08 RU RU2017125365A patent/RU2017125365A/ru not_active Application Discontinuation
- 2015-12-08 TN TN2017000243A patent/TN2017000243A1/en unknown
- 2015-12-08 JP JP2017532168A patent/JP2017537960A/ja active Pending
- 2015-12-08 CA CA2970866A patent/CA2970866A1/en not_active Abandoned
- 2015-12-08 CN CN201580068503.5A patent/CN107106555A/zh active Pending
- 2015-12-08 EP EP15813923.8A patent/EP3233083A1/en not_active Withdrawn
- 2015-12-08 US US15/534,324 patent/US20170368038A1/en not_active Abandoned
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- 2015-12-08 KR KR1020177019415A patent/KR20170095965A/ko not_active Withdrawn
- 2015-12-08 WO PCT/IB2015/059450 patent/WO2016097933A1/en not_active Ceased
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| BR112017011972A2 (pt) | 2017-12-26 |
| CL2017001566A1 (es) | 2018-03-23 |
| TN2017000243A1 (en) | 2018-10-19 |
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| US20170368038A1 (en) | 2017-12-28 |
| RU2017125365A (ru) | 2019-01-21 |
| TW201628615A (zh) | 2016-08-16 |
| CA2970866A1 (en) | 2016-06-23 |
| EP3233083A1 (en) | 2017-10-25 |
| CN107106555A (zh) | 2017-08-29 |
| AU2015365481A1 (en) | 2017-06-22 |
| MX2017008057A (es) | 2017-09-28 |
| SG11201704340VA (en) | 2017-07-28 |
| PH12017501046A1 (en) | 2017-11-27 |
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