KR20170065956A - A composition comprising bark of Cinnamomum loureirii extract having anti-oxidative or anti-inflammatory activity - Google Patents
A composition comprising bark of Cinnamomum loureirii extract having anti-oxidative or anti-inflammatory activity Download PDFInfo
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- KR20170065956A KR20170065956A KR1020150172379A KR20150172379A KR20170065956A KR 20170065956 A KR20170065956 A KR 20170065956A KR 1020150172379 A KR1020150172379 A KR 1020150172379A KR 20150172379 A KR20150172379 A KR 20150172379A KR 20170065956 A KR20170065956 A KR 20170065956A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
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- Nutrition Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to an antioxidant or anti-inflammatory cosmetic composition or food composition containing an extract of broccoli wood bark as an active ingredient. More specifically, the composition comprising the extract of broccoli wood bark of the present invention exhibits antioxidant or anti-inflammatory activity, and thus can be used for cosmetics or foods for preventing or improving diseases caused by oxidative and inflammatory actions .
Description
The present invention is Cinnamomum cassia (Cinnamomum The present invention relates to a composition for antioxidant or antiinflammatory activity , which comprises an extract of broccoli bark, loureirii bark extract, and more particularly to a cosmetic composition or food composition for antioxidant or antiinflammation comprising an extract of broccoli wood bark as an active ingredient.
Antioxidation refers to the prevention of many oxidative effects in the body. Oxidation refers to the phenomenon that when various kinds of unsaturated fatty acids present in the body are oxidized by oxygen, a substance called lipid peroxidation is produced, and when it is increased, aging phenomenon is promoted. When various factors cause the body to lose balance and accelerate oxidation, it causes oxidative stress in the living body and causes cell damage and pathological diseases. Reactive oxygen species (ROS), which is a direct cause of oxidative stress, are chemically unstable and highly reactive, and can easily react with various biomaterials such as DNA, protein, lipid and carbohydrate. Attacks, causing irreversible damage to cells and tissues, or causing mutations, cytotoxicity, and cancer.
Inflammation refers to the pathological state of abscess formed by the invasion of external bacteria. The causes of inflammation include physical factors caused by trauma, phase, and bronze, chemical factors by chemical substances, and immunological factors by antibody reaction In addition, blood vessels and hormone imbalance also cause inflammation. In the inflammatory reaction, various free radicals are produced along with various inflammation inducers. Normal free radicals are involved in maintaining the homeostasis of cells and affect cell differentiation, growth, survival, and aging. These free radicals are produced in the intracellular mitochondria through oxidation and reduction of oxygen by respiration and immune reaction. Harmful ROS are usually caused by superoxide dismutase, catalase, glutathione peroxidase, glutamine reductase, vitamin C, vitamin E, uric acid, bilirubin, It is eliminated by the action of the same antioxidant system. However, when the balance of generation and elimination of free radicals is collapsed, oxidative stress occurs, which causes various pathological changes such as inflammation, aging, or cancer.
For this reason, research on the development of antioxidants and anti-inflammatory agents has been actively carried out, but there is a problem in that the use of the synthetic products is limited because the safety of the synthetic products is long when applied to human skin. Therefore, there is an urgent need to develop natural antioxidants and anti-inflammatory agents which are excellent in stability against skin and have high efficacy.
Broiler tree ( Cinnamomum loureirii ) is an evergreen arboreous tree with rust, about 8m in height, and the leaves are alternate long oval. In June, a thin green flower blooms on the axil and the fruit is black, the flesh is used as a spice, and the shell of the stems and branches is called cinnamon. Cinnamon promotes blood circulation, eliminates the coldness of the thoracic region, promotes appetite, promotes digestion, and is used for limb paralysis. It suppresses gastrointestinal spasticity and promotes gastrointestinal motility, thereby releasing gas and improving absorption. There is also a preservative effect that suppresses abnormal fermentation in the intestines. It has been reported that the pharmacological action is to inhibit improving bacteria, to inhibit white spore strain, to act on the surface, and to stimulate saliva and gastric secretion. Although there have been reports of antioxidant activity of broiler chickens in the past, there has been no study comparing antioxidant or anti-inflammatory effects of broiler chickens (stem, petiole, bark).
The present invention relates to an extract of broccoli wood bark, which effectively scavenges reactive oxygen species (ROS) and reduces the expression level of interleukin-1? (IL-1?), An inflammatory expression gene, Anti-inflammatory activity.
Accordingly, an object of the present invention is to provide a cosmetic composition or food composition for antioxidant or anti-inflammation containing an extract of broccoli wood bark as an active ingredient.
In order to achieve the above object, the present invention provides a cosmetic composition for antioxidant or anti-inflammation comprising an extract of broccoli wood bark as an active ingredient.
The present invention also provides a food composition for antioxidant or anti-inflammation comprising an extract of broccoli wood bark as an active ingredient.
In one embodiment of the present invention, the brook bark extract may be water, an organic solvent, or an extract derived from a mixed solvent thereof.
In one embodiment of the present invention, the organic solvent may be selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate and methylene chloride.
In one embodiment of the present invention, the antioxidant effect may be achieved through a process of eliminating ROS.
In one embodiment of the present invention, the anti-inflammatory effect may be achieved through inhibition of IL-1? Expression.
In one embodiment of the present invention, the broiler chestnut bark extract may be contained in an amount of 0.1 to 10% by weight based on the total weight of the composition.
Since the composition comprising the extract of broccoli wood bark extract according to the present invention exhibits antioxidant or anti-inflammatory activity by effectively eradicating ROS and inhibiting the expression of IL-1 ?, it is possible to prevent or ameliorate diseases caused by oxidative and inflammatory actions For example, cosmetics or foods.
Fig. 1A shows a photograph of a broth extract of Curcuma zeae obtained by filtration.
FIG. 1B is a photograph showing the concentration of broiler tree extract using a rotary evaporator, Buchi.
FIG. 1C is a photograph showing drying of a broiler tree extract liquid to remove water in the extract by applying a hot water vapor stream.
FIG. 1D shows a photograph of a final broodstock extract stored in a cold room at -10 ° C.
FIG. 2 shows the results of ROS scavenging analysis of the extracts of broiler chickens.
FIG. 3 shows the results of comparing the expression levels of IL-1β, an inflammation-expressing gene, for the anti-inflammatory efficacy of the extracts of broiler chickens.
The present invention is Cinnamomum cassia (Cinnamomum loureirii bark extract of the present invention, which is characterized by providing an antioxidant or anti-inflammatory composition.
In one embodiment of the present invention, the brook bark extract is extracted with water, an organic solvent or a mixed solvent thereof.
In one embodiment of the present invention, the organic solvent is selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate and methylene chloride.
In one embodiment of the present invention, the antioxidant effect is achieved through a process of eliminating ROS.
In one embodiment of the present invention, the anti-inflammatory effect is achieved by inhibiting the expression of IL-1 ?.
In one embodiment of the present invention, the bark extract of broiler chickens comprises 0.1 to 10% by weight based on the total weight of the composition.
The term " extract " of the present invention means a preparation which is obtained by squeezing a herbal medicine with an appropriate leaching solution and concentrating the liquid by evaporating the leaching solution, and is not limited thereto. The extract is obtained by drying the extract, diluted solution, Dried products, controlled products thereof or purified products thereof.
The extract of the present invention can be prepared by extracting with an extraction solvent or extracting with an extraction solvent and fractionating the extract with a fraction solvent. The extraction solvent may be, but is not limited to, water, an organic solvent or a mixed solvent thereof. The organic solvent may be selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, Methylene chloride or a mixed solvent thereof may be used. In one embodiment of the present invention, an extract using 95% ethanol as the solvent was prepared.
As the "extraction method" for extracting the extract of the present invention, any one of the methods such as a flow extraction method, a hot water extraction method, a cold extraction extraction method, a reflux cooling extraction method, a solvent extraction method, a steam distillation method, an ultrasonic extraction method, a leaching method, . In addition, the desired extract may be further subjected to a conventional fractionation process or may be purified using a conventional purification method.
The antioxidant or anti-inflammatory cosmetic composition comprising the extract of broccoli wood bark according to the present invention as an active ingredient can be widely used for a cosmetic or a skin cleanser for improving the skin such as prevention of aging of skin and improvement of wrinkles.
The cosmetic composition according to the present invention may further comprise a water-soluble vitamin, an oil-soluble vitamin, a polymeric peptide, a polymeric polysaccharide, a sphingoglycolipid, and a seaweed extract in addition to an extract of an effective brooderma tree bark extract.
As the water-soluble vitamin, any water-soluble vitamin can be used as long as it can be compounded in cosmetics. Preferably, vitamin B, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinamide, folic acid, vitamin C, And may also include salts thereof (thiamine hydrochloride, sodium ascorbate, etc.) or derivatives (sodium ascorbic acid-2-phosphate, ascorbic acid-2-phosphate magnesium salt, etc.). The water-soluble vitamin can be obtained by a conventional method such as a microorganism conversion method, a purification method from a culture of a microorganism, an enzymatic method, or a chemical synthesis method.
The useful vitamins may be vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d-alpha-tocopherol), and derivatives thereof (palmitic acid ascorbin, Acid ascorbic, dipalmitic acid ascorbin, L-pantothenyl alcohol, D-pantothenyl alcohol, pantothenyl ethyl ether, and the like). Usability Vitamins can be obtained by a conventional method such as a microorganism conversion method, a purification method from a culture of a microorganism, an enzyme or a chemical synthesis method.
The polymeric peptide may be any of those that can be compounded in cosmetics, but may be preferably collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin, and the polymeric peptide may be purified from a culture broth of a microorganism, And can be purified from natural products such as ducks such as pigs and cows and silk fiber of silkworms.
The polymeric polysaccharide may be any one as long as it can be compounded in cosmetics. The polysaccharide may be preferably hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt, etc.), for example, chondroitin Sulfuric acid or a salt thereof can be usually purified from mammals or fishes.
The sphingoglycolipids may be ceramides, phytosphingosines and sphingoglycolipids, and the sphingoglyphids may be any conventional ones that are commonly used in mammals, fish, shellfish, yeast or plants. Method or by a chemical synthesis method.
The seaweed extract may be any of those which can be compounded in cosmetics, but may be preferably a brown algae extract, a red algae extract, or a green algae extract, and may also be color guanine, arginic acid, sodium alginate, Potassium sulfate and the like are also included in the seaweed extract used in the present invention. Seaweed extract can be obtained from seaweed by a conventional method.
In addition, the components contained in the cosmetic composition of the present invention may contain, in addition to the above-mentioned extracts, the components conventionally used in cosmetic compositions, for example, stabilizers, solubilizers, vitamins, pigments, Phosphorous adjuvants and a carrier.
Further, the cosmetic composition of the present invention can be manufactured into any formulations conventionally manufactured in the art, and it can be manufactured in various forms such as lotion, nutrition lotion, nutritional cream, massage cream, nutritional essence, pack, makeup base, foundation , Body oil, hair oil, shampoo or rinse.
In addition, the antioxidant or anti-inflammatory food composition containing the extract of broccoli wood bark according to the present invention as an active ingredient may be used as an independent composition or may be mixed with other food ingredients. The amount of the active ingredient to be mixed can be suitably determined according to the intended use (prevention, health or therapeutic treatment), and may further include a food-acceptable food-aid additive. Since the composition of the present invention contains an extract derived from a natural substance as an active ingredient, there is no problem in terms of stability, so there is no great limitation on the amount of the mixture.
The food composition of the present invention may include all foods having a conventional meaning, and may be mixed with terms known in the art such as functional foods, health functional foods, and the like.
The term " functional food " as used herein means food prepared or processed by using raw materials or ingredients having useful functions in the human body, and " functional " means that the nutrients are controlled or physiological functions And the like, for the purpose of obtaining a beneficial effect for health use.
The term " health functional food " of the present invention refers to a food prepared by processing a specific ingredient as a raw material for the purpose of health assisting or by extracting, concentrating, refining, mixing, or the like a specific ingredient contained in a food raw material, Refers to a food which is designed and processed so that the body control function such as bio-defense, regulation of biorhythm, prevention and recovery of disease and the like can be sufficiently exhibited to the living body by the above components. Recovery, and so on.
There is no limitation on the kind of food in which the food composition of the present invention can be used. In addition, the composition comprising the extract of broccoli wood bark of the present invention as an active ingredient may be prepared by mixing other suitable auxiliary ingredients that may be contained in food with known additives according to the selection of a person skilled in the art. Examples of foods that can be added include dairy products, such as meat, sausage, bread, chocolates, candies, snacks, confectionery, pizza, ramen, other noodles, gums, ice cream, various soups, drinks, tea, Vitamin complex, and the like, and can be prepared by adding to the juice, tea, jelly, and juice prepared from the extract of the present invention as a main component.
When the food composition of the present invention is used in the form of a drink, it may contain various sweetening agents, flavoring agents, or natural carbohydrates as an additional ingredient such as ordinary beverages. In addition to the above, the food composition of the present invention may contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloid thickeners, pH adjusters, stabilizers, preservatives, glycerin, , A carbonating agent used in carbonated drinks, and the like. It may also contain flesh for the production of natural fruit juices, fruit juice drinks and vegetable drinks.
Hereinafter, the present invention will be described in detail with reference to the following examples. However, the following examples are provided to aid understanding of the present invention, and the scope of the present invention is not limited to the following examples.
[ Example 1] Preparation of broiler tree extract
Broccoli trees (FBM014-13, 14, 15) were purchased from the Biological Resources Center of the Institute of Medicinal Plants, Yunnan Provincial Institute of Agriculture, China. The stem, petiole and bark extracts of broiler chickens were extracted using a 95% ethanol solvent and extracted at 40 to 50 ° C for about 2 days (see FIG. 1A). When the extraction yield was low, extraction was tried again. Then, the mixture was filtered using a filter paper and concentrated using a rotary evaporator (Buchi, Switzerland) at 45 ° C (see FIG. 1b). The extract liquid was placed on the dish at 45 ° C, Followed by drying to remove moisture (see FIG. 1C). When the extracted sample became solid, drying was stopped and recovered. The final extract was then stored in a cold room at -10 ° C (see FIG. 1d).
[ Example 2] Extracts of broiler chickens Active oxygen species ( ROS ) Scatters analysis
In order to analyze the ROS scavenging ability of extracts of broiler chickens, the following experiment was conducted. Bone marrow-derived macrophages are isolated from the thigh bone of 6-8 week old C57BL / 6 mice and then differentiated for 7 days. After 20 ng / ml of lipid polysaccharide (LPS) and stem, petiole and bark extracts of broiler chickens were treated with 20 ug / ml for 24 hours, the cells were stained with a H2DCFDA ROS detector and the cells were collected and analyzed by flow cytometry The amount of ROS was measured by measuring the expression of fluorescence with flow cytometry. The results are shown in FIG.
2, it was confirmed that the extracts of broccoli wood bark extract effectively inhibited hydrogen peroxide-induced ROS generation from stem extracts and leaf spot extracts, and thus it was confirmed that the broccoli bark extract had a strong antioxidant ability there was.
[ Example 3] Analysis of anti-inflammatory efficacy of extracts of broiler chickens
In order to compare the antioxidant ability of each part of the broth tree extract, the following experiment was conducted. Bone marrow-derived macrophages are isolated from the thigh bone of 6-8 week old C57BL / 6 mice and then differentiated for 7 days. After that, 200 ng / ml of lipopolysaccharide (LPS) and stem, petiole and bark extracts of broiler chickens were treated with 20 ug / ml for 24 hours, respectively, and RNA was isolated using trizol reagent. After that, cDNA was synthesized and the expression level of IL-1β, an inflammatory expression gene, was confirmed by quantitative PCR (qPCR). The results are shown in FIG.
FIG. 3 shows that the extract of broiler chestnut bark extract effectively inhibited the expression of IL-1β, an inflammatory expression gene, from stem extracts and petiole extracts, which are other site extracts, .
That is, from the above results, it was confirmed that a composition containing an extract of broccoli wood bark as an active ingredient can be effectively used as a cosmetic composition or food composition for antioxidant or anti-inflammation.
The present invention has been described with reference to the preferred embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.
Claims (12)
Wherein the brook tree bark extract is extracted with water, an organic solvent or a mixed solvent thereof.
Wherein the antioxidant effect is achieved through a process of eliminating reactive oxygen species (ROS).
Wherein the anti-inflammatory effect is achieved by inhibiting the expression of interleukin-1? (IL-1?).
Wherein the composition comprises 0.1 to 10% by weight of an extract of broccoli wood bark, based on the total weight of the composition.
Wherein the brook tree bark extract is extracted with water, an organic solvent or a mixed solvent thereof.
Wherein the antioxidant effect is achieved through a process of eliminating reactive oxygen species (ROS).
Wherein the anti-inflammatory effect is achieved by inhibiting the expression of interleukin-1? (IL-1?).
Wherein the composition comprises 0.1 to 10% by weight of an extract from broccoli wood bark, based on the total weight of the composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150172379A KR20170065956A (en) | 2015-12-04 | 2015-12-04 | A composition comprising bark of Cinnamomum loureirii extract having anti-oxidative or anti-inflammatory activity |
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020150172379A KR20170065956A (en) | 2015-12-04 | 2015-12-04 | A composition comprising bark of Cinnamomum loureirii extract having anti-oxidative or anti-inflammatory activity |
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| KR1020150172379A KR20170065956A (en) | 2015-12-04 | 2015-12-04 | A composition comprising bark of Cinnamomum loureirii extract having anti-oxidative or anti-inflammatory activity |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020059906A1 (en) * | 2018-09-20 | 2020-03-26 | 김숙경 | Composition comprising extract of cinnamomum aromaticum, lonicera japonica, elsholtzia ciliate, schisandra chinensis, arctium lappa, and paeonia suffruticosa for prevention or treatment of skin aging or dermatitis and method using same |
| KR20200077090A (en) * | 2018-12-20 | 2020-06-30 | 동의대학교 산학협력단 | Composition for prevention or treatment of dental disease comprising an extract of cinnamon |
-
2015
- 2015-12-04 KR KR1020150172379A patent/KR20170065956A/en not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020059906A1 (en) * | 2018-09-20 | 2020-03-26 | 김숙경 | Composition comprising extract of cinnamomum aromaticum, lonicera japonica, elsholtzia ciliate, schisandra chinensis, arctium lappa, and paeonia suffruticosa for prevention or treatment of skin aging or dermatitis and method using same |
| KR20200077090A (en) * | 2018-12-20 | 2020-06-30 | 동의대학교 산학협력단 | Composition for prevention or treatment of dental disease comprising an extract of cinnamon |
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