KR20170059340A - Cosmetic Cmposition Comprising Silicate - Google Patents
Cosmetic Cmposition Comprising Silicate Download PDFInfo
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- KR20170059340A KR20170059340A KR1020150163605A KR20150163605A KR20170059340A KR 20170059340 A KR20170059340 A KR 20170059340A KR 1020150163605 A KR1020150163605 A KR 1020150163605A KR 20150163605 A KR20150163605 A KR 20150163605A KR 20170059340 A KR20170059340 A KR 20170059340A
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- cosmetic composition
- elasticity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
(I) a silicate; And (ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13; or (i) a silicate; (Ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13; And (iii) a wrinkle-improving agent selected from the group consisting of acetylhexapeptide-8, palmitoylpentapeptide-4 and capper tripeptide-1. When the cosmetic composition of the present invention is used, Of immediate and sustained improvement of wrinkles, improvement of elasticity, or reduction of swelling of the eyes.
Description
More particularly, the present invention relates to a cosmetic composition comprising a silicate and a thickening agent, or a cosmetic composition comprising a silicate, a thickener and a wrinkle-improving agent.
Typically, the goal of cosmetic compositions is to keep the skin clean and beautiful, to maintain healthy skin, and to delay or prevent skin aging.
The skin of a person is damaged due to various contaminants and stresses as it gets older, and the damaged skin cells do not grow properly and the skin loses its elasticity and wrinkles.
Healthy normal skin has a protective ability to protect the skin from external damage factors, but when exposed to sustained external stimuli, the skin's ability to protect itself is deteriorated, resulting in reduced skin elasticity, wrinkles and skin aging And so on.
To prevent wrinkles and elasticity of the skin, it is recommended to provide less moisture and nutrients to the skin, less exposure to ultraviolet rays and various pollutants, less stress.
However, such efforts alone can not completely avoid the occurrence of wrinkles, and a cosmetic composition having an effect of improving wrinkles and improving elasticity, which alleviates the wrinkles generated, has been demanded.
To solve this problem, Japanese Patent Laid-Open No. 5-246838 discloses a cosmetic composition containing ammonium acetate, ammonium tartrate, and ammonium nitrate to revitalize collagen metabolism to prevent skin aging. US Patent No. 5,340,568 Discloses a composition containing 2-deoxy-2-halo-lysophosphatidic acid to inhibit wrinkle formation of the skin. However, the composition disclosed in the prior art is very unstable and is not easily transferred to the skin, so that a special stabilization system and delivery system are required, and the effect of improving skin wrinkles is not visible.
European Patent No. 1586106 discloses a system for stabilizing a retinoid having an anti-aging effect, comprising a chelating agent, an oil-soluble antioxidant, a chelating agent and a water-soluble antioxidant, An oil-in-water (W / O) type emulsion composition containing a free base type imidazole is proposed. However, the emulsion composition does not chemically change retinol until 6 months and the method of stabilizing the retinoid is too complicated, There is a problem that the effectiveness is preserved only in a short period of time.
Accordingly, the present inventors have made intensive efforts to develop a cosmetic composition which is stable and has an effect of improving wrinkles, improving elasticity, or reducing swelling under eyes. As a result, it has been found that (i) And (ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13, or (i) a silicate; (Ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13; And (iii) a cosmetic composition comprising a wrinkle-improving agent selected from the group consisting of acetylhexapeptide-8, palmitoylpentapeptide-4, and capric tripeptide-1 has an immediate and sustained effect of improving wrinkles, improving elasticity, And that the present invention has been completed
It is an object of the present invention to provide a cosmetic composition having an immediate and sustained effect of improving wrinkles, improving elasticity, or reducing swelling under eyes.
In order to achieve the above objects, And (ii) a thickening agent selected from the group consisting of magnesium aluminum silicate and polyacrylate-13, for immediate wrinkle improvement, elasticity improvement or sublingual swelling.
The present invention also relates to a process for the preparation of (i) silicates; (Ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13; And (iii) an anti-wrinkle agent selected from the group consisting of acetylhexapeptide-8, palmitoylpentapeptide-4 and capecripteptide-1, for immediate and sustained improvement of wrinkles, A composition for cosmetics is provided.
According to the present invention, a composition comprising a silicate and a thickening agent has an immediate wrinkle improving effect, a resilience improving effect or a sublingual swelling reduction effect on the skin, and a composition including a silicate, a thickener and a wrinkle improving agent can provide an immediate and sustained wrinkle- , A resilience improving effect, or a sublingual swelling reduction effect.
FIG. 1 is a graph showing the parameters of eye wrinkles measured before and after the cosmetic use according to an embodiment.
FIG. 2 is a graph showing the parameters of the wrinkles of the wrist measured before and after using the cosmetic according to an embodiment.
FIG. 3 is a graph showing the parameters of the fine wrinkles measured before and after the cosmetic use according to one embodiment.
FIG. 4 is a graph showing the parameters of the forehead wrinkles measured before and after the cosmetic use according to one embodiment.
FIG. 5 is a graph showing the parameters of neck wrinkles measured before and after the cosmetic use according to one embodiment.
FIG. 6 is a graph showing the parameters of the elastic modulus of the eyes measured before, immediately after, and two weeks after the cosmetic use according to one embodiment.
FIG. 7 is a graph showing the parameters of the arm elasticity measured before, immediately after, and two weeks after the cosmetic use according to one embodiment.
FIG. 8 is a graph showing the elastic modulus measured before, immediately after, and two weeks after use of cosmetics according to one embodiment.
FIG. 9 is a graph showing the parameters of forehead elasticity measured before, immediately after, and two weeks after using cosmetics according to one embodiment.
10 is a graph showing variables of neck elasticity measured before, immediately after, and two weeks after using cosmetics according to one embodiment.
FIG. 11 is a graph showing the parameters of the sublingual swelling measured before, immediately after, and two weeks after the cosmetic use according to one embodiment.
12 is a graph showing the parameters of eye wrinkles measured before and after using cosmetics according to another embodiment.
FIG. 13 is a graph showing the parameters of the wrinkles of the wrist measured before and after use of the cosmetic according to another embodiment.
FIG. 14 is a graph showing the parameters of the fine wrinkles measured before and after using the cosmetic according to another embodiment.
15 is a graph showing the parameters of the forehead wrinkles measured before and after use of the cosmetic according to another embodiment.
16 is a graph showing the parameters of neck wrinkles measured before and after using cosmetics according to another embodiment.
17 is a graph showing the parameters of the elastic modulus of eyes measured before, immediately after, and two weeks after use of cosmetics according to another embodiment.
18 is a graph showing the parameters of the elasticity of arms measured before, immediately after, and two weeks after use of cosmetics according to another embodiment.
FIG. 19 is a graph showing variables of hair elasticity measured before, immediately after, and two weeks after using cosmetics according to another embodiment.
FIG. 20 is a graph showing the parameters of the forehead elasticity measured before, immediately after, and two weeks after using cosmetics according to another embodiment.
FIG. 21 is a graph showing variables of neck elasticity measured before, immediately after, and two weeks after use of cosmetics according to another embodiment.
22 is a graph showing the parameters of the sublingual swelling measured before, immediately after, and two weeks after using cosmetics according to another embodiment.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein and the experimental methods described below are well known and commonly used in the art.
Due to the increase of ultraviolet ray due to environmental pollution, air pollution and excessive fatigue and stress of modern people, the skin loses its elasticity, and skin wrinkles are formed and skin aging occurs. The present invention provides a cosmetic composition having an effect of improving wrinkles, improving elasticity, or reducing swelling of the eyes, in order to improve skin aging such as skin sagging, elasticity loss and skin wrinkle formation.
In the present invention, it was confirmed that a cosmetic composition containing a silicate and a thickening agent has an immediate wrinkle-improving effect, a resilience improving effect, or a sublingual swelling effect on the skin.
In one embodiment of the invention, (i) a silicate; And (ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13. As a result, it was confirmed that the immediate wrinkle improving effect, the elasticity improving effect, or the sublingual swelling reduction effect of the skin can be confirmed.
Accordingly, in one aspect, the present invention relates to a process for preparing (i) silicate; And (ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13. The present invention also relates to a composition for use in cosmetics for immediate wrinkle improvement, elasticity improvement, or reduction of sublingual swelling.
In the present invention, the silicate is preferably sodium silicate or potassium silicate. Silicate is a substance in which the hydrogen atom of the silicic acid is replaced with a metal atom. The sodium silicate is a substance in which the hydrogen atom of the silicic acid is substituted with sodium, and the potassium silicate is the material in which the hydrogen atom of the silicic acid is substituted with potassium. The sodium silicate and the potassium silicate may be characterized by giving immediate tension to the skin when used as a cosmetic composition, thereby imparting a lifting effect to the wrinkled or stretched skin.
In the present invention, the content of the silicate is preferably 0.01 to 10% by weight based on the total weight of the composition. When the silicate is added as a basic substance in an amount exceeding 10% by weight based on the total weight of the cosmetic composition, the pH of the cosmetic itself may increase to 9.0 or more, which may result in a problem that it can not be used as a cosmetic product. If the content of the silicate is less than 0.01% by weight based on the total weight of the cosmetic composition, the amount of the silicate is too small to cause immediate lifting effect of the skin. Therefore, the content of the silicate is preferably 0.01 to 10% by weight based on the total weight of the composition.
In the present invention, the thickening agent is a substance for increasing the viscosity and is used for increasing the viscosity of the silicate. The thickener can be divided into polymers, waxes, butter and inorganic materials. Specific examples of the thickener include magnesium aluminum silicate, xanthan gum, pantin, starch, alginic acid, carboxymethyl cellulose, carboxyethyl cellulose, carboxyvinyl polymer, Mango butter, beeswax, cetearyl alcohol and paraffin wax. Among them, in the present invention, it is preferable to use magnesium aluminum silicate or polyacrylate-13 as a thickener. Magnesium aluminum silicate and polyacrylate-13 stabilize formulations as well as thickening effects and are suitable for cosmetics that are not toxic and applied directly to the human body. In addition, magnesium aluminum silicate and polyacrylate-13 thickener can stabilize the cosmetic composition as an inorganic thickener and an acrylate thickener, respectively.
In the present invention, the content of the thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13 is preferably 0.01 to 20% by weight based on the total weight of the composition. When the content of the thickener is less than 0.01% by weight of the total amount of the cosmetic composition, the thickening effect and the cosmetic formulation can not be stabilized. If the content of the thickening agent exceeds 20% It may cause a problem that the face is whitened at the time of application or the film is formed after a certain period of time after application to the skin and it is not suitable for use as a cosmetic product. Therefore, the content of the thickener is preferably 0.01 to 20% by weight based on the weight of the composition. The formulation of the cosmetic composition containing the thickening agent is preferably a liquid, an emulsion or a cream.
In another embodiment of the present invention, there is provided a composition comprising: (i) a silicate; (Ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13; And (iii) a cosmetic composition comprising a wrinkle-improving agent selected from the group consisting of acetylhexapeptide-8, palmitoylpentapeptide-4 and capper tripeptide-1. As a result, it was confirmed that the immediate and continuous wrinkle improvement effect, the elasticity improvement effect, or the sublingual swelling reduction effect of the skin was confirmed.
Thus, in another aspect, the present invention provides a process for the preparation of (i) a silicate; (Ii) a thickener selected from the group consisting of magnesium aluminum silicate and polyacrylate-13; And (iii) an anti-wrinkle agent selected from the group consisting of acetylhexapeptide-8, palmitoylpentapeptide-4 and capecripteptide-1, for immediate and sustained improvement of wrinkles, And a cosmetic composition.
In the present invention, the silicate and the thickener are the same as the conditions for producing a cosmetic composition according to one aspect of the invention.
In the present invention, the anti-wrinkle agent is used to continuously exhibit the anti-wrinkle effect. Examples of the wrinkle improving agent include acetyl hexapeptide-8, palmitoylpentapeptide-4, capper tripeptide-1, retinol, retinyl palmitate and adenosine. In the present invention, acetylhexapeptide-8, palmitoylpentapeptide- And capper tripeptide-1 may be used. Acetylhexapeptide-8, palmitoylpentapeptide-4 and capper tripeptide-1 inhibit the release of vesicles containing acetylcholine, a neurotransmitter that causes muscle contraction, It is harmless to the human body and is suitable for use as cosmetics.
In the present invention, the amount of the wrinkle-reducing agent selected from the group consisting of acetylhexapeptide-8, palmitoylpentapeptide-4 and capper tripeptide-1 is preferably 0.0001 to 10% by weight based on the total weight of the composition . The anti-wrinkle agent may be characterized in that it immediately maintains the lifting effect of the skin caused by the silicate. When the content of the wrinkle-reducing agent is less than 0.0001 wt% of the total weight of the cosmetic composition, there may be a problem that the lifting effect of the skin is not continuously exhibited. When the wrinkle-improving agent content exceeds 10 wt% There is a problem in stabilizing the efficacy and cosmetic formulation. Therefore, it is preferable that the content of the antiwrinkle agent is 0.0001 to 10% by weight based on the total weight of the composition.
Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.
[Example 1]
1.2% by weight of sodium silicate, 6.0% by weight of magnesium aluminum silicate, 20% by weight of other additives and 72.8% by weight of purified water. The cosmetics were tested for clinical application through KC Skin Clinical Research Center. The subjects were 21 women with an average age of 47.053 ± 4.813 years. After the morning and evening cleansing twice daily, the cream was applied to the face and the results were measured. Skin tests were performed to measure wrinkles, skin elasticity and submergence swelling. For mechanical skin measurements, the subjects were first rinsed with the prepared cleanser followed by a constant temperature and humidity condition (temperature 20 ~ 24 ℃, humidity 40 ~ 60% The skin was stabilized for about 30 minutes and adapted to the measurement environment. The measurement sites were photographed and processed by the same researchers under the same conditions every time.
1-1. Skin wrinkle measurement
Wrinkle measurement was performed using Antera 3D to measure the wrinkles before, after, after, and after cosmetic use. The degree of wrinkles was analyzed by specifying a specific part of the photographed image and used as a wrinkle evaluation data. The measured wrinkle variable is Overall Size. The analytical value and the degree of wrinkle improvement are in inverse proportion to each other.
Improvement rate (%) = [(measured value after using cosmetics - measured value before using cosmetics) / measured value before using cosmetics] x100
(Overall Size)
(Overall Size)
(Overall Size)
(Overall Size)
(Overall Size)
As a result, as shown in Tables 1 to 5 and Fig. 1 to Fig. 5, it was confirmed that the cosmetic composition of Example 1 improved the wrinkles, wrinkles, fine lines, forehead and neck wrinkles. That is, the cosmetic composition of the present invention has an effect of improving wrinkles of the skin.
1-2. Skin elasticity measurement
Skin elasticity was measured by using a cutometer, and skin elasticity was measured before, after, and two weeks after use of cosmetics in eyes, forehead, forehead, forehead and neck. The value of R2 was used as the skin elasticity evaluation data. The measured skin elasticity unit is A.U (Arbitrary Unit), and the measured value is proportional to the skin elasticity.
Improvement rate (%) = [(measured value after using cosmetics - measured value before using cosmetics) / measured value before using cosmetics] x100
(R2)
(R2)
(R2)
(R2)
(R2)
As a result, as shown in Tables 6 to 10 and Figs. 6 to 10, it was confirmed that the cosmetic composition of Example 1 improved and sustained the elasticity of eyes, legs, forehead and neck. That is, it was confirmed that the cosmetic composition of the present invention has an effect of improving the elasticity of the skin, and the effect thereof continues.
1-3. Swelling of the eyes
Eye swelling was measured using Antera 3D after 2 weeks before, after, and 2 weeks after using cosmetics. Specified areas of the photographed images were used to analyze the submandibular volume and used as an evaluation of submandibular swelling. The variable of the measured eye bag is Volume, and the unit is mm 3 . The analytical value is proportional to the degree of swelling under the eyes, so that the lower the analytical value, the less (improved) the swelling in the eyes.
Improvement rate (%) = [(measured value after using cosmetics - measured value before using cosmetics) / measured value before using cosmetics] x100
(mm)
As a result, as shown in Table 11 and Fig. 11, it was confirmed that the cosmetic composition of Example 1 reduced swelling under the eyes. That is, the cosmetic composition of the present invention has an effect of reducing swelling under the eyes.
[Example 2]
A cosmetic product was prepared comprising 1.2% by weight of sodium silicate, 6.0% by weight of magnesium aluminum silicate, 0.005% by weight of acetylhexapeptide-8, 20% by weight of other additives and 72.795% by weight of purified water. The cosmetics were tested for clinical application through KC Skin Clinical Research Center. The subjects were 21 women with an average age of 47.053 ± 4.813 years. After the morning and evening cleansing twice daily, the cream was applied to the face and the results were measured. Skin test was performed to measure wrinkles, skin elasticity and submergence swelling. To measure mechanical skin, the subject was first skin cleansed with a prepared cleanser and then subjected to constant temperature and humidity (temperature 20 ~ 24 ℃, humidity 40 ~ 60% The skin was stabilized for about 30 minutes and adapted to the measurement environment. The measurement sites were photographed and processed by the same researchers under the same conditions every time.
2-1. Skin wrinkle measurement
Wrinkle measurement was performed using Antera 3D to measure the wrinkles before, after, after, and after cosmetic use. The degree of wrinkles was analyzed by specifying a specific part of the photographed image and used as a wrinkle evaluation data. The measured wrinkle variable is Overall Size. The analytical value and the degree of wrinkle improvement are in inverse proportion to each other.
Improvement rate (%) = [(measured value after using cosmetics - measured value before using cosmetics) / measured value before using cosmetics] x100
(Overall Size)
(Overall Size)
(Overall Size)
(Overall Size)
(Overall Size)
As a result, as shown in Tables 12 to 16 and Figs. 12 to 16, it was confirmed that the cosmetic composition of Example 2 improved the wrinkles of eyes, forehead, forehead, forehead and neck. Further, when compared with Tables 1 to 5 and 1 to 5 of Example 1, it was confirmed that the improvement ratio of the cosmetic composition of Example 2 was higher. That is, the cosmetic composition of the present invention has an effect of improving wrinkles of the skin, and the effect thereof is continuous.
2-2. Skin elasticity measurement
Skin elasticity was measured by using a cutometer, and skin elasticity was measured before, after, and two weeks after use of cosmetics in eyes, forehead, forehead, forehead and neck. The value of R2 was used as the skin elasticity evaluation data. The measured skin elasticity unit is A.U (Arbitrary Unit), and the measured value is proportional to the skin elasticity.
Improvement rate (%) = [(measured value after using cosmetics - measured value before using cosmetics) / measured value before using cosmetics] x100
(R2)
(R2)
(R2)
(R2)
(R2)
As a result, as shown in Tables 17 to 21 and Figs. 17 to 21, it was confirmed that the cosmetic composition of Example 2 improved and continued the elasticity of eyes, legs, forehead and neck. Further, when compared with Tables 6 to 10 and 6 to 10 of Example 1, it was confirmed that the improvement ratio of the cosmetic composition of Example 2 was higher. That is, the cosmetic composition of the present invention has an effect of improving skin elasticity, and the effect thereof is continuous.
2-3. Swelling of the eyes
Eye swelling was measured using Antera 3D after 2 weeks before, after, and 2 weeks after using cosmetics. Specified areas of the photographed images were used to analyze the submandibular volume and used as an evaluation of submandibular swelling. The variable of the measured eye bag is Volume, and the unit is mm 3 . The analytical value is proportional to the degree of swelling under the eyes, so that the lower the analytical value, the less (improved) the swelling in the eyes.
Improvement rate (%) = [(measured value after using cosmetics - measured value before using cosmetics) / measured value before using cosmetics] x100
(mm)
As a result, as shown in Table 22 and Fig. 22, it was confirmed that the cosmetic composition of Example 2 reduced swelling under the eyes. Further, when compared with Table 11 of Example 1 and Fig. 11, it was confirmed that the improvement ratio of the cosmetic composition of Example 2 was higher. That is, the cosmetic composition of the present invention not only reduces swelling under eyes, but also has a continuous effect.
While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will appreciate that such specific embodiments are merely preferred embodiments and that the scope of the present invention is not limited thereby will be. Accordingly, the actual scope of the invention will be defined by their equivalents.
Claims (9)
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Cited By (2)
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PL423409A1 (en) * | 2017-11-09 | 2019-05-20 | Oceanic Spolka Akcyjna | Composition, method for producing the composition, application of the composition and a cosmetic product containing that composition |
FR3110411A1 (en) * | 2020-05-20 | 2021-11-26 | Laboratoire Dermatologique Inderma | Complex based on retinol, tripeptide-1 and menthyl lactate and its cosmetic applications |
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FR2825271B1 (en) | 2001-05-31 | 2003-08-08 | Oreal | COMPOSITION OF AEROSOL CONTAINING SILICATE PARTICLES AND POLYMERS |
US20130195783A1 (en) | 2012-01-19 | 2013-08-01 | The Procter & Gamble Company | Methods For Smoothing Wrinkles and Skin Texture Imperfections |
ITBS20130177A1 (en) * | 2013-11-27 | 2015-05-28 | Gianpaolo Pizzoli | COSMETIC PREPARATION |
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PL423409A1 (en) * | 2017-11-09 | 2019-05-20 | Oceanic Spolka Akcyjna | Composition, method for producing the composition, application of the composition and a cosmetic product containing that composition |
FR3110411A1 (en) * | 2020-05-20 | 2021-11-26 | Laboratoire Dermatologique Inderma | Complex based on retinol, tripeptide-1 and menthyl lactate and its cosmetic applications |
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