KR20170004034A - 리카르바제핀 아세테이트를 포함하는 경구 투여형 - Google Patents
리카르바제핀 아세테이트를 포함하는 경구 투여형 Download PDFInfo
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- KR20170004034A KR20170004034A KR1020167036806A KR20167036806A KR20170004034A KR 20170004034 A KR20170004034 A KR 20170004034A KR 1020167036806 A KR1020167036806 A KR 1020167036806A KR 20167036806 A KR20167036806 A KR 20167036806A KR 20170004034 A KR20170004034 A KR 20170004034A
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- Prior art keywords
- pharmaceutical composition
- acetate
- composition according
- oral dosage
- binder
- Prior art date
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- Ceased
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| PCT/PT2008/000043 WO2009054743A1 (en) | 2007-10-26 | 2008-10-24 | Oral dosage forms comprising licarbazξpine acetate |
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| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| US8372431B2 (en) | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
| KR101665968B1 (ko) | 2009-07-21 | 2016-10-13 | 케릭스 바이오파마슈티컬스 인코포레이티드 | 구연산철 투여형태 |
| UA106384C2 (ru) | 2009-07-27 | 2014-08-26 | БИАЛ-ПОРТЕЛА энд КА., С.А. | ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ 5H-ДИБЕНЗ/б,ф/АЗЕПИН-5-КАРБОКСАМИДА ДЛЯ ЛЕЧЕНИЯ ФИБРОМИАЛГИИ |
| JP6122639B2 (ja) * | 2009-10-26 | 2017-04-26 | メルク・シャープ・エンド・ドーム・コーポレイション | インテグラーゼ阻害剤を含有する固形医薬組成物 |
| US20120121703A1 (en) * | 2010-07-20 | 2012-05-17 | Japan Tobacco Inc. | Tablet containing ferric citrate |
| TR201008460A1 (tr) | 2010-10-15 | 2012-05-21 | Sanovel İlaç San.Ve Ti̇c.A.Ş. | Eslikarbazepinin saşe formülasyonları. |
| US20140302152A1 (en) * | 2010-12-31 | 2014-10-09 | Bial-Portela & Ca., S.A. | Granulates comprising eslicarbazepine acetate |
| US9750747B2 (en) | 2011-08-26 | 2017-09-05 | Bail-Portela & Ca, S.A. | Treatments involving eslicarbazepine acetate or eslicarbazepine |
| EP3103444A1 (en) | 2015-06-09 | 2016-12-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical compositions of lacosamide and eslicarbazepine |
| EP3957302A1 (en) * | 2015-12-18 | 2022-02-23 | Jubilant Generics Limited | Solid oral dosage forms of eslicarbazepine |
| WO2018004391A1 (ru) * | 2016-06-29 | 2018-01-04 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Фармацевтическая композиция, содержащая комбинацию мемантина и мелатонина |
| CN106913550B (zh) * | 2017-03-10 | 2019-12-17 | 扬子江药业集团北京海燕药业有限公司 | 一种醋酸艾司利卡西平片的制备方法 |
| WO2019058354A1 (en) * | 2017-09-25 | 2019-03-28 | Jubilant Generics Limited | SUSPENSION OF ESLICARBAZÉPINE |
| US11318145B2 (en) | 2018-09-25 | 2022-05-03 | Jubilant Generics Limited | Eslicarbazepine suspension |
| EA037195B1 (ru) * | 2018-03-28 | 2021-02-18 | Акционерное Общество "Химфарм" | Биологически активная добавка для улучшения функционального состояния дыхательной системы и восстановления иммунной системы (варианты) |
| CN112912495A (zh) | 2018-09-14 | 2021-06-04 | 学校法人庆应义塾 | 星形胶质细胞的制造方法 |
| HUP1900153A1 (hu) | 2019-05-14 | 2020-11-30 | Meditop Gyogyszeripari Kft | Eszlikarbazepin-acetát tartalmú granulátum, ennek elõállítása, ezt tartalmazó egyéb gyógyszerkészítmények, és ezek alkalmazása |
| WO2021226256A1 (en) * | 2020-05-05 | 2021-11-11 | Neurobo Pharmaceuticals, Inc. | Niclosamide formulations and methods of use |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5326570A (en) * | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
| ZA953078B (en) | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| PT101732B (pt) | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| US6296873B1 (en) * | 1997-01-23 | 2001-10-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Zero-order sustained release delivery system for carbamazephine derivatives |
| CO4920215A1 (es) | 1997-02-14 | 2000-05-29 | Novartis Ag | Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones |
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| GB0111566D0 (en) | 2001-05-11 | 2001-07-04 | Portela & Ca Sa | Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide |
| GB0112812D0 (en) | 2001-05-25 | 2001-07-18 | Portela & Ca Sa | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
| WO2003075830A2 (en) * | 2002-03-14 | 2003-09-18 | Sun Pharmaceutical Industries Limited | Oral controlled drug delivery system containing carbamazepine |
| DE10224170A1 (de) | 2002-05-31 | 2003-12-11 | Desitin Arzneimittel Gmbh | Pharmazeutische Zusammensetzung mit verzögerter Wirkstofffreisetzung |
| CA2485932A1 (en) | 2002-05-31 | 2003-12-11 | Desitin Arzneimittel Gmbh | Pharmaceutical composition containing oxcarbazepine and having a controlled active substance release |
| DE10230027A1 (de) | 2002-07-04 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen auf der Basis von Natriumkanalblockern und Magnesiumsalzen |
| GB0221956D0 (en) | 2002-09-20 | 2002-10-30 | Novartis Ag | Organic compounds |
| AU2003280393A1 (en) | 2002-10-17 | 2004-05-04 | Novartis Ag | Pharmaceutical composition for treating pain comprising oxicarbazepine, or derivatives thereof, and cox2 inhibitors |
| US20040087642A1 (en) | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain |
| GB2401605A (en) | 2003-05-12 | 2004-11-17 | Portela & Ca Sa | Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof |
| EP1750717B1 (en) * | 2004-02-11 | 2017-07-19 | Rubicon Research Private Limited | Controlled release pharmaceutical compositions with improved bioavailability |
| BRPI0508887B1 (pt) | 2004-03-17 | 2015-08-11 | Lanxess Elastomers Bv | Processo para preparação de um polímero, catalisador iônico compreendendo um composto organometálico, catalisador suportado e processo para produção de um composto organometálico |
| AR048672A1 (es) | 2004-03-22 | 2006-05-17 | Novartis Ag | Tabletas de desintegracion que comprenden licarbazepina |
| AR048318A1 (es) * | 2004-03-22 | 2006-04-19 | Novartis Ag | Formulaciones de matriz orales que comprenden licarbazepina |
| GB2416167A (en) | 2004-07-13 | 2006-01-18 | Portela & Ca Sa | Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides |
| EP1787642A1 (en) | 2004-11-10 | 2007-05-23 | Teva Pharmaceutical Industries Ltd. | Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby |
| GB0425320D0 (en) | 2004-11-17 | 2004-12-22 | Johnson Matthey Plc | Diamines |
| GB2422149A (en) | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| EP2380573B1 (en) | 2005-05-06 | 2015-02-25 | Bial-Portela & CA, S.A. | Eslicarbazepine acetate and methods of use |
| BRPI0520258A2 (pt) | 2005-05-06 | 2009-09-15 | Portela & Ca Sa | uso de uma composição farmacêutica, método para preparar uma composição farmacêutica, e, uso de uma quantidade eficaz de acetato de eslicarbazepina |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| US8059672B2 (en) | 2005-05-18 | 2011-11-15 | Sprint Communications Company L.P. | Internet communications between wireless base stations and service nodes |
| US20070071819A1 (en) * | 2005-05-30 | 2007-03-29 | Kesarwani Amit K | Multiple unit modified release compositions of carbamazepine and process for their preparation |
| WO2007008576A2 (en) | 2005-07-08 | 2007-01-18 | Taro Pharmaceuticals U.S.A., Inc. | Oxcarbazepine formulation |
| GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
| WO2007029093A2 (en) | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | Pharmaceutical dosage forms of oxcarbazepine |
| AU2007211210A1 (en) | 2006-01-31 | 2007-08-09 | Teva Pharmaceutical Industries Ltd. | Oxcarbazepine pharmaceutical formulation and its method of preparation, wherein oxcarbazepine has a broad and multi-modal particle size distribution |
| JP2008538783A (ja) | 2006-01-31 | 2008-11-06 | テバ ファーマシューティカル インダストリーズ リミティド | ブロード且つ多峰性の粒度分布を有するオキシカルバゼピンを含む医薬製剤及びその調製方法 |
| GB0603008D0 (en) | 2006-02-14 | 2006-03-29 | Portela & Ca Sa | Method |
| GB2437078A (en) | 2006-04-11 | 2007-10-17 | Portela & Ca Sa | 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives |
| WO2008037044A1 (en) | 2006-09-27 | 2008-04-03 | Medley S.A. Indústria Farmacêutica | Oxcarbazepine-containing oral formulation and a process to obtain the same |
| US20080138403A1 (en) | 2006-12-08 | 2008-06-12 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical dosage forms of oxcarbazepine |
| US8372431B2 (en) | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
| EP3957302A1 (en) | 2015-12-18 | 2022-02-23 | Jubilant Generics Limited | Solid oral dosage forms of eslicarbazepine |
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2013
- 2013-01-30 US US13/754,439 patent/US20130150348A1/en not_active Abandoned
- 2013-12-17 US US14/108,615 patent/US9566244B2/en active Active
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2014
- 2014-07-10 JP JP2014141894A patent/JP6043758B2/ja not_active Expired - Fee Related
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2016
- 2016-07-27 JP JP2016147183A patent/JP2017014233A/ja active Pending
- 2016-12-14 CY CY20161101294T patent/CY1118350T1/el unknown
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2017
- 2017-01-04 US US15/397,945 patent/US10912781B2/en active Active
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2018
- 2018-06-26 JP JP2018120334A patent/JP2018172407A/ja active Pending
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2021
- 2021-01-29 US US17/248,581 patent/US20210322436A1/en not_active Abandoned
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