KR20160103554A - 당쇄 관련 유전자, 및 그의 이용 - Google Patents

당쇄 관련 유전자, 및 그의 이용 Download PDF

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KR20160103554A
KR20160103554A KR1020167022756A KR20167022756A KR20160103554A KR 20160103554 A KR20160103554 A KR 20160103554A KR 1020167022756 A KR1020167022756 A KR 1020167022756A KR 20167022756 A KR20167022756 A KR 20167022756A KR 20160103554 A KR20160103554 A KR 20160103554A
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South Korea
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sirna
tissue
manufactured
gene
inhibitor
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Korean (ko)
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히로유키 요네야마
쥰 코야마
마사토 후지
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가부시끼가이샤 스텔릭 사이세이 이카가꾸 겐뀨쇼
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Publication of KR20160103554A publication Critical patent/KR20160103554A/ko
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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KR1020167022756A 2007-12-27 2008-12-26 당쇄 관련 유전자, 및 그의 이용 Ceased KR20160103554A (ko)

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JPJP-P-2007-336518 2007-12-27
JP2007336518 2007-12-27
PCT/JP2008/004025 WO2009084232A1 (ja) 2007-12-27 2008-12-26 糖鎖関連遺伝子、およびその利用

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KR1020197037818A Active KR102244872B1 (ko) 2007-12-27 2008-12-26 당쇄 관련 유전자, 및 그의 이용
KR1020187034630A Ceased KR20180132162A (ko) 2007-12-27 2008-12-26 당쇄 관련 유전자, 및 그의 이용
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009004995A1 (ja) * 2007-06-29 2009-01-08 Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. 生理活性物質を定着および発現させる方法
US20120117671A1 (en) 2009-07-31 2012-05-10 Hiroyuki Yoneyama Steatohepatitis-liver cancer model animal
RU2637372C2 (ru) 2011-11-18 2017-12-04 Нитто Денко Корпорейшн Средство для лечения фиброза кишечника
EP2876162A4 (en) * 2012-07-17 2016-03-16 Stelic Institute&Co MUCOSA CURE PROMOTER
AU2014259756B2 (en) * 2013-05-01 2017-02-23 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating apolipoprotein C-III expression
JP6302183B2 (ja) * 2013-07-12 2018-03-28 株式会社エンザミン研究所 アディポサイトカイン産生バランス調整剤及び脂肪組織の炎症・酸化ストレス抑制剤並びに脂肪組織のマクロファージ浸潤抑制剤
EP3265567B1 (en) 2015-03-02 2020-07-29 Conagen Inc. Regulatory elements from labyrinthulomycetes microorganisms
WO2017078054A1 (ja) 2015-11-04 2017-05-11 株式会社ステリック再生医科学研究所 ＲＮＡｉ分子とＮ－アセチル化キトサンとを含む複合体
US10633454B2 (en) 2016-11-01 2020-04-28 Conagen Inc. Expression of modified glycoproteins and glycopeptides
WO2018106959A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
US20200093850A1 (en) 2016-12-07 2020-03-26 Stelic Institute & Co., Inc. Pharmaceutical composition for treatment and prevention of chronic disease
CA3054159A1 (en) 2017-03-30 2018-10-04 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor
WO2019173226A1 (en) * 2018-03-05 2019-09-12 Synthetic Genomics, Inc. Organisms and methods for producing glycomolecules with low sulfation
CN109897812B (zh) * 2019-03-19 2021-09-03 江南大学 一种表达软骨素4-硫酸转移酶基因的重组菌及其应用
CN113811313A (zh) * 2019-05-08 2021-12-17 Tme治疗医学有限公司 食管狭窄抑制剂
CN116254296A (zh) * 2023-03-27 2023-06-13 中国科学院微生物研究所 利用昆虫细胞杆状病毒表达系统表达硫酸软骨素修饰酶的方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4571242B2 (ja) * 1996-07-24 2010-10-27 生化学工業株式会社 ヒト由来のグリコサミノグリカンスルホトランスフェラーゼのポリペプチド及びそれをコードするｄｎａ
CA2285940A1 (en) * 1997-04-11 1998-10-22 K. Ramakrishnan Bhaskar Use of chondroitinase in the manufacture of a medicament in the treatment and prevention of mucoid secretions
EP1839671A3 (en) * 1999-12-02 2007-10-31 BioMarin Pharmaceutical Inc. Attenuation of fibroblast proliferation
CA2393186A1 (en) * 1999-12-02 2001-06-07 Ibex Technologies, Inc. Attenuation of fibroblast proliferation
US6713274B2 (en) * 2002-05-13 2004-03-30 The Regents Of The University Of California Method for identifying modulators of sulfotransferase activity
EP1541580B1 (en) * 2002-07-10 2013-02-27 Seikagaku Corporation Sulfotransferase inhibitors
EP3175855B1 (en) * 2004-03-12 2020-07-15 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using fxr ligands
WO2007049361A1 (ja) * 2005-10-27 2007-05-03 Stelic Corp. 肝線維化抑制剤
JP2009286695A (ja) * 2006-09-08 2009-12-10 Stelic Institute Of Regenerative Medicine 眼線維性血管新生抑制剤
US20090202515A1 (en) * 2006-09-08 2009-08-13 Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. Agents for suppressing neural fibrotic degeneration
WO2009004995A1 (ja) * 2007-06-29 2009-01-08 Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. 生理活性物質を定着および発現させる方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Ajit Varki, Nature 446: 1023-1029 (2007)
Christopher J. Thibodeaux et. Al., Nature 446: 1008-1016 (2007)
Christopher N. et. Al., Nature 446: 1038-1045 (2007)
Danica P. Galonic and David Y. GiN, Nature 446: 1000-1007 (2007)
Gerald W. Hart et. Al., Nature 446: 1017-1022 (2007)
Joseph R. Bishop et. Al., Nature 446: 1030-1037 (2007)
Peter H. Seeberger and Daniel B. Werz, Nature 446: 1046-1051 (2007)

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