KR20160093816A

KR20160093816A - Medicinal herb extract for growing or restoring hair and cosmetic composition comprising the same

Info

Publication number: KR20160093816A
Application number: KR1020150014627A
Authority: KR
Inventors: 김동희; 최학주; 김청택
Original assignee: 대전대학교 산학협력단; 주식회사 알엔에스
Priority date: 2015-01-29
Filing date: 2015-01-29
Publication date: 2016-08-09
Also published as: KR101742819B1

Abstract

The present invention relates to a hot water extract of medicinal herbs having an excellent effect of supplying nutrients or growing hair, and to a cosmetic composition comprising the same. The medicinal herbs of the hot water extract are mixed medicinal herbs including Pleuropterus multiflorus TURCZ., Thuja orientalis L. leaves, Cudrania tricuspidata fruit, the fruit of Chinese matrimony vines, and Houttuynia cordata.

Description

[0001] The present invention relates to a medicinal herb extract for growing wool or hair growth, and to a cosmetic composition containing the same,

The present invention relates to a herbal medicine extract for promoting wool or hair growth and a cosmetic composition containing the same, and more particularly, to a hot water extract of an herbal medicine having excellent effect on wool or hair growth and a cosmetic composition containing the same.

Conventionally, baldness or hair loss is considered to be caused by activation of male hormone, hair loss in hair follicle, excessive secretion of sebum and scalp due to generation of peroxide, and the like in organs such as hair follicles and sebaceous glands. For this reason, a compound having an action to eliminate or alleviate the above causes is generally added to conventional hair dyes (sometimes referred to as hair restorers and hair growth promoting agents). For example, there are vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as extracts and acetylcholine derivatives at the beginning of the month, antiinflammatory agents such as rice currant extract and hinoxthiol and female hormones such as estradiol , And a skin aggressive agent such as sepharastatin are mixed and used for prevention and treatment of alopecia.

However, although various attempts have been made to formulate such compounds, conventional wool products have not had sufficient hair wool effects such as hair loss prevention and hair growth. This is thought to be caused by various causes of hair loss, and the mechanism of hair growth is also very complicated.

Therefore, researches on materials and ingredients capable of improving the condition of scalp and hair, including prevention of hair loss, have been actively carried out. As such materials and ingredients, Korean Patent Nos. 10-0038819, 10-0026222, 0002207, 10-0046064, etc., anti-male hormones, anti-seborrheic agents, keratolytic agents and removers, antiseptic disinfectants and amino acids, vitamins and the like have been used. However, it is pointed out that such conventional materials and ingredients are not excellent in preventing hair loss and improving hair, and there are restrictions on the content thereof due to safety and skin irritation.

In addition, a coating liquid containing a chemical agent such as minoxidil (for example, trade name "myoxylic liquid") has been commercialized, but such minoxidil

1) Skin: Local irritation such as itching, scurvy, erythema / redness, dermatitis, skin dryness, hirsutism other than the area where the medicine was applied (facial hair growth in case of wife), folliculitis, burning sensation and pidgin, , Acne, nasal congestion, bruising, eczema, abnormal hair;

2) Digestive system: Occasionally diarrhea, nausea, vomiting, etc. may appear;

3) Circulatory system: Sometimes chest pain, blood pressure changes, pulse changes, palpitations can occur;

4) Respiratory system: bronchitis, upper respiratory tract infection, sinusitis, sometimes shortening respiration;

5) Autonomic nervous system: Sometimes fractures, backache, tendonitis, pain, neuritis (such as multiple neuritis), weakness may occur;

6) Central nervous system: Occasionally dizziness, headache, blurred vision, fainting may occur;

7) Liver: Sometimes hepatitis can appear;

8) Kidney: sometimes edema, kidney stones can appear;

9) Allergies: Occasionally, fever, allergic reactions, urticaria, allergic rhinitis, systemic erythema and facial edema, hypersensitivity, chills may occur;

10) Others: Sometimes it is known that eye irritation, bitter taste, mite (especially otitis externa), taste change, visual impairment, erectile dysfunction, Particularly, it is known that hair loss may occur during side effects rather than side effects such as hirsutism at sites other than the area where the drug is applied.

Unlike direct pharmacological treatments such as the above chemical agents, oriental medicine has traditionally been associated with skin-related enhancement of the liver and kidney function associated with skin and hair enhancement, increased blood flow in the scalp due to improvement of blood and blood circulation, And to provide indirect treatment and prevention through herbal remedies.

Korean Patent Registration No. 10-0969269 (title of the invention: a cosmetic composition for prevention of hair loss and promoting wool comprising a top palm extract, a callus root extract, a marigold extract and a walnut extract) The present invention discloses a composition of a cosmetic composition having hair loss prevention effect and hair wool promoting effect containing muscle, mashihi, and walnut extract, wherein the same natural product is compared with a conventional hot water extraction method by using an ultrasonic method And extracts the active ingredient without damaging it, thereby demonstrating excellent hair loss prevention and hair growth effect through a mouse test and a simple clinical test.

Korean Patent Registration No. 10-1141779 (the name of the invention: composition for promoting hair or wool comprising the extract of Dodok or Dodok saponin) is a composition for promoting hair growth or wool which contains saponin as an active ingredient, Compositions and methods for promoting hair growth or wool using a composition comprising an extract of Rootgrass or saponin of the above composition as an active ingredient, It is disclosed that the product containing the compound can be applied not only to humans but also to pets, hairs and animals using fur.

Korean Patent Laid-Open Publication No. 10-2011-0099858 (title of the invention: a hair growth inhibitor composition containing Changmaokin extract) relates to a hair growth inhibitor composition comprising a Changmachi root extract obtained by hot water heating an iris root, 100 parts by weight of the crude extract obtained by heating with hot water, The flaxseed is heated at 80 to 120 ° C for 10 to 40 minutes to remove moisture from the flaxseed, followed by rapid cooling. The rapidly cooled flaxseed is put into a milking machine, milked at a temperature of 80 to 120 ° C, filtered at 200 mesh, The resulting flaxseed oil was recovered by natural precipitation of the filtered flaxseed oil for 10 to 20 days, and the upper layer was recovered to obtain refined flaxseed oil. Then, the flaxseed oil and cyanide (-CN) 20 parts by weight of milk; And 20 parts by weight of d-alpha-tocopherol are further added.

However, there is a continuing need for the development of a composition which is excellent in hair growth and wool effect and high in stability.

It is an object of the present invention to provide a hot-water extract of a herbal medicine having excellent hair growth and wool effect and high stability, and a cosmetic composition containing the same.

The herbal composition for accelerating hair growth or hair growth according to the present invention is characterized by containing a hot-water extract of a mixed medicinal herb which is a mixture of Hassuo, Paekjibyeol, Gujimpong, Gugija and Hwasungcho.

Preferably, the mixed medicinal herb may be a mixture of desserts, papaya, cucurbitans, gugija, and rhizomes of equal weight in a weight ratio.

In addition, the cosmetic composition comprising the extract of herbal medicine or herbal medicine for promoting hair growth according to the present invention is any one selected from the group consisting of lotion, lotion, cream and shampoo.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a hot-water extract of a herbal medicine having excellent hair growth and wool effect and high stability, and a cosmetic composition containing the same.

FIG. 1 is a graph showing the results of hair growth and wool effects of a Chinese medicinal herb extract for promoting hair growth or hair growth in comparison with a control group and a positive control group according to an embodiment of the present invention, wherein the hair of the control group, the positive control group, And the length of the test piece is measured.
FIG. 2 is a photograph showing hair growth and wool effects of a Chinese medicinal herb extract for promoting hair growth or hair growth according to an embodiment of the present invention compared with a control group and a positive control group.
FIG. 3 is a photograph showing hair growth and wool effects of a herbal extract for promoting hair growth or hair growth according to an embodiment of the present invention compared with a control group and a positive control group.
FIG. 4 is photographs showing hair growth and wool effects of a herbal medicine extract for promoting hair growth or hair growth according to an embodiment of the present invention compared with a control group and a positive control group.
FIG. 5 is photographs showing the results of hair growth and wool effects of the herbal extracts for promoting hair growth or hair growth in comparison with the control group and the positive control group according to the example of the present invention.

In order to accomplish the object of the present invention, the present invention provides a herbal extract for promoting hair growth or hair growth, comprising a hydrothermal extract of a mixed medicinal herb mixed with a medicinal herb, a papaya leaf,

The mixed medicinal herbs are preferably mixed in equal proportions by weight in terms of a weight ratio of horseradish, mulberry, cucumber, gugija, and rhizome.

The extract of herbal medicines for promoting hair growth or hair growth according to the present invention and the cosmetic composition containing the same are excellent in promoting wool or hair growth and do not cause side effects such as skin irritation.

Hereinafter, the extract of herbal medicines for promoting wool or hair growth and the cosmetic composition containing the same according to the present invention will be described in more detail.

First, the constituents of the herbal medicine extract for accelerating hair growth or hair growth according to the present invention are as follows.

Pleuropterus multiflorus TURCZ is a perennial herbaceous perennial herbaceous plant belonging to the genus Euphorbiaceae . It is a medicinal plant that has been grown in China for a long time. In the herb, the root of the herb has been used for body weakness, back pain, arteriosclerosis, , Chronic hepatitis, tuberculous lymphadenitis, enteritis, constipation, constipation, etc. There are no hairs in the whole, and the roots extend into the ground and sometimes form round root roots. In one room, root roots are used as medicines. The weakness is warm, cold and bitter. It is known to have the efficacy of tonic, gangjeong, blood (blood), interpolation, giant wind, and scion. It is used as a remedy for symptoms such as weakness of the body, low back pain, arteriosclerosis, hypertension, hypertension, chronic hepatitis, tuberculous lymphadenitis, enteritis, plague and constipation. Ingredients consist of 1.1% nitrogen, 45.2% starch, 3.1% fat, 4.5% mineral, 3.7% lecithin and 26.4% water soluble. The medicinal herb, called Baekwasuo from one room, is a large mockery belonging to the pupa, and is a botanically different plant from Sasa.

The lateral leaf (柏) refers to the leaf of the cabbage tree. In Korea, it refers to the branches and leaves of the perennial tree ( Thuja orientalis L. ). In China, Platycladus orientalis (L.) Franco is called, and it is not found in process medicine in Japan. It means that all the trees are facing the sun, and only the side branches are facing to the west alone. It is said that the tree with the incision has been given the name "yanashi" according to the practice of writing white. There are various kinds of kashiwara in one thing, but it is said that it is called a side cage because it uses only the leaf which grows in one side to put in medicine. The taste of this medicine is written, flat, and the quality is cold [苦澁寒]. Hematocrit is used for nosebleeds, hematemesis, hemorrhage, urine bleeding, uterine hemorrhage, and is used for seawater, asthma, sputum, hair loss, seborrheic dermatitis, trauma hemorrhage. It has been reported that the pharmacological action is to shorten the bleeding time, to reduce the blood pressure, to have antibacterial effect, to the seawater and to asthma.

Cucumber ( Cudrania tricuspidata ) is a deciduous broad-leaved arboreous tree of the dicotyledonous plant Nettlesoptera. It is also called gut thorn tree. It grows in the foothills and near the village. The fruit is male and the length is 5㎜. The fruit is gathered to form a lump with a diameter of 2 to 3 cm, rounded, fleshy and ripened red in September. Leaves can be used for mulberry leaves, berries can be eaten, jams made, and booze, and bark and roots for medicinal or paper raw materials.

The Gugija refers to the fruit of the Gugija that belongs to the branch, the Gugija is a deciduous broad-leaved shrub (broad leaf bush), the fruit is a round or elliptical berry And watery seeds), and ripen red in August and September. The length is 10 mm and the diameter is about 5 mm. It is sweet at first and bitter afterwards. When it is dry, it crumble on the outside, and there are many seeds inside. The seeds are flat, kidney-shaped, about 2 mm in diameter and yellowish white. Because the shape and color of the fruit is pretty and small, it is said to be the "좃좃 木夏" in ancient times. Currently, Cheongyang County in Chungcheongnam-do is the distribution center in Korea. The ingredients include betaine, zeazanthin, carotene, thiamine, vitamin A, vitamin B1, vitamin B2 and vitamin C. Animal studies have shown that beta-linolenic acid is one of the in vivo metabolites of lipid (parent lipid). It inhibits the accumulation of fat in the liver, promotes hepatocyte development, and lowers blood pressure. Medicinal (medicinal) is mediocre and not poisonous. The efficacy of chronic hepatitis, liver cirrhosis, etc., when the inflammation is removed and the function is activated. Generally, the reproductive function is fragile, and it is effective for symptoms such as back, knee sore, aching, fatigue, and fever. It is effective for the reduction of visual acuity due to ophthalmologic diseases and it is applied to the early symptoms of cataract in the elderly. Long-term use of gojija lighter and stronger energy, stronger legs and waist strength, and has the effect of inhibiting the aging of cells. In the private sector, it is used as 枸杞茶 or 기 酒. Do not administer to people with fever. In one room, it is used as a tonic, and as a typical prescription, there is a Kigyu Hwanghwang (杞菊地黄丸).

The above-mentioned urchin grass is the ground part of the flowering period of Houttuynia cordata Thunberg in Korea. In Japan, the same plant is called 약 薬 (十药). In China, the same plants are used, but they are called outposts or overheads. It is a name attached because it is fishy fish in the leaf. In ancient China 's Qin country, it was called the author (菹子), a plant that smells like a salted fish. This medicine has a fishy smell when it rubs the leaves, and the taste is spicy and the quality is a bit cold. Hwasungcho is excellent for diarrhea and drainage. It is used for coughing caused by lung abscesses, pneumonia, pneumonia, acute bronchitis, enteritis, urinary tract infections, boils, and it is used when you can not see urine. Antimicrobial activity, immune enhancement, antiinflammatory, diuretic, and calming action have been reported by pharmacological actions.

In the present invention, the above-mentioned medicinal materials are preferably extracted by known extraction method in which the medicinal materials are mixed at an equivalent ratio on the basis of weight, the medicinal materials are extracted by hot water extraction, that is, water is boiled, water is boiled, and the medicinal materials are cooled down. It should be understood that the hot water extraction is well known to those skilled in the art, and it is preferable to immerse the herbal medicines in water so that the water content becomes 90 to 50% by weight based on the total weight of the herbal medicinal herb medicines, , Boiling the mixture for about 20 minutes, and heating the mixture at a heating temperature lower than the boiling point of water for a further 10 minutes to 10 hours.

In addition, the cosmetic composition comprising the herbal composition for accelerating hair growth or hair growth according to the present invention preferably comprises 1 to 80% by weight, more preferably 10 to 50% by weight, of the herbal medicine extract as a main component.

The cosmetic composition of the present invention may contain, in addition to the herbal medicine extract for improving the hair, a moisturizer, a thickener, a surfactant, a fatty base, a preservative, an antioxidant, an alcohol, a flavor, And the like, as well as a scalp and a hair improving component of a chemical component for doubling the scalp and hair improving effect can be blended in an appropriate amount.

Meanwhile, the cosmetic composition prepared by containing the medicinal herb extract may be prepared in various formulations such as cosmetics, lotions, creams, shampoos and the like. Specifically, it can be applied in various form such as emulsion, cream, And can be produced using a conventional cosmetic preparation method. In particular, the cosmetic composition is more preferably used as a cosmetic for improving hair.

Hereinafter, preferred embodiments and comparative examples of the present invention will be described.

The following examples are intended to illustrate the invention and should not be construed as limiting the scope of the invention.

Example

1. Materials

1) Test substance: 100 g of herbal medicines mixed with 5 kinds of medicinal herbs, such as Hassuo, Paekjibyeo, Gujiljong, Gugija, and Rhizoctonia, were weighed and boiled for about 20 minutes from boiling The hot-water extract was further heated for 2 hours in a state in which the heating temperature was lowered to be lower than the boiling point of water, and the hot-water extract was used as an example.

2) Classification of C57bl / 6 mouse animal test group

Control group: 1% TXN control group (10 weeks 1% testosterone + physiological saline) (n = 10)

2) 1% TXN + 3% MXD (10 weeks 1% testosterone + 5% minoxidil) (n = 10)

③ 1% TXN + mixed hot water extract (10 week 1% testosterone + example) (n = 10)

2. Method

1) Sample administration method

The hot water extract of mixed medicinal herb according to the present invention was applied once a day to the back skin of 0.2 ml / day of natural hair growth promoting agent (RNB) for percutaneous application. The positive control group was coated with 5% minoxidil in the same manner, and the control group was washed several times with a certain amount of distilled water to give the same stress, and then a certain amount of physiological saline was sprayed.

2) Observation method

end. Growth hair growth measurement

C57bl / 6N mice were treated with 1% TXN for 1 week after hair removal. Then, two kinds of natural extracts were applied 0.2 ml per day for 49 days, and the growth of hair growth was observed to 0.1 mm with a vernier caliper based on gross changes in the control group and hair growth.

3. Statistical processing

Results from various experiments were recorded as mean ± standard deviation, and significance tests were determined using the Student's T-test.

4. Results and discussion

Growth hair growth measurement

C57bl / 6N mice were treated with 1% TXN for 1 week after hair removal. Two natural extracts were applied 0.2ml per day for 5 weeks, and the growth of hair growth was observed to 0.1 mm with vernier calipers based on the gross changes in the control group and the hair growth. As a result, the control group (treated with physiological saline solution) showed 0.22 ± 0.15 at 5 weeks, the positive control group (minoxidil treated group) showed 0.48 ± 0.09 and the example (mixed medicinal hot water extract treated group) showed 0.56 ± 0.05 (FIG.

Hair growth photo

1) After 1 week of application

FIG. 2 shows the appearance of C57BL / 6 after one week of drug application. In the control group, hair growth was hardly observed. In the positive control group, hair growth was observed from the neck region, and in the examples, hair growth was observed as a whole.

2) After 2 weeks of application

FIG. 3 shows the appearance of C57BL / 6 after 2 weeks of drug application. In the control group, the growth of the hair was slightly observed, and in the positive control group, hair growth was observed from the neck portion as a whole, and in the example, hair growth was observed in the neck portion and the whole body.

3) After 3 weeks of application

FIG. 4 shows the appearance of C57BL / 6 after 3 weeks of drug application. In the control group, the growth of the hair was observed as a whole, and in the positive control group, the number of hair-growing mice was increased to 2/3 or more. In the examples, the hair was completely grown and 2/3 or more was grown.

4) After 4 weeks of application

FIG. 5 shows the appearance of C57BL / 6 after 4 weeks of application of the drug. In the control group, mice with 2/3 or more hair growth were observed. In the positive control group, 2/3 or more hair-growing mice and fully-grown mice were increased, and in the examples, hair was completely grown.

5. Conclusion

1. The hair growth was observed in the positive control group and the example in the first week after the visual evaluation, but the hair growth was remarkable in the second week after the second week.

2. As a result of measuring the length of hair after 5 weeks of drug administration, hair length in the example was longer than that in the positive control.

(Without reference numerals)

Claims

Wherein the extract comprises hot water extract of mixed medicinal herbs mixed with at least one medicinal herb containing at least one medicinal herb,

The method according to claim 1,
Wherein the mixed medicinal herbs are mixed in equal proportions by weight in the ratio of Hashuo, Hwasaekjibyeol, Jurijipon, Gugija and Hwasungcho.

A cosmetic composition comprising the herbal composition for accelerating hair growth or hair growth according to any one of claims 1 to 6.

The method of claim 3,
Wherein the cosmetic composition is any one selected from the group consisting of lotion, lotion, cream, and shampoo.