KR20160082139A - Composition for covering body odor comprising extract of hydrangea serrata - Google Patents

Abstract

Provided is a composition for reducing body odor comprising a hydrangea extract as an active ingredient. Also provided is a pharmaceutical, food, or cosmetic composition comprising the same. The composition for reducing body odor of the present invention can reduce body odor generating due to germs acting by sweat, thereby removing displeasure aroused by body odor, and exhibiting excellent fragrance preferences. In addition, the pharmaceutical, food, or cosmetic composition of the present invention can be effectively used for reducing body odor of people.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for inhibiting body odor including extracts from mountainous plants,

The present disclosure relates to a composition comprising an extract from a mountain maize plant.

Body odor occurs when sweat secreted from the sweat glands is decomposed by microorganisms or bacteria. It occurs in the eccrine sweat gland distributed throughout the body and in the apocrine sweat gland distributed in areas with many hairs such as the armpit Fat, protein, sebum, and contaminants contained in the secreted sweat are decomposed by microorganisms and bacteria, resulting in an odor causing an unpleasant feeling such as an odor, a jewel, or a dodeca.

Excessive sweat and sebum secretion due to intense exercise and stress, and protein and fat due to the ingestion of oily foods cause perspiration and secretion, which causes severe body odor. Many foods such as onion, garlic, curry and caffeine Including coffee, chocolate, cola, alcohol that increases protein and fat in the body, and smoking, which keeps a pleasant smell in itself, also cause body odor. Such body odor has a different odor depending on sex, age, etc., such as male, female, baby, and elderly.

In general, methods such as restriction, deodorization, and masking are used to control body odor. A commonly used masking method is a method of masking body odor using fragrance. However, when the wrong fragrance is used to cover the body odor, it is rather odorous and can be adversely affected, so the choice of the fragrance is of utmost importance and the essential oil components of various plants are used to achieve this purpose. Therefore, the present inventors have studied the possibility of application as an external preparation for skin from a plant not yet widely known.

KR10-0785974 B1

It is an object of the present invention to provide a composition capable of effectively inhibiting body odor, having an antibacterial effect by using an extract of mountain juice to solve the harmful problem of the synthetic antibacterial raw material.

In order to achieve the above object, the present invention provides a composition for suppressing body odor comprising an extract of a mountain plant extract as an active ingredient.

The composition for suppressing body odor of the present invention has an effect of eliminating discomfort to the body odor by suppressing the body odor generated by the action of microorganisms due to perspiration, and has an excellent flavor palatability.

More particularly, the present invention relates to a composition for inhibiting body odor comprising an extract from a mountain plant, and more particularly, to an extract of a plant of the Ministry of Agriculture, Forestry and Fisheries having an antimicrobial effect and fundamentally inhibiting the generation of body odor by microorganisms, And a fragrance composition for suppressing body odor excellent in palatability.

In one aspect, the present disclosure may relate to a composition comprising an extract of Hydrangea serrata as an active ingredient.

In one aspect of the present disclosure, the composition may be a composition for suppressing body odor.

In one aspect of the present disclosure, the composition may be a pharmaceutical, food or cosmetic composition.

In one aspect of the present disclosure, the composition may be a perfume composition.

In one aspect of the present disclosure, the cosmetic composition may comprise a composition for suppressing body odor according to the present specification.

In one aspect of the present disclosure, the composition may be characterized as inhibiting the growth of Micrococcus or Corynebacterium microorganisms. In addition, the microcode kusu in (Micrococcus) is microcode kusu base Proteus may be a (Micrococcus luteus), the genus Corynebacterium (Corynebacterium) is Corynebacterium diphtheria (Corynebacterium diphtheriae) or Corynebacterium zero sheath (Corynebacterium xerosis .

In one aspect of the disclosure, the inhibition may be inhibition to a minimum inhibitory concentration (MIC) of 0.2 mg / mL or less, and preferably inhibition to a minimum inhibitory concentration (MIC) of 0.04 mg / mL or less have. In one aspect of the disclosure, the minimum inhibitory concentration of inhibition is 0.25 mg / mL or less, 0.2 mg / mL or less, 0.16 mg / mL or less, 0.15 mg / mL or less, 0.12 mg / mL or less, 0.10 mg / mL or less , Not more than 0.05 mg / mL, not more than 0.04 mg / mL, not more than 0.03 mg / mL, not more than 0.02 mg / mL, or not more than 0.01 mg / mL.

In one aspect of the present invention, the mountaineering station may be at least one selected from the group consisting of whole plants of the mountain plant, roots, leaves, stem, branches, bark, flowers, seeds and fruits of the mountain trees.

In one aspect of the present invention, the extract of Araliaceae may be a mixture of leaves, fruits and bark in a weight ratio of 7: 2: 1. The weight ratio may be a weight ratio of 1 to 10: 1 to 3: 1, or a weight ratio of 6 to 8: 1.5 to 2.5: 1.

In one aspect of the present disclosure, the extract may be one or more extracts selected from the group consisting of water, organic solvents, and mixtures thereof. The organic solvent may be one or more selected from the group consisting of ethanol, butylene glycol, and propylene glycol.

In one aspect of the present disclosure, the composition may be in the form of a solid stick deodorant, a liquid roll-on deodorant, an aerosol deodorant, a pump spray deodorant, a semi-solid gel deodorant, a soap bar, an ointment, a suspension, Wherein the composition is a composition selected from the group consisting of the composition for external application for skin.

In one aspect of the present disclosure, the cosmetic composition may be selected from the group consisting of softening longevity, astringent lotion, nutritional lotion, nutritional lotion, nutritional essence, nutritional cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, Wherein the composition is selected from the group consisting of gels, powders, makeup bases, body lotions, body creams, body oils, body essences, lotions, ointments, gels, creams, patches and sprays

In one aspect of the present disclosure, the composition may be a skin external composition.

In one aspect of the present disclosure, the body composition for suppressing body odor may be a body odor improver for ingesting the body by ingesting such a food composition orally and improving body odor to the body surface to improve the body. Such a body odor improving agent for body-wasting is disclosed in Korean Patent Publication No. 10-2008-0026130. In one aspect of the present invention, the food composition may be a supplemental food composition for reducing body odor.

There is no particular limitation on the method for preparing the extract of Sclerotinia used in the present specification, and in this specification, the extract of Scr. Succinaceus is a concentrate obtained by leaching out the extract from the acid plant, the concentrate obtained by partially or completely concentrating the extract, An extract obtained by drying the concentrate, or an oil containing the chemical substance itself exhibiting the main effect contained in the extract or obtained by distillation.

And arithmetic station (Hydrangea serrata) is in hydrangea plants (Hydrangea) herein, the genus Hydrangea macrophylla, Hydrangea and belongs to the (Hydrangeaceae), consists of a neck nature shrub of about 23 species. Western Hemisphere and eastern Asia are the origin. Hydrangea plants that grow in Korea include H. serrata and an ascendant. Mountain and vegetation countries are grown in mountains and fields. Hydroponics and their varieties are planted in gardens. Mountains can be seen all over Korea, but the country of origin grows only on Ulleungdo and Jeju Island. In addition, tree hydrangeas and American hydrangeas are imported from abroad and planted in garden landscapes.

The Hydrangea serrata referred to herein includes hydrangea serrata for acuminata (Siebold & Zucc) Wilson, hydrangea serratapo Hydrangea serrata for buergeri Nakai, hydrangea ceratapo koreana tea. Hydrangea serrata for coreana T. Lee and Hydrangea serrata for fertilis Nakai.

In this specification, Hydrangea Serrata for acuminata (Siebold & Zucc) Wilson) is referred to as the hydroponics (Lee Changbok, Korean Plants Illustrations, 1984) It is also called the country (Song Ju Taek, 1980, Korean botanical resource), sometimes called hydrangea. It is a bushy shrub on the side of a dicotyledonous plant roeae. It is native to the altitude of 200 ~ 1,400m in the southern part of Korea, and is distributed in Japan and Taiwan. It grows up to 1m in length and grows with many stems under the stem. The roots have fine roots and common roots. Leaves are opposite, oval or ovate, end is long like tail, peak is basal or oval, length is 5 ~ 15cm, width is 2 ~ 10cm, There are hairs on the veins and back veins. The flower has a large flat inflorescence at the end of the branch which grew up in July to August. It has hairs, and the silent flower around it is 2-3cm in diameter. The calyx is like petal, 3-5, white-pink or wrinkled. The positive flowers are small with calyxes and five each with petals. There are 5 stamens, 3 ~ 4mm long with style, 1 pistil and 3 ~ 4 styles. Fruit is ripened in September - October and is a small, honey-colored egg-shaped stem.

In the present specification, hydrangea serrata for buergeri nakai is also called Hydrangea serrata ( Hydrangea serrata for buergeri Nakai), also known as Hydrangea (Lee Changbok, Korean Botanical Garden, 1984) or Koryo hydrangea . It is distributed in the central and southern parts of Jeju Island including Korea, Japan, and Taiwan. The growth temperature is 16 ~ 30 ℃. It grows well in the water or valley where the soil moisture is high. It grows up to 1m in height. Leaves are opposite, long oval, pointed end. Leaf length is 5 ~ 15cm, width is 2 ~ 10cm with sawtooth on margin and hairs on veins. The flower is white or blue violet, and runs from July to August at the tip of the branch. Neutralization (Neutral flower) around the calyx is 3 ~ 5 with sawteeth and petals. The center is bisexual, with 5 petals and calyx pieces. Fruit is capillary (朔 果) ripened in October, and has a fine root.

As used herein, the term " hydrogene ceratapo < / RTI > ( Hydrangea serrata for. Coreana T. Lee) is a leafy shrub on the side of a dicotyledonous rosemary bract, which is referred to as the Rape Cropping Bureau (Lee Changbok, Korean Botanical Garden, 1984) . It is distributed in south central part of Korea. It grows up to 1m in length, flourishes with many stems under the stem, and there are fine hairs on annual branches. The roots have fine roots and common roots. Leaves are opposite, oval or ovate, end is long like tail, peak is basal or oval, length is 5 ~ 15cm, width is 2 ~ 10cm, There are hairs on the veins and back veins, and the leaves are particularly thick. The flowering period is from July to August, and many positive flowers form a flat inflorescence with ornamental flowers at the end of the branch which grows in the field. Ornamental flower is calyx shaped like petal, 3 ~ 5, blue or white. The positive flowers are small with calyxes and five each with petals. Surgery is 10, longer than petal. There are one pistil and three to four styles. The fruit is ripe in autumn and is egg-shaped.

In this specification, Hydrangea serrata for fertilis Nakai. Is called deciduous hydrangea (Songju Lake, Korean botanical resources, 1980) or an island hydrangea, and is a deciduous shrub of a dicotyledonous rosemary. It is distributed in Jeju Island in Korea and grows at the foot of a mountain or the edge of a forest. Tamra mountain range grows up to about 1m in height, and it grows with a lot of stem from bottom and there are hairs on annual branch. Leaves are opposite, oval or ovate, long apical long tail, with bottom or basal end, 5 ~ 15 cm long, 2 ~ 10 cm wide, sharp teeth, hairs on the lateral veins of the surface and back vein . Flowers bloom from July to August, and there are large flat inflorescence on the end of the branch that grows in this area, and there are hairs. Many benign flowers form large flat inflorescence with silky flowers of 2 ~ 3cm in diameter. Silky flower is calyx shaped like petal, 3-5, blue or purple. The benign flowers are small with calyxes and five with petals. There are 10 stamens, longer than petals, 1 pistil, 3 ~ 4 styles. The fruit is egg-shaped and ripens in autumn.

The mountain water station used in the present specification was sampled by tubular water planting at the Oseulokrothi Museum, Seogwangdowon.

As used herein, the acid-hydrolyzate may be contained in the form of an extract, or may be contained as a pulverized product of the herbal medicine itself or as a dried product of herbal medicine, but is not limited thereto. In addition, there is no limitation to the method of obtaining the mountain water station used in the present invention, and there is no limitation on the method of obtaining the mountain water. And fruit.

As used herein, the term " extract "includes all substances obtained by extracting components of a natural product, regardless of the extraction method, extraction solvent, extracted component or extract form, It is a broad concept that includes all of the materials that can be obtained by processing or processing in a process.

In the present specification, "extract of mountain juice" includes all of the substances obtained by extracting ingredients of mountain and vegetation, regardless of the extraction method, extraction solvent, extracted ingredient or extract form, and in the process of extracting the ingredients, (eg, acid, base, enzyme, etc.), and also extracts the components of the acid plant and extracts the extracted material, which is then processed or processed by other methods. It is a broad concept that encompasses all of the substances in question.

In one aspect of the present disclosure, the extract of Sclerotinia cornus is obtained by washing and drying the acid station; Solvent extraction of the dried mountain water station; And filtering the extracted acid water station. The solvent includes at least one selected from the group consisting of water, an organic solvent, and a mixture of water and an organic solvent. Wherein the water comprises distilled or purified water and the organic solvent is selected from the group consisting of alcohols such as C ₁ -C ₅ lower alcohols, acetone, ether, ethyl acetate, diethyl ether, ethyl methyl ketone and chloroform But is not limited thereto.

The extract may contain an acid hydrolyzate-C ₁ -C ₆ alcohol extract. Specifically, the alcohol may be methanol or ethanol.

The arthropod extract may be a crude extract of a solvent selected from the group consisting of water, C ₁ -C ₆ alcohols, and combinations thereof. The C ₁ -C ₆ alcohol may specifically be methanol. It is preferable that the extract is extracted by adding a solvent of about 5 to 15 times that of a mountain plant to extract the extractant with a solvent. Specifically, it is preferable to extract the extract by adding about 10 times of a solvent. However, the extraction is not limited thereto. The extraction may be performed by heat extraction, cold extraction, reflux cooling extraction, ultrasonic extraction or the like, and there is no limitation as long as it is an extraction method that is obvious to a person skilled in the art. The extraction may be carried out at room temperature, but it may be carried out under heating at a temperature of about 40 to 100 ° C, more preferably about 80 ° C, for a more efficient extraction, It is not. The extraction time is preferably about 2 to 4 hours, more preferably about 3 hours, but it is not limited thereto and may be varied depending on conditions such as extraction solvent and extraction temperature. The extraction may be carried out one or more times several times to obtain a larger amount of the active ingredient, preferably 1 to 5 times, more preferably 3 times of continuous extraction.

In the present specification, the extract of Araliaceae may contain a crude extract of a mountainous plant as described above, and may be included as a soluble fraction of an organic solvent obtained by further extracting the crude extract with an organic solvent having a low polarity. Examples of the organic solvent include, but are not limited to, hexane, methylene chloride, ethyl acetate, n-butanol, and the like. The extract or the soluble fraction of the extract may be used as it is, or may be used as an extract form by concentration after filtration, and may be used as a form of a lyophilizate by concentration and freeze-drying.

The extract of the mountain plant of the present invention comprises a step of finishing and drying the mountain water plant; Adding water, an organic solvent, or a combination thereof to the dried mountain water station and refluxing it; Precipitating the extract and filtering with a filter cloth; Centrifuging the filtrate to separate the residue and the filtrate; And concentrating the separated filtrate under reduced pressure to obtain an extract of mountain gill plant.

In one aspect of the present invention, the extract of Sclerotinia cornus is prepared in such a way that the concentrated hydrocolloid concentrate according to the above method comprises 5% by weight, based on the total weight of the extract, of purified water, ethanol, butylene glycol and propylene glycol Lt; RTI ID = 0.0 > dispersing / dissolving < / RTI >

For example, water or an organic solvent is added to a fertilized and dried fruit juice soup in the process of extracting the fruit of the present invention, and the mixture is subjected to reflux extraction, followed by filtration, filtration and centrifugation to separate the residue and the filtrate, The separated filtrate can be concentrated under reduced pressure to obtain an extract of mountain juice. The organic solvent which can be used in the present invention may be selected from ethanol, methanol, butanol, ether, ethyl acetate, chloroform or a mixed solvent of water and organic solvent. In consideration of the safety of raw materials, 100% water, 70% Or Butylene Glycol is used. At this time, the extraction temperature is preferably 18 to 80 ° C in the case of water, and preferably 18 to 40 ° C in the case of 70% ethanol and butylene glycol, and the extraction time is preferably 6 to 168 hours. If the extraction temperature and the extraction time are exceeded, the extraction efficiency may be deteriorated or the component may be changed. After obtaining the extract using a solvent, the extract can be obtained by cooling, heating and filtering at room temperature by a conventional method known in the art, or the solvent can be further evaporated, spray dried or freeze-dried.

1 kg of the sample is immersed in water and the water is cooled at 100 ° C. for 2 hours with water vapor. The volatile compounds containing the water-soluble fraction are allowed to stand for 20 minutes. The oil layer is filtered by microfiltration I will.

In one aspect of the present disclosure, it is preferred that the composition comprises the extract of Cornucopia in an amount of 0.001 to 50% by weight based on the total weight of the composition. More preferably from 0.001 to 10% by weight, from 0.1 to 1% by weight, from 2 to 5% by weight, from 0.5 to 10% by weight, or from 1 to 50% by weight. When the content is 0.001% by weight or less, the effect thereof is difficult to expect, and when the content is 50% by weight, problems of the form are caused. Specifically, the extract of Scutellariae Radix is at least 0.001% by weight, at least 0.01% by weight, at least 0.1% by weight, at least 0.3% by weight, at least 0.5% by weight, at least 0.8% by weight, at least 1% by weight, at least 2% by weight At least 3 wt%, at least 4 wt%, at least 5 wt%, at least 7 wt%, at least 10 wt%, at least 15 wt%, at least 20 wt%, at least 25 wt%, at least 30 wt% , Or 40 wt% or more, and 60 wt% or less, or 50 wt% or less.

In one aspect of the present invention, the composition for suppressing body odor may be contained in an amount of 0.0001 to 15% by weight based on the total weight of the cosmetic composition or the composition for external application for skin. If it is less than 0.0001% by weight, the expected effect can not be obtained. If it is more than 15% by weight, the palatability to the fragrance is poor. The fragrance composition for body odor suppression may further contain at least 0.0001% by weight, at least 0.001% by weight, at least 0.01% by weight, at least 0.1% by weight, at least 0.5% by weight, at least 1% by weight based on the total weight of the cosmetic composition or composition for external application for skin, At least 5 wt%, at least 7 wt%, at least 9 wt%, at least 10 wt%, at least 12 wt%, or at least 14 wt% and may be at most 20 wt% or at most 15 wt%.

In one embodiment of the present disclosure, the composition for external application for skin is used in combination with solid stick deodorant, liquid roll-on deodorant, aerosol deodorant, pump spray deodorant, semi-solid deodorant, soap bar, ointment, Cream, but is not limited thereto and may be formulated in any base known in the art.

In addition, in the respective formulations, components other than the above-mentioned essential ingredients can be appropriately selected and blended by those skilled in the art according to the kind of the other formulations or the purpose of use.

The pharmaceutical compositions according to the present disclosure may be of various oral or parenteral formulations. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, soft or hard capsules, etc. These solid preparations may contain at least one excipient such as starch, calcium carbonate, sucrose, Or lactose, gelatin, and the like. In addition to simple excipients, lubricants such as magnesium stearate, talc, and the like are also used. Liquid preparations for oral administration include suspensions, solutions, emulsions, syrups and the like. Various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included in addition to water and liquid paraffin, which are simple diluents commonly used. have. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like can be used as the non-aqueous solvent and suspension agent. Examples of the suppository base include witepsol, macrogol, tween 61, cacao paper, laurin, glycerogelatin and the like.

The pharmaceutical dosage forms of the compositions herein may be used in the form of their pharmaceutically acceptable salts and may also be used alone or in combination with other pharmaceutically active compounds, as well as in a suitable set. The salt is not particularly limited as long as it is pharmaceutically acceptable so long as it is pharmaceutically acceptable and includes, for example, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid, formic acid acetic acid, tartaric acid, lactic acid, citric acid, fumaric acid, , Benzenesulfonic acid, toluenesulfonic acid, and naphthalenesulfonic acid.

The composition of the present invention may be administered parenterally or orally, and may be administered in one to several divided doses in an amount of 0.1 to 500 mg, preferably 1 to 100 mg per kg of body weight per day have. The dosage for a particular patient may vary depending on the patient's body weight, age, sex, health condition, diet, time of administration, administration method, excretion rate, severity of disease, and the like.

The pharmaceutical composition according to the present invention may be formulated into various forms such as powders, granules, tablets, soft or hard capsules, oral formulations such as suspensions, emulsions, syrups and aerosols, external preparations such as ointments and creams, suppositories, Sterile injectable solutions, and the like, and may be formulated and used in any form suitable for pharmaceutical preparations.

The compositions according to the present disclosure can be administered to mammals such as rats, mice, livestock, humans, and the like in a variety of routes including parenterally, orally, and all manner of administration can be expected, for example, Or by intravenous, intramuscular, subcutaneous, intramural or intracerebroventricular injection.

In one aspect of the present disclosure, the food composition may be a health functional food composition.

The formulation of the food composition according to the present specification is not particularly limited, but may be formulated into, for example, tablets, granules, powders, liquid preparations such as a drink, caramels, gels, bars and the like. The food composition of each formulation can be blended with the ingredients commonly used in the field in addition to the active ingredient without difficulty by those skilled in the art depending on the purpose of formulation or use, and synergistic effect can be obtained when the composition is applied simultaneously with other ingredients.

In the food composition according to the present specification, the dosage determination of the active ingredient is within the level of those skilled in the art, and its daily dosage is, for example, from 0.1 mg / kg / day to 5000 mg / kg / day, mg / kg / day to 500 mg / kg / day, but it is not limited thereto, and may vary depending on various factors such as the age, health condition, and complication of the subject.

The food composition according to the present invention may be used as a food or beverage such as various foods such as chewing gum, caramel product, candy, ice cream, confectionery, beverage such as soft drink, mineral water, alcoholic beverage, healthful food including vitamins and minerals .

In addition to the above, the food composition which is one aspect of the present invention may be in the form of a flavoring agent such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, colorants and enhancers (cheese, chocolate etc.), pectic acid and its salts, Alginic acid and its salts, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated beverages and the like. In addition, the functional food compositions of the present disclosure may include natural fruit juice and pulp for the production of fruit juice drinks and vegetable drinks. These components may be used independently or in combination. The proportion of such additives is not so critical, but is generally comprised in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition herein.

The formulation of the cosmetic composition according to one aspect of the present specification is not particularly limited and can be appropriately selected according to the purpose. For example, skin lotion, skin softener, skin toner, astringent, lotion, milky lotion, moisturizing lotion, nutrition lotion, massage cream, nutritional cream, moisturizing cream, hand cream, foundation, essence, nutrition essence, pack, soap, cleansing But the present invention is not limited thereto, and may be manufactured by any one or more formulations selected from the group consisting of a foam, a cleansing lotion, a cleansing cream, a body lotion and a body cleanser.

When the formulation of the cosmetic composition according to the present invention is a paste, a cream or a gel, the carrier component may be an animal fiber, a plant fiber, a wax, a paraffin, a starch, a tracer, a cellulose derivative, a polyethylene glycol, a silicone, a bentonite, Etc. may be used.

When the formulation of the cosmetic composition according to the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as the carrier component, Propellants such as hydrocarbons, propane / butane or dimethyl ether.

Solvents, solubilizing agents or emulsifying agents are used as carrier components in the case of formulations of cosmetic compositions according to the present invention in the form of solutions or emulsions, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the cosmetic composition according to the present disclosure is a suspension, it may contain, as carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester , Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

In the case of an interface-active agent-containing cleansing of the cosmetic composition according to the present invention, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, Fatty acid amide ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linolenic derivative or ethoxylated glycerol fatty acid ester.

The cosmetic composition according to the present invention may further contain components included in functional additives and common cosmetic compositions in addition to the extract of mountain saury. The functional additives may include water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymeric polysaccharides, sphingolipids and seaweed extracts.

The cosmetic composition of the present invention may further contain, in addition to the above-described functional additive, components contained in a general cosmetic composition as required. Examples of the other ingredients that can be included in the composition include humectants, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbents, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, Accelerators, coolants, antiperspirants, purified water, and the like.

Furthermore, the present specification relates to an external preparation for skin containing an extract of mountain gill plant as an active ingredient, wherein the external preparation for skin is a generic term that may include any substance applied outside the skin, and cosmetics of various formulations may be included.

Hereinafter, the present specification will be described in detail with reference to Examples, Comparative Examples and Test Examples of the present specification. It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the limits of the embodiments, It will be self-evident.

[Example 1] Preparation of hydranase ceratapoacumina (S. et z.) Wilson extract

The leaves, fruit, and bark of Hydrangea Serrata for acuminata (Siebold & Zucc) Wilson were shredded at a weight ratio of 7: 2: 1. 1 kg was refluxed for 3 hours with 70% aqueous ethanol solution for 3 hours, cooled down, and filtered through Whatman # 5 filter paper. The filtered extract was concentrated under reduced pressure at 45 ° C or less and freeze-dried at -60 ° C for 3 days.

The extract was prepared by dispersing / dissolving the concentrated extract under reduced pressure using ethanol so as to contain 5% by weight based on the total weight of the extract.

[Example 2] Preparation of Jelly Nakai extract in hydranase ceratosa

An extract of Hydrangea serrata for buergeri nakai. Was prepared in the same manner as in Example 1.

[Example 3] Hydranase ceratapo Koreana tea. Preparation of extract

In the same manner as in Example 1, (Hydrangea serrata for. Coreana T. Lee) were prepared.

[Example 4] Preparation of hydranase ceratapoptilis nachei extract

An extract of Hydrangea serrata for fertilis Nakai was prepared in the same manner as in Example 1. [

[Test Example 1]

Antimicrobial activity of extract

Microcococcus luteus and corynebacterium, which are known as typical odor bacterium that decompose the sweat used in the experiment and cause odor, are used as the test bacteria. Corynebacterium diphtheriae (ATCC 11951, purchased from KORAM Biotech) was cultivated in Brain Heart Infusion medium at a concentration of 1 x 10 < 6 > Corynebacterium xerosis (ATCC 7711, purchased from Gene Bank) was inoculated into a medium supplemented with 10% of calf serum in a Brain Heart Infusion medium and cultured at 32 ° C for 24 hours with shaking A dilution of 1/20 diluted with the same medium as the culture medium was used as the test solution.

0.15 ml of the above test solution was added to 15 ml of each medium solution, and the mixture was used as a diluting solution. The extracts of Examples 1 to 4 of 0.1 μg / mL were sequentially added to the 96-well 96-well plate 1 to 4, and 16 μl of salicylic acid was added as a comparative example. 184 μl Respectively. 100 μl of diluted solution was added to the remaining wells. The mixed solutions of the first to fourth rows were mixed well and then 100 쨉 l were taken and placed in each of the rows 5 to 8 and mixed well. Then 100 쨉 l was taken again and diluted twice in the manner of putting in the rows 11 to 16. After incubation at 32 ° C for 48 hours, the microbial proliferation was determined by suspension and microscope to determine the minimum inhibitory concentration (MIC) value. The results are shown in Table 1.

Material name Minimum inhibitory concentration (MIC), mg / mL Micro Kokusuruteusu Corynebacterium diphtheria Corynebacterium zerosis Example 1 0.04 0.16 0.04 Example 2 0.05 0.17 0.04 Example 3 0.039 0.155 0.037 Example 4 0.041 0.157 0.038 Salicylic acid 0.25 0.25 0.25

The minimum inhibitory concentration of salicylic acid, which is generally known to have antimicrobial activity, is 0.25 mg / mL. Compared with the efficacy of the extract of Araliaceae according to the present specification, the extracts of Examples 1 to 4 exhibit a low concentration of less than 0.2 mg / mL And it was found that there was an antibacterial effect. In particular, it was confirmed that Example 1 had a low MIC concentration of 0.04 mg / mL for microcoxidase and Corynebacterium genocystis, and thus the effect was 50 times superior to that of salicylic acid.

Accordingly, the composition containing the extract of the present invention can effectively inhibit the unique body odor generated during sweating, thereby eliminating the uncomfortable feeling due to body odor.

[Test Example 2]

 (Deodorant) of Examples 5 to 8 and Comparative Example 1 were prepared according to the compositions shown in Table 2 below (hydrogensceratapoacimminata (S. et z.) Wilson (Example 6), Hydranase ceratapo koreana tea (Example 7), Hydranase ceratapoptilis nacai (Example 8), Hydrogenase ceratophyceae jelinacai (Example 6) ),).

ingredient Examples 5 to 8 (% by weight) Comparative Example 1 (% by weight) 1. Purified water Balance Balance 2. Surfactants 0.5 0.5 3. Polyol 10 10 4. Alcohol 70 70 5. Salicylic acid - 0.5 6. An extract of a plant of any one of Examples 1 to 4 0.5 -

[Test Example 2] Measuring effect of body odor inhibition

Experiments were conducted to measure the body odor inhibitory effect sensibly after directly applying the body odor inhibitor of Examples 5 to 8 and Comparative Example 1 to human body.

The sensory evaluation was conducted on 10 normal people over 20 years old who feel that armpits or foot odor is subjective or extraterrestrial, and one side does not use the product and the other side uses only the contents of the anti-odor agent. Was conducted by the expert panel directly.

The odor inhibition and flavor preference of the body odor inhibitor composition were evaluated on a scale of 5 points (the higher the score, the higher the degree of inhibition of body odor and the better the palatability). The sensory evaluation results of the body odor inhibitor are shown in Table 3 below.

Rating agent
Degree of body odor suppression Purity Comparative Example 1 Example Comparative Example 1 Example 5 6 7 8 5 6 7 8 One 3 5 5 4 5 3 4 5 5 5 2 3 5 5 4 5 2 5 4 4 5 3 3 5 5 4 4 2 5 4 5 5 4 2 5 4 5 5 3 5 4 4 5 5 4 5 4 4 4 3 5 4 5 5 6 3 5 5 4 4 One 4 5 4 5 7 4 4 5 5 4 2 4 5 5 4 8 3 4 5 5 4 2 4 5 4 4 9 4 4 4 5 5 3 5 5 5 5 10 3 5 5 5 5 3 5 4 4 5 11 4 4 5 5 5 2 5 4 4 4 12 3 5 5 5 5 2 4 5 5 4 13 3 5 5 4 5 3 5 5 5 4 14 3 5 5 4 5 2 4 4 5 5 15 3 4 5 5 5 3 5 4 5 5 Average 3.2 4.667 4.8 4.53 4.667 2.4 4.6 4.467 4.55 4.533

As shown in Table 3, the body odor inhibitor using the fragrance composition for suppressing body odor according to the present invention showed higher degree of body odor suppression than the contents using salicylic acid having a body burr level of 3.2, . The body odor inhibitor using the fragrance composition for suppressing body odor made by using the extract of the mountain saury was found to have a body odor suppressing effect and excellent palatability.

Therefore, it was confirmed that the fragrance composition for suppressing body odor of the present invention effectively suppressed bad body odor, thereby eliminating the uncomfortable feeling on the body odor and also having good flavor palatability.

Formulation examples of compositions according to one aspect of the present disclosure are described below, but are also applicable to various other formulations, which are intended to be illustrative only and not for purposes of limitation.

Formulation Example 1 Formulation inhibitor (deodorant)

An anti-feel agent was prepared according to the composition of Table 4 below in a manner customary in the technical field of the invention.

ingredient Content (% by weight) Purified water Balance Surfactants 0.5 Polyol 10 Alcohol 70 The extract of Scr respectively from any one of Examples 1 to 4 or the composition of any one of Examples 5 to 8 0.5

[Formulation Example 2] Supplementary food composition for reducing body odor

Tablets were prepared in a manner customary in the art of the invention as supplemental food compositions which were ingested according to the composition of Table 5 below to reduce body odor.

ingredient Content (mg) The extract of Scr respectively from any one of Examples 1 to 4 or the composition of any one of Examples 5 to 8 300 Lactose 100 Starch 100 Talc 2 Magnesium stearate Suitable amount

[Formulation Example 3] Softening lotion (skin lotion)

The softening longevity was prepared by a conventional method according to the composition shown in Table 6 below.

Compounding ingredient Content (% by weight) The extract of Scr respectively from any one of Examples 1 to 4 or the composition of any one of Examples 5 to 8 0.2 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxyvinyl polymer 0.1 Phage-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 4] Nutritional lotion (milk lotion)

Nutrition lotion was prepared according to a conventional method according to the composition shown in Table 7 below.

Compounding ingredient Content (% by weight) The extract of Scr respectively from any one of Examples 1 to 4 or the composition of any one of Examples 5 to 8 1.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Wax 4.0 Polysorbate 60 1.5 Caprylic / capric triglyceride 5.0 Squalane 5.0 Sorbitacecequioleate 1.5 Liquid paraffin 0.5 Cetearyl alcohol 1.0 Triethanolamine 0.2 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 5] Nourishing cream

Nutritive creams were prepared according to the compositions listed in Table 8 below in a conventional manner.

Compounding ingredient Content (% by weight) The extract of Scr respectively from any one of Examples 1 to 4 or the composition of any one of Examples 5 to 8 2.0 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / capric triglyceride 3.0 Squalane 5.0 Cetearyl glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 6] Massage cream

Massage creams were prepared in a conventional manner according to the composition shown in Table 9 below.

Compounding ingredient Content (% by weight) The extract of Scr respectively from any one of Examples 1 to 4 or the composition of any one of Examples 5 to 8 2.0 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 45.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / capric triglyceride 3.0 Wax 4.0 Cetearyl glucoside 1.5 Sesquioleic acid sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 7] Pack

Packs were prepared in a conventional manner according to the composition shown in Table 10 below.

Compounding ingredient Content (% by weight) The extract of Scr respectively from any one of Examples 1 to 4 or the composition of any one of Examples 5 to 8 0.2 glycerin 4.0 Polyvinyl alcohol 15.0 Hyaluronic acid extract 5.0 Beta Glucan 7.0 Allantoin 0.1 Nonyl phenyl ether 0.4 Polysorbate 60 1.2 Ethanol preservative 6.0 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 8] Body cleaner

A body cleanser was prepared by a conventional method according to the composition shown in Table 11.

ingredient Content (% by weight) The extract of Scr respectively from any one of Examples 1 to 4 or the composition of any one of Examples 5 to 8 0.3 Sodium lauryl sulfate 20.0 Sodium laureth sulfate 20.0 glycerin 15.0 Cocamidopropyl betaine 5.0 Spices Suitable amount Purified water Balance

Having described specific portions of the disclosure in detail, those skilled in the art will appreciate that these specific details are merely exemplary in nature and are not intended to limit the scope of the disclosure. Accordingly, the actual scope of the disclosure will be defined by the appended claims and their equivalents.

Claims (12)

Arithmetic station (Hydrangea serrata) for inhibiting body-odor composition comprising the extract as an active ingredient. 2. The method of claim 1, wherein the mountaineering station is selected from the group consisting of hydrangea serrata (S. et < RTI ID = 0.0 > z.) & for. acuminata (Siebold & Zucc) Wilson, Hydrangea serrata for buergeri Nakai, hydrangea ceratapo koreana tea. Wherein the composition is at least one selected from the group consisting of Hydrangea serrata for coreana T. Lee and Hydrangea serrata for fertilis Nakai. The composition of claim 1, wherein the composition inhibits the growth of Micrococcus or Corynebacterium microorganisms. 4. The composition of claim 3, wherein the inhibition is inhibited to a minimum inhibitory concentration (MIC) of 0.2 mg / mL (w / v) or less. 5. The composition of claim 4, wherein the inhibition is inhibited to a minimum inhibitory concentration (MIC) of 0.04 mg / mL (w / v) or less. 4. The composition of claim 3, wherein the composition inhibits the growth of Micrococcus luteus , Corynebacterium diphtheriae or Corynebacterium xerosis microorganisms. 3. The composition of claim 1, wherein the extract comprises from 0.001 to 50% by weight, based on the total weight of the composition. 8. The composition according to claim 7, wherein the extract is in the range of 0.5 to 10% by weight based on the total weight of the composition. The composition according to claim 1, wherein the mountain plant is at least one selected from the group consisting of whole plants, roots, trees, flowers, leaves, stems, branches, bark, seeds and fruits. The composition of claim 1, wherein the extract is at least one extract selected from the group consisting of water, organic solvents, and mixtures thereof. 11. The composition of claim 10, wherein the organic solvent is at least one selected from the group consisting of ethanol, butylene glycol, and propylene glycol. 12. The composition according to any one of claims 1 to 11, wherein the composition is a solid stick deodorant, a liquid roll-on deodorant, an aerosol deodorant, a pump spray deodorant, a semi-solid deodorant, a soap bar, Skin lotion, deodorant lotion and cream. ≪ RTI ID = 0.0 > 11. < / RTI >