KR102275551B1 - Composition for covering body odor comprising extract of hydrangea serrata - Google Patents

Abstract

The present specification provides a composition for inhibiting body odor comprising an extract of cornflower hydrangea as an active ingredient, or a pharmaceutical, food or cosmetic composition comprising the same. The composition for inhibiting body odor of the present specification has an effect of relieving discomfort about body odor by suppressing body odor generated while bacteria act due to sweat, and has an excellent odor palatability. In addition, the pharmaceutical, food or cosmetic composition of the present specification can be effectively used for suppressing human body odor.

Description

Composition for suppressing body odor comprising an extract of cornflower hydrangea {COMPOSITION FOR COVERING BODY ODOR COMPRISING EXTRACT OF HYDRANGEA SERRATA}

The present specification relates to a composition comprising an extract of cornflower hydrangea.

Body odor occurs when sweat secreted from sweat glands is decomposed by microorganisms or bacteria, such as eccrine sweat glands distributed throughout the body and apocrine sweat glands distributed in areas with a lot of body hair such as armpits. In the process of decomposing fat, protein, sebum, and contaminants contained in secreted sweat by microorganisms or bacteria, body odors that cause unpleasant odors such as liquid odor, foot odor, and head odor are generated.

Excessive sweat and sebum secretion due to strenuous exercise or stress, and protein and fat secretion along with sweat from eating greasy and oily food are the causes of severe body odor. Contained coffee, chocolate, cola, alcohol that increases protein and fat in the body, and smoking, which in itself has a pleasant smell, can also cause body odor. These body odors have different specific odors according to gender and age, such as men, women, babies, and the elderly.

In general, methods such as restriction, deodorization, antibacterial, and masking are used to control body odor. A commonly used masking method is a method of masking body odor using fragrance. However, if the wrong scent is used to mask the body odor, it can give off a bad smell and have an adverse effect. Therefore, the choice of the scent is more important than anything else, and essential oils of various plants are used to achieve this purpose. Accordingly, the present inventors have studied the possibility of application as external preparations for skin from plants that are not widely known so far.

US 10-0785974 B1

An object of the present specification is to provide a composition capable of effectively suppressing body odor and having an antibacterial effect by using an extract of cornflower hydrangea in order to solve the harmful problem of the synthetic antibacterial raw material.

In order to achieve the above object, the present specification provides a composition for inhibiting body odor comprising an extract of cornflower hydrangea as an active ingredient.

The composition for inhibiting body odor of the present specification has an effect of relieving discomfort about body odor by suppressing body odor generated while bacteria act due to sweat, and has an excellent odor palatability.

The present specification relates to a composition for suppressing body odor comprising an extract of cornflower hydrangea, and more particularly, by using an extract of cornflower hydrangea having an antibacterial effect to fundamentally suppress the generation of body odor caused by microorganisms, thereby relieving discomfort caused by body odor It may relate to a perfume composition for suppressing body odor having excellent palatability.

The present specification, in one aspect, may relate to a composition comprising an extract of hydrangea ( Hydrangea serrata ) as an active ingredient.

In one aspect of the present specification, the composition may be a composition for inhibiting body odor.

In one aspect of the present specification, the composition may be a pharmaceutical, food or cosmetic composition.

In one aspect of the present specification, the composition may be a perfume composition.

In one aspect of the present specification, the cosmetic composition may include the composition for inhibiting body odor according to the present specification.

In one aspect of the present specification, the composition may be characterized in that it inhibits the growth of microorganisms of the genus Micrococcus or Corynebacterium. In addition, the Micrococcus genus ( Micrococcus ) may be a Micrococcus luteus ( Micrococcus luteus ), and the Corynebacterium genus ( Corynebacterium ) is Corynebacterium diphtheriae ) Or Corynebacterium zerosis ( Corynebacterium xerosis ) may be present.

In one aspect of the present specification, the inhibition may be inhibition with a minimum inhibitory concentration (MIC) of 0.2 mg/mL or less, and preferably inhibition with a minimum inhibitory concentration (MIC) of 0.04 mg/mL or less. have. Also in one aspect of the present specification, the minimum inhibitory concentration of inhibition is 0.25 mg/mL or less, 0.2 mg/mL or less, 0.16 mg/mL or less, 0.15 mg/mL or less, 0.12 mg/mL or less, 0.10 mg/mL or less , 0.05 mg/mL or less, 0.04 mg/mL or less, 0.03 mg/mL or less, 0.02 mg/mL or less, or 0.01 mg/mL or less.

In one aspect of the present specification, the hydrangea may be one or more selected from the group consisting of whole hydrangea plants, roots, leaves, stems, branches, bark, flowers, seeds and fruits.

In one aspect of the present specification, the corn hydrangea extract may be extracted by mixing leaves, fruits and bark in a weight ratio of 7:2:1. The weight ratio may be a weight ratio of 1 to 10:1 to 3:1, or a weight ratio of 6 to 8: 1.5 to 2.5:1.

In one aspect of the present specification, the extract of cornflower hydrangea may be one or more extracts selected from the group consisting of water, an organic solvent, and mixtures thereof. The organic solvent may be at least one selected from the group consisting of ethanol, butylene glycol, and propylene glycol.

In one aspect of the present specification, the composition is a solid stick deodorant, a liquid roll-on deodorant, an aerosol deodorant, a pump spray deodorant, a semi-solid gel deodorant, a soap bar, an ointment, a suspension, a warning agent, a patch, a water pars, a deodorant lotion and a cream. It may be a composition for external application to the skin, characterized in that it is a formulation selected from the group consisting of.

In one aspect of the present specification, the cosmetic composition is a softening lotion, astringent lotion, nutrient lotion, nutrient lotion, nutrient essence, nutrient cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack , gel, powder, makeup base, body lotion, body cream, body oil, body essence, lotion, ointment, gel, cream, a composition selected from the group consisting of patches and sprays

In one aspect of the present specification, the composition may be a composition for external application to the skin.

In one aspect of the present specification, the food composition for suppressing body odor may be a body odor improving agent for ingestion that improves body odor by orally ingesting such a food composition and releasing a substance improving body odor to the body surface. Such a body odor improving agent for ingestion is disclosed in Korean Patent Laid-Open Publication No. 10-2008-0026130. Alternatively, in one aspect of the present invention, the food composition may be a supplementary food composition for reducing body odor.

The method for preparing the extract of cornflower hydrangea used in the present specification is not particularly limited, and in the present specification, the extract of cornflower hydrangea is a leachate obtained by leaching and discharging from cornflower hydrangea, a concentrate obtained by concentrating part or all of the leachate again, and again the It includes an extract prepared by drying the concentrate, or an oil obtained by distillation or containing a chemical substance that exerts the main effect contained in the extract.

And arithmetic station (Hydrangea serrata) is in hydrangea plants (Hydrangea) herein, the genus Hydrangea macrophylla, Hydrangea and belongs to the (Hydrangeaceae), consists of a neck nature shrub of about 23 species. It is native to the Western Hemisphere and Eastern Asia. Hydrangea plants growing in Korea include hydrangea ( H. serrata ) and hydrangea. Hydrangeas and hydrangeas grow in mountains or fields, and the varieties planted in the garden are hydrangeas and their varieties. Mountain hydrangea can be found all over Korea, but water hydrangea only grows on Ulleungdo and Jeju Island. In addition, tree hydrangeas and American hydrangeas are imported from abroad and planted for landscaping in gardens.

Hydrangea serrata referred to herein is, Hydrangea Serrata for . acuminata (Siebold & Zucc) Wilson), Hydrangea serrata for Hydrangea serrata for. buergeri Nakai., Hydrangea serrata for Koreana tea. Lee ( Hydrangea serrata for. coreana T. Lee) and Hydrangea serrata for. fertilis Nakai.

In the present specification, hydrangea Serrata for acuminata (S. et z.) Wilson (Hydrangea Serrata for. acuminata (Siebold & Zucc) Wilson), hydrangea (Lee Chang-bok, Korean botanical encyclopedia, 1984) or flower landscape It is also called soup (Songhoop, 1980, Korea Plant Resources) and also called hairy hydrangea. It is a dicotyledonous broad-leaved shrub in the family Rosaceae. It grows wild at an altitude of 200-1,400m in the south central part of Korea, and is also distributed in Japan and Taiwan. It usually grows up to 1m, prospers by giving out many stems under the stem, and there are fine hairs on the annual branches. The root has fine roots and normal roots, and the leaves are opposite, oval or egg-shaped, with a long pointed tip like a tail, and the lower part is round or acute, 5-15cm long and 2-10cm wide, with sharp saw teeth on the edge. There are hairs on the side veins and the back veins. Flowers have large flat inflorescences at the end of branches grown in the current year in July-August, hairy, and the non-sexual flowers around them are 2-3cm in diameter, and sepals are like petals, with 3-5 pieces, white, reddish-walled or wall-colored. Bisexual flowers have small sepals and 5 each together with petals. Stamens are 5 and the length is 3~4mm together with the style, and there is 1 pistil, and the style is 3~4. The fruits ripen in September-October and are small, large honey egg-shaped capsules.

In the present specification, Hydrangea serrata for. buergeri Nakai. is also called Flowering Landscape Hydrangea (Lee Chang-bok, Korean Botanical Encyclopedia, 1984) or Goryeo Hydrangea (Songjiok, 1980, Korea Plant Resources). . It is distributed in the south central part of Korea including Jeju Island, Japan, and Taiwan. The growing temperature is 16~30℃, and it grows well in waterside or valleys with a lot of soil moisture. Grows up to 1 m in height. The leaves are opposite, long oval, and pointed at the tip. The length of the leaf is 5~15cm and the width is 2~10cm, with saw teeth on the edge and hairs on the veins. The flowers are white or blue-purple, and hang in coaxial inflorescences at the end of branches in July-August. Nearby neuter flowers have 3 to 5 sepals, serrated, and look like petals. A bisexual flower hangs in the center, and there are 5 petals and 5 sepals each. The fruit is a capsule (朔果) that ripens in October and has fine roots.

In the present specification, hydrange Serrata for Koreana tea. Lee ( Hydrangea serrata for. coreana T. Lee), also called cotyledonous hydrangea (Lee Chang-bok, Korean Botanical Encyclopedia, 1984) or long-leaved mountain hydrangea (Songjiok, Korea Plant Resources, 1980), is a deciduous broad-leaved shrub of the dicotyledonous family Rosaceae. . Distributed in central and south of Korea, it usually grows up to 1 m, grows by giving out many stems under the stem, and has fine hairs on annual branches. The root has fine roots and normal roots, and the leaves are opposite, oval or egg-shaped, with a long pointed tip like a tail, and the lower part is round or acute, 5-15cm long and 2-10cm wide, with sharp saw teeth on the edge. There are hairs on the side veins and the back veins, and the leaves are especially thick. Flowering period is July-August, and numerous bisexual flowers form flat inflorescences together with decorative flowers at the ends of branches grown in the current year. Decorative flowers have sepals in the shape of petals, 3 to 5 pieces, and are blue or white. Bisexual flowers have small sepals and 5 each together with petals. Stamens are 10, longer than petals. There is 1 pistil and 3 to 4 styles. The fruits ripen in autumn and are egg-shaped capsules.

In the present specification, hydrangea serrata for fertilis Nakai (Hydrangea serrata for. fertilis Nakai.) is called Tamna hydrangea (Songjiok, Korea Plant Resources, 1980) or island hydrangea, and is a deciduous shrub of the dicotyledonous Rosaceae family. It is distributed in Jeju Island, Korea, and grows at the foot of a mountain or at the edge of a forest. Tamna mountain hydrangea grows up to about 1m in height, grows by producing many stems from the bottom, and has fine hairs on annual branches. Leaves are opposite, oval or egg-shaped, with a long pointed tip like a tail, with a round or acute bottom at the bottom, 5-15 cm long and 2-10 cm wide, with sharp saw teeth, and hairs on the side veins on the surface and on the veins on the back side. . Flowers bloom in July-August, and large flat inflorescences hang at the tip of the branch grown in the current year, and there are hairs. A large number of bisexual flowers form a large flat inflorescence along with asexual flowers with a diameter of 2-3 cm. Asexual flowers have sepals in the form of petals, 3 to 5, and are blue or purple. Bisexual flowers have small sepals and 5 each together with petals. Stamens are 10, longer than petals, and pistil is 1, and style is 3-4. The fruits are egg-shaped and ripen in autumn.

The hydrangea used in this specification was sampled from plants planted as ornamental trees at the Osulloc Tea Museum in Seogwang Dawon, Jeju.

Cornflower hydrangea as used herein may be included in the form of an extract, a pulverized product of the crude drug itself, or a dry pulverized product of the crude drug, but is not limited thereto. In addition, the corn hydrangea used in the present specification is not limited in the method of obtaining it, and it can be cultivated and used or can be purchased and used on the market, and the entire corn hydrangea plant, leaves, stems, branches, bark, flowers, seeds And it may be at least one selected from the group consisting of fruits.

In the present specification, "extract" includes all substances obtained by extracting the components of natural products, regardless of the extraction method, extraction solvent, extracted components, or the form of the extract, and also extracts the substances obtained by extracting the components of natural products after extracting other substances. It is a broad concept that includes all substances obtainable by processing or processing by a method.

In the present specification, "corn hydrangea extract" includes all substances obtained by extracting the components of corn hydrangea, regardless of the extraction method, extraction solvent, extracted component or the form of the extract, and in the process of extracting the component, heat, acid (acid), base (base), includes a substance obtained through an extraction method including a process of enzyme treatment, etc., and can also be obtained by extracting the material obtained by extracting the components of cornflower hydrangea and processing or treating it by another method It is a broad concept that includes all substances that exist.

In one aspect of the present specification, the corn hydrangea extract comprises the steps of washing and drying corn hydrangea; solvent extraction of dried cornflower; and filtering the extracted cornflower hydrangea. In the above, the solvent includes at least one selected from the group consisting of water, an organic solvent, and a mixture of water and an organic solvent. In the above, water includes distilled water or purified water, and the organic solvent is selected from the group consisting of alcohol, acetone, ether, ethyl acetate, diethyl ether, ethyl methyl ketone, and chloroform, for example, _{C 1} to C _{5 lower alcohol.} One or more include, but are not limited to.

The cornflower extract may include a cornflower-C ₁ ~C ₆ alcohol extract, and specifically, the alcohol may be methanol or ethanol.

In the present specification, the cornflower extract may be a crude extract of a solvent selected from the group consisting _{of water, C 1} -C _{6 alcohol, and a combination thereof.} The C ₁ -C ₆ alcohol may be specifically methanol. When extracting cornflower hydrangea with a solvent, it is preferable to extract by adding a solvent corresponding to about 5 to 15 times that of cornflower hydrangea, and specifically, it is preferable to extract by adding about 10 times the solvent, but is not limited thereto. Heat extraction, cold extraction, reflux cooling extraction, ultrasonic extraction, etc. may be used for the extraction, and there is no limitation as long as the extraction method is obvious to those skilled in the art. The extraction may be performed at room temperature, but for more efficient extraction, it may be performed under a heating condition, preferably at a temperature of about 40 to 100°C, more preferably at a temperature of about 80°C, but limited thereto it is not The extraction time is preferably about 2 to 4 hours, more preferably about 3 hours, but is not limited thereto, and may vary depending on conditions such as extraction solvent and extraction temperature. The extraction may be performed one or more times in order to obtain a larger amount of the active ingredient, preferably 1 to 5 times, more preferably 3 times consecutive extraction, and the combined extract may be used.

In the present specification, the extract of cornflower hydrangea may include a crude extract of cornflower hydrangea as described above, and may be included as a soluble fraction of an organic solvent obtained by further extracting the crude extract with an organic solvent having low polarity. The organic solvent may be hexane, methylene chloride, ethyl acetate, n-butanol, or the like, but is not limited thereto. The extract extracted by the above method or a soluble fraction of the extract may be used as it is, but it may be used in the form of an extract by concentration after filtration, or in the form of a freeze-dried product after concentration and freeze-drying.

Corneous hydrangea extract of the present specification comprises the steps of chopping and drying the cornflower hydrangea; Adding water, an organic solvent, or a combination thereof to the dried cornflower hydrangea and extracting under reflux; filtration with a filter cloth after depositing the extract; centrifuging the filtrate to separate the residue and the filtrate; It can be obtained by a method comprising; concentrating the separated filtrate under reduced pressure to obtain an extract of cornflower hydrangea.

In one aspect of the present specification, the cornflower extract is composed of purified water, ethanol, butylene glycol, and propylene glycol so that the cornflower hydrangea concentrate concentrated under reduced pressure according to the above method is included in 5% by weight based on the total weight of the extract. It may be prepared by dispersing/dissolving using one or more solvents selected from the group.

In the process of extracting cornflower hydrangea extract of the present specification, for example, water or organic solvent is added to chopped and dried cornflower hydrangea, extracted under reflux and deposited, and then the residue and the filtrate are separated through filter cloth filtration and centrifugation, The separated filtrate can be concentrated under reduced pressure to obtain a cornflower extract. The organic solvent usable herein may be selected from ethanol, methanol, butanol, ether, ethyl acetate, chloroform, or a mixed solvent of these organic solvents and water, and preferably 100% water, 70% ethanol in consideration of the safety of the raw material. Or butylene glycol (Butylene Glycol) is used. At this time, the extraction temperature is preferably 18 ~ 80 ℃ in the case of water, 18 ~ 40 ℃ in the case of 70% ethanol and butylene glycol, and the extraction time is preferably 6 ~ 168 hours. If the extraction temperature and extraction time are out of the range, extraction efficiency may decrease or a change in components may occur. After obtaining the extract using the solvent in the above, it is possible to obtain a liquid product by cooling, heating, and filtration at room temperature by a conventional method known in the art, or additionally evaporating the solvent, spray drying or freeze drying.

After distilling 1 kg of sample in water and cooling it with steam at 100°C for 2 hours at 4°C, volatile compounds containing water-soluble fractions are allowed to stand for 20 minutes, and the essential oil layer is filtered through microfiltration. pay

In one aspect of the present specification, the composition preferably includes the cornflower extract in an amount of 0.001 to 50% by weight based on the total weight of the composition. More preferably, 0.001 to 10% by weight, 0.1 to 1% by weight, 2 to 5% by weight, 0.5 to 10% by weight, or 1 to 50% by weight may be used. In the case of less than 0.001% by weight, it is difficult to expect its efficacy, and when 50% by weight is included, a problem in formulation occurs. Specifically, the cornflower extract is 0.001% by weight or more, 0.01% by weight or more, 0.1% by weight or more, 0.3% by weight or more, 0.5% by weight or more, 0.8% by weight or more, 1% by weight or more, 2% by weight or more, based on the total weight of the composition. , 3 wt% or more, 4 wt% or more, 5 wt% or more, 7 wt% or more, 10 wt% or more, 15 wt% or more, 20 wt% or more, 25 wt% or more, 30 wt% or more, 35 wt% or more , or 40% by weight or more, and may be 60% by weight or less or 50% by weight or less.

In one aspect of the present specification, the composition for inhibiting body odor may be included in an amount of 0.0001 to 15% by weight based on the total weight of the cosmetic composition or the composition for external application for skin including the composition. If it is less than 0.0001% by weight, the expected effect cannot be obtained, and if it is more than 15% by weight, the palatability for the fragrance is not good. In addition, the perfume composition for suppressing body odor is 0.0001% by weight or more, 0.001% by weight or more, 0.01% by weight or more, 0.1% by weight or more, 0.5% by weight or more, 1% by weight or more, based on the total weight of the cosmetic composition or composition for external application for skin containing the same. 5 wt% or more, 7 wt% or more, 9 wt% or more, 10 wt% or more, 12 wt% or more, or 14 wt% or more, and may be 20 wt% or less or 15 wt% or less.

In one embodiment of the present specification, the composition for external application for skin includes a solid stick deodorant, a liquid roll-on deodorant, an aerosol deodorant, a pump spray deodorant, a semi-solid gel deodorant, a soap bar, an ointment, a suspension, a warning agent, a patch, a water paste, a deodorant lotion and It may be a formulation selected from the group consisting of creams, but is not necessarily limited thereto, and may be formulated with any base well known in the art.

In addition, in each formulation, other components other than the above essential components can be appropriately selected and formulated by those skilled in the art without difficulty depending on the type or purpose of use of other formulations.

The pharmaceutical composition according to the present specification may be in various oral or parenteral formulations. In the case of formulation, it is prepared using diluents or excipients, such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants. Solid preparations for oral administration include tablets, pills, powders, granules, soft or hard capsules, etc., and these solid preparations include at least one excipient in one or more compounds, for example, starch, calcium carbonate, sucrose. Or it is prepared by mixing lactose, gelatin, etc. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid preparations for oral administration include suspensions, internal solutions, emulsions, syrups, etc. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, etc. can be used.

The pharmaceutical dosage form of the composition of the present specification may be used in the form of a pharmaceutically acceptable salt thereof, and may be used alone or in combination with other pharmaceutically active compounds as well as in an appropriate group. The salt is not particularly limited as long as it is pharmaceutically acceptable, and for example, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid, formic acid acetic acid, tartaric acid, lactic acid, citric acid, fumaric acid, maleic acid, succinic acid, methanesulfonic acid , benzenesulfonic acid, toluenesulfonic acid, naphthalenesulfonic acid, and the like can be used.

The composition of the present specification may be administered parenterally or orally as desired, and may be administered in 1 to several divided doses to be administered in an amount of 0.1 to 500 mg, preferably 1 to 100 mg per 1 kg of body weight per day. have. The dosage for a specific patient may vary depending on the patient's weight, age, sex, health status, diet, administration time, administration method, excretion rate, severity of disease, and the like.

The pharmaceutical composition according to the present specification may be prepared according to a conventional method according to a conventional method; oral dosage forms such as powders, granules, tablets, soft or hard capsules, suspensions, emulsions, syrups, aerosols, external preparations for skin such as ointments, creams, suppositories, and injections And it may be formulated and used in any form suitable for pharmaceutical preparations, including sterile injection solutions.

The composition according to the present specification may be administered to mammals such as rats, mice, livestock, and humans by various routes such as parenteral and oral administration, and all modes of administration can be expected, for example, oral, rectal Or it may be administered by intravenous, intramuscular, subcutaneous, intrauterine dural or intracerebroventricular injection.

In one aspect of the present specification, the food composition may be a health functional food composition.

The formulation of the food composition according to the present specification is not particularly limited, but may be formulated as, for example, tablets, granules, powders, liquids such as drinks, caramel, gels, bars, and the like. In addition to the active ingredient, the food composition of each dosage form can be appropriately selected by those skilled in the art without difficulty depending on the dosage form or purpose of use in addition to the active ingredient, and a synergistic effect may occur when applied simultaneously with other raw materials.

In the food composition according to the present specification, the determination of the dosage of the active ingredient is within the level of those skilled in the art, and the daily dosage thereof is, for example, 0.1 mg/kg/day to 5000 mg/kg/day, more specifically 50 It may be mg/kg/day to 500 mg/kg/day, but is not limited thereto, and may vary depending on various factors such as age, health status, and complications of the subject to be administered.

The food composition according to the present specification is, for example, various foods such as chewing gum, caramel products, candies, ice creams, and confectionery, beverage products such as soft drinks, mineral water, alcoholic beverages, vitamins and minerals, etc. Health functional foods can

In addition to the above, the food composition of one aspect of the present specification includes various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavoring agents and natural flavoring agents, coloring agents and enhancers (cheese, chocolate, etc.), pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. In addition, the functional food compositions of the present specification may include natural fruit juice and pulp for the production of fruit juice beverages and vegetable beverages. These components may be used independently or in combination. The proportion of these additives is not so important, but is generally included in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition herein.

The cosmetic composition according to one aspect of the present specification is not particularly limited in formulation, and may be appropriately selected according to the purpose. For example, skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nourishing lotion, massage cream, nourishing cream, moisture cream, hand cream, foundation, essence, nourishing essence, pack, soap, cleansing It may be prepared in any one or more formulations selected from the group consisting of foam, cleansing lotion, cleansing cream, body lotion and body cleanser, but is not limited thereto.

When the formulation of the cosmetic composition according to the present specification is a paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as a carrier component etc. may be used.

When the formulation of the cosmetic composition according to the present specification is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluoro propellants such as hydrocarbons, propane/butane or dimethyl ether.

When the formulation of the cosmetic composition according to the present specification is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol oil, glycerol aliphatic esters, fatty acid esters of polyethylene glycol or sorbitan.

When the formulation of the cosmetic composition according to the present specification is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester , microcrystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracanth may be used.

In the case of surfactant-containing cleansing of the cosmetic composition according to the present specification, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, Fatty acid amide ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linoline derivative or ethoxylated glycerol fatty acid ester and the like can be used.

The cosmetic composition according to the present specification may further include functional additives and components included in general cosmetic compositions in addition to the extract of cornflower hydrangea. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, sphingolipids, and seaweed extract.

In the cosmetic composition of this specification, you may mix|blend the component contained in a general cosmetic composition as needed with the said functional additive further. Other ingredients included include oils and fats, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, blood circulation An accelerator, a cooling agent, a limiting agent, purified water, etc. are mentioned.

Furthermore, the present specification relates to an external preparation for skin containing an extract of cornflower hydrangea as an active ingredient, and the external preparation for skin is a generic term that may include anything applied outside the skin, and cosmetics of various formulations may be included here.

Hereinafter, the present specification will be described in detail with reference to Examples, Comparative Examples and Test Examples of the present specification. These are only presented by way of example to describe the present specification in more detail, and it is for those of ordinary skill in the art that the scope of the present specification is not limited by these Examples, Comparative Examples and Test Examples. it will be self-evident

[Example 1] Preparation of hydranase Serrata for acuminata (S. et z.) Wilson extract

The leaves, fruits, and bark of Hydrangea Serrata for . acuminata (Siebold & Zucc) Wilson, chopped and dried in the shade, were mixed in a weight ratio of 7:2:1. 1 kg was extracted under reflux three times for 24 hours with 70% ethanol aqueous solution, cooled, and filtered with Whatman #5 filter paper. The filtered extract was concentrated under reduced pressure at 45°C or lower and freeze-dried at -60°C for 3 days.

The extract was prepared by dispersing/dissolving the concentrated under reduced pressure using ethanol in an amount of 5% by weight based on the total weight of the cornflower extract.

[Example 2] Preparation of hydranase Serrata for Bujeri Nakai extract

An extract of Hydrangea serrata for. buergeri Nakai. was prepared in the same manner as in Example 1.

[Example 3] Hydrant Serrata for Koreana Tea. Preparation of Li extract

Hydrant Serrata for Koreana Tea in the same manner as in Example 1. An extract of Hydrangea serrata for. coreana T. Lee was prepared.

[Example 4] Preparation of hydranase Serrata p. pertilis Nakai extract

An extract of Hydrangea serrata for. fertilis Nakai. was prepared in the same manner as in Example 1.

[Test Example 1]

Measurement of antibacterial activity of cornflower extract

Micrococcus luteus and Corynebacterium, which are known as representative odor bacteria that decompose sweat substances used in the experiment and cause bad odor, were used as test bacteria. Micrococcus luteus (ATCC 10240, purchased from KORAM Biotech) and Corynebacterium diphtheriae (ATCC 11951, purchased from KORAM Biotech) in Brain Heart Infusion medium, Corynebacter Corynebacterium xerosis (ATCC 7711, purchased from Genbank) was inoculated into a medium supplemented with 10% calf serum in Brain Heart Infusion medium and cultured with shaking at 32°C for 24 hours. A diluted solution obtained by diluting each culture medium by 1/20 with the same medium was used as the test bacterial solution.

0.15 ml of the test bacteria solution was added to 15 ml of each medium solution, and the mixture was well mixed and used as a dilution solution. The corn hydrangea extract of Examples 1 to 4 at a concentration of 0.1 ug/mL was sequentially added to rows 1 to 4 of a 96 well plate, and 16 μl of salicylic acid was added as a comparative example, and the diluted solution was added to 184 μl. put each 100 μl of the dilution solution was added to the remaining wells. After mixing the mixture solution in rows 1 to 4 well, take 100 μl, put it in rows 5 to 8, mix well, and then take 100 μl again and put it in rows 11 to 16, and then dilute it twofold. After culturing at 32 °C for 48 hours, bacterial growth was confirmed with suspension and microscopy to determine the minimum inhibitory concentration (MIC) value, and the results are shown in Table 1.

substance name Minimum inhibitory concentration (MIC), mg/mL Micrococcus luteus Corynebacterium diphtheria Corynebacterium zerosis Example 1 0.04 0.16 0.04 Example 2 0.05 0.17 0.04 Example 3 0.039 0.155 0.037 Example 4 0.041 0.157 0.038 salicylic acid 0.25 0.25 0.25

In general, the minimum inhibitory concentration of salicylic acid, which is known to have an antibacterial effect, is 0.25 mg/mL, and compared with the efficacy of the corn hydrangea extract according to the present specification, the extracts of Examples 1 to 4 were obtained at a small concentration of 0.2 mg/mL or less. It was found to have an antibacterial effect. In particular, Example 1 had a low MIC concentration of 0.04 mg/mL for Micrococcus luteus and Corynebacterium zerosis, and thus it was confirmed that the effect was 50 times superior to that of salicylic acid.

Therefore, the composition comprising the extract of cornflower hydrangea of the present specification can effectively suppress the characteristic body odor generated during sweating, thereby relieving the discomfort caused by the body odor.

[Test Example 2]

According to the composition shown in Table 2 below, compositions for external application for skin, which are body odor inhibitors (deodorants) of Examples 5 to 8 and Comparative Example 1, were prepared (Hydrant Serrata for Acuminata (S. et z.) Wilson (Execution) Example 5), Hydrant Serrata for Bujeri Nakai (Example 6), Hydrant Serrata for Koreana T. Lee (Example 7), Hydrant Serrata for Pertilis Nakai (Example 8) ),).

ingredient Examples 5 to 8 (wt%) Comparative Example 1 (wt%) 1. Purified water remaining amount remaining amount 2. Surfactant 0.5 0.5 3. Polyols 10 10 4. Alcohol 70 70 5. Salicylic Acid - 0.5 6. Cornflower extract of any one of Examples 1 to 4 0.5 -

[Test Example 2] Measurement of body odor inhibitory effect

After applying the prepared body odor inhibitors of Examples 5 to 8 and Comparative Example 1 directly to the human body, an experiment was performed to measure the body odor inhibitory effect.

The sensory evaluation was conducted on 10 ordinary people over the age of 20 who usually feel that the smell of armpits or feet is subjectively or subjectively severe. One side does not use the product and only the other side uses the body odor control agent, and then the odor emanating from the armpits and feet. The sensory evaluation was conducted by an expert panel directly.

The degree of body odor suppression and the palatability of the body odor inhibitor composition were sensory evaluated on a 5-point scale, respectively (the higher the score, the higher the degree of inhibition of body odor and the better the palatability). The sensory evaluation results of the body odor inhibitor are shown in Table 3 below.

evaluator
Degree of suppression of body odor palatability Comparative Example 1 Example Comparative Example 1 Example 5 6 7 8 5 6 7 8 One 3 5 5 4 5 3 4 5 5 5 2 3 5 5 4 5 2 5 4 4 5 3 3 5 5 4 4 2 5 4 5 5 4 2 5 4 5 5 3 5 4 4 5 5 4 5 4 4 4 3 5 4 5 5 6 3 5 5 4 4 One 4 5 4 5 7 4 4 5 5 4 2 4 5 5 4 8 3 4 5 5 4 2 4 5 4 4 9 4 4 4 5 5 3 5 5 5 5 10 3 5 5 5 5 3 5 4 4 5 11 4 4 5 5 5 2 5 4 4 4 12 3 5 5 5 5 2 4 5 5 4 13 3 5 5 4 5 3 5 5 5 4 14 3 5 5 4 5 2 4 4 5 5 15 3 4 5 5 5 3 5 4 5 5 Average 3.2 4.667 4.8 4.53 4.667 2.4 4.6 4.467 4.55 4.533

As shown in Table 3 above, the body odor inhibitor using the perfume composition for suppressing body odor according to the present specification had a higher degree of suppression of body odor than the contents using salicylic acid, which had a degree of suppression of body odor of 3.2 points, and the palatability of the scent was at least 4.2. . It was found that the body odor inhibitor applied with the perfume composition for suppressing body odor made using the corn hydrangea extract had an effect of suppressing body odor and also had excellent palatability.

Therefore, it was confirmed that the perfume composition for suppressing body odor of the present specification can relieve unpleasant feeling about body odor by effectively suppressing bad body odor, and has good odor taste.

Formulation examples of the composition according to one aspect of the present specification are described below, but other various formulations are also applicable, which is not intended to limit the present specification, but only to be specifically described.

[Formulation Example 1] Body odor inhibitor (deodorant)

According to the composition of Table 4 below, body odor inhibitors were prepared in a conventional manner in the art.

ingredient content (wt%) Purified water remaining amount Surfactants 0.5 polyol 10 Alcohol 70 The cornflower extract of any one of Examples 1-4 or the composition of any one of Examples 5-8 0.5

[Formulation Example 2] Supplementary food composition for reducing body odor

As a supplementary food composition capable of reducing body odor by ingestion according to the composition of Table 5 below, tablets were prepared by a conventional method in the art.

ingredient Content (mg) The cornflower extract of any one of Examples 1-4 or the composition of any one of Examples 5-8 300 lactose 100 starch 100 talc 2 magnesium stearate appropriate amount

[Formulation Example 3] Softening lotion (skin lotion)

A softening lotion was prepared in a conventional manner according to the composition shown in Table 6 below.

compounding ingredients content (% by weight) The cornflower extract of any one of Examples 1-4 or the composition of any one of Examples 5-8 0.2 glycerin 3.0 butylene glycol 2.0 propylene glycol 2.0 Carboxyvinyl Polymer 0.1 PEG-12 Nonylphenyl Ether 0.2 Polysorbate 80 0.4 ethanol 10.0 triethanolamine 0.1 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 4] Nutrient lotion (milk lotion)

Nutrient lotion was prepared in a conventional manner according to the composition shown in Table 7 below.

compounding ingredients content (% by weight) The cornflower extract of any one of Examples 1-4 or the composition of any one of Examples 5-8 1.0 glycerin 3.0 butylene glycol 3.0 propylene glycol 3.0 Carboxyvinyl Polymer 0.1 beeswax 4.0 Polysorbate 60 1.5 Caprylic/Capric Triglycerides 5.0 squalane 5.0 Sorbitasequioleate 1.5 liquid paraffin 0.5 cetearyl alcohol 1.0 triethanolamine 0.2 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 5] Nourishing cream

Nutrient creams were prepared in a conventional manner according to the composition shown in Table 8 below.

compounding ingredients content (wt%) The cornflower extract of any one of Examples 1-4 or the composition of any one of Examples 5-8 2.0 glycerin 3.0 butylene glycol 3.0 liquid paraffin 7.0 beta glucan 7.0 Carbomer 0.1 Caprylic/Capric Triglycerides 3.0 squalane 5.0 cetearyl glucoside 1.5 Sorbitan Stearate 0.4 Polysorbate 60 1.2 triethanolamine 0.1 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 6] Massage Cream

A massage cream was prepared in a conventional manner according to the composition shown in Table 9 below.

compounding ingredients content (wt%) The cornflower extract of any one of Examples 1-4 or the composition of any one of Examples 5-8 2.0 glycerin 8.0 butylene glycol 4.0 liquid paraffin 45.0 beta glucan 7.0 Carbomer 0.1 Caprylic/Capric Triglycerides 3.0 beeswax 4.0 cetearyl glucoside 1.5 Sesqui oleate sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 7] Pack

A pack was prepared in a conventional manner according to the composition shown in Table 10 below.

compounding ingredients content (wt%) The cornflower extract of any one of Examples 1-4 or the composition of any one of Examples 5-8 0.2 glycerin 4.0 polyvinyl alcohol 15.0 Hyaluronic Acid Extract 5.0 beta glucan 7.0 allantoin 0.1 nonyl phenyl ether 0.4 Polysorbate 60 1.2 Ethanol preservative 6.0 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 8] Body Cleanser

A body cleanser was prepared in a conventional manner according to the composition shown in Table 11.

ingredient content (wt%) The cornflower extract of any one of Examples 1-4 or the composition of any one of Examples 5-8 0.3 Sodium Lauryl Sulfate 20.0 Sodium Laureth Sulfate 20.0 glycerin 15.0 Cocamidopropyl Betaine 5.0 Spices appropriate amount Purified water remaining amount

As the specific parts of the present specification have been described in detail above, for those of ordinary skill in the art, these specific techniques are only preferred embodiments, and it is clear that the scope of the present specification is not limited thereto. Accordingly, the substantial scope of the present specification will be defined by the appended claims and their equivalents.

Claims (13)

Contains Hydrangea serrata extract as an active ingredient,
The composition is Micrococcus genus ( Micrococcus ) or Corynebacterium genus ( Corynebacterium ) Food composition for inhibiting body odor, characterized in that it inhibits the growth of microorganisms. Contains Hydrangea serrata extract as an active ingredient,
The composition is a cosmetic composition for inhibiting body odor, characterized in that it inhibits the growth of microorganisms of the genus Micrococcus or Corynebacterium. Contains Hydrangea serrata extract as an active ingredient,
The composition is an antibacterial composition for odor bacteria, characterized in that it inhibits the growth of microorganisms of the genus Micrococcus or Corynebacterium. According to any one of claims 1 to 3, wherein the hydrangea, Hydrangea Serrata for. acuminata (S. et z.) Wilson (Hydrangea Serrata for. acuminata (Siebold & Zucc) Wilson), hydrangea Hydrangea serrata for. buergeri Nakai., Hydrangea serrata for Buergeri Nakai. Lee ( Hydrangea serrata for. coreana T. Lee) and Hydrangea serrata for. fertilis Nakai (Hydrangea serrata for. fertilis Nakai.) at least one composition selected from the group consisting of. The composition of any one of claims 1 to 3, wherein the growth inhibition of the microorganism is inhibited to a minimum inhibitory concentration (MIC) of 0.2 mg/mL (w/v) or less. The composition of claim 5, wherein the growth inhibition of the microorganism is inhibited to a minimum inhibitory concentration (MIC) of 0.04 mg/mL (w/v) or less. According to any one of claims 1 to 3, wherein the composition Micrococcus luteus ( Micrococcus luteus ), Corynebacterium diphtheriae ( Corynebacterium diphtheriae ) or Corynebacterium xerosis ( Corynebacterium xerosis ) Growth of microorganisms A composition characterized in that it inhibits. The composition of any one of claims 1 to 3, wherein the cornflower extract is included in an amount of 0.001 to 50% by weight based on the total weight of the composition. The composition of claim 8, wherein the cornflower extract is included in an amount of 0.5 to 10% by weight based on the total weight of the composition. The composition according to any one of claims 1 to 3, wherein the hydrangea is at least one selected from the group consisting of whole hydrangea, roots, woody flowers, leaves, stems, branches, bark, seeds and fruits of hydrangea. The composition according to any one of claims 1 to 3, wherein the cornflower extract is at least one extract selected from the group consisting of water, an organic solvent, and mixtures thereof. The composition of claim 11, wherein the organic solvent is at least one selected from the group consisting of ethanol, butylene glycol, and propylene glycol. 4. The method according to claim 2 or 3, wherein the composition is a solid stick deodorant, a liquid roll-on deodorant, an aerosol deodorant, a pump spray deodorant, a semi-solid gel deodorant, a soap bar, an ointment, a suspension, a warning agent, a patch, a water paste, a deodorant lotion And a composition for external application to the skin, characterized in that the formulation selected from the group consisting of creams.