KR20160079823A - 티에노트리아졸로디아제핀 화합물을 함유하는 제약 제제를 사용하여 백혈병을 치료하는 방법 - Google Patents

티에노트리아졸로디아제핀 화합물을 함유하는 제약 제제를 사용하여 백혈병을 치료하는 방법 Download PDF

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KR20160079823A
KR20160079823A KR1020167013580A KR20167013580A KR20160079823A KR 20160079823 A KR20160079823 A KR 20160079823A KR 1020167013580 A KR1020167013580 A KR 1020167013580A KR 20167013580 A KR20167013580 A KR 20167013580A KR 20160079823 A KR20160079823 A KR 20160079823A
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compound
solid dispersion
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carbon atoms
pharmaceutically acceptable
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마리아 이 리베이로
에릭 레이몬드
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온코에틱스 게엠베하
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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KR1020167013580A 2013-11-27 2014-11-26 티에노트리아졸로디아제핀 화합물을 함유하는 제약 제제를 사용하여 백혈병을 치료하는 방법 Withdrawn KR20160079823A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361909702P 2013-11-27 2013-11-27
US61/909,702 2013-11-27
US201462012128P 2014-06-13 2014-06-13
US62/012,128 2014-06-13
US201462080804P 2014-11-17 2014-11-17
US62/080,804 2014-11-17
PCT/EP2014/075709 WO2015078929A1 (en) 2013-11-27 2014-11-26 Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds

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KR20160079823A true KR20160079823A (ko) 2016-07-06

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KR1020167013580A Withdrawn KR20160079823A (ko) 2013-11-27 2014-11-26 티에노트리아졸로디아제핀 화합물을 함유하는 제약 제제를 사용하여 백혈병을 치료하는 방법

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US (1) US9757385B2 (enExample)
EP (1) EP3074018A1 (enExample)
JP (1) JP2016538310A (enExample)
KR (1) KR20160079823A (enExample)
CN (1) CN105960239A (enExample)
WO (1) WO2015078929A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106029077A (zh) * 2013-08-01 2016-10-12 翁科埃斯克斯有限公司 包含噻吩并三唑并二氮杂卓化合物的药物制剂
EP3137085A4 (en) * 2014-05-02 2017-12-27 Oncoethix GmbH Method of treating acute myeloid leukemia and/or acute lymphoblastic leukemia using thienotriazolodiazepine compounds
US20170095484A1 (en) * 2014-05-02 2017-04-06 Oncoethix Gmbh Method of treating resistant non-hodgkin lymphoma, medulloblastoma, and/or alk+non-small cell lung cancer using thienotriazolodiazepine compounds
US20170281642A1 (en) * 2014-08-28 2017-10-05 Oncoethix Gmbh Methods of treating acute myeloid leukemia or acute lymphoid leukemia using pharmaceutical compositions containing thienotriazolodiazepine compounds
US10702517B2 (en) 2015-04-22 2020-07-07 Celgene Quanticel Research, Inc. Bromodomain inhibitor
BR112018002550A2 (en) 2015-08-10 2018-09-18 Dana-Farber Cancer Institute, Inc. inhibitor resistance mechanism
EP3795563B1 (en) 2016-03-31 2024-07-17 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
CA3029851A1 (en) * 2016-07-29 2018-02-01 Oncternal Therapeutics, Inc. Uses of indoline compounds such as tk216 for the treatment of cancer
EP3528810A4 (en) * 2016-10-20 2020-06-17 Celgene Quanticel Research, Inc. BROMDOMAIN INHIBITOR
AU2019284971A1 (en) 2018-06-13 2020-12-03 Worg Pharmaceuticals (Zhejiang) Co., Ltd. Preparation of condensed triazepine derivatives and their use as BET inhibitors
CN108743591A (zh) * 2018-07-17 2018-11-06 苏州大学 用于治疗癌症的药物组合物及其应用
WO2022261204A1 (en) 2021-06-08 2022-12-15 The Regents Of The University Of California Anticancer compounds
WO2023229535A1 (en) 2022-05-27 2023-11-30 Engine Biosciences Pte. Ltd. Bet polypeptide therapeutic agents for generating synthetic lethality in tumors
CN116098870B (zh) * 2023-04-10 2023-07-25 上海赛默罗生物科技有限公司 α5-GABAA受体调节剂的固体分散体及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001095912A1 (fr) * 2000-06-16 2001-12-20 Mitsubishi Pharma Corporation Compositions permettant de reguler la plage et/ou la vitesse de liberation du ph
JP5199666B2 (ja) * 2004-08-10 2013-05-15 タロン セラピューティクス インコーポレイテッド 白血病を治療するための組成物および方法
US20070010478A1 (en) 2005-07-06 2007-01-11 Branimir Sikic Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer
JP2009501707A (ja) * 2005-07-06 2009-01-22 カニサ・ファーマシューティカルズ・インコーポレイテッド 癌の処置のためのゾスキダル、ダウノルビシン、およびシタラビン
US8093220B2 (en) * 2006-12-04 2012-01-10 Novartis Ag Combination of an HDAC inhibitor and an antimetabolite
KR101600634B1 (ko) 2007-12-28 2016-03-07 미쓰비시 타나베 파마 코퍼레이션 항암제
PL2902030T3 (pl) * 2010-05-14 2017-07-31 Dana-Farber Cancer Institute, Inc. Związki tienotriazolodiazepinowe do leczenia nowotworu
MX354217B (es) * 2010-05-14 2018-02-19 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
PL2696878T3 (pl) * 2011-04-14 2020-01-31 Cyclacel Limited Schemat dawkowania dla sapacytabiny i decytabiny w kombinacji do leczenia ostrej białaczki szpikowej
DE102011082013A1 (de) * 2011-09-01 2013-03-07 Bayer Pharma AG 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
AU2013283378B2 (en) * 2012-06-25 2017-07-13 Oncoethix Gmbh Method of treating lymphoma using thienotriazolodiazepine compounds
JP2015531365A (ja) * 2012-09-28 2015-11-02 オンコエシックス エスエー チエノトリアゾロジアゼピン化合物を含む医薬製剤
CN106029077A (zh) * 2013-08-01 2016-10-12 翁科埃斯克斯有限公司 包含噻吩并三唑并二氮杂卓化合物的药物制剂

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US20170157141A1 (en) 2017-06-08
WO2015078929A1 (en) 2015-06-04

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