JP2016538310A - チエノトリアゾロジアゼピン化合物を含む医薬製剤を用いる白血病の治療方法 - Google Patents

チエノトリアゾロジアゼピン化合物を含む医薬製剤を用いる白血病の治療方法 Download PDF

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JP2016538310A
JP2016538310A JP2016534995A JP2016534995A JP2016538310A JP 2016538310 A JP2016538310 A JP 2016538310A JP 2016534995 A JP2016534995 A JP 2016534995A JP 2016534995 A JP2016534995 A JP 2016534995A JP 2016538310 A JP2016538310 A JP 2016538310A
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compound
solid dispersion
formula
carbon atoms
thienotriazolodiazepine
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JP2016538310A5 (enExample
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リベイロ、マリア、イー．
レイモンド、エリック
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オンコエシックス ゲーエムベーハー
オンコエシックス ゲーエムベーハー
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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JP2016534995A 2013-11-27 2014-11-26 チエノトリアゾロジアゼピン化合物を含む医薬製剤を用いる白血病の治療方法 Pending JP2016538310A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361909702P 2013-11-27 2013-11-27
US61/909,702 2013-11-27
US201462012128P 2014-06-13 2014-06-13
US62/012,128 2014-06-13
US201462080804P 2014-11-17 2014-11-17
US62/080,804 2014-11-17
PCT/EP2014/075709 WO2015078929A1 (en) 2013-11-27 2014-11-26 Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds

Publications (2)

Publication Number Publication Date
JP2016538310A true JP2016538310A (ja) 2016-12-08
JP2016538310A5 JP2016538310A5 (enExample) 2018-01-11

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JP2016534995A Pending JP2016538310A (ja) 2013-11-27 2014-11-26 チエノトリアゾロジアゼピン化合物を含む医薬製剤を用いる白血病の治療方法

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US (1) US9757385B2 (enExample)
EP (1) EP3074018A1 (enExample)
JP (1) JP2016538310A (enExample)
KR (1) KR20160079823A (enExample)
CN (1) CN105960239A (enExample)
WO (1) WO2015078929A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3027194A1 (en) * 2013-08-01 2016-06-08 Oncoethix GmbH Pharmaceutical formulation containing thienotriazolodiazepine compounds
JP2017514907A (ja) * 2014-05-02 2017-06-08 オンコエシックス ゲーエムベーハー チエノトリアゾロジアゼピン化合物を用いる耐性非ホジキンリンパ腫、髄芽腫及び／又はａｌｋ＋非小細胞肺癌の治療方法
WO2015168621A1 (en) * 2014-05-02 2015-11-05 Oncoethix Sa Method of treating acute myeloid leukemia and/or acute lymphoblastic leukemia using thienotriazolodiazepine compounds
CN107427524A (zh) * 2014-08-28 2017-12-01 翁科埃斯克斯有限公司 利用包含噻吩并三唑并二氮杂*化合物的药物组合物治疗急性髓细胞白血病或急性淋巴性白血病的方法
US10702517B2 (en) 2015-04-22 2020-07-07 Celgene Quanticel Research, Inc. Bromodomain inhibitor
BR112018002550A2 (en) 2015-08-10 2018-09-18 Dana-Farber Cancer Institute, Inc. inhibitor resistance mechanism
WO2017172368A1 (en) 2016-03-31 2017-10-05 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
CN109789127B (zh) * 2016-07-29 2022-03-25 英克特诺治疗公司 吲哚啉酮化合物的用途
CN110099685A (zh) * 2016-10-20 2019-08-06 赛尔基因光迪斯研究公司 溴结构域抑制剂
EA202092635A1 (ru) 2018-06-13 2021-03-23 Дибли Аг Получение конденсированных производных триазепина и их применение в качестве ингибиторов bet
CN108743591A (zh) * 2018-07-17 2018-11-06 苏州大学 用于治疗癌症的药物组合物及其应用
EP4351560A4 (en) 2021-06-08 2025-06-04 The Regents of the University of California ANTI-CANCER COMPOUNDS
WO2023229535A1 (en) 2022-05-27 2023-11-30 Engine Biosciences Pte. Ltd. Bet polypeptide therapeutic agents for generating synthetic lethality in tumors
CN116098870B (zh) * 2023-04-10 2023-07-25 上海赛默罗生物科技有限公司 α5-GABAA受体调节剂的固体分散体及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008509911A (ja) * 2004-08-10 2008-04-03 ハナ バイオサイエンシズ インコーポレイテッド 白血病を治療するための組成物および方法
WO2008070011A2 (en) * 2006-12-04 2008-06-12 Novartis Ag Combination of an hdac inhibitor and an antimetabolite
JP2009501707A (ja) * 2005-07-06 2009-01-22 カニサ・ファーマシューティカルズ・インコーポレイテッド 癌の処置のためのゾスキダル、ダウノルビシン、およびシタラビン
WO2009084693A1 (ja) * 2007-12-28 2009-07-09 Mitsubishi Tanabe Pharma Corporation 抗癌剤
JP4875277B2 (ja) * 2000-06-16 2012-02-15 田辺三菱製薬株式会社 放出ｐＨ域及び／又は速度制御組成物
WO2012140436A1 (en) * 2011-04-14 2012-10-18 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070010466A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer
CN103154246B (zh) 2010-05-14 2015-11-25 达那-法伯癌症研究所 用于治疗白血病的组合物和方法
ES2606958T3 (es) 2010-05-14 2017-03-28 Dana-Farber Cancer Institute, Inc. Compuestos de tienotriazolodiazepina para tratar una neoplasia
DE102011082013A1 (de) * 2011-09-01 2013-03-07 Bayer Pharma AG 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CA2877434A1 (en) 2012-06-25 2014-01-03 Oncoethix Sa Method of treating lymphoma using thienotriazolodiazepine compounds
WO2014068402A2 (en) * 2012-09-28 2014-05-08 Oncoethix Sa Pharmaceutical formulation containing thienotriazolodiazepine compounds
EP3027194A1 (en) * 2013-08-01 2016-06-08 Oncoethix GmbH Pharmaceutical formulation containing thienotriazolodiazepine compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4875277B2 (ja) * 2000-06-16 2012-02-15 田辺三菱製薬株式会社 放出ｐＨ域及び／又は速度制御組成物
JP2008509911A (ja) * 2004-08-10 2008-04-03 ハナ バイオサイエンシズ インコーポレイテッド 白血病を治療するための組成物および方法
JP2009501707A (ja) * 2005-07-06 2009-01-22 カニサ・ファーマシューティカルズ・インコーポレイテッド 癌の処置のためのゾスキダル、ダウノルビシン、およびシタラビン
WO2008070011A2 (en) * 2006-12-04 2008-06-12 Novartis Ag Combination of an hdac inhibitor and an antimetabolite
WO2009084693A1 (ja) * 2007-12-28 2009-07-09 Mitsubishi Tanabe Pharma Corporation 抗癌剤
WO2012140436A1 (en) * 2011-04-14 2012-10-18 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEUKEMIA RESEARCH, vol. 33, JPN6018029648, 1 May 2009 (2009-05-01), pages 135 - 136, ISSN: 0004006935 *

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