KR20160021084A - 사람에서 고형 종양의 치료를 위한 씨. 노비 - Google Patents

사람에서 고형 종양의 치료를 위한 씨. 노비 Download PDF

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KR20160021084A
KR20160021084A KR1020157031284A KR20157031284A KR20160021084A KR 20160021084 A KR20160021084 A KR 20160021084A KR 1020157031284 A KR1020157031284 A KR 1020157031284A KR 20157031284 A KR20157031284 A KR 20157031284A KR 20160021084 A KR20160021084 A KR 20160021084A
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tumor
novi
human
cfu
administering
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사우랍 사하
스빈 저우
베르트 보겔슈타인
케니쓰 더블유. 킨즐러
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바이오메드 밸리 디스커버리즈, 인코포레이티드
더 존스 홉킨스 유니버시티
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/08Solutions
    • AHUMAN NECESSITIES
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    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • AHUMAN NECESSITIES
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    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11Medicinal preparations comprising living procariotic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
KR1020157031284A 2013-03-29 2014-03-28 사람에서 고형 종양의 치료를 위한 씨. 노비 Ceased KR20160021084A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361806497P 2013-03-29 2013-03-29
US61/806,497 2013-03-29
PCT/US2014/032196 WO2014160950A1 (en) 2013-03-29 2014-03-28 C. novyi for the treatment of solid tumors in humans

Publications (1)

Publication Number Publication Date
KR20160021084A true KR20160021084A (ko) 2016-02-24

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KR1020157031284A Ceased KR20160021084A (ko) 2013-03-29 2014-03-28 사람에서 고형 종양의 치료를 위한 씨. 노비

Country Status (20)

Country Link
US (3) US10617723B2 (enExample)
EP (4) EP4108248B1 (enExample)
JP (6) JP6756609B2 (enExample)
KR (1) KR20160021084A (enExample)
CN (2) CN116570628A (enExample)
AU (2) AU2014240872A1 (enExample)
BR (2) BR112015024621B1 (enExample)
CA (2) CA2908508C (enExample)
DK (1) DK2988760T3 (enExample)
ES (3) ES2815564T3 (enExample)
HK (1) HK1222134A1 (enExample)
IL (1) IL241823B (enExample)
MX (1) MX377118B (enExample)
NZ (1) NZ712691A (enExample)
PH (1) PH12015502260B1 (enExample)
RU (1) RU2718670C2 (enExample)
SG (2) SG11201508071VA (enExample)
UA (1) UA120036C2 (enExample)
WO (1) WO2014160950A1 (enExample)
ZA (2) ZA201507412B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015240884B2 (en) * 2014-03-31 2020-06-18 Biomed Valley Discoveries, Inc. Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-CTLA-4 and/or anti-PD-1 antibodies to treat solid tumor malignancies
CN105912930B (zh) * 2016-04-11 2019-02-01 北京奇虎科技有限公司 移动终端及其系统资源安全控制方法
WO2018039185A1 (en) * 2016-08-23 2018-03-01 Mayo Foundation For Medical Education And Research Methods and materials for treating estrogen receptor positive breast cancer
CN110799245B (zh) * 2017-05-16 2022-08-09 生物医学谷探索股份有限公司 用于治疗具有非典型braf突变的癌症的组合物和方法
CN109985039A (zh) * 2017-12-29 2019-07-09 深圳微芯生物科技股份有限公司 用于治疗白血病的联合用药物及其在制备用于治疗急性髓性白血病的药物中的用途
WO2021231611A1 (en) * 2020-05-12 2021-11-18 Splash Pharmaceuticals, Inc. Methods for treating cancer using spl-108 polypeptide based on tp53 mutational status
US11717787B2 (en) 2021-01-04 2023-08-08 Saudi Arabian Oil Company High free volume membrane for gas separation
CN116917009A (zh) 2021-02-19 2023-10-20 美国迈胜医疗系统有限公司 用于粒子治疗系统的机架
CN113855710B (zh) * 2021-10-09 2024-02-20 施慧达药业集团(吉林)有限公司 戈氏梭菌联合肿瘤血管生成抑制剂的应用
CN115350145A (zh) * 2022-09-06 2022-11-18 华中科技大学同济医学院附属协和医院 细菌介导负载二甲双胍的多肽水凝胶在肿瘤免疫治疗中的应用
WO2025163852A1 (ja) * 2024-02-01 2025-08-07 ミヤリサン製薬株式会社 Cd4-cd8-t細胞を増殖および/または活性化させるための組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599331A (en) 1984-12-24 1986-07-08 Syntex (U.S.A.) Inc. Etianic acids as antiangiogenics
EP0245357B1 (en) 1985-10-23 1991-08-07 The Upjohn Company Angiostatic steroids
US4771042A (en) 1985-11-25 1988-09-13 The Upjohn Company Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments
EP0477195A1 (en) 1989-06-16 1992-04-01 The Upjohn Company Suramin type compounds and angiostatic steroids to inhibit angiogenesis
AU678961B2 (en) 1991-11-22 1997-06-19 Alcon Laboratories, Inc. Angiostatic steroids
WO2002067796A1 (en) 2001-02-28 2002-09-06 Rex Medical, L.P. Apparatus for delivering ablation fluid to treat neoplasms
DK1446012T3 (da) 2001-11-21 2013-10-14 Univ Johns Hopkins Bakteriolytisk kombinationsterapi til behandling af tumorer
WO2005018332A1 (en) * 2003-08-13 2005-03-03 The General Hospital Corporation Modified microorganisms for anti-cancer therapy
ATE459364T1 (de) 2003-10-22 2010-03-15 Univ Johns Hopkins Verbesserte bakteriolyse-kombinationstherapie für die behandlung von tumoren
US20070015738A1 (en) * 2005-07-15 2007-01-18 Walker Stephen G Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells
TW200819540A (en) * 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
US9163091B2 (en) * 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid

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Publication number Publication date
JP7788114B2 (ja) 2025-12-18
JP2020152734A (ja) 2020-09-24
ES2922378T3 (es) 2022-09-14
EP3730146B1 (en) 2022-05-04
EP2988760B1 (en) 2020-06-17
JP6756609B2 (ja) 2020-09-16
SG11201508071VA (en) 2015-10-29
CN105451750B (zh) 2023-03-10
US20160051597A1 (en) 2016-02-25
JP2019011376A (ja) 2019-01-24
JP2022022392A (ja) 2022-02-03
ZA201706402B (en) 2019-01-30
PH12015502260A1 (en) 2016-02-01
US20200330525A1 (en) 2020-10-22
JP7445893B2 (ja) 2024-03-08
ES2815564T3 (es) 2021-03-30
JP2024056012A (ja) 2024-04-19
CA2908508C (en) 2023-09-19
SG10201902765VA (en) 2019-04-29
UA120036C2 (uk) 2019-09-25
CN105451750A (zh) 2016-03-30
AU2014240872A1 (en) 2015-10-22
RU2020111670A (ru) 2020-04-13
MX2015013784A (es) 2016-08-08
EP4653054A2 (en) 2025-11-26
US11439669B2 (en) 2022-09-13
RU2718670C2 (ru) 2020-04-13
JP2016515586A (ja) 2016-05-30
ZA201507412B (en) 2018-05-30
CA3206655A1 (en) 2014-10-02
WO2014160950A1 (en) 2014-10-02
MX377118B (es) 2025-03-07
DK2988760T3 (da) 2020-07-13
BR122020006408B1 (pt) 2021-09-28
HK1222134A1 (zh) 2017-06-23
CA2908508A1 (en) 2014-10-02
BR112015024621B1 (pt) 2021-09-28
JP2017088619A (ja) 2017-05-25
AU2019200276B2 (en) 2020-06-11
EP2988760A4 (en) 2016-10-05
PH12015502260B1 (en) 2022-11-16
NZ712691A (en) 2020-01-31
EP4108248B1 (en) 2025-09-17
RU2015146199A (ru) 2017-05-10
EP3730146A1 (en) 2020-10-28
CN116570628A (zh) 2023-08-11
IL241823B (en) 2021-02-28
ES3048113T3 (en) 2025-12-09
EP2988760A1 (en) 2016-03-02
AU2019200276A1 (en) 2019-02-07
US10617723B2 (en) 2020-04-14
US20220378852A1 (en) 2022-12-01
EP4108248A1 (en) 2022-12-28
BR112015024621A8 (pt) 2019-12-10
BR112015024621A2 (pt) 2017-07-18

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