ATE66002T1 - Angiostatische steroide. - Google Patents

Angiostatische steroide.

Info

Publication number
ATE66002T1
ATE66002T1 AT86906631T AT86906631T ATE66002T1 AT E66002 T1 ATE66002 T1 AT E66002T1 AT 86906631 T AT86906631 T AT 86906631T AT 86906631 T AT86906631 T AT 86906631T AT E66002 T1 ATE66002 T1 AT E66002T1
Authority
AT
Austria
Prior art keywords
bond
alkyl
beta
integer
forms
Prior art date
Application number
AT86906631T
Other languages
English (en)
Inventor
Paul A Aristoff
Harvey I Skulnick
Wendell Wierenga
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE66002T1 publication Critical patent/ATE66002T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT86906631T 1985-10-23 1986-10-16 Angiostatische steroide. ATE66002T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79056485A 1985-10-23 1985-10-23
US81186685A 1985-12-20 1985-12-20
PCT/US1986/002189 WO1987002672A1 (en) 1985-10-23 1986-10-16 Tetrahydro angiostatic steroids
EP86906631A EP0245357B1 (de) 1985-10-23 1986-10-16 Angiostatische steroide

Publications (1)

Publication Number Publication Date
ATE66002T1 true ATE66002T1 (de) 1991-08-15

Family

ID=27121047

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86906631T ATE66002T1 (de) 1985-10-23 1986-10-16 Angiostatische steroide.

Country Status (9)

Country Link
EP (2) EP0245357B1 (de)
JP (1) JP2545522B2 (de)
AT (1) ATE66002T1 (de)
DE (1) DE3680788D1 (de)
ES (1) ES2041245T3 (de)
GR (1) GR3002675T3 (de)
HK (1) HK129594A (de)
SG (1) SG99594G (de)
WO (1) WO1987002672A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876250A (en) * 1988-10-31 1989-10-24 Alcon Laboratories, Inc. Methods for controlling ocular hypertension with angiostatic steroids
US5407926A (en) * 1987-12-29 1995-04-18 Alcon Laboratories, Inc. Ophthalmic composition
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
ATE190623T1 (de) * 1990-06-11 2000-04-15 Alcon Lab Inc Verwendung von steroiden zur inhibierung von angiogenesis
CA2425841C (en) * 1991-11-22 2006-01-10 Alcon Laboratories, Inc. Angiostatic steroids
US5929111A (en) * 1996-12-18 1999-07-27 Alcon Laboratories, Inc. A-seco steroids effective at treating ophthalmic pathological neovascularization and controlling intraocular pressure
US6596703B1 (en) 1997-07-11 2003-07-22 Jagotec Ag Promotion of wound healing utilizing steroids having reduced deteriorous systemic side effects typical of glucocorticoids, mineralocorticoids and sex steroids
US6011023A (en) * 1997-08-27 2000-01-04 Alcon Laboratories, Inc. Angiostatic steroids
EP3730146B1 (de) 2013-03-29 2022-05-04 Biomed Valley Discoveries, Inc. C. novyi zur behandlung von soliden tumoren in menschen
WO2015191602A2 (en) 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies targeting tumor-associated stroma or tumor cells
CA3276518A1 (en) 2015-01-30 2025-10-30 Biomed Valley Discoveries, Inc. Crystalline c21h22cl2n4o2 malonate
MX382289B (es) 2015-01-30 2025-03-13 Biomed Valley Discoveries Inc Formas cristalinas de c21h22cl2n4o2.
AU2019359899B2 (en) * 2018-10-19 2024-07-04 Sage Therapeutics, Inc. 9(11)-unsaturated neuroactive steroids and their methods of use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2868783A (en) * 1958-04-14 1959-01-13 Upjohn Co 11-oxygenated-17alpha, 21-dihydroxy-4-pregnen-20-ones and the 21-esters thereof
US3098085A (en) * 1958-07-04 1963-07-16 Ciba Geigy Corp Process for the manufacture of 16alpha-methyl-allopregnanes substituted in the 21-position
US3083199A (en) * 1961-01-11 1963-03-26 Farmaceutici Italia delta3-5alpha-steroids and 3alpha-hydroxy-5alpha-steroids and the preparation thereof
US3045033A (en) * 1961-05-10 1962-07-17 Schering Corp Water soluble cyclophosphate esters of steroids and process for preparing same
US3402173A (en) * 1965-03-19 1968-09-17 Syntex Corp 18-lower alkyl pregnanes and derivatives
US3780177A (en) * 1967-06-16 1973-12-18 Warner Lambert Co 17-butyrate,21-ester derivatives of 6alpha,9alpha-difluoroprednisolone,compositions and use
DE2257132C3 (de) * 1972-11-18 1982-05-13 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Reduktion von 3-Ketosteroiden
US3980778A (en) * 1973-10-25 1976-09-14 The Upjohn Company Anti-inflammatory steroid
EP0001737B1 (de) * 1977-10-26 1981-01-07 Schering Aktiengesellschaft 17-Alpha-(3-Jodbenzoyloxy)-9-Alpha-chlor-4-pregnen-3.20-dione, deren D-Homo-analoga und Verfahren zu ihrer Herstellung
US4318853A (en) * 1980-01-31 1982-03-09 The Upjohn Company 9β,11β-Epoxy-5β-corticoids
ZA817929B (en) * 1980-12-22 1982-10-27 Upjohn Co 5alpha-and 5beta-androstane-17beta-carboxylates
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids

Also Published As

Publication number Publication date
EP0245357A1 (de) 1987-11-19
JPS63501292A (ja) 1988-05-19
ES2041245T3 (es) 1993-11-16
WO1987002672A1 (en) 1987-05-07
JP2545522B2 (ja) 1996-10-23
SG99594G (en) 1994-10-28
HK129594A (en) 1994-11-25
DE3680788D1 (de) 1991-09-12
EP0221705A1 (de) 1987-05-13
EP0245357B1 (de) 1991-08-07
GR3002675T3 (en) 1993-01-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time