ES8405420A1 - Nuevo proceso para la preparacion de esteres de esteroides. - Google Patents

Nuevo proceso para la preparacion de esteres de esteroides.

Info

Publication number
ES8405420A1
ES8405420A1 ES514708A ES514708A ES8405420A1 ES 8405420 A1 ES8405420 A1 ES 8405420A1 ES 514708 A ES514708 A ES 514708A ES 514708 A ES514708 A ES 514708A ES 8405420 A1 ES8405420 A1 ES 8405420A1
Authority
ES
Spain
Prior art keywords
group
formula
hydrogen
carbon atoms
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514708A
Other languages
English (en)
Other versions
ES514708A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Plurichemie Anstalt
Original Assignee
Plurichemie Anstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PT7347981A external-priority patent/PT73479B/pt
Priority claimed from PT7386481A external-priority patent/PT73864B/pt
Application filed by Plurichemie Anstalt filed Critical Plurichemie Anstalt
Publication of ES514708A0 publication Critical patent/ES514708A0/es
Publication of ES8405420A1 publication Critical patent/ES8405420A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ESTERES DE ESTEROIDES, DE FORMULA GENERAL (I), EN LA QUE X ES HIDROGENO, FLUOR O CLORO, R1 ES HIDROGENO, FLUOR, CLORO O METILO; R2 ES HIDROXILO; R3 ES HIDROGENO; R4 ES UN GRUPO ACILO; R5 ES HIDROGENO O HALOGENO; Y ... SIGNIFICA UN DOBLE ENLACE.CONSISTE EN LA ESTERIFICACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE X, R1, R3 Y R5 TIENEN EL SIGNIFICADO YA INDICADO; R7 ES HIDROXILO; Y R8 ES TRIHALOACETATO, CON UN ANHIDRIDO DEL ACIDO QUE CONTIENE EL GRUPO QUE SE DESEA INTRODUCIR EN LA POSICION RESPECTIVA,ELIMINANDO INMEDIATAMENTE DESPUES EL SUSTITUYENTE DEL 11-TRIHALOACETATO, PARA FORMAR UN COMPUESTO DE FORMULA (I).DE APLICACION EN EL TRATAMIENTO DE LA DERMATOSIS SENSIBLE A LOS CORTICOESTEROIDES.
ES514708A 1981-08-04 1982-08-03 Nuevo proceso para la preparacion de esteres de esteroides. Expired ES8405420A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT7347981A PT73479B (en) 1981-08-04 1981-08-04 Process for a selective remotion of trihaloacetates of corticosteroids
PT7386481A PT73864B (fr) 1981-10-22 1981-10-22 Nouveau procede pour la preparation de steres de cortisteroides

Publications (2)

Publication Number Publication Date
ES514708A0 ES514708A0 (es) 1984-06-16
ES8405420A1 true ES8405420A1 (es) 1984-06-16

Family

ID=26653432

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514708A Expired ES8405420A1 (es) 1981-08-04 1982-08-03 Nuevo proceso para la preparacion de esteres de esteroides.

Country Status (8)

Country Link
US (1) US4655971A (es)
EP (1) EP0072200B1 (es)
KR (1) KR850000769B1 (es)
AT (1) ATE16601T1 (es)
DE (1) DE3267586D1 (es)
ES (1) ES8405420A1 (es)
HK (1) HK43190A (es)
IL (1) IL66432A0 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3133081A1 (de) * 1981-08-18 1983-03-10 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 6(alpha)-methylprednisolon-derivate, ihre herstellung und verwendung
EP0095894A3 (en) * 1982-05-31 1985-01-02 Ohta Seiyaku Kabushiki Kaisha. 6 alpha-methylprednisolone derivatives
PT78973A (en) * 1984-07-25 1984-08-01 Joao Emerico Villax New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid
JPH07116215B2 (ja) * 1989-04-19 1995-12-13 エスエス製薬株式会社 新規なステロイド化合物
DE4328819A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Corticosteroid-17-alkylcarbonat-21/0/-Carbonsäure- und Kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4333920A1 (de) * 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US7214672B2 (en) * 2000-12-22 2007-05-08 Nippon Shinyaku Co., Ltd. Preventives/remedies for inflammatory airway diseases
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800489A (en) * 1953-08-14 1957-07-23 Reichstein Tadeus 11-trifluoroacetoxy steroids and process
GB1047518A (en) * 1963-06-11 1966-11-02 Glaxo Lab Ltd 17ª‡-monoesters of 11,17,21-trihydroxy steroid compounds
US3383394A (en) * 1965-08-30 1968-05-14 Schering Corp Novel 17-acylating process and products thereof
CH481085A (de) * 1965-08-30 1969-11-15 Scherico Ltd Verfahren zur Herstellung von 11B-Hydroxy-17 -alkanoyloxysteroiden der Pregnanreihe
SE418294B (sv) * 1974-03-27 1981-05-18 Plurichemie Anstalt Sett att framstella en 16alfa- eller 16beta-9alfa-klor eller -fluorsteroidester
DE2645104C2 (de) * 1976-10-04 1986-04-24 Schering AG, 1000 Berlin und 4709 Bergkamen 11β-Hydroxy-1,4,8-pregnatrien-3,20-dion-Derivate und Verfahren zu ihrer Herstellung
PT71309A (en) * 1980-05-27 1980-06-01 Hovione Sociedade Quimica Lda Process of selective

Also Published As

Publication number Publication date
EP0072200B1 (en) 1985-11-21
EP0072200A2 (en) 1983-02-16
US4655971A (en) 1987-04-07
KR850000769B1 (ko) 1985-05-29
ES514708A0 (es) 1984-06-16
HK43190A (en) 1990-06-15
ATE16601T1 (de) 1985-12-15
KR840001182A (ko) 1984-03-28
IL66432A0 (en) 1982-12-31
DE3267586D1 (en) 1986-01-02
EP0072200A3 (en) 1983-06-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102