KR20150122730A - 암의 치료에서 항-gcc 항체-약물 콘주게이트 및 dna 손상 제제의 투여 - Google Patents

암의 치료에서 항-gcc 항체-약물 콘주게이트 및 dna 손상 제제의 투여 Download PDF

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KR20150122730A
KR20150122730A KR1020157026431A KR20157026431A KR20150122730A KR 20150122730 A KR20150122730 A KR 20150122730A KR 1020157026431 A KR1020157026431 A KR 1020157026431A KR 20157026431 A KR20157026431 A KR 20157026431A KR 20150122730 A KR20150122730 A KR 20150122730A
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cancer
gcc
immunoconjugate
agent
seq
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올레 피터 베이비
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밀레니엄 파머슈티컬스 인코퍼레이티드
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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KR1020157026431A 2013-02-28 2014-02-27 암의 치료에서 항-gcc 항체-약물 콘주게이트 및 dna 손상 제제의 투여 Withdrawn KR20150122730A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361770802P 2013-02-28 2013-02-28
US61/770,802 2013-02-28
US201361892854P 2013-10-18 2013-10-18
US61/892,854 2013-10-18
PCT/US2014/019034 WO2014134311A1 (en) 2013-02-28 2014-02-27 Administration of an anti-gcc antibody-drug conjugate and a dna damaging agent in the treatment of cancer

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KR20150122730A true KR20150122730A (ko) 2015-11-02

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KR1020157026431A Withdrawn KR20150122730A (ko) 2013-02-28 2014-02-27 암의 치료에서 항-gcc 항체-약물 콘주게이트 및 dna 손상 제제의 투여

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US (1) US20140356383A1 (cg-RX-API-DMAC10.html)
EP (1) EP2961424A4 (cg-RX-API-DMAC10.html)
JP (1) JP2016511257A (cg-RX-API-DMAC10.html)
KR (1) KR20150122730A (cg-RX-API-DMAC10.html)
CN (1) CN105142664A (cg-RX-API-DMAC10.html)
CA (1) CA2902757A1 (cg-RX-API-DMAC10.html)
TW (1) TW201444577A (cg-RX-API-DMAC10.html)
WO (1) WO2014134311A1 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY173390A (en) 2009-10-23 2020-01-22 Takeda Pharmaceuticals Co Anti-gcc antibody molecules and related compositions and methods
HRP20191690T1 (hr) * 2012-04-27 2019-12-27 Millennium Pharmaceuticals, Inc. Molekule anti-gcc antitijela i njihova uporaba u ispitivanju osjetljivosti na gcc-ciljanu terapiju
WO2021205325A1 (en) * 2020-04-08 2021-10-14 Pfizer Inc. Anti-gucy2c antibodies and uses thereof
WO2024027815A1 (zh) 2022-08-05 2024-02-08 江苏恒瑞医药股份有限公司 特异性结合gucy2c和cd3的抗原结合分子及其医药用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1274861B1 (en) * 2000-03-27 2009-12-23 Thomas Jefferson University Compositions and methods for identifying and targeting cancer cells
EP2370098A4 (en) * 2008-12-03 2013-07-17 Morphosys Ag Antibodies for guanylyl cyclase receptors
MY173390A (en) * 2009-10-23 2020-01-22 Takeda Pharmaceuticals Co Anti-gcc antibody molecules and related compositions and methods

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CN105142664A (zh) 2015-12-09
US20140356383A1 (en) 2014-12-04
TW201444577A (zh) 2014-12-01
EP2961424A4 (en) 2016-10-19
WO2014134311A1 (en) 2014-09-04
EP2961424A1 (en) 2016-01-06
JP2016511257A (ja) 2016-04-14
CA2902757A1 (en) 2014-09-04

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