KR20150100661A - 치환된 옥사졸리디논의 알데히드 유도체 - Google Patents
치환된 옥사졸리디논의 알데히드 유도체 Download PDFInfo
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- KR20150100661A KR20150100661A KR1020157015903A KR20157015903A KR20150100661A KR 20150100661 A KR20150100661 A KR 20150100661A KR 1020157015903 A KR1020157015903 A KR 1020157015903A KR 20157015903 A KR20157015903 A KR 20157015903A KR 20150100661 A KR20150100661 A KR 20150100661A
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- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 16
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 24
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- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3359/MUM/2012 | 2012-12-26 | ||
| PCT/IN2013/000801 WO2014102822A2 (en) | 2012-12-26 | 2013-12-24 | Aldehyde derivative of substitute oxazolidinones |
| IN3359MU2012 IN2012MU03359A (cg-RX-API-DMAC7.html) | 2012-12-26 | 2013-12-24 |
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| Publication Number | Publication Date |
|---|---|
| KR20150100661A true KR20150100661A (ko) | 2015-09-02 |
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| KR1020157015903A Ceased KR20150100661A (ko) | 2012-12-26 | 2013-12-24 | 치환된 옥사졸리디논의 알데히드 유도체 |
Country Status (15)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20161588T1 (hr) | 2012-12-26 | 2017-01-13 | Wanbury Limited | Intermedijer rivaroksabana i njegova priprava |
| US20160251342A1 (en) * | 2012-12-26 | 2016-09-01 | Wanbury Ltd. | Aldehyde derivative of substituted oxazolidinones |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| DE102004002044A1 (de) | 2004-01-15 | 2005-08-04 | Bayer Healthcare Ag | Herstellverfahren |
| GT200600196A (es) | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
| DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| CA2624310C (en) | 2005-10-04 | 2014-01-07 | Bayer Healthcare Ag | Polymorphic form of 5-chloro-n-({5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide |
| DE102006007146A1 (de) * | 2006-02-16 | 2007-08-23 | Bayer Healthcare Ag | Aminoacyl-Prodrugs |
| DE102006039589A1 (de) * | 2006-08-24 | 2008-03-06 | Bayer Healthcare Ag | Aminoacyl-Prodrugs II |
| JP5389028B2 (ja) | 2007-08-14 | 2014-01-15 | コンサート ファーマシューティカルズ インコーポレイテッド | 置換オキサゾリジノン誘導体 |
| US7816355B1 (en) | 2009-04-28 | 2010-10-19 | Apotex Pharmachem Inc | Processes for the preparation of rivaroxaban and intermediates thereof |
| EP2459555B1 (en) | 2009-07-31 | 2021-11-03 | KRKA, D.D., Novo Mesto | Processes for crystallization of rivaroxaban |
| US20120283434A1 (en) | 2010-01-04 | 2012-11-08 | Enantia, S.L. | Process for the preparation of rivaroxaban and intermediates thereof |
| EP2354128A1 (en) | 2010-02-10 | 2011-08-10 | Sandoz Ag | Method for the preparation of rivaroxaban |
| EA201370107A1 (ru) * | 2010-11-11 | 2013-11-29 | Редкс Фарма Лимитед | Производные лекарственных средств |
| WO2012140061A1 (en) | 2011-04-11 | 2012-10-18 | Sandoz Ag | Method for the preparation of substituted oxazolidinones |
| GEP20156397B (en) | 2011-05-06 | 2015-11-10 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Process for the preparation of a rivaroxaban and intermediates formed in said process |
| ES2395304B1 (es) | 2011-05-20 | 2014-01-16 | Interquim, S.A. | Procedimiento de obtención de una tiofen-2-carboxamida. |
| HRP20161588T1 (hr) | 2012-12-26 | 2017-01-13 | Wanbury Limited | Intermedijer rivaroksabana i njegova priprava |
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2013
- 2013-12-24 IN IN3359MU2012 patent/IN2012MU03359A/en unknown
- 2013-12-24 CA CA2883323A patent/CA2883323A1/en not_active Abandoned
- 2013-12-24 AU AU2013368847A patent/AU2013368847B2/en not_active Expired - Fee Related
- 2013-12-24 US US14/436,018 patent/US9359341B2/en not_active Expired - Fee Related
- 2013-12-24 EP EP13869179.5A patent/EP2897619A4/en not_active Withdrawn
- 2013-12-24 RU RU2015112195A patent/RU2015112195A/ru not_active Application Discontinuation
- 2013-12-24 BR BR112015011033A patent/BR112015011033A2/pt not_active IP Right Cessation
- 2013-12-24 KR KR1020157015903A patent/KR20150100661A/ko not_active Ceased
- 2013-12-24 MX MX2015003319A patent/MX2015003319A/es unknown
- 2013-12-24 CN CN201380068642.9A patent/CN105431429A/zh active Pending
- 2013-12-24 JP JP2015550211A patent/JP2016504348A/ja active Pending
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2015
- 2015-05-25 ZA ZA2015/03700A patent/ZA201503700B/en unknown
- 2015-07-22 PH PH12015501625A patent/PH12015501625A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015003319A (es) | 2015-08-14 |
| CN105431429A (zh) | 2016-03-23 |
| IN2012MU03359A (cg-RX-API-DMAC7.html) | 2015-06-26 |
| US9359341B2 (en) | 2016-06-07 |
| EP2897619A2 (en) | 2015-07-29 |
| EP2897619A4 (en) | 2016-08-17 |
| RU2015112195A (ru) | 2017-01-31 |
| CA2883323A1 (en) | 2014-07-03 |
| HK1217101A1 (zh) | 2016-12-23 |
| ZA201503700B (en) | 2016-10-26 |
| AU2013368847B2 (en) | 2017-03-16 |
| BR112015011033A2 (pt) | 2017-07-11 |
| WO2014102822A2 (en) | 2014-07-03 |
| US20150259333A1 (en) | 2015-09-17 |
| WO2014102822A3 (en) | 2015-10-29 |
| PH12015501625A1 (en) | 2015-09-28 |
| AU2013368847A1 (en) | 2015-05-28 |
| JP2016504348A (ja) | 2016-02-12 |
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