KR20150091434A - 다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법 - Google Patents

다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법 Download PDF

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KR20150091434A
KR20150091434A KR1020157020493A KR20157020493A KR20150091434A KR 20150091434 A KR20150091434 A KR 20150091434A KR 1020157020493 A KR1020157020493 A KR 1020157020493A KR 20157020493 A KR20157020493 A KR 20157020493A KR 20150091434 A KR20150091434 A KR 20150091434A
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compound
formula
additional
additional embodiment
alkyl
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KR1020157020493A
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Korean (ko)
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장-미셸 베르니에르
콜린 에드워드 롤링스
장-뤼크 지라르데
스튜어트 디모크
배리 쿼트
제프리 엔. 마이너
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아디아 바이오사이언스즈 인크.
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Priority claimed from US11/830,733 external-priority patent/US8101799B2/en
Application filed by 아디아 바이오사이언스즈 인크. filed Critical 아디아 바이오사이언스즈 인크.
Publication of KR20150091434A publication Critical patent/KR20150091434A/ko

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04Sulfonic acids; Derivatives thereof
    • A01N41/06Sulfonic acid amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02Immunomodulators
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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/28Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Neurology (AREA)
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  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Pain & Pain Management (AREA)
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  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Vascular Medicine (AREA)
  • Dentistry (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
KR1020157020493A 2007-07-30 2008-07-28 다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법 KR20150091434A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US11/830,733 US8101799B2 (en) 2005-07-21 2007-07-30 Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
US11/830,733 2007-07-30
US3446608P 2008-03-06 2008-03-06
US3446408P 2008-03-06 2008-03-06
US61/034,466 2008-03-06
US61/034,464 2008-03-06
US4488608P 2008-04-14 2008-04-14
US61/044,886 2008-04-14
PCT/US2008/071392 WO2009018233A1 (en) 2007-07-30 2008-07-28 Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107004742A Division KR20100092424A (ko) 2007-07-30 2008-07-28 다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법

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KR20150091434A true KR20150091434A (ko) 2015-08-10

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KR1020147017261A KR20140098185A (ko) 2007-07-30 2008-07-28 다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법
KR1020157020493A KR20150091434A (ko) 2007-07-30 2008-07-28 다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법
KR1020107004742A KR20100092424A (ko) 2007-07-30 2008-07-28 다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법

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KR1020147017261A KR20140098185A (ko) 2007-07-30 2008-07-28 다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법

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KR1020107004742A KR20100092424A (ko) 2007-07-30 2008-07-28 다형체를 포함하는, mek의 억제제로서의 n-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법

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EP (1) EP2184984A4 (ja)
JP (3) JP2010535232A (ja)
KR (3) KR20140098185A (ja)
CN (2) CN103479604B (ja)
AP (1) AP2817A (ja)
AU (2) AU2008282338B2 (ja)
BR (1) BRPI0815659A2 (ja)
CA (1) CA2693390C (ja)
CO (1) CO6470808A2 (ja)
CR (1) CR11244A (ja)
DO (1) DOP2010000045A (ja)
EA (2) EA020624B1 (ja)
EC (1) ECSP109910A (ja)
HK (1) HK1147396A1 (ja)
HN (1) HN2010000203A (ja)
IL (1) IL203296A (ja)
MA (1) MA31881B1 (ja)
MX (1) MX2010001244A (ja)
NZ (1) NZ582929A (ja)
PH (1) PH12015501914A1 (ja)
SV (1) SV2010003469A (ja)
TN (1) TN2010000049A1 (ja)
WO (1) WO2009018233A1 (ja)

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EP2184984A1 (en) 2010-05-19
EP2184984A4 (en) 2013-07-24
EA032294B1 (ru) 2019-05-31
AP2817A (en) 2013-12-31
TN2010000049A1 (en) 2011-09-26
HK1147396A1 (en) 2011-08-12
EA201400552A1 (ru) 2014-09-30
WO2009018233A1 (en) 2009-02-05
MA31881B1 (fr) 2010-12-01
AU2015200390B2 (en) 2017-02-23
JP2015078199A (ja) 2015-04-23
KR20140098185A (ko) 2014-08-07
MX2010001244A (es) 2010-08-31
PH12015501914A1 (en) 2017-07-31
EA201000268A1 (ru) 2010-08-30
JP2010535232A (ja) 2010-11-18
CN103479604B (zh) 2016-08-10
CN103479604A (zh) 2014-01-01
HN2010000203A (es) 2012-11-19
JP2017125021A (ja) 2017-07-20
DOP2010000045A (es) 2010-10-31
CO6470808A2 (es) 2012-06-29
CN101808516B (zh) 2013-08-28
IL203296A (en) 2017-06-29
ECSP109910A (es) 2010-04-30
CN101808516A (zh) 2010-08-18
KR20100092424A (ko) 2010-08-20
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NZ582929A (en) 2012-03-30
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CA2693390A1 (en) 2009-02-05
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