KR20150086308A - 벤다무스틴 유도체 및 그의 사용 방법 - Google Patents

벤다무스틴 유도체 및 그의 사용 방법 Download PDF

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Publication number
KR20150086308A
KR20150086308A KR1020157015682A KR20157015682A KR20150086308A KR 20150086308 A KR20150086308 A KR 20150086308A KR 1020157015682 A KR1020157015682 A KR 1020157015682A KR 20157015682 A KR20157015682 A KR 20157015682A KR 20150086308 A KR20150086308 A KR 20150086308A
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KR
South Korea
Prior art keywords
alkyl
cancer
formula
rti
mmol
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KR1020157015682A
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English (en)
Korean (ko)
Inventor
로져 피. 바케일
피터 디. 브라운
지안 첸
앤쏘니 에스. 드레이져
레이첼 와이. 라벨
로버트 이. 맥킨
피유쉬 알. 파텔
리니 씨. 로엠멜르
Original Assignee
이그니타, 인코포레이티드
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Publication of KR20150086308A publication Critical patent/KR20150086308A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
KR1020157015682A 2012-11-12 2013-11-12 벤다무스틴 유도체 및 그의 사용 방법 Withdrawn KR20150086308A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261725213P 2012-11-12 2012-11-12
US61/725,213 2012-11-12
US201361776951P 2013-03-12 2013-03-12
US61/776,951 2013-03-12

Publications (1)

Publication Number Publication Date
KR20150086308A true KR20150086308A (ko) 2015-07-27

Family

ID=49667594

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157015682A Withdrawn KR20150086308A (ko) 2012-11-12 2013-11-12 벤다무스틴 유도체 및 그의 사용 방법

Country Status (17)

Country Link
US (7) US9452988B2 (enExample)
EP (1) EP2917183A1 (enExample)
JP (1) JP6262246B2 (enExample)
KR (1) KR20150086308A (enExample)
AR (1) AR093457A1 (enExample)
AU (1) AU2013342015B2 (enExample)
BR (1) BR112015010501A2 (enExample)
CA (1) CA2890462A1 (enExample)
CL (1) CL2015001246A1 (enExample)
EA (1) EA029706B1 (enExample)
HK (2) HK1215701A1 (enExample)
IL (1) IL238662A (enExample)
MX (1) MX2015005805A (enExample)
PH (1) PH12015501024A1 (enExample)
SG (1) SG11201503560TA (enExample)
TW (1) TWI598341B (enExample)
WO (1) WO2014075035A1 (enExample)

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HUE044025T2 (hu) 2010-05-20 2019-09-30 Array Biopharma Inc Makrociklusos vegyületek mint TRK-kináz inhibitorok
CA2890462A1 (en) 2012-11-12 2014-05-15 Ignyta, Inc. Bendamustine derivatives and methods of using same
WO2014164957A1 (en) * 2013-03-12 2014-10-09 Cephalon, Inc. Nanoparticulate and macroparticulate formulations
PL3322706T3 (pl) 2015-07-16 2021-07-19 Array Biopharma, Inc. Podstawione związki pirazolo[1,5-a]pirydynowe jako inhibitory kinazy ret
WO2018013783A1 (en) * 2016-07-13 2018-01-18 Cephalon, Inc. Pharmaceutical prodrugs and methods of their preparation and use
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
US11168090B2 (en) 2017-01-18 2021-11-09 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CA3087578C (en) 2018-01-18 2023-08-08 Array Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
EP3740486A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN117281803A (zh) 2018-07-31 2023-12-26 罗索肿瘤学公司 喷雾干燥的分散体和制剂
WO2020055672A1 (en) 2018-09-10 2020-03-19 Array Biopharma Inc. Fused heterocyclic compounds as ret kinase inhibitors

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US5834025A (en) 1995-09-29 1998-11-10 Nanosystems L.L.C. Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions
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AU2002239405A1 (en) 2000-12-01 2002-06-11 Enzon, Inc. Tetrapartate prodrugs
AU2003227147A1 (en) * 2002-04-05 2003-10-27 Universite De Montreal Stealthy polymeric biodegradable nanospheres and uses thereof
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US9149441B2 (en) * 2008-09-29 2015-10-06 The Corporation Of Mercer University Nanospheres encapsulating bioactive material and method for formulation of nanospheres
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TWI578997B (zh) 2010-06-04 2017-04-21 輝瑞疫苗有限責任公司 用於預防或治療菸鹼成癮之共軛體
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DE102010055499A1 (de) * 2010-12-22 2011-06-16 W.C. Heraeus Gmbh Prozess zur Herstellung von Bendamustinalkylester, Bendarmustin sowie Derivaten davon
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Also Published As

Publication number Publication date
US20160289198A1 (en) 2016-10-06
IL238662A (en) 2017-08-31
EP2917183A1 (en) 2015-09-16
CA2890462A1 (en) 2014-05-15
EA201590925A1 (ru) 2015-09-30
SG11201503560TA (en) 2015-06-29
US20180147186A1 (en) 2018-05-31
IL238662A0 (en) 2015-06-30
US9452988B2 (en) 2016-09-27
US9913827B2 (en) 2018-03-13
US20150246023A1 (en) 2015-09-03
PH12015501024A1 (en) 2015-07-27
CL2015001246A1 (es) 2016-01-15
JP6262246B2 (ja) 2018-01-17
TW201439069A (zh) 2014-10-16
AR093457A1 (es) 2015-06-10
TWI598341B (zh) 2017-09-11
US20170182008A1 (en) 2017-06-29
US9630926B2 (en) 2017-04-25
HK1212977A1 (zh) 2016-06-24
WO2014075035A1 (en) 2014-05-15
BR112015010501A2 (pt) 2017-07-11
US9150517B2 (en) 2015-10-06
AU2013342015A1 (en) 2015-05-28
JP2015536996A (ja) 2015-12-24
US20160016912A1 (en) 2016-01-21
CN105051016A (zh) 2015-11-11
EA029706B1 (ru) 2018-05-31
HK1215701A1 (zh) 2016-09-09
AU2013342015B2 (en) 2016-11-24
MX2015005805A (es) 2016-04-15
US20150274675A1 (en) 2015-10-01
US9149464B2 (en) 2015-10-06
US20150232427A1 (en) 2015-08-20

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PA0105 International application

Patent event date: 20150612

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid