KR20150035550A - 신경성 장애 치료용 판토테네이트 유도체 - Google Patents

신경성 장애 치료용 판토테네이트 유도체 Download PDF

Info

Publication number
KR20150035550A
KR20150035550A KR20147033141A KR20147033141A KR20150035550A KR 20150035550 A KR20150035550 A KR 20150035550A KR 20147033141 A KR20147033141 A KR 20147033141A KR 20147033141 A KR20147033141 A KR 20147033141A KR 20150035550 A KR20150035550 A KR 20150035550A
Authority
KR
South Korea
Prior art keywords
compound
subject
substituted
unsubstituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR20147033141A
Other languages
English (en)
Korean (ko)
Inventor
앤드류 바이노
마렉 비에스텍
마틴 셔크렐리
Original Assignee
레트로핀, 인코포레이티드
마렉 비에스텍
마틴 셔크렐리
앤드류 바이노
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 레트로핀, 인코포레이티드, 마렉 비에스텍, 마틴 셔크렐리, 앤드류 바이노 filed Critical 레트로핀, 인코포레이티드
Publication of KR20150035550A publication Critical patent/KR20150035550A/ko
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/242—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyaryl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
KR20147033141A 2012-04-27 2013-04-26 신경성 장애 치료용 판토테네이트 유도체 Abandoned KR20150035550A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261639602P 2012-04-27 2012-04-27
US61/639,602 2012-04-27
PCT/US2013/038458 WO2013163576A1 (en) 2012-04-27 2013-04-26 Pantothenate derivatives for the treatment of neurologic disorders

Publications (1)

Publication Number Publication Date
KR20150035550A true KR20150035550A (ko) 2015-04-06

Family

ID=48428654

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20147033141A Abandoned KR20150035550A (ko) 2012-04-27 2013-04-26 신경성 장애 치료용 판토테네이트 유도체

Country Status (24)

Country Link
US (3) US8673883B2 (https=)
EP (3) EP2841438B1 (https=)
JP (3) JP6254151B2 (https=)
KR (1) KR20150035550A (https=)
CN (2) CN106977544B (https=)
AU (3) AU2013251345B2 (https=)
BR (1) BR112014026817A2 (https=)
CA (1) CA2879314A1 (https=)
CY (2) CY1118198T1 (https=)
DK (2) DK2841438T3 (https=)
ES (2) ES2600179T3 (https=)
HR (2) HRP20161389T1 (https=)
HU (2) HUE042199T2 (https=)
IN (1) IN2014DN09584A (https=)
LT (2) LT2841438T (https=)
MX (1) MX360149B (https=)
PL (2) PL3112372T3 (https=)
PT (2) PT3112372T (https=)
RS (2) RS55319B1 (https=)
RU (2) RU2653497C2 (https=)
SI (2) SI2841438T1 (https=)
SM (2) SMT201900007T1 (https=)
TR (1) TR201819263T4 (https=)
WO (1) WO2013163576A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2841438T3 (en) * 2012-04-27 2016-11-28 Retrophin Inc Pantothenate derivatives for the treatment of neurological disorders
EP3060570B1 (en) 2013-10-25 2018-09-19 Retrophin, Inc. Pantothenate derivatives for the treatment of neurological disorders
EP2868662A1 (en) * 2013-11-04 2015-05-06 Acies Bio d.o.o. Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds
AU2016366977A1 (en) 2015-12-08 2018-07-12 Retrophin, Inc. Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders
MX2019009342A (es) * 2017-02-07 2019-10-02 Retrophin Inc Formulaciones de fosmetpantotenato solido.
US12065404B2 (en) 2022-03-18 2024-08-20 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2676976A (en) 1950-12-04 1954-04-27 Nat Res Dev Synthesis of pantothenic acid-4' phosphate
US2870188A (en) 1955-10-03 1959-01-20 Hoffmann La Roche Process for the manufacture of pantothenic acid 4'-phosphate and its salts
RU2002110463A (ru) * 1999-09-21 2004-02-27 Басф Акциенгезелльшафт (De) Способ и микроорганизмы для получения пантосоединений
AU2002326412A1 (en) 2001-07-20 2003-03-03 Oregon Health And Science University Novel human nucleic acids encoding a pantothenate kinase and methods of use
CA2491137A1 (en) * 2002-07-03 2004-01-15 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
WO2007020193A2 (en) 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Antiviral phosphoramidates of 4 ' -substituted pronucleotides
DK2841438T3 (en) * 2012-04-27 2016-11-28 Retrophin Inc Pantothenate derivatives for the treatment of neurological disorders

Also Published As

Publication number Publication date
SI3112372T1 (sl) 2019-04-30
AU2017239508B9 (en) 2019-06-13
AU2019219733A1 (en) 2019-09-05
AU2017239508A1 (en) 2017-10-26
PT3112372T (pt) 2019-01-17
ES2600179T3 (es) 2017-02-07
JP2017141257A (ja) 2017-08-17
LT2841438T (lt) 2016-11-10
HUE042199T2 (hu) 2019-06-28
IN2014DN09584A (https=) 2015-07-17
EP2841438A1 (en) 2015-03-04
HRP20161389T1 (hr) 2016-12-02
CY1121238T1 (el) 2020-05-29
JP6254151B2 (ja) 2017-12-27
HRP20190038T1 (hr) 2019-02-22
JP6560284B2 (ja) 2019-08-14
BR112014026817A2 (pt) 2017-07-18
RU2018112720A (ru) 2019-02-28
LT3112372T (lt) 2019-01-10
CN104520307B (zh) 2016-12-21
RS55319B1 (sr) 2017-03-31
RS58336B1 (sr) 2019-03-29
ES2708813T3 (es) 2019-04-11
TR201819263T4 (tr) 2019-01-21
MX360149B (es) 2018-10-24
HK1207863A1 (en) 2016-02-12
DK2841438T3 (en) 2016-11-28
CA2879314A1 (en) 2013-10-31
CY1118198T1 (el) 2017-06-28
EP3489248A1 (en) 2019-05-29
AU2017239508B2 (en) 2019-05-23
US20140135294A1 (en) 2014-05-15
HUE029474T2 (en) 2017-02-28
SMT201600395B (it) 2017-01-10
EP3112372B1 (en) 2018-11-07
JP2015515496A (ja) 2015-05-28
CN106977544B (zh) 2019-06-07
PT2841438T (pt) 2016-11-22
AU2013251345A1 (en) 2014-11-27
AU2013251345B2 (en) 2017-08-31
US9181286B2 (en) 2015-11-10
WO2013163576A1 (en) 2013-10-31
EP3112372A1 (en) 2017-01-04
US8673883B2 (en) 2014-03-18
RU2653497C2 (ru) 2018-05-10
CN106977544A (zh) 2017-07-25
SMT201900007T1 (it) 2019-02-28
PL3112372T3 (pl) 2019-05-31
MX2014013048A (es) 2015-04-10
PL2841438T3 (pl) 2017-08-31
DK3112372T3 (en) 2019-02-18
US20130289001A1 (en) 2013-10-31
EP2841438B1 (en) 2016-08-10
CN104520307A (zh) 2015-04-15
SI2841438T1 (sl) 2016-12-30
US9629862B2 (en) 2017-04-25
AU2017239508C1 (en) 2019-11-07
US20160015727A1 (en) 2016-01-21
JP2019206553A (ja) 2019-12-05
RU2014147739A (ru) 2016-06-20

Similar Documents

Publication Publication Date Title
AU2017239508B9 (en) Pantothenate derivatives for the treatment of neurologic disorders
US10407447B2 (en) Pantothenate derivatives for the treatment of neurological disorders
WO2016110822A1 (en) Carboxylic biacyl creatine derivative, uses and method of synthesis thereof
AU2017301488A1 (en) Pantetheine derivatives for the treatment of neurologic disorders
HK1232544A1 (en) Pantothenate derivatives for the treatment of neurologic disorders
HK1207863B (en) Pantothenate derivatives for the treatment of neurologic disorders
HK1232544B (en) Pantothenate derivatives for the treatment of neurologic disorders

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20141125

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20150730

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20180424

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20190411

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20190925

NORF Unpaid initial registration fee
PC1904 Unpaid initial registration fee