KR20140082699A - 플라빈 아데닌 디뉴클레오티드 또는 그의 염을 유효 성분으로서 함유하는 각막상피세포사의 억제제 - Google Patents

플라빈 아데닌 디뉴클레오티드 또는 그의 염을 유효 성분으로서 함유하는 각막상피세포사의 억제제 Download PDF

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Publication number
KR20140082699A
KR20140082699A KR1020147009783A KR20147009783A KR20140082699A KR 20140082699 A KR20140082699 A KR 20140082699A KR 1020147009783 A KR1020147009783 A KR 1020147009783A KR 20147009783 A KR20147009783 A KR 20147009783A KR 20140082699 A KR20140082699 A KR 20140082699A
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KR
South Korea
Prior art keywords
corneal epithelial
cell death
epithelial cell
salt
adenine dinucleotide
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Withdrawn
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KR1020147009783A
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English (en)
Korean (ko)
Inventor
아스카 사카모토
마사츠구 나카무라
Original Assignee
산텐 세이야꾸 가부시키가이샤
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Publication of KR20140082699A publication Critical patent/KR20140082699A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020147009783A 2011-09-27 2012-09-26 플라빈 아데닌 디뉴클레오티드 또는 그의 염을 유효 성분으로서 함유하는 각막상피세포사의 억제제 Withdrawn KR20140082699A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2011-210875 2011-09-27
JP2011210875 2011-09-27
PCT/JP2012/074662 WO2013047567A1 (ja) 2011-09-27 2012-09-26 フラビンアデニンジヌクレオチドまたはその塩を有効成分として含有する角膜上皮細胞死の抑制剤

Publications (1)

Publication Number Publication Date
KR20140082699A true KR20140082699A (ko) 2014-07-02

Family

ID=47995597

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147009783A Withdrawn KR20140082699A (ko) 2011-09-27 2012-09-26 플라빈 아데닌 디뉴클레오티드 또는 그의 염을 유효 성분으로서 함유하는 각막상피세포사의 억제제

Country Status (9)

Country Link
JP (1) JP5969872B2 (https=)
KR (1) KR20140082699A (https=)
CN (1) CN103826642B (https=)
IN (1) IN2014DN03350A (https=)
MY (1) MY185239A (https=)
PH (1) PH12014500660A1 (https=)
SG (2) SG11201400947XA (https=)
TW (1) TWI561238B (https=)
WO (1) WO2013047567A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016046734A2 (en) * 2014-09-22 2016-03-31 University Of The Western Cape Compounds and compositions for treatment of tuberculosis
EP4512395A1 (en) 2023-08-21 2025-02-26 Bio Even Composition comprising flavin adenine dinucleotide (fad), l-gsh, atp and myristic acid, alone or with a drug

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773076B1 (fr) * 1997-12-29 2000-05-19 Chauvin Lab Sa Utilisation de la flavine-adenine-dinucleotide pour la preparation de compositions ophtalmiques utiles pour le traitement de l'oeil sec
JP4836401B2 (ja) * 2002-04-01 2011-12-14 ロート製薬株式会社 眼科用組成物
JP2004203836A (ja) * 2002-12-26 2004-07-22 Rohto Pharmaceut Co Ltd 眼科用局所適用製剤
JP2005239622A (ja) * 2004-02-26 2005-09-08 Rohto Pharmaceut Co Ltd 角膜障害治療剤
JP4999304B2 (ja) * 2004-09-27 2012-08-15 ロート製薬株式会社 ヒアルロン酸又はその塩を含有する粘膜適用組成物
JP4969052B2 (ja) * 2005-03-31 2012-07-04 小林製薬株式会社 眼科用組成物
CN101301305A (zh) * 2008-05-14 2008-11-12 北京润德康医药技术有限公司 一种黄素腺嘌呤二核苷酸二钠冻干粉针制剂及其制备方法
JP5506357B2 (ja) * 2009-12-02 2014-05-28 ロート製薬株式会社 シリコーンハイドロゲルコンタクトレンズ用眼科組成物
EP2735303A1 (en) * 2012-11-23 2014-05-28 Pilosciences Hair growth compositions and methods

Also Published As

Publication number Publication date
JP5969872B2 (ja) 2016-08-17
CN103826642A (zh) 2014-05-28
JP2013082696A (ja) 2013-05-09
WO2013047567A1 (ja) 2013-04-04
TWI561238B (en) 2016-12-11
IN2014DN03350A (https=) 2015-06-05
SG10201602401PA (en) 2016-04-28
TW201318628A (zh) 2013-05-16
SG11201400947XA (en) 2014-07-30
CN103826642B (zh) 2016-02-17
PH12014500660A1 (en) 2014-05-05
MY185239A (en) 2021-04-30

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PA0105 International application

Patent event date: 20140414

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20170925

Comment text: Request for Examination of Application

PC1202 Submission of document of withdrawal before decision of registration

Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment)

Patent event code: PC12021R01D

Patent event date: 20180105

WITB Written withdrawal of application