KR20140060263A - 비드-기반 면역분석 내에서 사용하기 위한 미소유체 디스크 - Google Patents

비드-기반 면역분석 내에서 사용하기 위한 미소유체 디스크 Download PDF

Info

Publication number
KR20140060263A
KR20140060263A KR1020137033623A KR20137033623A KR20140060263A KR 20140060263 A KR20140060263 A KR 20140060263A KR 1020137033623 A KR1020137033623 A KR 1020137033623A KR 20137033623 A KR20137033623 A KR 20137033623A KR 20140060263 A KR20140060263 A KR 20140060263A
Authority
KR
South Korea
Prior art keywords
channel
flow
beads
particle
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020137033623A
Other languages
English (en)
Korean (ko)
Inventor
그렉 켈로그
제리 오브라이언
에오인 오누올라인
다미안 컬틴
Original Assignee
라디센스 다이어그나스틱스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 라디센스 다이어그나스틱스 리미티드 filed Critical 라디센스 다이어그나스틱스 리미티드
Publication of KR20140060263A publication Critical patent/KR20140060263A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
KR1020137033623A 2011-06-03 2012-06-05 비드-기반 면역분석 내에서 사용하기 위한 미소유체 디스크 Ceased KR20140060263A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161493234P 2011-06-03 2011-06-03
EP11168702.6 2011-06-03
EP11168702 2011-06-03
US61/493,234 2011-06-03
PCT/IE2012/000026 WO2012164552A1 (en) 2011-06-03 2012-06-05 Microfluidic disc for use in with bead-based immunoassays

Publications (1)

Publication Number Publication Date
KR20140060263A true KR20140060263A (ko) 2014-05-19

Family

ID=47258481

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137033623A Ceased KR20140060263A (ko) 2011-06-03 2012-06-05 비드-기반 면역분석 내에서 사용하기 위한 미소유체 디스크

Country Status (5)

Country Link
US (1) US9897596B2 (https=)
EP (1) EP2715357B1 (https=)
JP (1) JP6200419B2 (https=)
KR (1) KR20140060263A (https=)
WO (1) WO2012164552A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019098532A1 (ko) * 2017-11-17 2019-05-23 주식회사 엘지화학 고상 추출용 마이크로 디바이스
US11260319B2 (en) 2018-08-21 2022-03-01 Lg Chem, Ltd. Solid phase extraction method using micro device

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105008895B (zh) 2012-10-15 2019-02-15 纳诺赛莱克特生物医药股份有限公司 颗粒分选的系统、设备和方法
US10197480B2 (en) 2012-11-07 2019-02-05 Sandstone Diagnostics, Inc. Methods and devices for processing samples and counting cells
JP6590697B2 (ja) 2012-11-07 2019-10-16 サンドストーン ダイアグノスティックス インコーポレイテッドＳａｎｄｓｔｏｎｅ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． サンプル処理及び細胞計数のための方法及びデバイス
US10130947B2 (en) * 2012-12-05 2018-11-20 Radisens Diagnostics Limited Valving system for use in centrifugal microfluidic platforms
US10888862B2 (en) 2012-12-05 2021-01-12 Radisens Diagnostics Limited Acceleration-primed valving system for centrifugal microfluidics
US10376877B2 (en) 2013-02-07 2019-08-13 Sandstone Diagnostics, Inc. Automated sample processing, fluid distribution, and sedimentation assay
WO2015172255A1 (en) 2014-05-16 2015-11-19 Qvella Corporation Apparatus, system and method for performing automated centrifugal separation
US10539582B2 (en) 2014-06-30 2020-01-21 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles
WO2016002727A1 (ja) 2014-06-30 2016-01-07 パナソニックヘルスケアホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
JP6588910B2 (ja) * 2014-06-30 2019-10-09 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
EP3163306A4 (en) * 2014-06-30 2018-01-24 Panasonic Healthcare Holdings Co., Ltd. Substrate for sample analysis, and sample analysis apparatus
GB2528954B (en) * 2014-08-07 2017-05-24 Clyde Process Ltd Adjustable multi-hole orifice plate in a pneumatic conveying apparatus
US10073091B2 (en) 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral flow assay device
JP6146388B2 (ja) * 2014-09-30 2017-06-14 ブラザー工業株式会社 検査装置及び検査プログラム
JP6660305B2 (ja) 2014-12-12 2020-03-11 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
US11169167B2 (en) 2015-12-24 2021-11-09 Phc Holdings Corporation Sample analysis substrate, sample analysis device, sample analysis system, and program for sample analysis
CN108431610B (zh) * 2015-12-28 2022-04-05 普和希控股公司 试样分析用基板、试样分析装置、试样分析系统和记录介质
US10065187B2 (en) * 2016-02-12 2018-09-04 Schlumberger Technology Corporation Centrifugal platform and device for rapid analysis of oilfield fluids
WO2017161259A1 (en) * 2016-03-17 2017-09-21 Poietai Llc Microfluidic on-chip storage devices
CN107561298B (zh) 2016-06-30 2020-05-05 希森美康株式会社 测定装置以及测定方法
JP6470238B2 (ja) * 2016-06-30 2019-02-13 シスメックス株式会社 測定装置および測定方法
JP6457451B2 (ja) * 2016-06-30 2019-01-23 シスメックス株式会社 検出装置および検出方法
CN107561299B (zh) 2016-06-30 2021-08-31 希森美康株式会社 检测装置以及检测方法
JP6479730B2 (ja) * 2016-06-30 2019-03-06 シスメックス株式会社 化学発光測定装置
US11480525B2 (en) 2016-06-30 2022-10-25 Sysmex Corporation Chemiluminescence measurement apparatus
JP6635897B2 (ja) * 2016-08-30 2020-01-29 シスメックス株式会社 試料分析用カートリッジ及びその製造方法、並びにその利用
TWI655417B (zh) * 2017-05-05 2019-04-01 Feng Chia University 微流體檢驗裝置及其微流體控制方法
JP6435387B1 (ja) * 2017-09-29 2018-12-05 シスメックス株式会社 カートリッジ、検出方法、および検出装置
CN108444760A (zh) * 2018-05-11 2018-08-24 石家庄禾柏生物技术股份有限公司 一种定量式试剂采集光盘
CN109030813A (zh) * 2018-07-19 2018-12-18 东莞东阳光科研发有限公司 一种化学发光免疫检测微流控芯片、检测仪及检测方法
CN110118859B (zh) * 2019-05-27 2024-08-09 东莞东阳光医疗智能器件研发有限公司 一种离心式试剂盘
GB201915499D0 (en) * 2019-10-25 2019-12-11 Radisens Diagnostics Ltd A point-of-care test cartridge
WO2021189054A1 (en) * 2020-03-20 2021-09-23 Orbis Diagnostics Limited Multi-chambered assay devices and associated methods, systems and apparatuses thereof for detection of analytes
CN111205966B (zh) 2020-04-18 2020-07-21 博奥生物集团有限公司 样本提取芯片和生物反应装置
EP4139683A4 (en) * 2020-04-22 2023-09-06 Inanovate, Inc. HIGH-THROUGHPUT SEROLOGICAL ASSAY
TWI777177B (zh) * 2020-06-16 2022-09-11 逢甲大學 離心式純化平台及其使用方法
AU2022245951A1 (en) 2021-03-22 2023-10-05 Unisensor Control device
BE1029227B1 (fr) * 2021-03-22 2022-10-17 Unisensor Dispositif microfluidique rotatif
CN115872017A (zh) * 2022-11-14 2023-03-31 江西省科达动物药业有限公司 一种新型转盘兽药盒贴标机
DE102023101481A1 (de) * 2023-01-20 2024-07-25 Testo bioAnalytics GmbH Zentrifugierbarer Probenträger
WO2025083614A1 (en) * 2023-10-19 2025-04-24 Vital Biosciences Inc. Devices, systems, and methods for optical analysis of biological samples
WO2025141001A1 (en) * 2023-12-28 2025-07-03 Danmarks Tekniske Universitet A method of analyzing a first compound of a fluid sample and an apparatus therefor
WO2025216638A1 (en) * 2024-04-11 2025-10-16 Orbis Diagnostics Limited An assay device and method for performing an assay

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063589A (en) 1997-05-23 2000-05-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
US6632399B1 (en) 1998-05-22 2003-10-14 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays
CA2441206A1 (en) * 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
EP1874677B1 (en) 2005-04-14 2013-03-20 Gyros Patent Ab Microfluidic device with meander
JP2007024851A (ja) * 2005-07-16 2007-02-01 Adobic:Kk 検体分析チップおよび検体分析チップの使用方法
WO2007106013A1 (en) * 2006-03-13 2007-09-20 Gyros Patent Ab Enhanced magnetic particle steering
JP2007330857A (ja) * 2006-06-13 2007-12-27 Matsushita Electric Ind Co Ltd 送液装置及び送液方法
KR101343034B1 (ko) * 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템
JP4869205B2 (ja) * 2007-10-23 2012-02-08 シャープ株式会社 マイクロ流体デバイス及びマイクロ流体デバイス装置
EP2309266A1 (en) * 2009-09-21 2011-04-13 F. Hoffmann-La Roche AG Method for carrying out reactions in an analytical device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019098532A1 (ko) * 2017-11-17 2019-05-23 주식회사 엘지화학 고상 추출용 마이크로 디바이스
KR20190056500A (ko) * 2017-11-17 2019-05-27 주식회사 엘지화학 고상 추출용 마이크로 디바이스
US11065557B2 (en) 2017-11-17 2021-07-20 Lg Chem, Ltd. Micro device for solid phase extraction
US11260319B2 (en) 2018-08-21 2022-03-01 Lg Chem, Ltd. Solid phase extraction method using micro device

Also Published As

Publication number Publication date
EP2715357A1 (en) 2014-04-09
JP6200419B2 (ja) 2017-09-20
JP2014518374A (ja) 2014-07-28
WO2012164552A1 (en) 2012-12-06
US9897596B2 (en) 2018-02-20
EP2715357B1 (en) 2015-11-04
US20140242721A1 (en) 2014-08-28

Similar Documents

Publication Publication Date Title
EP2715357B1 (en) Microfluidic disc for use in with bead-based immunoassays
CN102695561B (zh) 样品处理盒以及在离心力下处理和/或分析样品的方法
JP4707035B2 (ja) マイクロ流体装置における混合
KR101722548B1 (ko) 원심력기반의 미세유동장치 및 이를 이용한 유체시료 내 분석대상물질 검출방법
Al-Faqheri et al. Particle/cell separation on microfluidic platforms based on centrifugation effect: A review
EP2309266A1 (en) Method for carrying out reactions in an analytical device
US9186668B1 (en) Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
JP2007502979A5 (https=)
EP2285491A1 (en) Flow control in microfluidic systems
JP2007520693A (ja) 被検体物のマイクロ流体デバイスへの取り込みならびに収納の方法および装置
WO2006076567A2 (en) Microfluidic rare cell detection device
JP2003510554A (ja) 複数の分析物の拡散に基づく化学センサ
CN119608256B (zh) 微流控芯片的检测方法及血浆分离导流一体式微流控芯片
Madadi et al. Separation of human granulocytes and mononuclear cells from whole blood using percoll on a centrifugal microfluidic disc
US20060204403A1 (en) Micro-fluidic fluid separation device and method
CN116855360A (zh) 一种全自动离心微流控芯片及其制备方法
CN116440971B (zh) 一种基于微流控的微型离心装置及应用
Weigl et al. Standard and high-throughput microfluidic disposables based on laminar fluid diffusion interfaces
HK1176329A (en) Sample processing cartridge and method of processing and/or analysing a sample under centrifugal force
Bessler et al. Journal of the Association for Laboratory

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20131218

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20170605

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20181121

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20190201

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20181121

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I