KR20140052992A - 뇌혈류에 영향을 미치는 뇌손상 후 결과를 개선시키기 위한 뇌실내 약물 전달 시스템 - Google Patents

뇌혈류에 영향을 미치는 뇌손상 후 결과를 개선시키기 위한 뇌실내 약물 전달 시스템 Download PDF

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KR20140052992A
KR20140052992A KR1020137029330A KR20137029330A KR20140052992A KR 20140052992 A KR20140052992 A KR 20140052992A KR 1020137029330 A KR1020137029330 A KR 1020137029330A KR 20137029330 A KR20137029330 A KR 20137029330A KR 20140052992 A KR20140052992 A KR 20140052992A
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therapeutic agent
calcium channel
cerebral
ventricle
pyrimidine
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Korean (ko)
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알. 로치 맥도날드
브라이언 에이. 레트너
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에쥐 세라피틱스, 인코포레이티드
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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KR1020137029330A 2011-04-05 2012-04-05 뇌혈류에 영향을 미치는 뇌손상 후 결과를 개선시키기 위한 뇌실내 약물 전달 시스템 Ceased KR20140052992A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161471779P 2011-04-05 2011-04-05
US61/471,779 2011-04-05
PCT/US2012/032317 WO2012138854A1 (en) 2011-04-05 2012-04-05 Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow

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KR20140052992A true KR20140052992A (ko) 2014-05-07

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US (2) US9364432B2 (enExample)
EP (1) EP2694133B1 (enExample)
JP (2) JP6336899B2 (enExample)
KR (1) KR20140052992A (enExample)
CN (1) CN103517726B (enExample)
AU (1) AU2012240131B2 (enExample)
CA (1) CA2832501A1 (enExample)
GB (1) GB2513675A (enExample)
HK (1) HK1198933A1 (enExample)
IL (1) IL228539B (enExample)
RU (2) RU2606169C2 (enExample)
SG (2) SG10201602665UA (enExample)
WO (1) WO2012138854A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10092524B2 (en) * 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
SG10201602665UA (en) * 2011-04-05 2016-05-30 Edge Therapeutics Intraventricular Drug Delivery System For Improving Outcome After A Brain Injury Affecting Cerebral Blood Flow
US9399019B2 (en) 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
EP3682912B1 (en) * 2012-08-17 2025-11-26 AMSilk GmbH Use of self-assembling polypeptides as tissue adhesives
CN103211812A (zh) * 2013-04-02 2013-07-24 苏州大学附属第一医院 Skf96365在治疗蛛网膜下腔出血后发生的脑血管痉挛的应用
BR112019005433B1 (pt) 2016-09-20 2023-04-04 Bracco Diagnostics Inc Sistemas e técnicas para gerar, infundir e controlar distribuição de radioisótopo
US10646227B2 (en) 2016-12-29 2020-05-12 Cerepeutics, LLC Systems and methods for acute treatment to limit intracerebral hemorrhage growth
WO2019018306A1 (en) * 2017-07-17 2019-01-24 Edge Therapeutics, Inc. ADVANCED MICROPARTICULAR FORMULATIONS CONTAINING FORM 2 OF MICRONIZED POLYMORPHIC NIMODIPINE
US20190060109A1 (en) * 2017-08-31 2019-02-28 Gregory Todd Johnson Method of Preventing Traumatic Brain Injury (TBI)
EP3776598B1 (en) 2018-03-28 2022-05-04 Bracco Diagnostics Inc. Systems and techniques for calibrating radioisotope delivery systems with a gamma detector
CN112106148B (zh) 2018-03-28 2024-10-29 布拉科诊断公司 放射性同位素发生器寿命的早期检测
US12016774B2 (en) 2020-05-08 2024-06-25 Medtronic Vascular, Inc. Delivery system for prosthetic valve device having controlled release of inflow and outflow ends
RU2763254C1 (ru) * 2020-08-31 2021-12-28 Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ФГБОУ ВО ВолгГМУ МЗ РФ Способ лечения церебрального вазоспазма при аневризматическом субарахноидальном кровоизлиянии
US11992642B2 (en) 2020-10-30 2024-05-28 Medtronic, Inc. Implantable medical device for delivery of pharmacological agents to the deep brain structures
US11745003B2 (en) 2020-10-30 2023-09-05 Medtronic, Inc. Implantable access port with one-directional filter
US11931545B2 (en) 2020-10-30 2024-03-19 Medtronic, Inc. Drug infusion port
US12226609B2 (en) 2020-12-16 2025-02-18 Medtronic, Inc. Method to detect inadvertent delivery of drug to a subcutaneous pocket

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040105888A1 (en) * 2002-11-26 2004-06-03 Daniel Pratt Buoyant polymer particles for delivery of therapeutic agents to the central nervous system
US20080287879A1 (en) * 2007-05-16 2008-11-20 Harkins Jr Thomas John system and method for treating erectile dysfunction
JP2009067771A (ja) * 2008-05-27 2009-04-02 Pacira Pharmaceuticals Inc 神経学的疾患の治療方法
JP2010529205A (ja) * 2007-06-11 2010-08-26 アール ロッチ マクドナルド 脳血管れん縮の予防用薬物送達システム

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757128A (en) 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
ATE133087T1 (de) 1989-05-04 1996-02-15 Southern Res Inst Einkapselungsverfahren
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
EP0740791A4 (en) 1994-01-05 2000-04-05 Arqule Inc SYSTEMATIC MODULAR PRODUCTION OF AMINIMID AND OXAZOLONE-BASED MOLECULES WITH SELECTED PROPERTIES
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US5968542A (en) 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
AT404429B (de) 1995-06-09 1998-11-25 Immuno Ag Anti-plasma-antikörper-präparation
JP2909418B2 (ja) 1995-09-18 1999-06-23 株式会社資生堂 薬物の遅延放出型マイクロスフイア
EP0932399B1 (en) 1996-03-12 2006-01-04 PG-TXL Company, L.P. Water soluble paclitaxel prodrugs
WO1998027963A2 (en) * 1996-12-20 1998-07-02 Alza Corporation Gel composition and methods
US6123956A (en) * 1997-07-10 2000-09-26 Keith Baker Methods for universally distributing therapeutic agents to the brain
WO1999018949A1 (en) * 1997-10-15 1999-04-22 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
JP2000070366A (ja) * 1998-09-02 2000-03-07 Arute:Kk 容器兼用注射器及び容器兼用注射器への凍結乾燥製剤の封入方法
CA2396016A1 (en) * 1999-12-29 2001-07-05 Andy Bernhardt System for reconstituting pastes and methods of using same
EP1250166B1 (en) 2000-01-25 2010-03-17 Edwards Lifesciences Corporation Delivery systems for treatment of restenosis and anastomotic intimal hyperplasia
AU2002335658A1 (en) * 2001-08-31 2003-03-18 Neuron Therapeutics, Inc. Treatment of neurologic hemorrhage
US20040235801A1 (en) 2001-10-25 2004-11-25 Jean-Pierre Julien Therapy for stroke
EP1459727B1 (en) 2001-11-22 2010-06-09 Japan Science and Technology Agency Nonhuman model animal unresponsive to immunopotentiating synthetic compound
JP2005524657A (ja) 2002-02-27 2005-08-18 ファーメイン, エルティーディー. 治療剤及び他の物質を送達するための組成物、及び、前記組成物を作製し使用する方法
TW200307011A (en) * 2002-04-18 2003-12-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modifier
CN1665925A (zh) 2002-04-30 2005-09-07 马克西根控股公司 凝血因子Ⅶ或Ⅶa多肽变体
CN1671400A (zh) 2002-07-03 2005-09-21 派瑞克科学公司 透明质酸组合物以及使用方法
DK1553927T3 (da) 2002-09-11 2011-01-31 Elan Pharma Int Ltd Gel-stabiliserede, nanopartikulære aktivstof-sammensætninger
JP4092994B2 (ja) * 2002-09-13 2008-05-28 ニプロ株式会社 プレフィルドシリンジキット
US20070207211A1 (en) 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
JP2007515392A (ja) 2003-04-10 2007-06-14 ピーアール ファーマシューティカルズ,インコーポレイテッド エマルジョンベースの微粒子の製造のための方法
CA2533592C (en) 2003-07-23 2015-11-10 Pr Pharmaceuticals, Inc. Controlled release compositions
US9149440B2 (en) * 2003-09-02 2015-10-06 University Of South Florida Nanoparticles for drug-delivery
WO2006002365A2 (en) * 2004-06-24 2006-01-05 Angiotech International Ag Microparticles with high loadings of a bioactive agent
US20060205733A1 (en) 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
US8034762B2 (en) * 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
WO2006084005A2 (en) 2005-02-02 2006-08-10 University Of Vermont And State Agricultural College Emergence of a r-type ca2+channel(cav2.3) contributes to cerebral artery constriction following subarachnoid hemorrhage
EP2500031A3 (en) 2005-02-24 2012-12-26 Joslin Diabetes Center, Inc. Compositions and Methods for Treating Vascular Permeability
US20060217340A1 (en) 2005-03-23 2006-09-28 University Of Vermont And State Agricultural College Methods and products for treating hypertension by modulation of TRPC3 channel activity
EP1865924B1 (en) * 2005-03-31 2015-12-09 Lidds Ab Method for treating prostate diseases based on local delivery of active substances
EP1893230A2 (en) 2005-04-26 2008-03-05 Maxygen Holdings Ltd. Use of modified factor vii for treating bleeding
EP1883465B1 (fr) * 2005-05-24 2010-01-20 Utéron Pharma S.A. Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses et procede
WO2006133045A1 (en) * 2005-06-03 2006-12-14 Elan Pharma International, Limited Nanoparticulate benidipine compositions
JP2009501188A (ja) 2005-07-15 2009-01-15 ノボ ノルディスク ヘルス ケア アーゲー 抗血小板療法で治療される患者における脳内出血(ICH)後の出血増大及び/又は浮腫形成を予防又は軽減するための第VIIa因子又は第VIIa因子等価物の使用
JP2009516751A (ja) * 2005-11-21 2009-04-23 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティー・オブ・アラバマ・フォー・アンド・オン・ビハーフ・オブ・ザ・ユニバーシティー・オブ・アラバマ 神経保護のための小分子化合物を使用する方法
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
JP5502751B2 (ja) 2007-12-20 2014-05-28 エボニック コーポレイション 低残留溶媒濃度を有する微粒子を調製するためのプロセス
US20100008968A1 (en) 2008-06-26 2010-01-14 Lampe John W Method for treating cardiovascular diseases using rho kinase inhibitor compounds
EP2331082B1 (en) 2008-09-11 2021-01-06 Evonik Corporation Solvent extraction microencapsulation with tunable extraction rates
EP2334288B1 (en) 2008-09-18 2021-05-19 Evonik Corporation Microencapsulation process with solvent and salt
US20100216948A1 (en) 2009-01-23 2010-08-26 Tipton Arthur J Polymer mixtures comprising polymers having different non-repeating units and methods for making and using same
US20130059008A1 (en) 2009-01-23 2013-03-07 Jeffrey L. Atkinson Drying methods for tuning microparticle properties
WO2010085609A2 (en) 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Controlled release systems from polymer blends
US20100291027A1 (en) 2009-05-14 2010-11-18 Jason Campbell Hyaluronic acid (ha) injection vehicle
US20110033463A1 (en) * 2009-08-06 2011-02-10 Medtronic, Inc. Apheresis, administration of agent, or combination thereof
WO2011087689A2 (en) 2009-12-22 2011-07-21 Surmodics Pharmaceuticals,Inc. Emulsion-based process for preparing microparticles and workhead assembly for use with same
GB2490084A (en) 2010-02-22 2012-10-17 Edge Therapeutics Inc Methods and compositions to treat hemorrhagic conditions of the brain
US9504643B2 (en) 2010-03-29 2016-11-29 Evonik Corporation Compositions and methods for improved retention of a pharmaceutical composition at a local administration site
JP5900805B2 (ja) * 2011-01-27 2016-04-06 エルジー・ケム・リミテッド 間隙充填用スウェリングテープ
SG10201602665UA (en) * 2011-04-05 2016-05-30 Edge Therapeutics Intraventricular Drug Delivery System For Improving Outcome After A Brain Injury Affecting Cerebral Blood Flow

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040105888A1 (en) * 2002-11-26 2004-06-03 Daniel Pratt Buoyant polymer particles for delivery of therapeutic agents to the central nervous system
US20080287879A1 (en) * 2007-05-16 2008-11-20 Harkins Jr Thomas John system and method for treating erectile dysfunction
JP2010529205A (ja) * 2007-06-11 2010-08-26 アール ロッチ マクドナルド 脳血管れん縮の予防用薬物送達システム
JP2009067771A (ja) * 2008-05-27 2009-04-02 Pacira Pharmaceuticals Inc 神経学的疾患の治療方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
일본 공표특허공보 특표2010-529205호(2010.08.26.) 1부. *

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