KR20140043934A - Ｆｃ-융합 단백질의 정제 방법 - Google Patents
Ｆｃ-융합 단백질의 정제 방법 Download PDFInfo
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- KR20140043934A KR20140043934A KR1020147002981A KR20147002981A KR20140043934A KR 20140043934 A KR20140043934 A KR 20140043934A KR 1020147002981 A KR1020147002981 A KR 1020147002981A KR 20147002981 A KR20147002981 A KR 20147002981A KR 20140043934 A KR20140043934 A KR 20140043934A
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- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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| KR20140043934A true KR20140043934A (ko) | 2014-04-11 |
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| DK (1) | DK2729482T3 (enExample) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20150056601A (ko) * | 2012-09-11 | 2015-05-26 | 코히러스 바이오사이언시즈, 인코포레이티드 | 고순도 및 탁월한 수율의 정확하게 폴딩된 에타너셉트 |
| WO2016108569A1 (ko) * | 2014-12-31 | 2016-07-07 | 주식회사 엘지생명과학 | 목적하는 함량으로 불순물을 포함하는 tnfr-fc 융합 단백질의 제조방법 |
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| BR112014009031A2 (pt) | 2011-10-18 | 2017-05-09 | Coherus Biosciences Inc | formulações de etanercept estabilizadas com íons de metais |
| EP3395423B1 (en) | 2013-03-14 | 2023-09-20 | Amgen Inc. | Removal of leaked affinity purification ligand |
| SG11201507875RA (en) * | 2013-03-26 | 2015-10-29 | Coherus Biosciences Inc | Protein production method |
| KR102382402B1 (ko) | 2014-02-04 | 2022-04-01 | 바이오젠 엠에이 인코포레이티드 | 번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도 |
| US11389783B2 (en) | 2014-05-02 | 2022-07-19 | W.R. Grace & Co.-Conn. | Functionalized support material and methods of making and using functionalized support material |
| MX383879B (es) | 2014-05-13 | 2025-03-14 | Amgen Inc | Sistema y métodos de control del proceso para usar con filtros y procesos de filtración. |
| BR112016029157A8 (pt) | 2014-06-13 | 2021-07-06 | Lupin Ltd | processo para purificar a proteína de fusão tnfr:fc |
| FR3025515B1 (fr) * | 2014-09-05 | 2016-09-09 | Lab Francais Du Fractionnement | Procede de purification d'un anticorps monoclonal |
| WO2016065273A1 (en) * | 2014-10-24 | 2016-04-28 | The University Of Chicago | Heat-inducible self-assembling protein domains |
| US20160130324A1 (en) | 2014-10-31 | 2016-05-12 | Shire Human Genetic Therapies, Inc. | C1 Inhibitor Fusion Proteins and Uses Thereof |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| PL3302784T3 (pl) * | 2015-06-05 | 2022-01-17 | W.R. Grace & Co.-Conn. | Adsorbentowe środki klarujące do bioprzetwarzania oraz sposoby ich wytwarzania i stosowania |
| CN108138147B (zh) | 2015-09-22 | 2022-11-01 | 豪夫迈·罗氏有限公司 | 含Fc蛋白的表达 |
| US20170101435A1 (en) * | 2015-10-13 | 2017-04-13 | Therapeutic Proteins International, LLC | Harvesting and perfusion apparatus |
| WO2017087882A1 (en) | 2015-11-19 | 2017-05-26 | Shire Human Genetic Therapies, Inc. | Recombinant human c1 esterase inhibitor and uses thereof |
| US11708390B2 (en) | 2016-05-11 | 2023-07-25 | Cytiva Bioprocess R&D Ab | Method of storing a separation matrix |
| EP3455243B1 (en) | 2016-05-11 | 2021-03-24 | Cytiva BioProcess R&D AB | Separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| ES2909833T3 (es) | 2016-05-11 | 2022-05-10 | Cytiva Bioprocess R & D Ab | Método de limpieza y/o desinfección de una matriz de separación |
| IL285146B (en) * | 2016-07-22 | 2022-09-01 | Amgen Inc | Methods for purifying proteins involving fc |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| CN109929027B (zh) * | 2017-12-15 | 2020-10-09 | 山东博安生物技术有限公司 | 采用线性洗脱步骤的重组融合蛋白纯化方法 |
| CN109929038B (zh) * | 2017-12-15 | 2020-10-09 | 山东博安生物技术有限公司 | Vegf捕获剂融合蛋白的纯化方法 |
| US12233356B2 (en) * | 2019-03-21 | 2025-02-25 | Lonza Sales Ag | Process for preparing extracellular vesicles |
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2012
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- 2012-07-03 EP EP12811874.2A patent/EP2729482B1/en not_active Not-in-force
- 2012-07-03 BR BR112014000352A patent/BR112014000352A2/pt not_active IP Right Cessation
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2017
- 2017-07-14 AU AU2017204893A patent/AU2017204893A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150056601A (ko) * | 2012-09-11 | 2015-05-26 | 코히러스 바이오사이언시즈, 인코포레이티드 | 고순도 및 탁월한 수율의 정확하게 폴딩된 에타너셉트 |
| WO2016108569A1 (ko) * | 2014-12-31 | 2016-07-07 | 주식회사 엘지생명과학 | 목적하는 함량으로 불순물을 포함하는 tnfr-fc 융합 단백질의 제조방법 |
| US10988527B2 (en) | 2014-12-31 | 2021-04-27 | Lg Chem, Ltd. | Method for preparing TNFR-Fc fusion protein containing target content of impurities |
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| US20140187751A1 (en) | 2014-07-03 |
| US9556258B2 (en) | 2017-01-31 |
| CA2840951A1 (en) | 2013-01-17 |
| WO2013009526A1 (en) | 2013-01-17 |
| EP2729482A1 (en) | 2014-05-14 |
| CN103814044A (zh) | 2014-05-21 |
| JP2014520814A (ja) | 2014-08-25 |
| EP2729482B1 (en) | 2018-03-07 |
| JP6280499B2 (ja) | 2018-02-14 |
| AU2012282960A1 (en) | 2014-01-16 |
| EP2729482A4 (en) | 2015-02-25 |
| DK2729482T3 (en) | 2018-05-07 |
| AU2017204893A1 (en) | 2017-08-03 |
| BR112014000352A2 (pt) | 2017-02-14 |
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