KR20140015157A - Ａｋｔ 활성 억제제 - Google Patents

Ａｋｔ 활성 억제제 Download PDF

Info

Publication number
KR20140015157A
KR20140015157A KR1020127019033A KR20127019033A KR20140015157A KR 20140015157 A KR20140015157 A KR 20140015157A KR 1020127019033 A KR1020127019033 A KR 1020127019033A KR 20127019033 A KR20127019033 A KR 20127019033A KR 20140015157 A KR20140015157 A KR 20140015157A
Authority
KR
South Korea
Prior art keywords
phenyl
pyrido
oxazin
aminocyclobutyl
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020127019033A
Other languages
English (en)
Korean (ko)
Inventor
리신 장
그레이엄 피터 트레비트
휴즈 미엘
프랑크 버캄프
티모시 해리슨
앤드류 존 윌킨슨
찰스-헨리 파브리티우스
Original Assignee
알막 디스커버리 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알막 디스커버리 리미티드 filed Critical 알막 디스커버리 리미티드
Publication of KR20140015157A publication Critical patent/KR20140015157A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127019033A 2009-12-23 2010-12-23 Ａｋｔ 활성 억제제 Ceased KR20140015157A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0922589.7A GB0922589D0 (en) 2009-12-23 2009-12-23 Pharmaceutical compounds
GB0922589.7 2009-12-23
PCT/GB2010/002329 WO2011077098A1 (en) 2009-12-23 2010-12-23 Inhibitors of akt activity

Publications (1)

Publication Number Publication Date
KR20140015157A true KR20140015157A (ko) 2014-02-06

Family

ID=41716932

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127019033A Ceased KR20140015157A (ko) 2009-12-23 2010-12-23 Ａｋｔ 활성 억제제

Country Status (21)

Country Link
US (1) US9221838B2 (https=)
EP (1) EP2516435B8 (https=)
JP (1) JP5923043B2 (https=)
KR (1) KR20140015157A (https=)
CN (1) CN102791708B (https=)
AU (1) AU2010334591C1 (https=)
BR (1) BR112012015677A2 (https=)
CA (1) CA2783340C (https=)
CY (1) CY1115686T1 (https=)
DK (1) DK2516435T3 (https=)
ES (1) ES2503794T3 (https=)
GB (1) GB0922589D0 (https=)
IL (1) IL220153A (https=)
MX (1) MX2012007274A (https=)
NZ (1) NZ600453A (https=)
PL (1) PL2516435T3 (https=)
PT (1) PT2516435E (https=)
RU (1) RU2579513C2 (https=)
SG (1) SG181517A1 (https=)
SI (1) SI2516435T1 (https=)
WO (1) WO2011077098A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201205164D0 (en) * 2012-03-23 2012-05-09 Almac Discovery Ltd Pharmaceutical compounds
JP6787899B2 (ja) * 2014-12-23 2020-11-18 ベルゲンビオ アーエスアー 医薬的活性化合物
US10323044B2 (en) * 2015-02-27 2019-06-18 Taiho Pharmaceutical Co., Ltd. Crystal of imidazo-oxazine, pharmaceutical composition containing said crystal, and method for producing said crystal
GB201603779D0 (en) 2016-03-04 2016-04-20 Mission Therapeutics Ltd Novel compounds
MA45865A (fr) * 2016-08-07 2021-04-14 Wistar Inst Procédés de détection et de traitement d'une tumeur exprimant pt346 pdk1
UA125730C2 (uk) * 2017-06-22 2022-05-25 Курадев Фарма Лімітед Низькомолекулярні модулятори sting людини
MX2020002611A (es) 2017-09-07 2020-07-13 Univ Res Inst Inc Augusta Activador especifico de akt3 y usos del mismo.
GB2600384A (en) * 2020-09-30 2022-05-04 Vaderis Therapeutics Ag Allosteric AKT inhibitors for use in the treatment of hereditary hemorrhagic telangiectasia
WO2025250545A1 (en) * 2024-05-28 2025-12-04 Alterome Therapeutics, Inc. Akt1 modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL181893B1 (pl) * 1994-11-14 2001-10-31 Warner Lambert Co Zwiazki bedace pochodnymi pirymidyny i naftyrydyny oraz preparat farmaceutyczny zawierajacy je PL PL PL
TWI301760B (en) * 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
US7910561B2 (en) * 2004-12-15 2011-03-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
EP1898903B8 (en) * 2005-06-10 2013-05-15 Merck Sharp & Dohme Corp. Inhibitors of akt activity
WO2008011032A1 (en) * 2006-07-17 2008-01-24 Amgen Inc. Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors
JP2010512312A (ja) 2006-12-06 2010-04-22 メルク エンド カムパニー インコーポレーテッド Ａｋｔ活性の阻害剤
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
US7999107B2 (en) * 2007-01-31 2011-08-16 Merck Sharp & Dohme Corp. Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
JP2011522048A (ja) * 2008-06-03 2011-07-28 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
US8536193B2 (en) 2008-06-03 2013-09-17 Merck Sharp & Dohme Corp. Inhibitors of AKT activity

Also Published As

Publication number Publication date
JP5923043B2 (ja) 2016-05-24
SI2516435T1 (sl) 2014-12-31
RU2579513C2 (ru) 2016-04-10
ES2503794T3 (es) 2014-10-07
PL2516435T3 (pl) 2015-01-30
MX2012007274A (es) 2012-10-03
AU2010334591B2 (en) 2014-04-10
GB0922589D0 (en) 2010-02-10
EP2516435B8 (en) 2014-10-15
AU2010334591C1 (en) 2014-07-31
IL220153A0 (en) 2012-07-31
BR112012015677A2 (pt) 2015-06-30
DK2516435T3 (da) 2014-10-13
EP2516435A1 (en) 2012-10-31
US9221838B2 (en) 2015-12-29
RU2012131115A (ru) 2014-01-27
HK1171013A1 (en) 2013-03-15
JP2013515710A (ja) 2013-05-09
US20130116243A1 (en) 2013-05-09
EP2516435B1 (en) 2014-08-06
CN102791708A (zh) 2012-11-21
IL220153A (en) 2015-05-31
NZ600453A (en) 2013-10-25
CA2783340C (en) 2015-11-24
CA2783340A1 (en) 2011-06-30
WO2011077098A1 (en) 2011-06-30
CY1115686T1 (el) 2017-01-25
WO2011077098A9 (en) 2012-04-19
CN102791708B (zh) 2016-03-02
AU2010334591A1 (en) 2012-06-21
PT2516435E (pt) 2014-11-13
SG181517A1 (en) 2012-07-30

Similar Documents

Publication Publication Date Title
AU2010334591B2 (en) Inhibitors of AKT activity
CA3210332A1 (en) Tricyclic-amido-bicyclic prmt5 inhibitors
US8546376B2 (en) Pharmaceutical compounds
US20120309739A1 (en) Akt / pkb inhibitors
WO2012019426A1 (zh) 酞嗪酮类衍生物、其制备方法及其在医药上的应用
BRPI0708615A2 (pt) compostos de pirazol heterobicìclicos e métodos de uso
EP2945939A1 (en) Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
CA3085460A1 (en) Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors
KR20160086930A (ko) 피롤로피롤론 유도체 및 bet 억제제로서의 그의 용도
RS66947B1 (sr) Jedinjenje inhibitora više kinaza, i njegova kristalna forma i upotreba
EP4055013A1 (en) Wdr5 inhibitors and modulators
CN110872296A (zh) 一种二氢异吲哚-1H-吡唑并[3,4-d]嘧啶酮化合物、其制备方法和应用
KR20140139023A (ko) 암을 치료하기 위한 6-(4-(1-아미노-3-하이드록시사이클로부틸)페닐)-5-페닐(퓨로, 싸이에노 또는 피롤로)[2,3-d]피리미딘-4-온 유도체
CN108699065A (zh) 作为激酶抑制剂的三环类化合物和组合物
WO2023168378A1 (en) Pi3ka inhibitors
EP4441034A1 (en) Fused pyrazole urea analogs as glucosylceramide synthase inhibitors
HK1171013B (en) Inhibitors of akt activity

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20120719

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20151217

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20170330

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20170621

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20170330

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I